Enriched GO by DAVID

The GO-enriched analysis was done by DAVID using 1239 MDD related genes from literature. GO terms with FDR < 0.05 were shown.

Biological Process (count: 45)
Cellular Component (count: 21)
Molecular Function (count: 5)

Biological Process (count: 45)

GO ID	Name	%	P-value	Fold Enrichment	FDR	Genes
GO:0019226	transmission of nerve impulse	11.89759036	2.08E-35	5.347570678	3.78E-32	79 genes SLC6A1 SYT4 GABRB2 SLC6A2 HEXA SLC6A4 GRIK5 CNP GABBR2 MBP SLC1A2 HTR1B SLC1A3 GRIN2B APOE GALR2 DLG4 GRID2 QKI OLIG2 HTR1D NQO1 FGF2 USP14 GABRG1 GABRG2 STX1A KCND2 GRIN2A LRTOMT PCLO GRM1 MAPK1 GRM3 GABRR1 PSEN1 PLLP PMP22 RAB3A DRD1 DRD2 DRD4 TAC1 COMT AMPH HCRTR1 GAD2 SYPL1 SYN1 SYN2 PRIMA1 GAD1 HTR3B SNAP25 GABRD KLK6 GLRB DLGAP1 PLP1 GABRA2 NOS1 GABRA3 MAOA GABRA5 NLGN1 MAL DBH SLC17A7 P2RX7 SLC17A6 NPY GRIA2 GRIA1 KCNN3 CORT CACNA1C HTR2C SST HTR2A
GO:0007268	synaptic transmission	10.9939759	3.81E-35	5.803688337	6.92E-32	73 genes SLC6A1 SYT4 GABRB2 SLC6A2 SLC6A4 GRIK5 CNP GABBR2 MBP SLC1A2 HTR1B SLC1A3 GRIN2B APOE GALR2 DLG4 GRID2 NQO1 HTR1D FGF2 USP14 GABRG1 GABRG2 STX1A KCND2 GRIN2A LRTOMT GRM1 PCLO MAPK1 GRM3 GABRR1 PSEN1 PMP22 RAB3A DRD1 DRD2 DRD4 TAC1 COMT AMPH HCRTR1 GAD2 SYPL1 SYN1 SYN2 PRIMA1 GAD1 HTR3B SNAP25 GABRD GLRB DLGAP1 PLP1 GABRA2 NOS1 GABRA3 MAOA GABRA5 NLGN1 DBH SLC17A7 P2RX7 SLC17A6 GRIA2 NPY GRIA1 KCNN3 CORT CACNA1C HTR2C SST HTR2A
GO:0007610	behavior	12.95180723	1.59E-31	4.344332877	2.89E-28	86 genes OPRM1 CCKAR SLC6A1 ADCY8 WFS1 LEPR HEXA CRHBP IL18 SLC6A3 CNP GDNF CALB1 IL10 PRKAR2B FOS BDNF SLC1A2 HTR1B HTR1A SLC1A3 GRIN2B SEMA3F IFNG GALR2 DLG4 RALA IL1B ROBO2 CHRNA7 FGF2 EGR1 GABRG2 CCKBR GRIN2A FOSB GAL GRM1 MAPK1 PROK2 PSEN1 RASGRF1 JUN DRD1 CCL2 DRD2 ENPP2 DRD4 TAC1 COMT APLP2 AMPH HCRTR1 NPAS2 NPAS3 RAC2 PDE1B CNR1 KAL1 CNR2 PTN ACSL4 SNAP25 FZD9 GLRB IL6 CREB3 IL8 MAOA GABRA5 NR4A2 ATP1A3 TBX1 DBH SOD2 S100B NPY EPS8 PENK GRIA1 NTRK2 SLC18A2 USP46 CACNA1C HTR2C HTR2A
GO:0007267	cell-cell signaling	14.45783133	2.09E-30	3.790683012	3.80E-27	96 genes SLC6A1 SYT4 GABRB2 FGF9 TOLLIP SLC6A2 IL18 EDN1 SLC6A4 GRIK5 IL13 CNP GABBR2 IL15 GDNF IL10 MBP BDNF HTR1B SLC1A2 SLC1A3 GRIN2B APOE GALR2 GRID2 DLG4 IL1B HTR1D NQO1 FGF1 FGF2 LTA USP14 GABRG1 GABRG2 STX1A AR KCND2 GRIN2A LRTOMT GAL PCLO GRM1 MAPK1 GRM3 GABRR1 PSEN1 GPR50 PMP22 RAB3A DRD1 DRD2 DRD4 TAC1 COMT GREM1 AMPH ADCYAP1 HCRTR1 GAD2 SYPL1 SYN1 INS SYN2 PRIMA1 GAD1 SNAP25 HTR3B GABRD IL3 GLRB PLP1 IL6 GABRA2 DLGAP1 NOS1 GABRA3 FADS1 MAOA GABRA5 NLGN1 DBH SLC17A7 P2RX7 SLC17A6 NPY GRIA2 GRIA1 KCNN3 NTRK2 CORT CACNA1C HTR2C SST IL2 HTR2A
GO:0007242	intracellular signaling cascade	18.6746988	7.17E-20	2.338996285	1.30E-16	124 genes ADCY3 THRA ADCY7 ADCY8 EDN1 LPAR1 IL10 RAB1A BTK PRKAR2B PRKAR2A HTR1B HTR1A MC1R TIAM1 APOE IFNG GALR2 RAPGEF6 RALA IL1B CHRNA7 GNG3 HTR1D RAB27B DFFA MED12 HTR4 PCLO CRHR1 CRHR2 SSTR5 MAPK1 UCN3 RASGRF1 MAPK8 RAB13 ARL8B ASB4 FGFR1 DRD1 CCL2 FGFR3 ERBB3 DRD2 DRD4 PTH1R MYO9B RAC2 GMIP INS CNR1 CNR2 PLCH1 ADRA2A EGF ARHGDIB CNKSR1 RAB8B EFS KAT5 ATM P2RX7 CBLB NPY NUP62 RGS4 PRKAR1A CORT OPRM1 CCKAR TOLLIP PREX1 MCTP2 AEN RHOA NOS2 FGF1 FGF2 LTA HTR5A RSU1 ARHGEF2 AR PIK3C2G CCKBR PIK3C2A RAB4B ESR1 PRKCI GRM1 PROK2 GNAL PRKCQ CCND1 ADRB2 PSEN1 CHRM2 RRAS2 GNAS GNB3 ARL4C RAB3A TNF CREM NR3C1 PTK2B DGKG RASA4 PIK3R1 RAB2A IL8 MSH2 DGKH RCAN3 YWHAE P2RY12 DUSP4 PRLR MAPK12 NUPR1 GSK3B HTR2C HTR2A
GO:0007611	learning or memory	5.120481928	1.24E-19	7.256938199	2.26E-16	34 genes DRD1 SLC6A1 ADCY8 DRD2 CRHBP TAC1 COMT CALB1 AMPH FOS PRKAR2B BDNF GRIN2B PDE1B GALR2 DLG4 PTN IL1B CHRNA7 ACSL4 SNAP25 FZD9 EGR1 GABRA5 ATP1A3 GRIN2A DBH S100B PSEN1 RASGRF1 GRIA1 JUN CACNA1C HTR2A
GO:0044057	regulation of system process	8.28313253	1.74E-19	4.216981506	3.16E-16	55 genes THRA SLC6A1 GRIK3 EDN1 SDC4 CALB1 GDNF IL10 HTR1B BDNF SLC1A3 GRIN2B APOE IFNG DLG4 IL1B NOS2 LTA EGR1 STX1A GRIN2A GRM1 PRKCQ PROK2 GRM3 ADRB2 PSEN1 CHRM2 RASGRF1 CELF2 RYR2 CNTN4 RAB3A TF DRD1 TNF CCL2 DRD2 DRD4 TAC1 ANXA6 ACE INS CAMK2A NOS1 NLGN1 DBH GRIA2 NTRK2 AVPR1B USP46 CACNA1C HTR2C IL2 HTR2A
GO:0042127	regulation of cell proliferation	13.85542169	2.84E-19	2.769558745	5.17E-16	92 genes OPRM1 FGF9 IGFBP7 IL18 EDN1 IL13 PAWR IL15 IL10 SSR1 FNTB BDNF HTR1A APOE IFNG SERPINE1 IL1B CHRNA7 NOS2 ASPH NRG1 FGF1 FGF2 IL1A LTA UBE2A ARHGEF2 CCKBR SF1 GAL MAPK1 SSTR5 PRKCQ PPM1D CCND1 ADRB2 BTG2 BTG1 JUN VEGFA IL12A NGFR PMP22 FGFR2 FGFR1 CCL2 TNF FGFR3 DRD2 ERBB3 PTH1R TAC1 ABI1 BCL2L1 ZBTB16 COMT RAC2 INS PTK2B NPM1 ADRA2A PTN BCL6 GPNMB EGF APC PTPN6 IL3 IL6 IL5 CREB3 IL8 IL9 CTLA4 DBH SIRT1 SOD2 CDKN1C CBLB HDAC2 NUP62 NUPR1 EEF1E1 BAX HGS BMP7 SST KLF4 FABP6 IL2 HTR2A TOB1
GO:0031644	regulation of neurological system process	5.722891566	1.61E-18	5.884230166	2.93E-15	38 genes TF RAB3A DRD1 TNF CCL2 SLC6A1 DRD2 GRIK3 EDN1 DRD4 TAC1 CALB1 GDNF IL10 HTR1B BDNF SLC1A3 GRIN2B APOE IFNG DLG4 CAMK2A LTA EGR1 STX1A NLGN1 GRIN2A GRM1 GRM3 ADRB2 GRIA2 PSEN1 RASGRF1 NTRK2 USP46 CNTN4 HTR2C HTR2A
GO:0019932	second-messenger-mediated signaling	6.927710843	5.34E-18	4.637537728	9.72E-15	46 genes OPRM1 ADCY3 CCKAR DRD1 CCL2 TNF ADCY7 DRD2 ADCY8 PTH1R DRD4 EDN1 BTK HTR1B HTR1A MCTP2 MC1R APOE CNR1 GALR2 CNR2 NOS2 HTR1D LTA HTR5A PIK3C2G CCKBR IL8 PIK3C2A HTR4 RCAN3 PCLO GRM1 P2RY12 CRHR1 GNAL SSTR5 CRHR2 ADRB2 UCN3 NPY CHRM2 GNAS CORT HTR2C HTR2A
GO:0010033	response to organic substance	12.65060241	1.69E-17	2.760206077	3.08E-14	84 genes ADCY3 THRA SLC6A1 ADCY7 ADCY8 LEPR SLC6A3 IGFBP7 DICER1 IL10 PRKAR2B FOS PRKAR2A HTR1B SLC1A2 GSTM3 GRIN2B APOE IFNG IL1B CHRNA7 GNG3 LTA EGR1 AR GATM ESR1 PRKCI GRIN2A GAL MAPK1 GNAL PRKCQ CCND1 UCN3 GLUL EP300 BTG2 JUN IL12A RYR2 SORT1 GNAS GNB3 TF DRD1 CCL2 TNF DRD2 ERBB3 DRD4 TAC1 BCL2L1 NR3C1 COMT TNFRSF1A HSPA2 INS PTK2B TOR1A AANAT PIK3R1 IL6 MSH2 CFB FADS1 CREB1 NR4A2 PDE3A DBH HDAC5 DUSP4 P2RX7 HDAC2 NUP62 EPS8 PRKAR1A SLC18A2 PTPN1 IGFBP2 BMP7 TJP2 HTR2C SST
GO:0051969	regulation of transmission of nerve impulse	5.421686747	2.35E-17	5.802065835	4.26E-14	36 genes RAB3A TF DRD1 TNF CCL2 SLC6A1 DRD2 GRIK3 EDN1 DRD4 TAC1 CALB1 GDNF HTR1B BDNF SLC1A3 GRIN2B APOE IFNG DLG4 CAMK2A LTA EGR1 STX1A NLGN1 GRIN2A GRM1 GRM3 GRIA2 PSEN1 RASGRF1 NTRK2 USP46 CNTN4 HTR2C HTR2A
GO:0050877	neurological system process	17.31927711	4.02E-17	2.251697037	7.31E-14	115 genes ADCY3 SLC6A1 SYT4 ADCY8 WFS1 GABRB2 SLC6A2 CRHBP SLC6A3 SLC6A4 GRIK5 CNP CALB1 PRKAR2B HTR1B BDNF GRIN2B APOE GALR2 GRID2 IL1B CHRNA7 OLIG2 HTR1D NQO1 KCND2 MYO3A GRIN2A LRTOMT PCLO NCAM2 MAPK1 GABRR1 RASGRF1 JUN PMP22 DRD1 DRD2 DRD4 HCRTR1 PDE6B GAD2 SYPL1 PRIMA1 GAD1 GABRD GABRA2 GABRA3 MAOA GABRA5 P2RX7 NPY S100B PENK CORT CACNA1C SST OPRM1 HEXA GABBR2 MBP FOS SLC1A2 SLC1A3 DLG4 QKI FGF2 USP14 EGR1 GABRG1 GABRG2 STX1A CCKBR GRM1 PROK2 GNAL GRM3 PSEN1 GNAS PLLP RAB3A TAC1 COMT DTNBP1 APLP2 MFRP AMPH PDE1B SYN1 PDE1C SYN2 PTN ACSL4 SNAP25 HTR3B FZD9 KLK6 DLGAP1 GLRB PLP1 NOS1 MAP1A NLGN1 ATP1A3 MAL TBX1 DBH SOD2 SLC17A7 SLC17A6 GRIA2 GRIA1 KCNN3 HTR2C HTR2A
GO:0050804	regulation of synaptic transmission	5.120481928	1.06E-16	5.922942207	2.00E-13	34 genes RAB3A DRD1 TNF CCL2 SLC6A1 DRD2 GRIK3 EDN1 DRD4 TAC1 CALB1 GDNF HTR1B BDNF SLC1A3 GRIN2B APOE DLG4 CAMK2A LTA EGR1 STX1A NLGN1 GRIN2A GRM1 GRM3 GRIA2 PSEN1 RASGRF1 NTRK2 USP46 CNTN4 HTR2C HTR2A
GO:0044093	positive regulation of molecular function	10.84337349	4.30E-16	2.910934054	8.10E-13	72 genes ADCY3 OPRM1 CCKAR ADCY7 ADCY8 EDN1 LPAR1 SDC4 GDNF IL10 PRKAR2B PRKAR2A APOE IFNG GALR2 IL1B CHRNA7 CAT BRD4 GNG3 NRG1 FGF2 CCKBR GRM1 CRHR1 GNAL PROK2 PRKCQ CCND1 ADRB2 UCN3 EP300 PSEN1 RASGRF1 CHRM2 GNAS FZR1 DRD1 TNF DRD2 CALD1 DRD4 PTH1R ADCYAP1 PSMB4 INS PTK2B DGKG NPM1 ADRA2A EGF CAMK2A IL6 CAP2 IL5 MSH3 MSH2 NR4A2 DGKH HDAC5 P2RX7 PRLR PSMD11 BAX AVPR1B NTRK2 PRKAR1A LRP8 HTR2C CALM2 IL2 HTR2A
GO:0019935	cyclic-nucleotide-mediated signaling	4.819277108	1.75E-15	5.831820019	3.23E-12	32 genes OPRM1 ADCY3 DRD1 CCL2 ADCY7 ADCY8 DRD2 PTH1R DRD4 HTR1B HTR1A MC1R APOE CNR1 GALR2 CNR2 NOS2 HTR1D HTR5A HTR4 PCLO CRHR1 P2RY12 GNAL SSTR5 CRHR2 UCN3 ADRB2 NPY CHRM2 GNAS CORT
GO:0009719	response to endogenous stimulus	8.584337349	2.55E-15	3.334397094	4.64E-12	57 genes ADCY3 THRA SLC6A1 ADCY7 ADCY8 IGFBP7 LEPR IL10 FOS PRKAR2B GSTM3 SLC1A2 HTR1B PRKAR2A IL1B GNG3 AR GATM PRKCI GRIN2A ESR1 GAL MAPK1 GNAL PRKCQ CCND1 UCN3 EP300 BTG2 SORT1 GNAS GNB3 DRD1 TNF CCL2 DRD2 ERBB3 DRD4 TAC1 BCL2L1 INS PTK2B AANAT PIK3R1 IL6 MSH2 FADS1 NR4A2 DBH HDAC5 NUP62 PRKAR1A SLC18A2 PTPN1 IGFBP2 BMP7 SST
GO:0001505	regulation of neurotransmitter levels	3.463855422	1.71E-14	8.132995269	3.11E-11	23 genes RAB3A GABRA2 STX1A NOS1 SYT4 MAOA SLC6A4 NLGN1 LRTOMT COMT DBH PCLO SLC17A7 GAD2 P2RX7 SLC1A3 SLC17A6 PSEN1 SYN1 SYN2 PRIMA1 GAD1 SNAP25
GO:0007187	G-protein signaling, coupled to cyclic nucleotide second messenger	4.36746988	2.36E-14	5.974446052	4.30E-11	29 genes OPRM1 ADCY3 DRD1 CCL2 ADCY7 ADCY8 DRD2 PTH1R DRD4 HTR1B HTR1A MC1R CNR1 CNR2 GALR2 NOS2 HTR1D HTR4 CRHR1 P2RY12 GNAL CRHR2 SSTR5 UCN3 ADRB2 NPY CHRM2 GNAS CORT
GO:0051050	positive regulation of transport	6.024096386	2.56E-14	4.249644633	4.64E-11	40 genes DRD1 TNF WFS1 DRD2 ERBB3 DRD4 EDN1 IL13 TAC1 GDNF IL10 SLC1A2 GRIN2B INS APOE IFNG RHOA IL1B SNAP25 LTA IL1A PIK3R1 STX1A IL6 RAB8B CREB3 CREB1 ARPP19 PRKCI P2RY12 PRKCQ UCN3 ADRB2 P2RX7 GSK3B BAX AVPR1B HTR2C CALM2 IL2
GO:0008285	negative regulation of cell proliferation	7.680722892	8.00E-14	3.347036593	1.46E-10	51 genes OPRM1 IGFBP7 IL15 PAWR IL10 FNTB BDNF APOE IFNG IL1B ASPH FGF2 LTA IL1A SF1 GAL SSTR5 PPM1D BTG2 BTG1 JUN IL12A PMP22 TNF DRD2 PTH1R ABI1 COMT ZBTB16 NPM1 BCL6 GPNMB APC PTPN6 IL6 IL8 CTLA4 SOD2 CDKN1C CBLB NUP62 NUPR1 BAX EEF1E1 HGS BMP7 SST KLF4 TOB1 IL2 FABP6
GO:0051046	regulation of secretion	5.572289157	1.44E-13	4.339581419	2.61E-10	37 genes RAB3A TNF ERBB3 DRD2 EDN1 DRD4 IL13 TAC1 GDNF IL10 HTR1B GRIN2B INS IFNG IL1B NOS2 RAB27B EGF NRG1 CAMK2A SNAP25 FGF2 IL1A STX1A IL6 RAB8B CREB1 PCLO SSTR5 PRKCQ UCN3 P2RX7 NTRK2 AVPR1B HTR2C HTR2A IL2
GO:0042493	response to drug	5.722891566	2.33E-13	4.167996368	4.24E-10	38 genes DRD1 CCL2 DRD2 ERBB3 SLC6A3 COMT HADHA FOS BDNF SLC1A2 SLC1A3 PTK2B PDE4A SEMA3C IL1B DNMT3B APC MSH2 CREB1 ATP1A3 GRIN2A ABCB1 PDE3A GAL CAPN3 SOD2 P2RX7 CCND1 EP300 HDAC2 JUN RYR2 GNAS IGFBP2 SST HTR2C LIPE HTR2A
GO:0030817	regulation of cAMP biosynthetic process	3.915662651	3.94E-13	6.098871183	7.16E-10	26 genes OPRM1 ADCY3 DRD1 ADCY7 ADCY8 DRD2 EDN1 DRD4 PTH1R GABBR1 GABBR2 ADCYAP1 HTR1B HTR1A GALR2 ADRA2A CAP2 CRHR1 SSTR5 GNAL UCN3 ADRB2 GRM3 NTRK2 GNAS CORT
GO:0030802	regulation of cyclic nucleotide biosynthetic process	4.06626506	4.27E-13	5.815252348	7.76E-10	27 genes OPRM1 ADCY3 DRD1 ADCY7 ADCY8 DRD2 EDN1 DRD4 PTH1R GABBR1 GABBR2 ADCYAP1 HTR1B HTR1A APOE GALR2 ADRA2A CAP2 CRHR1 SSTR5 GNAL UCN3 ADRB2 GRM3 NTRK2 GNAS CORT
GO:0030808	regulation of nucleotide biosynthetic process	4.06626506	4.27E-13	5.815252348	7.76E-10	27 genes OPRM1 ADCY3 DRD1 ADCY7 ADCY8 DRD2 EDN1 DRD4 PTH1R GABBR1 GABBR2 ADCYAP1 HTR1B HTR1A APOE GALR2 ADRA2A CAP2 CRHR1 SSTR5 GNAL UCN3 ADRB2 GRM3 NTRK2 GNAS CORT
GO:0030814	regulation of cAMP metabolic process	3.915662651	6.36E-13	5.9804465	1.16E-09	26 genes OPRM1 ADCY3 DRD1 ADCY7 ADCY8 DRD2 EDN1 DRD4 PTH1R GABBR1 GABBR2 ADCYAP1 HTR1B HTR1A GALR2 ADRA2A CAP2 CRHR1 SSTR5 GNAL UCN3 ADRB2 GRM3 NTRK2 GNAS CORT
GO:0014070	response to organic cyclic substance	4.21686747	6.66E-13	5.482392786	1.21E-09	28 genes TF DRD1 SLC6A1 DRD2 LEPR SLC6A3 IGFBP7 DRD4 TAC1 COMT BCL2L1 FOS HTR1B PTK2B IL1B AANAT CHRNA7 MSH2 FADS1 PRKCQ GNAL P2RX7 CCND1 HDAC2 BTG2 JUN RYR2 HTR2C
GO:0030799	regulation of cyclic nucleotide metabolic process	4.06626506	8.38E-13	5.660865118	1.52E-09	27 genes OPRM1 ADCY3 DRD1 ADCY7 ADCY8 DRD2 EDN1 DRD4 PTH1R GABBR1 GABBR2 ADCYAP1 HTR1B HTR1A APOE GALR2 ADRA2A CAP2 CRHR1 SSTR5 GNAL UCN3 ADRB2 GRM3 NTRK2 GNAS CORT
GO:0060341	regulation of cellular localization	6.024096386	8.75E-13	3.821253037	1.59E-09	40 genes RAB3A TNF DRD2 EDN1 DRD4 IL13 GDNF IL10 HTR1B GRIN2B INS IFNG RHOA IL1B NOS2 RAB27B EGF CAMK2A SNAP25 FGF2 IL1A APC STX1A IL6 RAB8B CREB1 SIRT1 PCLO SSTR5 PRKCQ UCN3 P2RX7 GSK3B NTRK2 AVPR1B RYR2 HTR2C CALM2 HTR2A IL2
GO:0043085	positive regulation of catalytic activity	9.186746988	8.86E-13	2.779226728	1.61E-09	61 genes OPRM1 ADCY3 CCKAR ADCY7 ADCY8 EDN1 LPAR1 SDC4 GDNF PRKAR2B PRKAR2A APOE IFNG GALR2 IL1B CHRNA7 GNG3 NRG1 FGF2 CCKBR GRM1 CRHR1 GNAL PROK2 CCND1 ADRB2 UCN3 PSEN1 CHRM2 RASGRF1 GNAS DRD1 FZR1 TNF DRD2 DRD4 PTH1R ADCYAP1 PSMB4 INS PTK2B DGKG NPM1 ADRA2A EGF CAP2 MSH3 MSH2 NR4A2 DGKH P2RX7 PRLR PSMD11 BAX AVPR1B NTRK2 PRKAR1A LRP8 HTR2C HTR2A IL2
GO:0006873	cellular ion homeostasis	7.530120482	1.21E-12	3.167348774	2.19E-09	50 genes CCKAR WFS1 GRIK3 HEXA EDN1 HP LPAR1 MBP GRIN2B APOE GALR2 GRID2 QKI IL1B CHRNA7 OLIG2 GNG3 IBTK KCND2 CCKBR GRIN2A PROK2 PSEN1 RHCG JUN RYR2 PLLP PMP22 TF DRD1 CCL2 DRD2 PTH1R DRD4 NR3C2 TAC1 BCL2L1 APLP2 PTK2B KLK6 PLP1 GLRB MAL ITPR1 SOD2 P2RX7 BAX AVPR1B CACNA1C IL2
GO:0043067	regulation of programmed cell death	12.04819277	1.57E-12	2.334164416	2.85E-09	80 genes WFS1 PREX1 PAWR GDNF IL10 BTK BDNF TIAM1 APOE AEN IFNG RHOA GRID2 IL1B CAT NQO1 NRG1 MX1 FGF2 IL1A LTA ARHGEF2 DFFA ESR1 PRKCI GRIN2A GAL MAPK1 PROK2 ADRB2 BTG2 CARD16 PSEN1 BTG1 RASGRF1 JUN VEGFA IL12A RYR2 SORT1 MAPK8 NGFR CTSB CCL2 TNF ERBB3 TNFRSF25 BCL2L1 NR3C1 ZBTB16 PLAGL1 INS COMP NPM1 BCL6 APC IL3 IL6 MSH2 CREB1 NR4A2 TRIO MAL PDE3A DBH YWHAE SIRT1 ATM SOD2 P2RX7 PRLR NUP62 NUPR1 GSK3B EEF1E1 BAX BMP7 SST DAP3 IL2
GO:0006140	regulation of nucleotide metabolic process	4.06626506	1.60E-12	5.514463434	2.92E-09	27 genes OPRM1 ADCY3 DRD1 ADCY7 ADCY8 DRD2 EDN1 DRD4 PTH1R GABBR1 GABBR2 ADCYAP1 HTR1B HTR1A APOE GALR2 ADRA2A CAP2 CRHR1 SSTR5 GNAL UCN3 ADRB2 GRM3 NTRK2 GNAS CORT
GO:0010941	regulation of cell death	12.04819277	1.91E-12	2.3255724	3.48E-09	80 genes WFS1 PREX1 PAWR GDNF IL10 BTK BDNF TIAM1 APOE AEN IFNG RHOA GRID2 IL1B CAT NQO1 NRG1 MX1 FGF2 IL1A LTA ARHGEF2 DFFA ESR1 PRKCI GRIN2A GAL MAPK1 PROK2 ADRB2 BTG2 CARD16 PSEN1 BTG1 RASGRF1 JUN VEGFA IL12A RYR2 SORT1 MAPK8 NGFR CTSB CCL2 TNF ERBB3 TNFRSF25 BCL2L1 NR3C1 ZBTB16 PLAGL1 INS COMP NPM1 BCL6 APC IL3 IL6 MSH2 CREB1 NR4A2 TRIO MAL PDE3A DBH YWHAE SIRT1 ATM SOD2 P2RX7 PRLR NUP62 NUPR1 GSK3B EEF1E1 BAX BMP7 SST DAP3 IL2
GO:0055082	cellular chemical homeostasis	7.530120482	2.19E-12	3.117338004	3.99E-09	50 genes CCKAR WFS1 GRIK3 HEXA EDN1 HP LPAR1 MBP GRIN2B APOE GALR2 GRID2 QKI IL1B CHRNA7 OLIG2 GNG3 IBTK KCND2 CCKBR GRIN2A PROK2 PSEN1 RHCG JUN RYR2 PLLP PMP22 TF DRD1 CCL2 DRD2 PTH1R DRD4 NR3C2 TAC1 BCL2L1 APLP2 PTK2B KLK6 PLP1 GLRB MAL ITPR1 SOD2 P2RX7 BAX AVPR1B CACNA1C IL2
GO:0042981	regulation of apoptosis	11.89759036	2.60E-12	2.327922559	4.72E-09	79 genes WFS1 PREX1 PAWR GDNF IL10 BTK BDNF TIAM1 APOE AEN IFNG RHOA GRID2 IL1B CAT NQO1 NRG1 MX1 IL1A LTA ARHGEF2 DFFA ESR1 PRKCI GRIN2A GAL MAPK1 PROK2 ADRB2 BTG2 CARD16 PSEN1 BTG1 RASGRF1 JUN VEGFA IL12A RYR2 SORT1 MAPK8 NGFR CTSB CCL2 TNF ERBB3 TNFRSF25 BCL2L1 NR3C1 ZBTB16 PLAGL1 INS COMP NPM1 BCL6 APC IL3 IL6 MSH2 CREB1 NR4A2 TRIO MAL PDE3A DBH YWHAE SIRT1 ATM SOD2 P2RX7 PRLR NUP62 NUPR1 GSK3B EEF1E1 BAX BMP7 SST DAP3 IL2
GO:0045761	regulation of adenylate cyclase activity	3.614457831	7.21E-12	5.922942207	1.31E-08	24 genes OPRM1 ADCY3 DRD1 CAP2 ADCY7 DRD2 ADCY8 PTH1R DRD4 GABBR1 GABBR2 ADCYAP1 CRHR1 GNAL SSTR5 GRM3 ADRB2 UCN3 HTR1A NTRK2 GALR2 ADRA2A GNAS CORT
GO:0009725	response to hormone stimulus	7.228915663	8.13E-12	3.098650964	1.48E-08	48 genes ADCY3 DRD1 THRA CCL2 TNF SLC6A1 ADCY7 ADCY8 ERBB3 IGFBP7 LEPR TAC1 BCL2L1 IL10 PRKAR2B FOS GSTM3 PRKAR2A HTR1B INS PTK2B AANAT IL1B GNG3 PIK3R1 IL6 AR GATM FADS1 ESR1 PRKCI GAL HDAC5 MAPK1 PRKCQ UCN3 CCND1 EP300 NUP62 BTG2 PRKAR1A SORT1 GNAS GNB3 PTPN1 IGFBP2 BMP7 SST
GO:0009628	response to abiotic stimulus	7.228915663	8.90E-12	3.090230717	1.62E-08	48 genes RAB3A DRD1 CCL2 TNF DRD2 IGFBP7 IL18 TAC1 BCL2L1 FOS PDE6B SLC1A2 SLC1A3 PDE1B MC1R GRIN2B PTK2B AEN IL1B CAT DNMT3B LTA STX1A UBE2A NOS1 MSH2 ATP1A3 GRIN2A DBH ATM SOD2 PRKCQ PPM1D ADRB2 P2RX7 CCND1 HDAC2 BTG2 JUN BAX AVPR1B IL12A MAPK8 NGFR IGFBP2 CACNA1C SST CLOCK
GO:0007166	cell surface receptor linked signal transduction	20.78313253	9.61E-12	1.761564708	1.75E-08	138 genes ADCY3 ADCY7 ADCY8 GABRB2 GRIK3 EDN1 LPAR1 HTR1B HTR1A GRIN2B MC1R TIAM1 APOE SOSTDC1 IFNG GALR2 GRID2 CLEC4A GNG3 HTR1D HTR4 GRIN2A PROKR2 PTPRT CRHR1 NCAM1 CRHR2 SSTR5 MAPK1 UCN3 GABRR1 JUN VEGFA GPR50 FGFR2 FGFR1 DRD1 CCL2 FGFR3 ENPP2 DRD2 ERBB3 PTH1R DRD4 KLRK1 ITGB5 ADCYAP1 HCRTR1 INS CNR1 CNR2 ADRA2A EGF NKX2-2 PTPN6 CNKSR1 GABRA2 GABRA1 GABRA3 RYK GABRA5 TRIO COL16A1 KCNK2 NTRK3 EPHA5 P2RX7 CBLB GPR37 NPY EPS8 PENK NUP62 NTRK2 AVPR1B PTPN1 CORT BMP7 SST OPRM1 CCKAR RGS7BP FGF9 LEPR GABBR1 GABBR2 FOS NOS2 FGF1 NRG1 FGF2 HTR5A GABRG1 GABRG2 CCKBR GAL GRM1 CLEC1A PROK2 GNAL GRM3 CCND1 ADRB2 PSEN1 CHRM2 SORT1 GNAS GNB3 TNFRSF25 PPM1A TAC1 ABI1 GPRC5B APLP2 TNFRSF1B PTK2B DGKG PTN HTR3B PIK3R1 APC FZD9 GLRB PLP1 IL8 CREB1 ATP1A3 RGS18 GRIA3 DGKH P2RY12 PRLR GSK3B HTR2C CALM2 IL2 TOB1 HTR2A
GO:0031279	regulation of cyclase activity	3.614457831	1.43E-11	5.743459109	2.60E-08	24 genes OPRM1 ADCY3 DRD1 CAP2 ADCY7 DRD2 ADCY8 PTH1R DRD4 GABBR1 GABBR2 ADCYAP1 CRHR1 GNAL SSTR5 GRM3 ADRB2 UCN3 HTR1A NTRK2 GALR2 ADRA2A GNAS CORT
GO:0006836	neurotransmitter transport	3.313253012	1.94E-11	6.279745954	3.52E-08	22 genes RAB3A GABRA2 STX1A SLC6A1 SYT4 SLC6A2 SLC6A3 SLC6A4 NLGN1 SLC6A15 PCLO SLC17A7 SLC32A1 P2RX7 SLC1A3 SLC17A6 PSEN1 SYN1 SYN2 SLC18A2 SV2B SNAP25
GO:0051339	regulation of lyase activity	3.614457831	2.22E-11	5.629727246	4.04E-08	24 genes OPRM1 ADCY3 DRD1 CAP2 ADCY7 DRD2 ADCY8 PTH1R DRD4 GABBR1 GABBR2 ADCYAP1 CRHR1 GNAL SSTR5 GRM3 ADRB2 UCN3 HTR1A NTRK2 GALR2 ADRA2A GNAS CORT
GO:0050801	ion homeostasis	7.530120482	3.30E-11	2.896304258	6.01E-08	50 genes CCKAR WFS1 GRIK3 HEXA EDN1 HP LPAR1 MBP GRIN2B APOE GALR2 GRID2 QKI IL1B CHRNA7 OLIG2 GNG3 IBTK KCND2 CCKBR GRIN2A PROK2 PSEN1 RHCG JUN RYR2 PLLP PMP22 TF DRD1 CCL2 DRD2 PTH1R DRD4 NR3C2 TAC1 BCL2L1 APLP2 PTK2B KLK6 PLP1 GLRB MAL ITPR1 SOD2 P2RX7 BAX AVPR1B CACNA1C IL2

Cellular Component (count: 21)

GO ID	Name	%	P-value	Fold Enrichment	FDR	Genes
GO:0044456	synapse part	8.734939759	4.58E-26	5.362352805	6.51E-23	58 genes SYT4 GABRB2 GRIK3 GABRB1 GABBR1 GRIK5 GABBR2 SLC1A2 GRIN2B DLG4 GRID2 CHRNA7 SV2B DLG2 GABRG1 GABRG2 STX1A KCND2 TANC1 GRIN2A RPH3A GRM1 PCLO GRM3 GABRR1 CHRM2 BIN1 RAB3A ERBB3 CALD1 AMPH SLC32A1 GAD2 SYPL1 SYN1 PTK2B SYN2 SLC30A3 HTR3B CAMK2A GABRD GLRB DLGAP1 GABRA2 GABRA1 GABRA3 GABRA5 NLGN1 GRIA3 ITPR1 SLC17A7 SYNE1 SLC17A6 EPS8 GRIA2 GRIA1 NTRK2 CACNA1C
GO:0045202	synapse	10.39156627	9.36E-26	4.42062052	1.33E-22	69 genes SYT4 GABRB2 GRIK3 GABRB1 GABBR1 GRIK5 GABBR2 SLC1A2 SLC1A3 GRIN2B DLG4 GRID2 SV2B CHRNA7 DLG2 GABRG1 GABRG2 STX1A KCND2 TANC1 GRIN2A RPH3A GRM1 PCLO PRKCQ GRM3 GABRR1 PSEN1 CHRM2 VAMP3 BIN1 RAB3A ERBB3 CALD1 ABI1 AMPH SLC32A1 GAD2 SYPL1 SYN1 PTK2B SYN2 SLC30A3 SNAP23 PRIMA1 GAD1 CAMK2A HTR3B SNAP25 GABRD GLRB DLGAP1 GABRA2 GABRA1 GABRA3 GABRA5 NLGN1 GRIA3 ITPR1 SLC17A7 SYNE1 P2RX7 SLC17A6 EPS8 GRIA2 GRIA1 NTRK2 PRKAR1A CACNA1C
GO:0044459	plasma membrane part	29.6686747	2.10E-25	2.033828022	2.98E-22	197 genes ADCY3 ADCY7 SYT4 AQP4 LPAR1 VPS33B HTR1B HTR1A GRIN2B MC1R APOE CD46 AIF1L CLEC4A GRID2 CHRNA7 GNG3 HTR1D GRIN2A HTR4 TANC1 PCLO CRHR1 SSTR5 CRHR2 NPC1 RHCG BACE1 RAB13 PMP22 ENPP2 ERBB3 PTH1R BCL2L1 HCRTR1 ACE GAD2 SYPL1 SLC31A2 CNKSR1 MAOA KCNK2 NTRK3 EPHA5 SYNE1 EPS8 NTRK2 AVPR1B HGS OPRM1 CCKAR TOLLIP SYNJ2 HTR5A SYMPK ARHGEF2 CCKBR RAB4B CACNG3 SIGMAR1 GRM1 CLEC1A GRM3 PRUNE PSEN1 SORT1 GNAS RAB3A TF ABI1 AMPH PTK2B SNAP23 SNAP25 HTR3B FZD9 IL6 DLGAP1 PTPRZ1 CTLA4 ATP1A3 NLGN1 GRIA3 CAPRIN1 SLC16A2 GRIA2 GRIA1 LRP8 HTR2C TJP2 HTR2A SLC6A1 SLC6A2 GABRB2 SLC6A3 GRIK3 GABRB1 SLC6A4 GRIK5 IL15 DYSF PDE4A RALA SLC4A2 ROBO2 SLC4A4 KCND2 RPH3A NCAM1 GABRR1 GPR50 VAMP3 AKAP2 FGFR1 DRD1 FGFR3 LITAF DRD2 DRD4 KCNA4 KLRK1 ITGB5 CNR1 CNR2 ADRA2A SLC30A3 SCARB2 PRIMA1 GABRD GABRA2 GABRA1 RAB8B MYO1C RYK GABRA3 GABRA5 SLC6A15 ABCB1 LAMP1 P2RX7 GPR37 SYT13 PTPN1 CACNA1C KCTD12 COPA GABBR1 GABBR2 SDC4 SYNGR2 MBP SLC1A2 SLC1A3 DLG4 RHOA CSF2RB SV2B MSN NRG1 TPR DLG2 GABRG1 GABRG2 PRKCI ESR1 M6PR PRKCQ FOLH1 ADRB2 CHRM2 RRAS2 CNTN2 CTSB NGFR TNF TNFRSF25 PPM1A RDX COMT ANXA6 TNFRSF1A SYN1 SYN2 GPNMB CAMK2A EHD3 APC PTPRB EBP GLRB MAL SLC17A7 SLC17A6 KCNN3 SLC18A2 IGFBP2 LIPE
GO:0043005	neuron projection	8.734939759	1.03E-18	3.857130965	1.46E-15	58 genes SLC6A1 SYT4 WFS1 GRIK3 GABBR2 MBP SLC1A2 HTR1A SLC1A3 MC1R GRIN2B APOE SYNJ2 ROBO2 AR KCND2 KIF5B OTX2 GRIN2A ESR1 SIGMAR1 GRM1 NCAM1 MAPK1 NCAM2 GRM3 ADRB2 UCN3 PSEN1 CHRM2 RASGRF1 BACE1 CNTN2 CNTN4 DRD1 DRD2 CALD1 VIM PPM1A TAC1 ABI1 DTNBP1 GAD2 PTK2B CNR2 TOR1A GAD1 SNAP25 APC NOS1 GRIA3 DBH CAPRIN1 P2RX7 GSK3B NTRK2 CACNA1C HTR2A
GO:0005886	plasma membrane	39.45783133	1.70E-18	1.577672313	2.42E-15	262 genes TGOLN2 ADCY3 ADCY7 SYT4 ADCY8 ATP1B2 AQP4 LPAR1 VPS33B MOG HTR1B HTR1A MC1R GRIN2B APOE CD46 SERPINE1 CLEC4A RAPGEF6 GRID2 AIF1L CHRNA7 GNG3 HTR1D TANC1 HTR4 GRIN2A PTPRT PCLO CRHR1 SSTR5 CRHR2 NPC1 F5 RHCG BACE1 RYR2 RAB13 PMP22 ERBB3 ENPP2 PTH1R BCL2L1 HCRTR1 GAD2 ACE SYPL1 SLC31A2 CNKSR1 LGALS3 CFB MAOA KCNK2 NTRK3 EPHA5 SYNE1 EPS8 AVPR1B NTRK2 HGS OPRM1 CCKAR TOLLIP UNC93A SYNJ2 QKI HTR5A SYMPK STX1A ARHGEF2 CCKBR PIK3C2A RAB4B CACNG3 SIGMAR1 GRM1 CLEC1A ATP6V1C1 GNAL GRM3 STYK1 PRUNE PSEN1 CLIC6 SORT1 GNAS TF RAB3A ABI1 ZBTB16 AMPH PTK2B SNAP23 ACSL4 SNAP25 RASA4 HTR3B FZD9 IL6 DLGAP1 CAP2 NOS1 SWAP70 PTPRZ1 CTLA4 ATP1A3 NLGN1 GRIA3 CAPRIN1 P2RY12 PLSCR1 SLC16A2 GRIA2 GRIA1 PTP4A2 CDH19 LRP8 TJP2 HTR2C CALM2 HTR2A CTNNAL1 SLC6A1 GABRB2 SLC6A2 GRIK3 GABRB1 SLC6A3 SLC6A4 GRIK5 IL15 PRKAR2A DYSF TIAM1 PDE4A GALR2 RALA SLC4A2 ROBO2 OLIG2 SLC4A4 KCND2 PROKR2 RPH3A NCAM1 NCAM2 GABRR1 RASGRF1 LSAMP GPR50 VAMP3 AKAP2 EMP1 ABCA8 FGFR2 FGFR1 DRD1 FGFR3 LITAF DRD2 DRD4 KLRK1 KCNA4 ITGB5 CNR1 CNR2 ADRA2A SLC30A3 SCARB2 PRIMA1 EGF GABRD SETDB1 GABRA2 RAB8B GABRA1 MYO1C GABRA3 RYK GABRA5 SLC6A15 ABCB1 LAMP1 LAMP2 P2RX7 GPR37 SYT13 PTPN1 CACNA1C KCTD12 COPA RGS7BP PREX1 LEPR GABBR1 GABBR2 PAWR SDC4 SYNGR2 MBP SLC1A2 SLC1A3 RHOA DLG4 ITIH4 CNTNAP3 CSF2RB SV2B MSN CAT TPR NRG1 DLG2 GABRG1 GABRG2 PRKCI ESR1 PCDH9 M6PR PRKCQ ADRB2 FOLH1 CHRM2 RRAS2 CNTN2 CNTN4 NGFR CTSB CPM TNF TNFRSF25 CALD1 VIM PPM1A TAC1 RDX COMT GPRC5B DTNBP1 APLP2 APLP1 ANXA6 RGMA TNFRSF1A TNFRSF1B SYN1 SYN2 GPNMB CAMK2A EHD3 APC PTPRB EBP MAG GLRB MAL SLC17A7 SLC17A6 KCNN3 SLC18A2 IGFBP2 LIPE
GO:0005626	insoluble fraction	13.85542169	3.24E-16	2.493953571	4.77E-13	92 genes OPRM1 COPA SLC6A1 ADCY8 SLC6A2 SLC6A3 PDLIM5 SLC6A4 CNP IL15 RAB1A PRKAR2B FOS PRKAR2A SLC1A2 MCTP2 SLC1A3 GRIN2B PDE4A PDE4B GRID2 DLG4 SYNJ2 SLC4A2 USP14 JAKMIP1 STX1A KCND2 CCKBR HTR4 GRIN2A GRM1 SLIT3 MAPK1 PRKCQ FOLH1 ADRB2 PSEN1 RASGRF1 CHRM2 BACE1 RYR2 SORT1 GNAS VAMP3 EMP1 RAB3A FGFR1 DRD1 RAP1GAP CALD1 PPM1A ABI1 COMT APLP1 TNFRSF1B ACE RAC2 PLCH1 HSD17B6 SLC30A3 SCARB2 SNAP23 ACSL4 SNAP25 MTMR7 CYP19A1 KLK6 EBP GLRB MLC1 RAB8B CYP2C9 RYK FADS1 MAL PDE3A GRIA3 ABCB1 DBH ITPR1 SLC17A7 LAMP1 SLC16A2 LAMP2 P2RX7 SLC17A6 EPS8 GRIA1 SLC18A2 PTPN1 CACNA1C
GO:0000267	cell fraction	16.26506024	3.58E-16	2.26807701	4.77E-13	108 genes SLC6A1 SLC6A2 ADCY8 PDLIM5 CRHBP SLC6A3 SLC6A4 IL13 CNP IL15 RAB1A PRKAR2B GSTM3 PRKAR2A GRIN2B PDE4A SERPINE1 PDE4B GRID2 SLC4A2 KCND2 HTR4 GRIN2A MAPK1 RASGRF1 BACE1 RYR2 VAMP3 EMP1 FGFR1 DRD1 MYO9B ADCYAP1 ACE RAC2 PLCH1 SLC30A3 SCARB2 EGF CYP19A1 MLC1 RAB8B MOBP CYP2C9 RYK ABCB1 LAMP1 P2RX7 LAMP2 EPS8 PTPN1 CORT CACNA1C OPRM1 COPA FOS SLC1A2 MCTP2 SLC1A3 DLG4 SYNJ2 USP14 JAKMIP1 STX1A CCKBR GRM1 SLIT3 PRKCQ FOLH1 ADRB2 PSEN1 CHRM2 SORT1 GNAS CTSB RAB3A RAP1GAP CALD1 PPM1A ABI1 COMT APLP1 PCSK2 TNFRSF1B TOR1A HSD17B6 SNAP23 ACSL4 SNAP25 MTMR7 KLK6 EBP GLRB IL5 FADS1 MAL PDE3A GRIA3 DBH ITPR1 SOD2 SLC17A7 SLC16A2 SLC17A6 MAPK12 GRIA1 BAX SLC18A2
GO:0005887	integral to plasma membrane	17.01807229	2.01E-15	2.163338606	2.84E-12	113 genes ADCY3 SLC6A1 ADCY7 GABRB2 SLC6A2 GABRB1 GRIK3 SLC6A3 SLC6A4 AQP4 LPAR1 IL15 HTR1B HTR1A MC1R GRIN2B CD46 GRID2 CLEC4A CHRNA7 SLC4A4 HTR1D KCND2 HTR4 GRIN2A CRHR1 CRHR2 SSTR5 NPC1 GABRR1 RHCG BACE1 GPR50 FGFR1 DRD1 FGFR3 ERBB3 DRD2 ENPP2 DRD4 PTH1R KCNA4 KLRK1 ITGB5 HCRTR1 SYPL1 CNR1 CNR2 ADRA2A SLC30A3 SCARB2 SLC31A2 GABRD GABRA1 RYK GABRA3 GABRA5 SLC6A15 KCNK2 EPHA5 NTRK3 LAMP1 P2RX7 GPR37 EPS8 AVPR1B NTRK2 SYT13 KCTD12 OPRM1 CCKAR TOLLIP GABBR1 GABBR2 SDC4 SYNGR2 DLG4 CSF2RB HTR5A GABRG2 CCKBR SIGMAR1 GRM1 M6PR CLEC1A GRM3 FOLH1 ADRB2 PSEN1 CHRM2 CNTN2 NGFR TNF TNFRSF25 TNFRSF1A GPNMB SNAP25 HTR3B PTPRB EBP GLRB IL6 PTPRZ1 NLGN1 ATP1A3 CTLA4 MAL CAPRIN1 SLC16A2 GRIA1 KCNN3 SLC18A2 HTR2A
GO:0031226	intrinsic to plasma membrane	17.1686747	3.91E-15	2.133983568	5.52E-12	114 genes ADCY3 SLC6A1 ADCY7 GABRB2 SLC6A2 GABRB1 GRIK3 SLC6A3 SLC6A4 AQP4 LPAR1 IL15 HTR1B HTR1A MC1R GRIN2B CD46 GRID2 CLEC4A CHRNA7 SLC4A4 HTR1D KCND2 HTR4 GRIN2A CRHR1 CRHR2 SSTR5 NPC1 GABRR1 RHCG BACE1 GPR50 FGFR1 DRD1 FGFR3 ERBB3 DRD2 ENPP2 DRD4 PTH1R KCNA4 KLRK1 ITGB5 HCRTR1 SYPL1 CNR1 CNR2 ADRA2A SLC30A3 SCARB2 SLC31A2 PRIMA1 GABRD GABRA1 RYK GABRA3 GABRA5 SLC6A15 KCNK2 EPHA5 NTRK3 LAMP1 P2RX7 GPR37 EPS8 AVPR1B NTRK2 SYT13 KCTD12 OPRM1 CCKAR TOLLIP GABBR1 GABBR2 SDC4 SYNGR2 DLG4 CSF2RB HTR5A GABRG2 CCKBR SIGMAR1 GRM1 M6PR CLEC1A GRM3 FOLH1 ADRB2 PSEN1 CHRM2 CNTN2 NGFR TNF TNFRSF25 TNFRSF1A GPNMB SNAP25 HTR3B PTPRB EBP GLRB IL6 PTPRZ1 NLGN1 ATP1A3 CTLA4 MAL CAPRIN1 SLC16A2 GRIA1 KCNN3 SLC18A2 HTR2A
GO:0030424	axon	5.271084337	8.10E-15	5.006490745	1.15E-11	35 genes DRD1 SLC6A1 DRD2 GRIK3 VIM TAC1 DTNBP1 MBP SLC1A2 GAD2 HTR1A MC1R PTK2B SYNJ2 ROBO2 GAD1 APC AR ESR1 GRIA3 DBH GRM1 NCAM1 MAPK1 NCAM2 GRM3 UCN3 ADRB2 P2RX7 PSEN1 CHRM2 BACE1 NTRK2 CNTN2 CNTN4
GO:0045211	postsynaptic membrane	4.819277108	1.60E-14	5.391116383	2.27E-11	32 genes GABRB2 ERBB3 GRIK3 GABRB1 GABBR1 GRIK5 GABBR2 GRIN2B DLG4 GRID2 CHRNA7 HTR3B DLG2 GABRG1 GABRD GABRG2 GABRA2 DLGAP1 GLRB GABRA1 GABRA3 GABRA5 NLGN1 GRIN2A TANC1 GRIA3 GRM3 SYNE1 GABRR1 GRIA2 GRIA1 CHRM2
GO:0005624	membrane fraction	12.80120482	6.46E-14	2.389642325	9.18E-11	85 genes OPRM1 COPA SLC6A1 ADCY8 SLC6A2 SLC6A3 PDLIM5 SLC6A4 CNP IL15 PRKAR2B FOS PRKAR2A SLC1A2 MCTP2 SLC1A3 GRIN2B PDE4A GRID2 DLG4 SLC4A2 USP14 JAKMIP1 STX1A KCND2 CCKBR HTR4 GRIN2A GRM1 SLIT3 PRKCQ FOLH1 ADRB2 PSEN1 RASGRF1 CHRM2 BACE1 RYR2 SORT1 GNAS VAMP3 EMP1 RAB3A FGFR1 DRD1 RAP1GAP CALD1 PPM1A ABI1 COMT APLP1 TNFRSF1B ACE RAC2 PLCH1 HSD17B6 SLC30A3 SCARB2 SNAP23 ACSL4 MTMR7 SNAP25 CYP19A1 KLK6 EBP GLRB MLC1 CYP2C9 RYK FADS1 MAL GRIA3 ABCB1 DBH ITPR1 SLC17A7 LAMP1 SLC16A2 LAMP2 P2RX7 SLC17A6 EPS8 GRIA1 SLC18A2 CACNA1C
GO:0031982	vesicle	10.84337349	2.70E-12	2.444106868	3.84E-09	72 genes TGOLN2 COPA SYT4 CNP VPS33B BTK BDNF DYSF GRIN2B DLG4 IL1B SV2B RAB27B SEC24C STX1A PIK3C2A CACNG3 RPH3A GAL PCLO ATP6V1C1 PSEN1 F5 RHCG BACE1 VEGFA SORT1 GNAS CTSB RAB13 BIN1 CHGB TF RAB3A AHCY GPRC5B AMPH ANXA6 SLC32A1 PCSK2 GAD2 SYPL1 SYN1 SYN2 SLC30A3 SNAP23 GPNMB EGF GAD1 CAMK2A EHD3 ARHGDIB RAB2A GABRA2 RAB8B CTLA4 GRIA3 DBH YWHAE ITPR1 ATM SLC17A7 LAMP1 LAMP2 SLC17A6 GRIA2 GRIA1 SLC18A2 SYT13 PTPN1 IGFBP2 BMP7
GO:0031410	cytoplasmic vesicle	10.39156627	8.59E-12	2.444424119	1.22E-08	69 genes TGOLN2 COPA SYT4 CNP VPS33B BTK BDNF DYSF GRIN2B DLG4 IL1B SV2B RAB27B SEC24C STX1A PIK3C2A CACNG3 RPH3A GAL PCLO ATP6V1C1 F5 PSEN1 RHCG BACE1 VEGFA SORT1 CTSB RAB13 BIN1 CHGB TF RAB3A AHCY GPRC5B AMPH ANXA6 SLC32A1 PCSK2 GAD2 SYPL1 SYN1 SYN2 SLC30A3 SNAP23 GPNMB EGF CAMK2A EHD3 ARHGDIB RAB2A GABRA2 RAB8B CTLA4 GRIA3 DBH YWHAE ATM ITPR1 SLC17A7 LAMP1 LAMP2 SLC17A6 GRIA2 GRIA1 SLC18A2 SYT13 PTPN1 IGFBP2
GO:0030054	cell junction	9.036144578	1.24E-11	2.634413773	1.76E-08	60 genes OPRM1 SYT4 GABRB2 GRIK3 GABRB1 GABBR1 GRIK5 GABBR2 SDC4 GRIN2B DLG4 AIF1L GRID2 CHRNA7 SV2B DLG2 GABRG1 SYMPK GABRG2 ARHGEF2 TANC1 GRIN2A RPH3A SIGMAR1 PCLO GABRR1 PRUNE CHRM2 VAMP3 RAB13 PMP22 ABI1 AMPH GAD2 SYN1 PTK2B SYN2 SLC30A3 SNAP23 PRIMA1 CAMK2A SNAP25 APC GABRD CNKSR1 GLRB DLGAP1 GABRA2 GABRA1 GABRA3 GABRA5 NLGN1 GRIA3 ABCB1 SLC17A7 P2RX7 SLC17A6 GRIA2 GRIA1 TJP2
GO:0042995	cell projection	10.69277108	4.82E-11	2.316797459	6.84E-08	71 genes SLC6A1 SYT4 WFS1 GRIK3 GABBR2 MBP SLC1A2 HTR1A SLC1A3 MC1R CEP250 GRIN2B APOE PDE4A SYNJ2 ROBO2 MSN AR KCND2 KIF5B MYO3A OTX2 ESR1 GRIN2A PCM1 SIGMAR1 GRM1 NCAM1 MAPK1 NCAM2 GRM3 ADRB2 UCN3 PSEN1 CHRM2 RASGRF1 BACE1 CNTN2 GNAS CNTN4 DRD1 DRD2 CALD1 PTH1R VIM PPM1A TAC1 MYO9B RDX ABI1 DTNBP1 GAD2 PTK2B TOR1A CNR2 GAD1 SNAP25 APC FZD9 NOS1 MYO1C SWAP70 GRIA3 DBH CAPRIN1 P2RX7 S100B GSK3B NTRK2 CACNA1C HTR2A
GO:0019717	synaptosome	3.313253012	6.68E-11	5.886623404	9.49E-08	22 genes RAB3A STX1A KCND2 SLC6A1 SLC6A3 GRIN2A ABI1 SLC17A7 FOS P2RX7 SLC17A6 PSEN1 EPS8 GRIN2B RASGRF1 GRID2 DLG4 RYR2 VAMP3 SNAP23 SNAP25 USP14
GO:0014069	postsynaptic density	3.012048193	1.22E-10	6.406696406	1.73E-07	20 genes DLGAP1 KCND2 CALD1 TANC1 NLGN1 GRIN2A GRIA3 GRM1 ITPR1 GRM3 GRIA2 EPS8 GRIN2B GRIA1 PTK2B NTRK2 GRID2 DLG4 CACNA1C DLG2
GO:0031988	membrane-bounded vesicle	8.885542169	1.38E-09	2.3624693	1.95E-06	59 genes TGOLN2 COPA SYT4 CNP VPS33B BDNF GRIN2B DLG4 IL1B SV2B RAB27B SEC24C STX1A PIK3C2A CACNG3 RPH3A GAL PCLO F5 VEGFA SORT1 CTSB BIN1 CHGB TF RAB3A AHCY AMPH ANXA6 SLC32A1 PCSK2 GAD2 SYPL1 SYN1 SYN2 SNAP23 SLC30A3 EGF GPNMB GAD1 CAMK2A EHD3 ARHGDIB RAB2A GABRA2 CTLA4 GRIA3 DBH YWHAE ATM ITPR1 SLC17A7 LAMP1 LAMP2 SLC17A6 GRIA2 GRIA1 SYT13 BMP7
GO:0016023	cytoplasmic membrane-bounded vesicle	8.584337349	2.96E-09	2.357081851	4.21E-06	57 genes TGOLN2 COPA SYT4 CNP VPS33B BDNF GRIN2B DLG4 IL1B SV2B RAB27B SEC24C STX1A PIK3C2A CACNG3 RPH3A GAL PCLO F5 VEGFA SORT1 CTSB BIN1 CHGB TF RAB3A AHCY AMPH ANXA6 SLC32A1 PCSK2 GAD2 SYPL1 SYN1 SYN2 SNAP23 SLC30A3 EGF GPNMB CAMK2A EHD3 ARHGDIB RAB2A GABRA2 CTLA4 GRIA3 DBH YWHAE ATM ITPR1 SLC17A7 LAMP1 LAMP2 SLC17A6 GRIA2 GRIA1 SYT13
GO:0008021	synaptic vesicle	2.861445783	3.25E-09	5.68594306	4.61E-06	19 genes RAB3A GABRA2 STX1A SYT4 RPH3A PCLO AMPH SLC17A7 SLC32A1 GAD2 SLC17A6 SYPL1 SYN1 GRIA2 GRIN2B SYN2 SV2B SLC30A3 BIN1

Molecular Function (count: 5)

GO ID	Name	%	P-value	Fold Enrichment	FDR	Genes
GO:0005230	extracellular ligand-gated ion channel activity	3.313253012	1.92E-12	6.971929311	3.01E-09	22 genes GABRG1 GABRD GABRG2 GLRB GABRA2 GABRA1 GABRB2 GABRA3 GRIK3 GABRB1 GABRA5 GRIN2A GRIK5 GRIA3 P2RX7 GABRR1 GRIA2 GRIN2B GRIA1 GRID2 CHRNA7 HTR3B
GO:0016917	GABA receptor activity	1.807228916	1.52E-09	11.4086116	2.38E-06	12 genes GABRD GABRG1 GABRG2 GABRA2 GABRR1 GABRA1 GABRA3 GABRB2 GABRB1 GABRA5 GABBR1 GABBR2
GO:0043176	amine binding	3.463855422	1.74E-09	4.770873942	2.74E-06	23 genes GLRB DRD1 NOS1 DRD2 SLC6A3 DRD4 CRP GRIN2A CAD YWHAE ADRB2 HTR1B SLC1A3 HTR1A GRIN2B CHRM2 CHRNA7 NOS2 TPH1 HTR1D HTR2C TPH2 HTR2A
GO:0015276	ligand-gated ion channel activity	3.614457831	5.64E-09	4.311916195	8.87E-06	24 genes GABRG1 GABRD GABRG2 GLRB GABRA2 GABRA1 GABRB2 GABRA3 GRIK3 GABRB1 GABRA5 GRIN2A GRIK5 GRIA3 ITPR1 P2RX7 GABRR1 GRIA2 GRIN2B GRIA1 GRID2 RYR2 CHRNA7 HTR3B
GO:0022834	ligand-gated channel activity	3.614457831	5.64E-09	4.311916195	8.87E-06	24 genes GABRG1 GABRD GABRG2 GLRB GABRA2 GABRA1 GABRB2 GABRA3 GRIK3 GABRB1 GABRA5 GRIN2A GRIK5 GRIA3 ITPR1 P2RX7 GABRR1 GRIA2 GRIN2B GRIA1 GRID2 RYR2 CHRNA7 HTR3B