Enriched GO by DAVID

The GO-enriched analysis was done by DAVID using 1239 MDD related genes from literature. GO terms with FDR < 0.05 were shown.

Biological Process (count: 355)
Cellular Component (count: 54)
Molecular Function (count: 29)

Biological Process (count: 355)

GO ID	Name	%	P-value	Fold Enrichment	FDR	Genes
GO:0007610	behavior	0.882089449	1.52E-38	3.550073807	2.83E-35	128 genes "SNCG HRAS SLC6A1 PTGS2 ADCY8 HMGCR WFS1 GRIK2 SLC6A3 IL18 CRHBP SNCA PGLYRP1 RPS6KB1 CNP GDNF CALB1 IL10 PRKAR2B HTR1B APP BDNF HTR1A GRIN2B IFNG GALR2 RALA IL1B ROBO2 CHRNA7 CHAT PLD1 GRIN2A MAPK1 CCR6 RASGRF1 JUN CSTB DRD1 CCL2 DRD3 DRD2 ENPP2 DRD4 CCL7 HCRTR1 KRAS RAC2 CNR1 KAL1 CNR2 MAOA GRIN1 GABRA5 NR4A2 NPY S100B PENK EPS8 NTRK2 CACNA1C OPRM1 CCKAR HEXA LEPR FOS EDNRB SLC1A2 SLC1A3 SAA1 SEMA3F DLG4 FGF2 EGR1 GABRG2 CCKBR PRKCG FOSB IL6R GAL GRM1 PROK2 GRM2 PSEN1 PTGDS CXCL3 OXT CXCL2 TAC1 OXTR COMT APLP2 AMPH CCL24 NPAS2 NPAS3 CCL20 PDE1B BCL2 AGT PTN ACSL4 SNAP25 FZD9 IL4 GLRB IL6 GNAO1 IL8 CREB3 ATP1A3 TBX1 NPY1R IDO1 ATP1A2 DBH SOD1 STAT3 SOD2 LEP NRAS GRIA1 MAPK14 SLC18A2 CRH USP46 HTR2C HTR2A"
GO:0019226	transmission of nerve impulse	0.751154297	1.87E-38	4.050967033	3.49E-35	109 genes "SLC6A1 SYT4 GABRB2 GRIK2 SLC6A2 SNCA SLC6A4 GRIK5 CNP TGFB1 CTNNB1 HTR1B APP S1PR1 GRIN2B APOE GALR2 GRID2 OLIG2 HTR1D NQO1 CHAT KCND2 GRIN2A LRTOMT PDYN PCLO MAPK1 GABRR1 PMP22 DRD1 ACHE DRD3 DRD2 DRD4 HCRTR1 GAD2 SYPL1 PVRL1 PRIMA1 GAD1 PLAT GABRD GABRA2 GABRA3 MAOA GABRA6 GRIN1 GABRA5 P2RX7 NPY CORT CACNA1C SST HEXA GABBR2 MBP SLC1A4 SLC1A2 SLC1A3 NMUR1 SLC1A6 DLG4 QKI FGF2 USP14 GABRG1 GABRG2 STX1A EGR3 STX1B GRM1 GRM5 GRM3 GRM2 PSEN1 PLLP NCAN RAB3A CPLX1 OXT OXTR TAC1 COMT AMPH HRH1 SYN1 SYN3 SYN2 SNAP25 HTR3B KLK6 DLGAP1 GLRB PLP1 NOS1 NLGN1 MAL ATP1A2 DBH SOD1 SLC17A7 SLC17A6 GRIA2 GRIA1 KCNN3 CRH HTR2C HTR2A"
GO:0007268	synaptic transmission	0.682241059	1.48E-37	4.321347445	2.78E-34	99 genes "SLC6A1 SYT4 GABRB2 GRIK2 SLC6A2 SNCA SLC6A4 GRIK5 CNP CTNNB1 HTR1B APP GRIN2B APOE GALR2 GRID2 HTR1D NQO1 CHAT KCND2 GRIN2A LRTOMT PDYN PCLO MAPK1 GABRR1 PMP22 ACHE DRD1 DRD3 DRD2 DRD4 HCRTR1 GAD2 SYPL1 PVRL1 PRIMA1 GAD1 PLAT GABRD GABRA2 GABRA3 GABRA6 MAOA GRIN1 GABRA5 P2RX7 NPY CORT CACNA1C SST GABBR2 MBP SLC1A4 SLC1A2 SLC1A3 SLC1A6 DLG4 FGF2 USP14 GABRG1 GABRG2 EGR3 STX1A STX1B GRM1 GRM5 GRM3 GRM2 PSEN1 NCAN RAB3A CPLX1 OXT OXTR TAC1 COMT AMPH HRH1 SYN1 SYN3 SYN2 SNAP25 HTR3B GLRB DLGAP1 PLP1 NOS1 NLGN1 ATP1A2 DBH SLC17A7 SLC17A6 GRIA2 GRIA1 KCNN3 CRH HTR2C HTR2A"
GO:0007267	cell-cell signaling	0.978567983	2.52E-35	3.078487179	4.72E-32	142 genes "SLC6A1 SYT4 SLC6A2 GABRB2 GRIK2 IL18 SNCA SLC6A4 EDN1 GRIK5 IL13 CNP IL15 GDNF IL10 CTNNB1 HOXD11 APP HTR1B BDNF GRIN2B APOE GALR2 GRID2 IL1B NQO1 HTR1D CHAT KCND2 GRIN2A LRTOMT PDYN PCLO MAPK1 GABRR1 GPR56 GPR50 PMP22 DRD1 ACHE DRD3 DRD2 DRD4 POMC GREM1 EPHB1 CCL7 ADCYAP1 HCRTR1 GAD2 IL17A SYPL1 PVRL1 INS ADRA2C PRIMA1 GAD1 PLAT GABRD GABRA2 GABRA3 MAOA GABRA6 GRIN1 GABRA5 P2RX7 NPY NTRK2 AREG CACNA1C CORT SST NRP1 FGF9 TOLLIP GABBR2 MBP SLC1A4 SLC1A2 SLC1A3 SLC1A6 DLG4 FGF1 FGF2 LTA USP14 FGF3 GABRG1 GABRG2 STX1A EGR3 AR GAL GRM1 STX1B GRM5 GRM3 GRM2 EREG PSEN1 ADM NCAN RAB3A CPLX1 OXT TAC1 OXTR TSHB COMT AMPH CALCA CCL24 HRH1 SYN1 CCL20 SYN3 AGT SYN2 PTH SNAP25 HTR3B IL3 DLGAP1 GLRB IL6 PLP1 NOS1 IL7 FADS1 NLGN1 ATP1A2 DBH LEP SLC17A7 SLC17A6 GRIA2 GRIA1 KCNN3 CRH HTR2C IL2 HTR2A"
GO:0010033	response to organic substance	1.047481221	8.85E-32	2.742259682	1.66E-28	152 genes "ADCY3 A2M THRA SLC6A1 PTGS2 ADCY7 ADCY8 SLC6A3 SNCA RPS6KB1 GRIN3A TGFB1 IL10 B2M CTNNB1 GOT2 PRKAR2B HTR1B GSTM3 APOA2 PRKAR2A GRIN2B CD44 APOE IFNG IL1B CHRNA7 PRKACA PRKACB GNG3 PLD1 GATM CRYAB RXRA GRIN2A MAPK1 UCN3 GLUL EP300 THBD JUN RYR2 AMFR COL1A1 DRD1 CYP1B1 CCL2 DRD3 ERBB3 DRD2 ALDOC DRD4 BDKRB1 ADRBK1 BCL2L1 HSPA1L KRAS INS AANAT CFB GRIN1 NR4A2 ABCG1 ABCB4 HDAC5 GH1 P2RX7 HDAC2 EPS8 NUP62 PRKAR1A FABP3 TGFBR3 PTPN1 MTOR HSPD1 BMP7 SST HSP90AB1 KYNU IGFBP7 LEPR DICER1 PRDX2 FOS SLC1A2 TNFRSF11B GSN NOS3 LTA HSP90AA2 EGR1 IRAK2 AR ESR1 PRKCI IL6R MMP14 GAL PRKCQ GNAL CCND1 GRM2 BTG2 ADM GNB1 IL12A SORT1 GNAS GNB3 TF PRF1 TNF OXT TAC1 OXTR TSHB COMT NR3C1 TNFRSF1A HSPA2 PTK2B BCL2 TOR1A ENO2 NEFL HSPA8 PIK3R1 SELP IL6 GNAO1 MSH2 FADS1 CREB1 BCKDHB MAP1B PDE3A NPY1R IDO1 DBH SOD1 ADIPOQ STAT3 LEP CDH13 DUSP4 MAPK14 SLC18A2 IRF3 IGFBP2 HTR2C TJP2"
GO:0044057	regulation of system process	0.640893116	1.79E-31	3.91493652	3.34E-28	93 genes "SNCG HRAS THRA SLC6A1 PTGS2 GRIK2 GRIK3 EDN1 SNCA RPS6KB1 SDC4 GDNF CALB1 IL10 SYP EDNRB BDNF HTR1B APOA2 APOA1 SLC1A3 NISCH GRIN2B APOE IFNG DLG4 IL1B PRKACA NOS3 NOS2 LTA CHAT EGR1 STX1A GRIN2A GRM1 PROK2 PRKCQ GRM3 ADRB2 ADM PSEN1 RASGRF1 CHRM2 RYR2 NPPB CELF2 CNTN4 SRI TF RAB3A ACHE DRD1 CCL2 TNF DRD3 DRD2 OXT DRD4 OXTR TAC1 ADRBK1 BDKRB2 ANXA6 CALCA ACE KRAS INS AGT CAMK2A PLAT GNAO1 NOS1 MAP1B GRIN1 NLGN1 ATP1A1 ATP1A2 NPY1R DBH SOD1 LEP NRAS GRIA2 SP4 AVPR1B NTRK2 CRH USP46 CACNA1C HTR2C IL2 HTR2A"
GO:0009611	response to wounding	0.826958859	7.02E-28	2.945137881	1.31E-24	120 genes "A2M IL13 RPS6KB1 IL15 TLR7 TGFB1 IL10 FNTB APOA2 DYSF CD44 CD46 SERPINE1 APOH IL1B CFD IL1A INA GATM RXRA GRIN2A SERPING1 F7 THBD F5 CD40LG F2 DSP ACHE CCL2 ERBB3 CLU BDKRB1 BDKRB2 ELK3 CCL7 IL17A FGG IL23A FGB INS CNR2 PLAT PTPN6 CFB HDAC5 P2RX7 CD59 NRP1 TOLLIP CRP PRDX2 NFKB1 GPX1 FOS SLC1A2 SLC1A3 GSN SAA1 ITIH4 NRG1 FGF2 IRAK2 NFKBIZ CHST2 NFAM1 IL6R GAL PROK2 PRKCQ ADM EREG PLA2G7 SERPINB2 PLLP VCAN NGFR CTSB GAP43 AOC3 TF TNF C3 CXCL3 CXCL2 TAC1 DTNBP1 MIF CCL24 TNFRSF1A TNFRSF1B HRH1 MEFV CCL20 BCL2 ENO3 PTX3 NEFL EPO KLK6 SELP IL6 IL5 IL2RA LIPA IL8 MAP1B IL9 IGF1 IDO1 SOD1 STAT3 SOD2 P2RY12 ORM1 PLSCR1 NUPR1 BAX CRH LTA4H"
GO:0009719	response to endogenous stimulus	0.682241059	1.15E-25	3.17965812	2.14E-22	99 genes "ADCY3 A2M THRA ADCY7 PTGS2 SLC6A1 ADCY8 RPS6KB1 IL10 TGFB1 CTNNB1 PRKAR2B PRKAR2A HTR1B APOA2 GSTM3 IL1B PRKACA PRKACB GNG3 PLD1 GATM CRYAB RXRA GRIN2A MAPK1 UCN3 EP300 COL1A1 DRD1 CCL2 DRD3 ERBB3 DRD2 ALDOC DRD4 BCL2L1 KRAS INS AANAT GRIN1 NR4A2 ABCG1 ABCB4 HDAC5 GH1 NUP62 PRKAR1A FABP3 TGFBR3 MTOR PTPN1 BMP7 SST LEPR IGFBP7 FOS SLC1A2 TNFRSF11B NOS3 AR PRKCI ESR1 IL6R MMP14 GAL GNAL PRKCQ CCND1 BTG2 ADM GNB1 SORT1 GNAS GNB3 TNF OXT OXTR TAC1 TSHB PTK2B BCL2 ENO2 NEFL PIK3R1 IL6 GNAO1 MSH2 FADS1 MAP1B BCKDHB NPY1R DBH ADIPOQ STAT3 LEP CDH13 SLC18A2 IGFBP2"
GO:0031644	regulation of neurological system process	0.399696782	2.34E-25	4.931020613	4.38E-22	58 genes "SNCG HRAS SLC6A1 PTGS2 GRIK2 GRIK3 SNCA EDN1 GDNF CALB1 IL10 SYP EDNRB HTR1B BDNF NISCH SLC1A3 GRIN2B APOE IFNG DLG4 PRKACA CHAT LTA EGR1 STX1A GRIN2A GRM1 GRM3 ADRB2 PSEN1 RASGRF1 CNTN4 TF RAB3A DRD1 ACHE TNF CCL2 DRD3 DRD2 OXT DRD4 TAC1 OXTR KRAS AGT CAMK2A PLAT MAP1B GRIN1 NLGN1 NRAS GRIA2 NTRK2 USP46 HTR2C HTR2A"
GO:0043067	regulation of programmed cell death	1.02680725	1.62E-24	2.3868795	3.02E-21	149 genes "HRAS CADM1 PTGS2 WFS1 GRIK2 SNCA GDNF TGFB1 IL10 BTK CITED2 APP BDNF CD44 TIAM1 APOE IFNG GRID2 APOH IL1B RARB MX1 NQO1 IL1A ACTN4 CRYAB DFFA RXRA BCL2A1 GRIN2A F7 MAPK1 RASGRF1 CD40LG JUN VEGFA F2 CSTB RYR2 MAPK8 TNFAIP3 CCL2 ERBB3 CLU BCL2L1 BDKRB2 CALR GCLM PLAGL1 TUBB KRAS INS ALB NPM1 DYRK2 RUNX3 GRIN1 NR4A2 TRIO ATM DLX1 P2RX7 NUP62 HSPD1 BMP7 SST DAP3 PDIA3 PREX1 PRDX2 NFKB1 PAWR GPX1 EDNRB AEN RHOA NOS3 CAT NRG1 FGF2 LTA TERT ARHGEF2 ARHGEF7 CYCS ESR1 PRKCI NDUFA13 IL6R PRKCE GAL PROK2 ADRB2 TNFRSF10B BTG2 PSEN1 CARD16 BTG1 IL12A SERPINB2 SORT1 CTSB NGFR IL12B TNF XIAP TNFRSF25 ZBTB16 NR3C1 MIF BCL2 COMP AGT PTH BCL6 HSPA5 NEFL HSPA9 APC IL4 IL3 IL2RB IL6 IL2RA IL7 MSH2 CREB1 IGF1 MAL PDE3A IDO1 DBH SOD1 YWHAE ADIPOQ SIRT1 SOD2 CDH13 NRAS HSP90B1 NUPR1 PRLR GSK3B EEF1E1 BAX CRH MPO IL2 DNM2"
GO:0042981	regulation of apoptosis	1.019915926	1.71E-24	2.394450823	3.20E-21	148 genes "HRAS CADM1 PTGS2 WFS1 GRIK2 SNCA GDNF TGFB1 IL10 BTK CITED2 APP BDNF CD44 TIAM1 APOE IFNG GRID2 APOH IL1B RARB MX1 NQO1 IL1A ACTN4 CRYAB DFFA RXRA BCL2A1 GRIN2A F7 MAPK1 RASGRF1 CD40LG JUN VEGFA F2 CSTB RYR2 MAPK8 TNFAIP3 CCL2 ERBB3 CLU BCL2L1 BDKRB2 CALR GCLM PLAGL1 TUBB KRAS INS ALB NPM1 DYRK2 RUNX3 GRIN1 NR4A2 TRIO ATM DLX1 P2RX7 NUP62 HSPD1 BMP7 SST DAP3 PDIA3 PREX1 PRDX2 NFKB1 PAWR GPX1 EDNRB AEN RHOA NOS3 CAT NRG1 LTA TERT ARHGEF2 ARHGEF7 CYCS ESR1 PRKCI NDUFA13 IL6R PRKCE GAL PROK2 ADRB2 TNFRSF10B BTG2 PSEN1 CARD16 BTG1 IL12A SERPINB2 SORT1 CTSB NGFR IL12B TNF XIAP TNFRSF25 ZBTB16 NR3C1 MIF BCL2 COMP AGT PTH BCL6 HSPA5 NEFL HSPA9 APC IL4 IL3 IL2RB IL6 IL2RA IL7 MSH2 CREB1 IGF1 MAL PDE3A IDO1 DBH SOD1 YWHAE ADIPOQ SIRT1 SOD2 CDH13 NRAS HSP90B1 NUPR1 PRLR GSK3B EEF1E1 BAX CRH MPO IL2 DNM2"
GO:0010941	regulation of cell death	1.02680725	2.37E-24	2.37809344	4.43E-21	149 genes "HRAS CADM1 PTGS2 WFS1 GRIK2 SNCA GDNF TGFB1 IL10 BTK CITED2 APP BDNF CD44 TIAM1 APOE IFNG GRID2 APOH IL1B RARB MX1 NQO1 IL1A ACTN4 CRYAB DFFA RXRA BCL2A1 GRIN2A F7 MAPK1 RASGRF1 CD40LG JUN VEGFA F2 CSTB RYR2 MAPK8 TNFAIP3 CCL2 ERBB3 CLU BCL2L1 BDKRB2 CALR GCLM PLAGL1 TUBB KRAS INS ALB NPM1 DYRK2 RUNX3 GRIN1 NR4A2 TRIO ATM DLX1 P2RX7 NUP62 HSPD1 BMP7 SST DAP3 PDIA3 PREX1 PRDX2 NFKB1 PAWR GPX1 EDNRB AEN RHOA NOS3 CAT NRG1 FGF2 LTA TERT ARHGEF2 ARHGEF7 CYCS ESR1 PRKCI NDUFA13 IL6R PRKCE GAL PROK2 ADRB2 TNFRSF10B BTG2 PSEN1 CARD16 BTG1 IL12A SERPINB2 SORT1 CTSB NGFR IL12B TNF XIAP TNFRSF25 ZBTB16 NR3C1 MIF BCL2 COMP AGT PTH BCL6 HSPA5 NEFL HSPA9 APC IL4 IL3 IL2RB IL6 IL2RA IL7 MSH2 CREB1 IGF1 MAL PDE3A IDO1 DBH SOD1 YWHAE ADIPOQ SIRT1 SOD2 CDH13 NRAS HSP90B1 NUPR1 PRLR GSK3B EEF1E1 BAX CRH MPO IL2 DNM2"
GO:0007611	learning or memory	0.330783544	6.16E-24	5.624948025	1.15E-20	48 genes "DRD1 HRAS SLC6A1 PTGS2 DRD3 HMGCR DRD2 ADCY8 CRHBP OXT TAC1 OXTR RPS6KB1 COMT CALB1 AMPH PRKAR2B FOS BDNF APP KRAS PDE1B GRIN2B GALR2 DLG4 PTN IL1B CHRNA7 ACSL4 SNAP25 FZD9 EGR1 GABRA5 GRIN1 ATP1A3 GRIN2A PRKCG ATP1A2 DBH NRAS S100B PSEN1 RASGRF1 GRIA1 JUN CRH CACNA1C HTR2A"
GO:0050804	regulation of synaptic transmission	0.365240163	7.44E-24	5.069174208	1.39E-20	53 genes "SNCG HRAS SLC6A1 PTGS2 GRIK2 GRIK3 SNCA EDN1 CALB1 GDNF SYP HTR1B BDNF NISCH SLC1A3 GRIN2B APOE DLG4 PRKACA CHAT LTA EGR1 STX1A GRIN2A GRM1 GRM3 PSEN1 RASGRF1 CNTN4 RAB3A DRD1 ACHE TNF CCL2 DRD3 DRD2 OXT DRD4 TAC1 OXTR KRAS AGT CAMK2A PLAT MAP1B GRIN1 NLGN1 NRAS GRIA2 NTRK2 USP46 HTR2C HTR2A"
GO:0007242	intracellular signaling cascade	1.357590793	8.90E-24	2.040219255	1.66E-20	197 genes "ADCY3 HRAS ADCY7 ADCY8 EDN1 LPAR1 RAB1A BTK CTNNB1 HTR1B S1PR1 HTR1A MC1R APOE IFNG RAPGEF6 CHRNA7 GNG3 RAB27B HTR1D PLD1 CRYAB RXRA HTR4 MED12 PCLO CRHR1 CRHR2 SSTR5 MAPK1 F2 MAPK8 ARL8B RAB13 ERBB3 GNAI1 PTH1R MYO9B CALR KRAS RAC2 INS CNKSR1 DVL3 ATM GH1 CBLB NUP62 NPY RGS4 PCNA TGFBR3 OPRM1 CCKAR TOLLIP EDNRB NISCH NMUR1 AEN NOS2 FGF1 FGF2 HTR5A RAP2B AR ARHGEF2 PIK3C2G CCKBR PIK3C2A ARHGEF7 PIK3C2B RAB4B NFAM1 GRM1 GRM5 PROK2 GNAL CCND1 TNFRSF10B DOK3 ADM PSEN1 GNB1 GNAS GNB3 ARL4C RAB3A RAB3D CREM DGKA PTK2B DGKG AGT RASA4 RAB2A GDI2 IL8 IGF1 DGKH NPY1R SOD1 YWHAE STAT3 P2RY12 NRAS DUSP4 CDH13 DUSP2 NUPR1 MAPK12 MAPK14 GSK3B APBB3 HTR2C HTR2A THRA RPS6KB1 ITPKB TLR7 IL10 PRKAR2B PRKAR2A APOA1 TIAM1 GALR2 RALA IL1B PRKACA PRKACB DFFA NTSR2 MAP4K4 UCN3 RASGRF1 ASB4 FGFR1 DRD1 FGFR3 CCL2 DRD3 DRD2 DRD4 TIPIN GMIP CNR1 PLCH1 CNR2 ADRA2A ADRA2C DYRK2 EGF ARHGDIB RAB8B EFS KAT5 P2RX7 PRKAR1A MTOR CORT HIST4H4 PREX1 PRDX2 CDC42 MCTP2 GSN RHOA RHOC PRL LTA IRAK2 RSU1 RAB39B ESR1 PRKCI PRKCH PRKCG PRKCE PRKCB PRKCQ ADRB2 CHRM2 RRAS2 TREM1 TNF OXTR NR3C1 CALCA HRH1 RASGRP1 PTH DCX PIK3R1 MSH2 RCAN3 LEP PRLR IRF3"
GO:0051969	regulation of transmission of nerve impulse	0.37902281	9.59E-24	4.866823653	1.79E-20	55 genes "SNCG HRAS SLC6A1 PTGS2 GRIK2 GRIK3 SNCA EDN1 CALB1 GDNF SYP HTR1B BDNF NISCH SLC1A3 GRIN2B APOE IFNG DLG4 PRKACA CHAT LTA EGR1 STX1A GRIN2A GRM1 GRM3 PSEN1 RASGRF1 CNTN4 RAB3A TF DRD1 ACHE TNF CCL2 DRD3 DRD2 OXT DRD4 TAC1 OXTR KRAS AGT CAMK2A PLAT MAP1B GRIN1 NLGN1 NRAS GRIA2 NTRK2 USP46 HTR2C HTR2A"
GO:0042127	regulation of cell proliferation	0.992350631	1.48E-23	2.3800606	2.77E-20	144 genes "RARRES3 HRAS PTGS2 IL18 EDN1 IL13 RPS6KB1 IL15 TGFB1 IL10 SSR1 CTNNB1 FNTB CD47 BDNF HTR1A S1PR1 APOE IFNG SERPINE1 APOH IL1B CHRNA7 RARB ASPH IL1A PTPRM RXRA SSTR5 MAPK1 NOP2 TIMELESS JUN VEGFA LAMC1 PMP22 FGFR2 FGFR1 CCL2 FGFR3 DRD3 ERBB3 DRD2 CLU PTH1R TIPIN BCL2L1 BDKRB2 CALR KRAS RAC2 INS NPM1 ADRA2A EGF RUNX3 PTPN6 CDKN1C CBLB ATF3 HDAC2 NUP62 FABP3 HGS TGFBR3 MTOR FABP7 BMP7 SST KLF4 FABP6 OPRM1 NRP1 FGF9 IGFBP7 PAWR GPX1 EDNRB NOS3 NOS2 FGF1 NRG1 FGF2 PRL LTA SERTAD1 ARHGEF2 UBE2A CCKBR SF1 IL6R GAL PRKCQ PPM1D CCND1 ADRB2 BTG2 EREG ADM BTG1 BTG3 IL12A IL12B NGFR VIP CSF3 TNF TAC1 ABI1 ZBTB16 COMT PTK2B MORC3 BCL2 AGT PTN BCL6 GPNMB EPO APC IL4 IL3 IL6 IL5 IL2RA IL8 CREB3 IL7 IL9 CTLA4 IGF1 IDO1 DBH SIRT1 SOD2 CDH13 NRAS NUPR1 EEF1E1 BAX ATP5A1 IL2 HTR2A TOB1"
GO:0006873	cellular ion homeostasis	0.627110468	1.86E-23	3.164973262	3.47E-20	91 genes "CCKAR GRIK2 WFS1 HEXA ATP5B GRIK3 EDN1 SNCA HP LPAR1 TGFB1 MBP EDNRB APP S1PR1 GRIN2B APOE SAA1 SLC1A6 GALR2 GRID2 IL1B QKI CHRNA7 SLC4A1 SV2A GNG3 OLIG2 NDUFS1 IBTK KCND2 CCKBR GRIN2A NTSR2 PRKCB PROK2 CCR6 RHCG PSEN1 ADM GNB1 JUN F2 RYR2 PLLP PMP22 SRI TF DRD1 CCL2 DRD3 DRD2 OXT DRD4 PTH1R NR3C2 OXTR TAC1 HFE BDKRB1 BCL2L1 BDKRB2 CALR GCLM APLP2 CCL7 CALCA CALCB PTK2B BCL2 AGT PTH KLK6 GLRB PLP1 GRIN1 ATP1A4 MAL ATP1A2 NPY1R SOD1 ADIPOQ ITPR1 SOD2 HSP90B1 P2RX7 HPX BAX AVPR1B CACNA1C IL2"
GO:0055082	cellular chemical homeostasis	0.627110468	6.07E-23	3.115	1.13E-19	91 genes "CCKAR GRIK2 WFS1 HEXA ATP5B GRIK3 EDN1 SNCA HP LPAR1 TGFB1 MBP EDNRB APP S1PR1 GRIN2B APOE SAA1 SLC1A6 GALR2 GRID2 IL1B QKI CHRNA7 SLC4A1 SV2A GNG3 OLIG2 NDUFS1 IBTK KCND2 CCKBR GRIN2A NTSR2 PRKCB PROK2 CCR6 RHCG PSEN1 ADM GNB1 JUN F2 RYR2 PLLP PMP22 SRI TF DRD1 CCL2 DRD3 DRD2 OXT DRD4 PTH1R NR3C2 OXTR TAC1 HFE BDKRB1 BCL2L1 BDKRB2 CALR GCLM APLP2 CCL7 CALCA CALCB PTK2B BCL2 AGT PTH KLK6 GLRB PLP1 GRIN1 ATP1A4 MAL ATP1A2 NPY1R SOD1 ADIPOQ ITPR1 SOD2 HSP90B1 P2RX7 HPX BAX AVPR1B CACNA1C IL2"
GO:0044093	positive regulation of molecular function	0.799393564	8.79E-22	2.574901549	1.64E-18	116 genes "ADCY3 ADCY7 ADCY8 EDN1 LPAR1 GDNF TGFB1 IL10 PRKAR2B PRKAR2A S1PR1 APOA1 APOE IFNG GALR2 APOH IL1B PRKACA CHRNA7 PRKACB GNG3 ACTN4 NTSR2 CRHR1 UCN3 EP300 RASGRF1 F2 ADD2 DRD1 FZR1 DRD3 DRD2 PTH1R DRD4 BDKRB1 GCLM ADCYAP1 PSMB4 KRAS INS NPM1 ADRA2A ADRA2C EGF GABARAPL2 NR4A2 HDAC5 GH1 P2RX7 PRKAR1A NTRK2 AVPR1B TGFBR3 HSPD1 OPRM1 CCKAR PRDX2 SDC4 CDC42 EDNRB NMUR1 NOS3 BRD4 CAT NRG1 FGF2 IRAK2 ICAM1 CCKBR SSBP1 CYCS NFAM1 GRM1 GRM5 PROK2 GNAL PRKCQ CCND1 ADRB2 TNFRSF10B EREG PSEN1 PSME1 CHRM2 GNB1 GNAS GAP43 TNF CALD1 CALCA DGKA HRH1 PTK2B BCL2 DGKG AGT PTH CAMK2A IL4 IL6 CAP2 GNAO1 IL5 MSH3 MSH2 DGKH SOD1 PRLR PSMD11 BAX LRP8 HTR2C CALM2 IL2 HTR2A CALM1"
GO:0050801	ion homeostasis	0.640893116	9.20E-22	2.957739327	1.72E-18	93 genes "CCKAR GRIK2 WFS1 HEXA ATP5B GRIK3 EDN1 SNCA HP LPAR1 TGFB1 MBP EDNRB APP S1PR1 GRIN2B APOE SAA1 SLC1A6 GALR2 GRID2 IL1B QKI CHRNA7 SLC4A1 SV2A GNG3 OLIG2 NDUFS1 IBTK KCND2 ATP4A CCKBR GRIN2A NTSR2 PRKCB PROK2 CCR6 RHCG PSEN1 ADM GNB1 JUN F2 RYR2 NPPB PLLP PMP22 SRI TF DRD1 CCL2 DRD3 DRD2 OXT DRD4 PTH1R NR3C2 OXTR TAC1 HFE BDKRB1 BCL2L1 BDKRB2 CALR GCLM APLP2 CCL7 CALCA CALCB PTK2B BCL2 AGT PTH KLK6 GLRB PLP1 GRIN1 ATP1A4 MAL ATP1A2 NPY1R SOD1 ADIPOQ ITPR1 SOD2 HSP90B1 P2RX7 HPX BAX AVPR1B CACNA1C IL2"
GO:0048878	chemical homeostasis	0.723589001	6.37E-21	2.667593149	1.19E-17	105 genes "WFS1 GRIK2 GRIK3 SNCA EDN1 LPAR1 TGFB1 APP APOA2 S1PR1 APOA1 GRIN2B APOE SERPINE1 GALR2 GRID2 IL1B CHRNA7 OLIG2 GNG3 SLC4A1 IBTK KCND2 GRIN2A NTSR2 SSTR5 NPC1 CCR6 NPC2 RHCG JUN VEGFA F2 RYR2 PMP22 SRI DRD1 CCL2 DRD3 DRD2 PTH1R DRD4 HFE BDKRB1 BCL2L1 BDKRB2 CALR GCLM CCL7 INS GRIN1 ABCG1 P2RX7 AVPR1B CACNA1C CCKAR ATP5B HEXA HP MBP EDNRB SAA1 SLC1A6 QKI SV2A NDUFS1 ATP4A CCKBR PRKCB PROK2 PSEN1 ADM GNB1 NPPB PLLP TF OXT NR3C2 TAC1 OXTR APLP2 CALCA CALCB PTK2B BCL2 AGT PTH KLK6 GLRB PLP1 IGF1 ATP1A4 MAL NPY1R ATP1A2 DBH SOD1 ADIPOQ STAT3 ITPR1 SOD2 HSP90B1 HPX BAX IL2"
GO:0019932	second-messenger-mediated signaling	0.454827372	1.25E-20	3.653224223	2.34E-17	66 genes "ADCY3 OPRM1 CCKAR HIST4H4 ADCY7 ADCY8 EDN1 BTK EDNRB HTR1B HTR1A MCTP2 S1PR1 MC1R GSN NMUR1 APOE GALR2 NOS2 PRKACB HTR1D HTR5A LTA PIK3C2G CCKBR PIK3C2A PIK3C2B HTR4 NTSR2 GRM1 PCLO GRM5 CRHR1 GNAL SSTR5 CRHR2 ADRB2 UCN3 ADM CHRM2 GNB1 GNAS DRD1 CCL2 TNF DRD3 GNAI1 DRD2 DRD4 PTH1R CALCA HRH1 CNR1 AGT PTH CNR2 IL8 IGF1 NPY1R RCAN3 P2RY12 NPY PCNA CORT HTR2C HTR2A"
GO:0009725	response to hormone stimulus	0.585762525	1.83E-20	3.01268078	3.42E-17	85 genes "ADCY3 A2M THRA SLC6A1 ADCY7 PTGS2 ADCY8 LEPR IGFBP7 RPS6KB1 IL10 TGFB1 CTNNB1 PRKAR2B FOS PRKAR2A HTR1B TNFRSF11B APOA2 GSTM3 IL1B PRKACA NOS3 PRKACB GNG3 PLD1 AR GATM CRYAB RXRA ESR1 PRKCI IL6R MMP14 GAL MAPK1 PRKCQ CCND1 UCN3 EP300 BTG2 ADM GNB1 SORT1 GNAS COL1A1 GNB3 DRD1 CCL2 TNF ERBB3 OXT OXTR TAC1 TSHB BCL2L1 KRAS PTK2B INS BCL2 ENO2 AANAT NEFL PIK3R1 IL6 FADS1 MAP1B BCKDHB NPY1R ADIPOQ STAT3 ABCG1 ABCB4 HDAC5 LEP GH1 NUP62 PRKAR1A FABP3 TGFBR3 PTPN1 MTOR IGFBP2 BMP7 SST"
GO:0019725	cellular homeostasis	0.675349735	2.38E-20	2.735523275	4.45E-17	98 genes "WFS1 GRIK2 GRIK3 SNCA EDN1 LPAR1 TGFB1 APP S1PR1 GRIN2B APOE GALR2 GRID2 IL1B CHRNA7 OLIG2 GNG3 SLC4A1 IBTK KCND2 GRIN2A NTSR2 CCR6 RHCG JUN F2 RYR2 PMP22 SRI ALDOA DRD1 CCL2 DRD3 DRD2 PTH1R DRD4 HFE BDKRB1 BCL2L1 BDKRB2 CALR GCLM CCL7 NPM1 GRIN1 P2RX7 AVPR1B CACNA1C CCKAR PDIA3 HEXA ATP5B HP PRDX2 PDIA4 MBP EDNRB GPX1 SAA1 SLC1A6 QKI SV2A NDUFS1 CCKBR PRKCB PROK2 PSEN1 ADM GNB1 PLLP TF OXT NR3C2 OXTR TAC1 APLP2 CALCA CALCB PTK2B BCL2 AGT PTH APC KLK6 GLRB PLP1 ATP1A4 MAL ATP1A2 NPY1R SOD1 ADIPOQ ITPR1 SOD2 HSP90B1 HPX BAX IL2"
GO:0043066	negative regulation of apoptosis	0.571979877	2.40E-20	3.049826163	4.49E-17	83 genes "HRAS GRIK2 WFS1 SNCA NFKB1 PRDX2 GDNF IL10 CITED2 EDNRB GPX1 BDNF APOE RHOA APOH IL1B NOS3 CAT NRG1 IL1A TERT DFFA CRYAB BCL2A1 ESR1 PRKCI F7 PROK2 BTG2 PSEN1 CD40LG VEGFA SERPINB2 SORT1 MAPK8 NGFR TNFAIP3 CCL2 TNF XIAP ERBB3 CLU BCL2L1 BDKRB2 GCLM MIF KRAS ALB INS AGT COMP BCL2 NPM1 BCL6 HSPA5 NEFL APC HSPA9 IL4 IL3 IL2RB IL6 IL7 MSH2 GRIN1 NR4A2 IGF1 PDE3A IDO1 SOD1 ATM SOD2 NRAS CDH13 HSP90B1 DLX1 PRLR NUP62 GSK3B BAX MPO HSPD1 IL2"
GO:0032101	regulation of response to external stimulus	0.365240163	2.78E-20	4.335897436	5.19E-17	53 genes "A2M PTGS2 SLC6A3 EDN1 GRIN3A TGFB1 IL10 GPX1 S1PR1 SAA1 APOE SERPINE1 APOH GRID2 CHRNA7 NOS3 SERPING1 IL6R F7 IL20 ADRB2 NPC1 SERPINF1 F2 VEGFA DRD1 DRD3 DRD2 C3 TAC1 GREM1 TNFRSF1A TNFRSF1B INS AGT HRG BCL6 SELP IL6 IL2RA CREB3 IL8 GRIN1 IDO1 ADIPOQ NTRK3 LEP CDH13 NPY HOPX MTOR FABP7 IL2"
GO:0014070	response to organic cyclic substance	0.317000896	2.98E-20	4.945073109	5.57E-17	46 genes "TF DRD1 SLC6A1 PTGS2 DRD3 DRD2 IGFBP7 OXT ALDOC SLC6A3 LEPR DRD4 TAC1 OXTR RPS6KB1 ADRBK1 BCL2L1 COMT TGFB1 CTNNB1 FOS HTR1B CD44 PTK2B BCL2 ENO2 AANAT IL1B NOS3 CHRNA7 GNAO1 MSH2 FADS1 RXRA GRIN1 STAT3 GNAL PRKCQ P2RX7 CCND1 GRM2 HDAC2 BTG2 JUN RYR2 HTR2C"
GO:0051046	regulation of secretion	0.413479429	4.20E-20	3.863670982	7.86E-17	60 genes "SNCG CADM1 SNCA EDN1 IL13 GDNF TGFB1 IL10 APOA2 HTR1B APOA1 GRIN2B SAA1 IFNG IL1B NOS2 RAB27B NRG1 FGF2 NSF IL1A STX1A STX1B PCLO SSTR5 PRKCQ UCN3 CD40LG PRAM1 RAB3A ACHE TNF RAB3D DRD3 DRD2 ERBB3 OXT GLUD1 DRD4 TAC1 OXTR ADRBK1 INS AGT EGF CAMK2A SNAP25 IL6 RAB8B CREB1 NPY1R ADIPOQ LEP P2RX7 NTRK2 AVPR1B CRH HTR2C IL2 HTR2A"
GO:0043069	negative regulation of programmed cell death	0.571979877	6.07E-20	3.007349475	1.14E-16	83 genes "HRAS GRIK2 WFS1 SNCA NFKB1 PRDX2 GDNF IL10 CITED2 EDNRB GPX1 BDNF APOE RHOA APOH IL1B NOS3 CAT NRG1 IL1A TERT DFFA CRYAB BCL2A1 ESR1 PRKCI F7 PROK2 BTG2 PSEN1 CD40LG VEGFA SERPINB2 SORT1 MAPK8 NGFR TNFAIP3 CCL2 TNF XIAP ERBB3 CLU BCL2L1 BDKRB2 GCLM MIF KRAS ALB INS AGT COMP BCL2 NPM1 BCL6 HSPA5 NEFL APC HSPA9 IL4 IL3 IL2RB IL6 IL7 MSH2 GRIN1 NR4A2 IGF1 PDE3A IDO1 SOD1 ATM SOD2 NRAS CDH13 HSP90B1 DLX1 PRLR NUP62 GSK3B BAX MPO HSPD1 IL2"
GO:0042493	response to drug	0.427262077	6.26E-20	3.733689459	1.17E-16	62 genes "PTGS2 SLC6A3 SNCA RPS6KB1 TGFB1 FOS BDNF APOA2 TNFRSF11B SLC1A2 SLC1A3 PDE4A SEMA3C IL1B NOS3 PTPRM ATP4A GRIN2A GAL CCND1 EP300 JUN RYR2 GNAS DRD1 CCL2 DRD3 ERBB3 DRD2 OXTR COMT GCLM HADHA PTK2B BCL2 ENO2 ENO3 DNMT3B APC GABRE GNAO1 MSH2 CREB1 MAP1B ATP1A3 ABCB1 ATP1A1 PDE3A SOD1 CAPN3 ADIPOQ STAT3 SOD2 ABCB4 P2RX7 HDAC2 FABP3 IGFBP2 HTR2C SST LIPE HTR2A"
GO:0060548	negative regulation of cell death	0.571979877	7.29E-20	2.998995726	1.36E-16	83 genes "HRAS GRIK2 WFS1 SNCA NFKB1 PRDX2 GDNF IL10 CITED2 EDNRB GPX1 BDNF APOE RHOA APOH IL1B NOS3 CAT NRG1 IL1A TERT DFFA CRYAB BCL2A1 ESR1 PRKCI F7 PROK2 BTG2 PSEN1 CD40LG VEGFA SERPINB2 SORT1 MAPK8 NGFR TNFAIP3 CCL2 TNF XIAP ERBB3 CLU BCL2L1 BDKRB2 GCLM MIF KRAS ALB INS AGT COMP BCL2 NPM1 BCL6 HSPA5 NEFL APC HSPA9 IL4 IL3 IL2RB IL6 IL7 MSH2 GRIN1 NR4A2 IGF1 PDE3A IDO1 SOD1 ATM SOD2 NRAS CDH13 HSP90B1 DLX1 PRLR NUP62 GSK3B BAX MPO HSPD1 IL2"
GO:0060341	regulation of cellular localization	0.454827372	2.72E-19	3.461724566	5.08E-16	66 genes "SNCG CADM1 SNCA EDN1 IL13 GDNF TGFB1 IL10 APOA2 HTR1B APOA1 GRIN2B SAA1 IFNG RHOA IL1B PRKACA NOS2 RAB27B FGF2 IL1A NSF STX1A CRYAB STX1B PKIA PCLO SSTR5 PRKCQ UCN3 CD40LG PRAM1 RYR2 RAB3A ACHE TNF RAB3D DRD3 DRD2 OXT GLUD1 DRD4 OXTR ADRBK1 INS AGT EGF CAMK2A SNAP25 APC IL6 RAB8B CREB1 NPY1R SIRT1 ADIPOQ LEP P2RX7 GSK3B AVPR1B NTRK2 CRH HTR2C CALM2 IL2 CALM1 HTR2A"
GO:0042592	homeostatic process	0.888980773	1.06E-18	2.234343952	1.99E-15	129 genes "WFS1 GRIK2 GRIK3 SNCA EDN1 LPAR1 TGFB1 CTNNB1 APP APOA2 S1PR1 APOA1 GRIN2B APOE IFNG SERPINE1 GALR2 GRID2 IL1B CHRNA7 SLC4A1 OLIG2 GNG3 IL1A IBTK KCND2 GRIN2A NTSR2 SSTR5 NPC1 EP300 CCR6 NPC2 RHCG JUN VEGFA F2 RYR2 PMP22 ALDOA SRI DRD1 CCL2 DRD3 DRD2 PTH1R DRD4 HFE BDKRB1 BCL2L1 BDKRB2 CALR GCLM CCL7 HSPA1L RAC2 INS NPM1 CREBBP GRIN1 ABCG1 P2RX7 AVPR1B TGFBR3 CACNA1C CCKAR PDIA3 ATP5B HEXA PRDX2 HP PDIA4 MBP GPX1 EDNRB SAA1 SLC1A6 QKI SV2A NDUFS1 TERT ATP4A CCKBR PRKCB PROK2 ADRB2 PSEN1 ADM GNB1 NPPB PLLP TF OXT NR3C2 TAC1 OXTR APLP2 CALCA CALCB PTK2B BCL2 AGT PTH BCL6 EPO APC KLK6 GLRB IL6 PLP1 IL2RA LIPA IL7 IGF1 ATP1A4 MAL NPY1R ATP1A2 DBH SOD1 ADIPOQ STAT3 ITPR1 SOD2 HSP90B1 HPX BAX IL2 HTR2A"
GO:0051240	positive regulation of multicellular organismal process	0.441044725	2.20E-18	3.41185372	4.12E-15	64 genes "PTGS2 FGF9 GRIK2 IL18 SLC6A3 EDN1 SNCA PEX5 TLR7 TGFB1 SLC1A3 SAA1 IFNG APOH IL1B NOS3 NRG1 FGF2 LTA IL1A NFAM1 IL6R PROK2 ADRB2 ADM PSEN1 EREG CD40LG F2 IL12A IL12B TF DRD1 CCL2 TNF DRD2 OXT KLRK1 OXTR TAC1 CALCA INS AGT BCL2 HRG IL6 NOS1 CREB1 ATP1A1 NPY1R IDO1 SOD1 DBH GH1 P2RX7 HDAC2 GRIA2 BAX AVPR1B NTRK2 CRH HSPD1 BMP7 HTR2A"
GO:0030005	"cellular di-, tri-valent inorganic cation homeostasis"	0.420370753	4.26E-18	3.495459166	7.97E-15	61 genes "CCKAR GRIK2 WFS1 EDN1 HP LPAR1 TGFB1 EDNRB APP S1PR1 SAA1 APOE GALR2 IL1B CHRNA7 GNG3 SV2A IBTK CCKBR PRKCB PROK2 CCR6 PSEN1 ADM GNB1 F2 RYR2 SRI TF DRD1 CCL2 DRD3 DRD2 OXT DRD4 PTH1R OXTR HFE TAC1 BDKRB1 BDKRB2 CALR APLP2 CCL7 CALCA CALCB PTK2B BCL2 PTH GRIN1 ATP1A2 NPY1R SOD1 ITPR1 HSP90B1 P2RX7 HPX BAX AVPR1B CACNA1C IL2"
GO:0030003	cellular cation homeostasis	0.447936049	4.46E-18	3.328740157	8.35E-15	65 genes "CCKAR GRIK2 WFS1 ATP5B EDN1 HP LPAR1 TGFB1 EDNRB APP S1PR1 SAA1 APOE GALR2 IL1B CHRNA7 GNG3 SV2A IBTK CCKBR PRKCB PROK2 CCR6 PSEN1 ADM GNB1 F2 RYR2 SRI TF DRD1 CCL2 DRD3 DRD2 OXT DRD4 PTH1R NR3C2 OXTR HFE TAC1 BDKRB1 BDKRB2 CALR APLP2 CCL7 CALCA CALCB PTK2B AGT BCL2 PTH GRIN1 ATP1A4 ATP1A2 NPY1R SOD1 ITPR1 HSP90B1 P2RX7 HPX BAX AVPR1B CACNA1C IL2"
GO:0006874	cellular calcium ion homeostasis	0.372131486	5.17E-18	3.838335435	9.67E-15	54 genes "CCKAR GRIK2 WFS1 EDN1 LPAR1 TGFB1 EDNRB APP S1PR1 SAA1 APOE GALR2 IL1B CHRNA7 GNG3 SV2A IBTK CCKBR PRKCB PROK2 CCR6 ADM PSEN1 GNB1 F2 RYR2 DRD1 CCL2 DRD3 DRD2 OXT DRD4 PTH1R OXTR TAC1 BDKRB1 BDKRB2 CALR CCL7 CALCA CALCB PTK2B BCL2 PTH GRIN1 ATP1A2 NPY1R ITPR1 P2RX7 HSP90B1 BAX AVPR1B CACNA1C IL2"
GO:0006875	cellular metal ion homeostasis	0.385914134	5.84E-18	3.716483516	1.09E-14	56 genes "CCKAR GRIK2 WFS1 EDN1 LPAR1 TGFB1 EDNRB APP S1PR1 SAA1 APOE GALR2 IL1B CHRNA7 GNG3 SV2A IBTK CCKBR PRKCB PROK2 CCR6 ADM PSEN1 GNB1 F2 RYR2 DRD1 CCL2 DRD3 DRD2 OXT DRD4 PTH1R NR3C2 OXTR TAC1 BDKRB1 BDKRB2 CALR CCL7 CALCA CALCB PTK2B AGT BCL2 PTH GRIN1 ATP1A2 NPY1R ITPR1 P2RX7 HSP90B1 BAX AVPR1B CACNA1C IL2"
GO:0055066	"di-, tri-valent inorganic cation homeostasis"	0.427262077	1.40E-17	3.374380431	2.62E-14	62 genes "CCKAR GRIK2 WFS1 EDN1 HP LPAR1 TGFB1 EDNRB APP S1PR1 SAA1 APOE GALR2 IL1B CHRNA7 GNG3 SV2A IBTK CCKBR PRKCB PROK2 CCR6 PSEN1 ADM GNB1 F2 RYR2 SRI TF DRD1 CCL2 DRD3 DRD2 OXT DRD4 PTH1R OXTR HFE TAC1 BDKRB1 BDKRB2 CALR APLP2 CCL7 CALCA CALCB PTK2B BCL2 PTH GRIN1 ATP1A2 NPY1R SOD1 ITPR1 SOD2 HSP90B1 P2RX7 HPX BAX AVPR1B CACNA1C IL2"
GO:0055074	calcium ion homeostasis	0.372131486	1.88E-17	3.736252046	3.52E-14	54 genes "CCKAR GRIK2 WFS1 EDN1 LPAR1 TGFB1 EDNRB APP S1PR1 SAA1 APOE GALR2 IL1B CHRNA7 GNG3 SV2A IBTK CCKBR PRKCB PROK2 CCR6 ADM PSEN1 GNB1 F2 RYR2 DRD1 CCL2 DRD3 DRD2 OXT DRD4 PTH1R OXTR TAC1 BDKRB1 BDKRB2 CALR CCL7 CALCA CALCB PTK2B BCL2 PTH GRIN1 ATP1A2 NPY1R ITPR1 P2RX7 HSP90B1 BAX AVPR1B CACNA1C IL2"
GO:0006928	cell motion	0.640893116	3.22E-17	2.546769231	6.01E-14	93 genes "CCKAR MTSS1 NRP1 PTGS2 HMGCR ATP5B IL13 PEX5 RPS6KB1 L1CAM GDNF IL10 TGFB1 NRCAM EDNRB GPX1 BDNF APP APOA1 CD44 ANK3 SAA1 SEMA3F IFNG SEMA3C IL1B ROBO2 NOS3 MSN FGF2 ICAM1 SATB2 PTPRM ARHGEF7 OTX2 IL6R MYH9 MMP14 SLIT3 ASCL1 CCR6 PSEN1 BTG1 CNTN2 IL12A MAPK8 CNTN4 VCAN IL12B AMFR NGFR LAMC1 GAP43 DRD1 CCL2 TNF DRD2 ENPP2 CXCL3 CALD1 VIM SPOCK1 CAPZB EPHB1 CALCA TUBB PVRL1 PTK2B KAL1 ADRA2A DCX RUNX3 ARHGDIB APC PLAT SELP IL6 IL8 MSH2 NR4A2 IGF1 ATP1A4 TBX1 DBH YWHAE STAT3 CDH13 NPY MAPK14 BAX TGFBR3 LRP8 BMP7"
GO:0055080	cation homeostasis	0.46861002	4.17E-17	3.092738031	7.79E-14	68 genes "CCKAR GRIK2 WFS1 ATP5B EDN1 HP LPAR1 TGFB1 EDNRB APP S1PR1 SAA1 APOE GALR2 IL1B CHRNA7 GNG3 SV2A IBTK ATP4A CCKBR PRKCB PROK2 CCR6 PSEN1 ADM RHCG GNB1 F2 RYR2 SRI TF DRD1 CCL2 DRD3 DRD2 OXT DRD4 PTH1R NR3C2 OXTR HFE TAC1 BDKRB1 BDKRB2 CALR APLP2 CCL7 CALCA CALCB PTK2B AGT BCL2 PTH GRIN1 ATP1A4 ATP1A2 NPY1R SOD1 ITPR1 SOD2 HSP90B1 P2RX7 HPX BAX AVPR1B CACNA1C IL2"
GO:0009628	response to abiotic stimulus	0.544414582	4.85E-17	2.792412207	9.07E-14	79 genes "HRAS HMGCR IL18 IGFBP7 RPS6KB1 TGFB1 FOS GPX1 APP SLC1A2 SLC1A3 GRIN2B MC1R AEN IL1B NOS3 CAT LTA STX1A UBE2A CRYAB GRIN2A IL6R MMP14 PRKCQ PPM1D CCND1 ADRB2 THBD BTG2 TIMELESS ADM ARRB1 JUN IL12A MAPK8 IL12B COL1A1 NGFR CLOCK RAB3A DRD1 CCL2 TNF DRD3 DRD2 OXT TAC1 KMO BCL2L1 BDKRB2 HSPA1L CALCA PDE6B PDE6C KRAS PDE1B PTK2B AGT BCL2 DNMT3B NOS1 MSH2 MAP1B GRIN1 ATP1A3 ATP1A2 DBH SOD1 ATM SOD2 NRAS P2RX7 HDAC2 BAX AVPR1B IGFBP2 CACNA1C SST"
GO:0055065	metal ion homeostasis	0.385914134	5.21E-17	3.553320826	9.74E-14	56 genes "CCKAR GRIK2 WFS1 EDN1 LPAR1 TGFB1 EDNRB APP S1PR1 SAA1 APOE GALR2 IL1B CHRNA7 GNG3 SV2A IBTK CCKBR PRKCB PROK2 CCR6 ADM PSEN1 GNB1 F2 RYR2 DRD1 CCL2 DRD3 DRD2 OXT DRD4 PTH1R NR3C2 OXTR TAC1 BDKRB1 BDKRB2 CALR CCL7 CALCA CALCB PTK2B AGT BCL2 PTH GRIN1 ATP1A2 NPY1R ITPR1 P2RX7 HSP90B1 BAX AVPR1B CACNA1C IL2"
GO:0043085	positive regulation of catalytic activity	0.675349735	5.70E-17	2.451449704	2.11E-13	98 genes "ADCY3 ADCY7 ADCY8 EDN1 LPAR1 GDNF TGFB1 PRKAR2B PRKAR2A S1PR1 APOA1 APOE GALR2 IFNG APOH IL1B PRKACA CHRNA7 GNG3 PRKACB NTSR2 CRHR1 UCN3 RASGRF1 F2 DRD1 FZR1 DRD3 DRD2 PTH1R DRD4 BDKRB1 GCLM ADCYAP1 PSMB4 KRAS INS NPM1 ADRA2A ADRA2C EGF GABARAPL2 NR4A2 GH1 P2RX7 NTRK2 AVPR1B PRKAR1A HSPD1 OPRM1 CCKAR PRDX2 SDC4 EDNRB CDC42 NMUR1 NOS3 NRG1 FGF2 SSBP1 CCKBR CYCS GRM1 GRM5 PROK2 GNAL ADRB2 CCND1 TNFRSF10B PSEN1 EREG PSME1 CHRM2 GNB1 GNAS GAP43 TNF CALCA DGKA HRH1 PTK2B DGKG AGT BCL2 PTH CAP2 GNAO1 MSH3 MSH2 DGKH SOD1 PRLR PSMD11 BAX LRP8 HTR2C HTR2A IL2"
GO:0048511	rhythmic process	0.296326924	1.06E-16	4.369771635	2.11E-13	43 genes "PRF1 DRD1 DRD3 ERBB3 DRD2 LEPR PGLYRP1 OXTR BCL2L1 GRIN3A NPAS2 CRY2 NR1D1 GRIN2B BCL2 AGT PER2 AANAT PER1 NOS3 ARNTL2 PER3 NFIL3 CRY1 CHAT EGR3 GRIN2A PROKR2 ARNTL MMP14 SOD1 SIRT1 LEP PROK2 PTGDS EREG TIMELESS JUN BAX VEGFA CRH FSHB CLOCK"
GO:0010647	positive regulation of cell communication	0.503066639	1.35E-16	2.886205284	2.11E-13	73 genes "HRAS PTGS2 FGF9 GRIK2 LEPR SNCA ITPKB L1CAM LPAR1 TGFB1 CTNNB1 CITED2 GPX1 SLC1A3 IFNG RHOA IL1B RHOC CAT PRL LTA ESR1 NFAM1 IL6R F7 IL20 NCAM1 ASCL1 ADRB2 TNFRSF10B EREG VEGFA IL12A DRD1 CCL2 TNF LITAF DRD3 ERBB3 OXT PPM1A OXTR TAC1 TNFRSF1A KRAS INS AGT PTH CC2D1A EGF EPO KLK6 IL4 IL3 IL6 IL5 IGF1 ADIPOQ CDKN1C LEP GH1 IKBKE NRAS CDH13 P2RX7 NUP62 GRIA2 HPX EEF1E1 NTRK2 MTOR BMP7 IL2"
GO:0051050	positive regulation of transport	0.399696782	1.52E-16	3.383166609	2.11E-13	58 genes "CADM1 WFS1 EDN1 SNCA IL13 GDNF IL10 TGFB1 SLC1A2 GRIN2B SAA1 APOE IFNG RHOA IL1B PRKACA LTA IL1A STX1A ACTN4 PRKCI PRKCQ ADRB2 UCN3 F2 ACHE DRD1 TNF ERBB3 C3 DRD2 OXT GLUD1 DRD4 OXTR TAC1 ADRBK1 BDKRB1 CALR INS PTX3 SNAP25 PIK3R1 IL6 RAB8B CREB3 CREB1 ARPP19 ADIPOQ P2RY12 P2RX7 GSK3B BAX AVPR1B CRH HTR2C CALM2 CALM1 IL2"
GO:0006954	inflammatory response	0.489283991	1.19E-15	2.841680473	2.29E-12	71 genes "A2M TOLLIP CRP IL13 PRDX2 NFKB1 IL15 TLR7 IL10 TGFB1 FOS APOA2 CD44 SAA1 CD46 ITIH4 IL1B CFD IL1A IRAK2 NFKBIZ RXRA CHST2 SERPING1 NFAM1 IL6R GAL PROK2 CD40LG F2 PLA2G7 AOC3 TF CCL2 TNF C3 CXCL3 CXCL2 CLU TAC1 BDKRB1 BDKRB2 CCL7 MIF CCL24 TNFRSF1A HRH1 TNFRSF1B IL17A IL23A MEFV CCL20 INS CNR2 PTX3 SELP IL6 IL2RA LIPA IL5 IL8 CFB IL9 IDO1 STAT3 HDAC5 ORM1 P2RX7 NUPR1 CRH LTA4H"
GO:0007626	locomotory behavior	0.441044725	1.28E-15	3.038293094	2.49E-12	64 genes "OPRM1 SNCG HRAS SLC6A3 HEXA SNCA CNP GDNF CALB1 IL10 EDNRB APP SAA1 SEMA3F IFNG IL1B RALA ROBO2 FGF2 CHAT PLD1 IL6R GRM1 MAPK1 PROK2 CCR6 GRM2 PTGDS CSTB DRD1 CCL2 DRD3 DRD2 ENPP2 CXCL3 CXCL2 DRD4 APLP2 CCL7 CCL24 NPAS2 NPAS3 RAC2 PDE1B CCL20 KAL1 IL4 GLRB IL6 GNAO1 CREB3 IL8 GRIN1 ATP1A3 NR4A2 ATP1A2 NPY1R SOD1 DBH SOD2 EPS8 MAPK14 SLC18A2 CACNA1C"
GO:0050877	neurological system process	1.17152505	2.18E-15	1.827527018	4.15E-12	170 genes "ADCY3 HRAS SLC6A1 SYT4 PTGS2 ADCY8 HMGCR SLC6A2 GRIK2 WFS1 GABRB2 SLC6A3 CRHBP SNCA SLC6A4 GRIK5 RPS6KB1 RORB CNP GRIN3A CALB1 TGFB1 CTNNB1 PRKAR2B HTR1B APP BDNF S1PR1 GRIN2B APOE GALR2 GRID2 IL1B CHRNA7 OLIG2 NQO1 HTR1D CHAT KCND2 MYO3A GRIN2A LRTOMT PDYN PCLO NTSR2 NCAM2 MAPK1 GABRR1 RASGRF1 ARRB1 JUN COL1A1 PMP22 DRD1 ACHE CYP1B1 DRD3 DRD2 DRD4 BDKRB1 PDE6B HCRTR1 GAD2 PDE6C SYPL1 KRAS PVRL1 PRIMA1 GAD1 PLAT GABRD GABRA2 GABRA3 MAOA GABRA6 GRIN1 GABRA5 P2RX7 NPY PENK S100B CACNA1C FABP7 CORT SST OPRM1 HEXA PEX5 GABBR2 MBP SLC1A4 GPX1 FOS SLC1A2 SLC1A3 NMUR1 SLC1A6 DLG4 QKI FGF2 USP14 EGR1 GABRG1 GABRG2 STX1A EGR3 CCKBR PRKCG GRM1 STX1B GRM5 PROK2 GNAL GRM3 GRM2 PSEN1 GNB1 PLLP GNAS IL12B NCAN AOC2 RAB3A CPLX1 OXT TAC1 OXTR COMT DTNBP1 APLP2 MFRP AMPH CALCA HRH1 SYN1 PDE1B PDE1C SYN3 AGT SYN2 PTN ACSL4 SNAP25 HTR3B NEFL FZD9 KLK6 PLP1 DLGAP1 GLRB NOS1 MAP1A NLGN1 ATP1A3 MAL TBX1 NPY1R ATP1A2 SOD1 DBH SOD2 SLC17A7 NRAS SLC17A6 GRIA2 GRIA1 KCNN3 CRH HTR2C HTR2A"
GO:0008285	negative regulation of cell proliferation	0.516849287	2.92E-15	2.70242915	5.40E-12	75 genes "OPRM1 RARRES3 PTGS2 IGFBP7 PAWR IL15 IL10 TGFB1 FNTB BDNF APOE IFNG APOH IL1B NOS3 RARB ASPH FGF2 IL1A LTA PTPRM RXRA SF1 GAL SSTR5 PPM1D BTG2 ADM EREG BTG1 JUN BTG3 IL12A IL12B PMP22 TNF DRD2 PTH1R ABI1 COMT BDKRB2 ZBTB16 MORC3 AGT BCL2 NPM1 BCL6 GPNMB RUNX3 APC PTPN6 IL6 IL2RA IL8 CTLA4 IDO1 SOD2 CDKN1C CDH13 CBLB NUP62 NUPR1 EEF1E1 BAX FABP3 HGS TGFBR3 ATP5A1 BMP7 FABP7 SST KLF4 TOB1 IL2 FABP6"
GO:0008284	positive regulation of cell proliferation	0.55819723	6.68E-15	2.544983278	1.25E-11	81 genes "HRAS NRP1 PTGS2 FGF9 IL18 EDN1 IL13 RPS6KB1 IL15 TGFB1 SSR1 FNTB CD47 HTR1A S1PR1 IFNG IL1B CHRNA7 NRG1 FGF1 FGF2 PRL SERTAD1 UBE2A CCKBR IL6R MAPK1 PRKCQ CCND1 ADRB2 NOP2 ADM EREG JUN VEGFA IL12A IL12B NGFR LAMC1 FGFR2 CSF3 VIP FGFR1 CCL2 TNF FGFR3 DRD3 DRD2 PTH1R CLU TIPIN TAC1 BCL2L1 CALR KRAS RAC2 PTK2B INS AGT BCL2 NPM1 ADRA2A PTN BCL6 EGF EPO IL4 IL3 IL6 IL2RA IL5 IL7 IL9 IGF1 NRAS CDH13 HDAC2 ATF3 MTOR IL2 HTR2A"
GO:0042325	regulation of phosphorylation	0.599545173	1.02E-14	2.428474744	1.91E-11	87 genes "ADCY3 ADCY7 ADCY8 HMGCR EDN1 PRDX2 LPAR1 SDC4 TGFB1 CDC42 PRKAR2B EDNRB PRKAR2A APP APOA1 MCM7 APOE IFNG IL1B PRKACA CHRNA7 PRKACB GNG3 NRG1 FGF2 SERTAD1 IBTK IL6R PRKCE PKIA GRM1 IL20 PROK2 CCND1 ADRB2 TNFRSF10B EREG PSEN1 JUN F2 IL12A GAP43 DRD1 TNF DRD4 BDKRB1 BDKRB2 APLP2 CALCA DGKA KRAS HEXIM1 PTK2B INS DGKG AGT BCL2 NPM1 ADRA2A ADRA2C EGF APC EPO IL4 IL3 IL6 IL5 IGF1 DGKH SOD1 ADIPOQ SIRT2 CDKN1C GH1 P2RX7 DUSP2 PRLR NUP62 HPX RGS4 BAX PRKAR1A LRP8 MTOR BMP7 IL2 HTR2A"
GO:0010243	response to organic nitrogen	0.192957067	1.93E-14	5.781196581	3.61E-11	28 genes "DRD1 CCL2 DRD3 PTGS2 SLC6A1 DRD2 ALDOC OXT DRD4 OXTR RPS6KB1 BCL2L1 SLC1A2 PTK2B NOS3 NEFL GNAO1 MSH2 GRIN1 NR4A2 GRIN2A DBH GNAL CCND1 BTG2 SLC18A2 MTOR SST"
GO:0007166	cell surface receptor linked signal transduction	1.578113156	3.31E-14	1.604936174	6.19E-11	229 genes "ADCY3 HRAS GPR125 ADCY7 ADCY8 EDN1 L1CAM GRIN3A LPAR1 CTNNB1 CD47 HTR1B APP HTR1A S1PR1 GRIN2B MC1R APOE SOSTDC1 IFNG CLEC4A GRID2 GNG3 CFD HTR1D KLRD1 KLRB1 GRIN2A HTR4 PTPRT MYH9 PDYN CRHR1 MAPK1 SSTR5 CRHR2 CCR6 JUN PRAM1 F2 VEGFA GNAI1 ENPP2 ERBB3 PTH1R BDKRB1 ADRBK1 BDKRB2 POMC EPHB1 ADCYAP1 HCRTR1 INS NKX2-2 PLAT DVL3 CNKSR1 TRIO COL16A1 KCNK2 NTRK3 EPHA5 GH1 CBLB NPY EPS8 NUP62 PENK CD59 NTRK2 AVPR1B TGFBR3 AREG BMP7 OPRM1 CCKAR NRP1 FGF9 EDNRB NMUR1 NOS3 NOS2 FGF1 FGF2 HTR5A FGF3 CCKBR CD160 NFAM1 GRM1 GRM5 CLEC1A GNAL PROK2 GRM3 CCND1 GRM2 TNFRSF10B ADM PSEN1 EREG GNB1 SORT1 NPPB GNAS IL12B GNB3 C3 CXCL3 CXCL2 ABI1 MIF DGKA CCL20 PTK2B DGKG AGT HTR3B FZD9 IL8 ATP1A3 GRIA3 DGKH NPY1R STAT3 P2RY12 CSNK1D GSK3B MAPK14 HTR2C CALM2 IL2 HTR2A TOB1 CALM1 MTSS1 GABRB2 GRIK2 GRIK3 ITPKB TGFB1 IL17RA CSNK2A1 APOA1 TIAM1 GALR2 PRKACB PROKR2 NTSR2 NCAM1 ASCL1 UCN3 GABRR1 GPR56 GPR50 FGFR2 FGFR1 DRD1 CCL2 FGFR3 DRD3 DRD2 DRD4 KLRK1 ITGB5 CNR1 CNR2 ADRA2A ADRA2C EGF GABRE PTPN6 GABRA2 GABRA1 GABRA3 RYK GABRA6 GABRA5 GRIN1 GPR35 P2RX7 GPR37 SPTBN1 PTPN1 CORT SST RGS7BP LEPR GABBR1 GABBR2 SKAP1 FOS NRG1 PRL IRAK2 GABRG1 GABRG2 GAL ADRB2 CHRM2 CNTN1 FSHB GAP43 VIP TNFRSF25 PPM1A OXTR TAC1 TSHB GPRC5B APLP2 CALCA CALCB TNFRSF1B HRH1 PTH PTN PIK3R1 APC PLP1 PTPRD GLRB IL2RA GNAO1 CREB1 RGS18 PRLR INVS CRH IRF3"
GO:0019220	regulation of phosphate metabolic process	0.606436496	3.97E-14	2.360158604	7.41E-11	88 genes "ADCY3 ADCY7 ADCY8 HMGCR EDN1 PRDX2 LPAR1 SDC4 TGFB1 CDC42 PRKAR2B EDNRB PRKAR2A APP APOA1 MCM7 APOE IFNG IL1B PRKACA CHRNA7 PRKACB GNG3 NRG1 FGF2 SERTAD1 IBTK IL6R PRKCE PKIA GRM1 IL20 PROK2 CCND1 ADRB2 TNFRSF10B EREG PSEN1 JUN F2 IL12A GAP43 DRD1 TNF DRD4 BDKRB1 BDKRB2 APLP2 DGKA CALCA KRAS HEXIM1 PTK2B INS DGKG AGT BCL2 NPM1 ADRA2A ADRA2C EGF APC EPO IL4 IL3 IL6 IL5 IGF1 DGKH SOD1 ADIPOQ YWHAE SIRT2 CDKN1C GH1 P2RX7 DUSP2 PRLR NUP62 HPX RGS4 BAX PRKAR1A LRP8 MTOR BMP7 IL2 HTR2A"
GO:0051174	regulation of phosphorus metabolic process	0.606436496	3.97E-14	2.360158604	7.41E-11	88 genes "ADCY3 ADCY7 ADCY8 HMGCR EDN1 PRDX2 LPAR1 SDC4 TGFB1 CDC42 PRKAR2B EDNRB PRKAR2A APP APOA1 MCM7 APOE IFNG IL1B PRKACA CHRNA7 PRKACB GNG3 NRG1 FGF2 SERTAD1 IBTK IL6R PRKCE PKIA GRM1 IL20 PROK2 CCND1 ADRB2 TNFRSF10B EREG PSEN1 JUN F2 IL12A GAP43 DRD1 TNF DRD4 BDKRB1 BDKRB2 APLP2 DGKA CALCA KRAS HEXIM1 PTK2B INS DGKG AGT BCL2 NPM1 ADRA2A ADRA2C EGF APC EPO IL4 IL3 IL6 IL5 IGF1 DGKH SOD1 ADIPOQ YWHAE SIRT2 CDKN1C GH1 P2RX7 DUSP2 PRLR NUP62 HPX RGS4 BAX PRKAR1A LRP8 MTOR BMP7 IL2 HTR2A"
GO:0043523	regulation of neuron apoptosis	0.227413686	4.24E-14	4.769487179	7.93E-11	33 genes "HRAS TNF WFS1 GRIK2 ERBB3 SNCA BCL2L1 NR3C1 GDNF GCLM GPX1 BDNF KRAS AGT BCL2 GRID2 RHOA NQO1 NEFL LTA MSH2 GRIN1 ESR1 NR4A2 SOD1 ATM SOD2 NRAS DLX1 PSEN1 JUN BAX CRH"
GO:0019935	cyclic-nucleotide-mediated signaling	0.275652953	4.39E-14	4.002366864	8.22E-11	40 genes "OPRM1 ADCY3 DRD1 CCL2 DRD3 ADCY7 GNAI1 DRD2 ADCY8 PTH1R DRD4 HTR1B HTR1A S1PR1 MC1R APOE AGT CNR1 PTH GALR2 CNR2 NOS2 PRKACB HTR1D HTR5A HTR4 NPY1R PCLO CRHR1 P2RY12 GNAL SSTR5 CRHR2 UCN3 ADRB2 NPY ADM CHRM2 GNAS CORT"
GO:0030182	neuron differentiation	0.565088554	5.72E-14	2.435230067	1.07E-10	82 genes "CCKAR NRP1 PEX5 L1CAM RORB CNP GRIN3A RORA GDNF NRCAM CDC42 BDNF APP SLC1A3 S1PR1 MC1R CD44 ANK3 ATXN10 GALR2 ROBO2 OLIG2 CHAT PTPRM RXRA OTX2 PRKCI LRTOMT SLIT3 NCAM2 ASCL1 PRKCQ SLITRK1 BTG2 ADM PSEN1 RASGRF1 VEGFA CNTN2 CNTN4 VCAN NGFR GAP43 RAB3A FGFR1 DRD1 ERBB3 DRD2 CLU NAPA EPHB1 TUBB PVRL1 PTK2B DGKG BCL2 KAL1 DCX NEFL SNAP25 RUNX3 NKX2-2 APC IL6 GNAO1 PTPRZ1 RYK CREB1 MAP1B NR4A2 SOD1 STAT3 SOD2 CDKN1C NTRK3 LEP DLX1 S100B MAP2 NTRK2 CYFIP1 BMP7"
GO:0001505	regulation of neurotransmitter levels	0.192957067	1.20E-13	5.436050517	2.25E-10	28 genes "RAB3A ACHE SYT4 SLC6A4 COMT GAD2 SLC1A3 SYN1 SYN3 SYN2 PRIMA1 SNAP25 GAD1 CHAT GABRA2 STX1A NOS1 MAOA NLGN1 LRTOMT ATP1A2 DBH PCLO SLC17A7 P2RX7 SLC17A6 GRM2 PSEN1"
GO:0048545	response to steroid hormone stimulus	0.337674867	1.21E-13	3.319671474	2.26E-10	49 genes "A2M CCL2 TNF SLC6A1 PTGS2 IGFBP7 OXT LEPR OXTR RPS6KB1 TSHB TGFB1 IL10 CTNNB1 FOS GSTM3 APOA2 HTR1B TNFRSF11B KRAS BCL2 ENO2 AANAT IL1B NOS3 NEFL IL6 CRYAB RXRA BCKDHB MAP1B ESR1 NPY1R IL6R MMP14 GAL ADIPOQ STAT3 ABCB4 MAPK1 GH1 UCN3 CCND1 EP300 ADM COL1A1 IGFBP2 BMP7 SST"
GO:0030808	regulation of nucleotide biosynthetic process	0.248087658	1.26E-13	4.257062937	2.36E-10	36 genes "OPRM1 ADCY3 DRD1 ADCY7 DRD3 ADCY8 DRD2 GNAI1 PTH1R EDN1 DRD4 GABBR1 GABBR2 ADCYAP1 CALCA EDNRB HTR1B HTR1A S1PR1 APOE PTH GALR2 ADRA2A NOS3 CAP2 NPY1R CRHR1 GNAL SSTR5 GRM3 UCN3 ADRB2 GRM2 NTRK2 GNAS CORT"
GO:0030802	regulation of cyclic nucleotide biosynthetic process	0.248087658	1.26E-13	4.257062937	2.36E-10	36 genes "OPRM1 ADCY3 DRD1 ADCY7 DRD3 ADCY8 DRD2 GNAI1 PTH1R EDN1 DRD4 GABBR1 GABBR2 ADCYAP1 CALCA EDNRB HTR1B HTR1A S1PR1 APOE PTH GALR2 ADRA2A NOS3 CAP2 NPY1R CRHR1 GNAL SSTR5 GRM3 UCN3 ADRB2 GRM2 NTRK2 GNAS CORT"
GO:0007568	aging	0.248087658	1.26E-13	4.257062937	2.36E-10	36 genes "HRAS SLC6A3 ALDOC PTH1R RPS6KB1 ADRBK1 IL15 CALR TGFB1 FOS SLC1A2 KRAS MORC3 GSN BCL2 SERPINE1 NPM1 IL1B ENO3 NOS3 TERT GNAO1 CRYAB MSH2 FADS1 RXRA SOD1 SIRT1 SOD2 NRAS PRKCQ NUP62 ADM JUN IGFBP2 HTR2A"
GO:0032102	negative regulation of response to external stimulus	0.165391772	2.65E-13	6.243692308	4.95E-10	24 genes "DRD1 IL2RA DRD3 DRD2 SLC6A3 GRIN1 GRIN3A GREM1 ADIPOQ IL10 LEP GPX1 TNFRSF1B NPC1 ADRB2 SERPINF1 SAA1 INS APOE GRID2 CHRNA7 MTOR FABP7 IL2"
GO:0030817	regulation of cAMP biosynthetic process	0.23430501	2.72E-13	4.378827113	5.09E-10	34 genes "OPRM1 ADCY3 DRD1 ADCY7 DRD3 ADCY8 DRD2 GNAI1 PTH1R EDN1 DRD4 GABBR1 GABBR2 ADCYAP1 CALCA EDNRB HTR1B HTR1A S1PR1 PTH GALR2 ADRA2A CAP2 NPY1R CRHR1 GNAL SSTR5 GRM3 UCN3 ADRB2 GRM2 NTRK2 GNAS CORT"
GO:0045471	response to ethanol	0.186065743	2.73E-13	5.487620192	5.10E-10	27 genes "PRF1 CCL2 DRD3 DRD2 SLC6A3 DRD4 RPS6KB1 GRIN3A GOT2 TNFRSF1A HTR1B GRIN2B APOE PTK2B GSN BCL2 NOS3 GRIN1 GRIN2A IL6R DBH SOD1 ADIPOQ STAT3 CCND1 EP300 EPS8"
GO:0030799	regulation of cyclic nucleotide metabolic process	0.248087658	3.11E-13	4.144043567	5.81E-10	36 genes "OPRM1 ADCY3 DRD1 ADCY7 DRD3 ADCY8 DRD2 GNAI1 PTH1R EDN1 DRD4 GABBR1 GABBR2 ADCYAP1 CALCA EDNRB HTR1B HTR1A S1PR1 APOE PTH GALR2 ADRA2A NOS3 CAP2 NPY1R CRHR1 GNAL SSTR5 GRM3 UCN3 ADRB2 GRM2 NTRK2 GNAS CORT"
GO:0007623	circadian rhythm	0.158500448	3.22E-13	6.503846154	6.01E-10	23 genes "PRF1 EGR3 DRD1 DRD3 ERBB3 DRD2 PGLYRP1 PROKR2 ARNTL PROK2 NPAS2 CRY2 TIMELESS NR1D1 PTGDS JUN CRH PER2 AANAT PER1 PER3 CRY1 CLOCK"
GO:0048666	neuron development	0.46861002	3.86E-13	2.609212616	7.22E-10	68 genes "CCKAR NRP1 RORB CNP L1CAM GRIN3A GDNF NRCAM BDNF APP SLC1A3 CD44 ANK3 ATXN10 GALR2 ROBO2 CHAT PTPRM RXRA OTX2 PRKCI LRTOMT SLIT3 NCAM2 ASCL1 SLITRK1 ADM PSEN1 RASGRF1 VEGFA CNTN2 CNTN4 VCAN NGFR GAP43 FGFR1 RAB3A DRD1 ERBB3 DRD2 CLU EPHB1 PVRL1 PTK2B DGKG BCL2 KAL1 DCX NEFL SNAP25 RUNX3 APC IL6 GNAO1 PTPRZ1 RYK CREB1 MAP1B NR4A2 SOD1 SOD2 CDKN1C LEP S100B MAP2 NTRK2 CYFIP1 BMP7"
GO:0007612	learning	0.179174419	3.93E-13	5.636666667	7.36E-10	26 genes "HRAS DRD1 DRD3 SLC6A1 HMGCR DRD2 TAC1 COMT AMPH FOS PRKAR2B APP KRAS GRIN2B PDE1B DLG4 PTN GRIN1 GABRA5 ATP1A3 GRIN2A ATP1A2 DBH NRAS JUN CACNA1C"
GO:0051241	negative regulation of multicellular organismal process	0.303218248	4.00E-13	3.489868668	7.48E-10	44 genes "DRD1 ACHE TNF SLC6A1 PTGS2 DRD2 GRIK2 GRIK3 OXT EDN1 TAC1 NFKB1 ADRBK1 IL10 CALCA HTR1B TNFRSF11B APOA1 INS APOE IFNG SERPINE1 APOH NOS3 CHRNA7 BCL6 IL6 CST3 ATP1A1 ATP1A2 IDO1 IL6R KAT5 SOD1 ADIPOQ ADRB2 P2RX7 ADM VEGFA F2 CRH NGFR HTR2A IL2"
GO:0009991	response to extracellular stimulus	0.358348839	4.97E-13	3.074545455	9.30E-10	52 genes "CCKAR LDHA KYNU A2M PTGS2 IGFBP7 LEPR RPS6KB1 TGFB1 FOS SLC1A2 TNFRSF11B CD44 MAP1LC3A GSN IL1B LTA GATM RXRA COX4I1 CCND1 UCN3 ADM PSEN1 JUN RYR2 COL1A1 CCL2 OXT HFE TSHB ENSA ALB BCL2 HSPA5 CFB FADS1 MAP1B BCKDHB NR4A2 SOD1 SIRT1 ADIPOQ SOD2 LEP P2RX7 NPY MTOR IGFBP2 BMP7 SST KLF4"
GO:0030814	regulation of cAMP metabolic process	0.23430501	5.10E-13	4.293801344	9.53E-10	34 genes "OPRM1 ADCY3 DRD1 ADCY7 DRD3 ADCY8 DRD2 GNAI1 PTH1R EDN1 DRD4 GABBR1 GABBR2 ADCYAP1 CALCA EDNRB HTR1B HTR1A S1PR1 PTH GALR2 ADRA2A CAP2 NPY1R CRHR1 GNAL SSTR5 GRM3 UCN3 ADRB2 GRM2 NTRK2 GNAS CORT"
GO:0007187	"G-protein signaling, coupled to cyclic nucleotide second messenger"	0.248087658	5.54E-13	4.071973244	1.04E-09	36 genes "OPRM1 ADCY3 DRD1 CCL2 DRD3 ADCY7 GNAI1 ADCY8 DRD2 PTH1R DRD4 HTR1B HTR1A S1PR1 MC1R AGT CNR1 PTH GALR2 CNR2 NOS2 PRKACB HTR1D HTR4 NPY1R CRHR1 P2RY12 GNAL SSTR5 CRHR2 UCN3 ADRB2 NPY CHRM2 GNAS CORT"
GO:0009967	positive regulation of signal transduction	0.427262077	5.78E-13	2.733820078	1.08E-09	62 genes "HRAS FGF9 LEPR ITPKB L1CAM LPAR1 TGFB1 CTNNB1 CITED2 GPX1 IFNG RHOA IL1B RHOC CAT PRL LTA ESR1 IL6R F7 NFAM1 IL20 NCAM1 ASCL1 ADRB2 TNFRSF10B EREG VEGFA IL12A TNF LITAF DRD3 ERBB3 PPM1A TNFRSF1A KRAS INS AGT PTH CC2D1A EGF EPO KLK6 IL4 IL3 IL6 IL5 IGF1 ADIPOQ LEP CDKN1C GH1 NRAS CDH13 IKBKE P2RX7 NUP62 HPX EEF1E1 MTOR BMP7 IL2"
GO:0006140	regulation of nucleotide metabolic process	0.248087658	7.36E-13	4.036870027	1.38E-09	36 genes "OPRM1 ADCY3 DRD1 ADCY7 DRD3 ADCY8 DRD2 GNAI1 PTH1R EDN1 DRD4 GABBR1 GABBR2 ADCYAP1 CALCA EDNRB HTR1B HTR1A S1PR1 APOE PTH GALR2 ADRA2A NOS3 CAP2 NPY1R CRHR1 GNAL SSTR5 GRM3 UCN3 ADRB2 GRM2 NTRK2 GNAS CORT"
GO:0031279	regulation of cyclase activity	0.227413686	8.75E-13	4.335897436	1.64E-09	33 genes "OPRM1 ADCY3 DRD1 ADCY7 DRD3 ADCY8 DRD2 GNAI1 DRD4 PTH1R GABBR1 GABBR2 ADCYAP1 CALCA EDNRB HTR1A S1PR1 PTH GALR2 ADRA2A NOS3 CAP2 NPY1R CRHR1 SSTR5 GNAL GRM3 UCN3 ADRB2 GRM2 NTRK2 GNAS CORT"
GO:0048585	negative regulation of response to stimulus	0.227413686	1.19E-12	4.292538462	2.23E-09	33 genes "A2M DRD1 DRD3 DRD2 SLC6A3 GRIN3A GREM1 TGFB1 IL10 GPX1 TNFRSF1B INS APOE SAA1 GRID2 IL1B CHRNA7 BCL6 IL2RA GRIN1 CTLA4 SERPING1 SIRT1 ADIPOQ LEP ADRB2 NPC1 SERPINF1 CRH MTOR PTPN1 FABP7 IL2"
GO:0002697	regulation of immune effector process	0.227413686	1.62E-12	4.250038081	3.03E-09	33 genes "A2M TNF CADM1 C3 TBX21 KLRK1 IL13 APOBEC3G IL15 TGFB1 IL10 B2M APOA2 APOA1 INS IFNG IL1B BCL6 NOS2 DPP4 IL4 ICAM1 IL6 SERPING1 AP2A2 P2RX7 HPX CD40LG PRAM1 IL12A IL12B HSPD1 IL2"
GO:0051339	regulation of lyase activity	0.227413686	1.62E-12	4.250038081	3.03E-09	33 genes "OPRM1 ADCY3 DRD1 ADCY7 DRD3 ADCY8 DRD2 GNAI1 DRD4 PTH1R GABBR1 GABBR2 ADCYAP1 CALCA EDNRB HTR1A S1PR1 PTH GALR2 ADRA2A NOS3 CAP2 NPY1R CRHR1 SSTR5 GNAL GRM3 UCN3 ADRB2 GRM2 NTRK2 GNAS CORT"
GO:0006916	anti-apoptosis	0.337674867	1.99E-12	3.094062733	3.73E-09	49 genes "CCL2 TNF XIAP CLU SNCA NFKB1 PRDX2 BCL2L1 GDNF IL10 CITED2 GPX1 BDNF APOE BCL2 COMP NPM1 IL1B NOS3 HSPA5 NRG1 IL1A TERT HSPA9 IL3 IL2RB IL7 CRYAB BCL2A1 ESR1 PRKCI IGF1 F7 SOD1 SOD2 CDH13 PROK2 HSP90B1 PRLR PSEN1 CD40LG GSK3B BAX VEGFA SERPINB2 MPO NGFR TNFAIP3 IL2"
GO:0045761	regulation of adenylate cyclase activity	0.220522362	2.05E-12	4.335897436	3.83E-09	32 genes "OPRM1 ADCY3 DRD1 ADCY7 DRD3 ADCY8 DRD2 GNAI1 DRD4 PTH1R GABBR1 GABBR2 ADCYAP1 CALCA EDNRB HTR1A S1PR1 PTH GALR2 ADRA2A CAP2 NPY1R CRHR1 GNAL SSTR5 UCN3 ADRB2 GRM3 GRM2 NTRK2 GNAS CORT"
GO:0043524	negative regulation of neuron apoptosis	0.158500448	4.38E-12	5.866214178	8.19E-09	23 genes "HRAS ERBB3 WFS1 MSH2 GRIK2 GRIN1 SNCA NR4A2 BCL2L1 SOD1 GDNF GCLM SOD2 NRAS BDNF DLX1 KRAS PSEN1 AGT BAX BCL2 RHOA NEFL"
GO:0031667	response to nutrient levels	0.32389222	5.34E-12	3.103358063	9.99E-09	47 genes "CCKAR KYNU A2M CCL2 PTGS2 IGFBP7 OXT LEPR HFE RPS6KB1 TSHB ENSA TGFB1 TNFRSF11B CD44 MAP1LC3A GSN ALB BCL2 IL1B HSPA5 LTA GATM CFB FADS1 RXRA BCKDHB MAP1B COX4I1 SOD1 SIRT1 ADIPOQ SOD2 LEP UCN3 CCND1 ADM NPY PSEN1 JUN RYR2 MTOR COL1A1 IGFBP2 BMP7 SST KLF4"
GO:0030030	cell projection organization	0.475501344	6.79E-12	2.438942308	1.27E-08	69 genes "CCKAR MTSS1 NRP1 CROCC CNP L1CAM GRIN3A LPAR1 GDNF NRCAM CDC42 BDNF APP CD44 ANK3 ATXN10 GALR2 ROBO2 CHAT PTPRM RXRA OTX2 MYH9 PCM1 SLIT3 NCAM2 SLITRK1 ADM RASGRF1 CNTN2 CNTN4 VCAN NGFR GAP43 FGFR1 RAB3A ERBB3 DRD2 CLU RDX CAPZB EPHB1 RAC2 PVRL1 PTK2B BCL2 KAL1 DCX NEFL SNAP25 RUNX3 APC DNM3 IL6 GNAO1 PTPRZ1 RYK PCNT CREB1 MAP1B NR4A2 SOD1 CDH13 P2RX7 S100B MAP2 CYFIP1 MTOR BMP7"
GO:0008217	regulation of blood pressure	0.220522362	6.88E-12	4.162461538	1.29E-08	32 genes "PTGS2 DRD3 DRD2 OXT EDN1 TAC1 OXTR BDKRB1 BDKRB2 POMC CALCA EDNRB ACE NISCH AGT NOS3 NOS2 ACTA2 ATP1A1 ATP1A2 NPY1R SOD1 ADIPOQ SOD2 CHGA ADRB2 NPY AVPR1B NPPB GNB3 CACNA1C NPPA"
GO:0006836	neurotransmitter transport	0.199848391	7.25E-12	4.544856348	1.36E-08	29 genes "RAB3A CPLX2 CPLX1 SLC6A1 SYT4 SLC6A2 SLC6A3 SLC6A4 SLC32A1 SLC1A3 SYN1 SYN3 SYN2 SV2B SV2A SNAP25 GABRA2 STX1A NLGN1 SLC6A15 ATP1A2 PCLO STX1B SLC17A7 P2RX7 SLC17A6 GRM2 PSEN1 SLC18A2"
GO:0007613	memory	0.137826476	8.88E-12	6.67061144	1.66E-08	20 genes "DRD1 PTGS2 ADCY8 OXT GRIN1 GRIN2A ATP1A3 OXTR TAC1 RPS6KB1 DBH PSEN1 GRIN2B RASGRF1 GRIA1 CRH IL1B CHRNA7 SNAP25 HTR2A"
GO:0006952	defense response	0.668458411	1.01E-11	2.051619762	1.89E-08	97 genes "A2M KYNU KLRC3 GRIK2 TOLLIP CRP SNCA PGLYRP1 IL13 NFKB1 PRDX2 HP APOBEC3G IL15 TLR7 IL10 TGFB1 FOS APOA2 GRIN2B CD44 SAA1 CD46 IFNG ITIH4 IL1B NOS2 MX1 CFD IL1A IRAK2 NFKBIZ PLD1 RXRA CST3 CHST2 CD160 SERPING1 NFAM1 IL6R GAL CLEC1A PROK2 CCR6 CD40LG F2 PLA2G7 IL12A