Gene Report

Basic Information

Approved Symbol	IBTK
Approved Name	inhibitor of Bruton agammaglobulinemia tyrosine kinase
Previous Symbol	BTKI
Previous Name	Bruton agammaglobulinemia tyrosine kinase inhibitor
Symbol Alias	DKFZP564B116, BTBD26
Location	6q14.3
Position	chr6:82879956-82957448 (-)
External Links	Entrez Gene: 25998 Ensembl: ENSG00000005700 UCSC: uc003pjl.1 HGNC ID: 17853
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between IBTK and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
Inhibitor of Bruton¡¯s tyrosine kinase	Tochigi, 2008	patients and normal controls		Genes differentially expressed in major depression Genes differentially expressed in major depression

Positive relationships between IBTK and other components at different levels (count: 0)

Positive relationship network of IBTK in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between IBTK and MDD (count: 0)

Negative relationships between IBTK and other components at different levels (count: 0)

IBTK related SNPs in MK4MDD (count: 0)

IBTK related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Inhibitor of Bruton tyrosine kinase	Q9P2D0	0(0/0)	Gene mapped

IBTK related GO terms (count: 9)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0061099	negative regulation of protein tyrosine kinase activity	biological process	IDA[11577348]
GO:0019901	protein kinase binding	molecular function	IDA[11577348]
GO:0005730	nucleolus	cellular component	IDA
GO:0030292	protein tyrosine kinase inhibitor activity	molecular function	IDA[11577348]
GO:0005634	nucleus	cellular component	IDA
GO:0016020	membrane	cellular component	IEA
GO:0001933	negative regulation of protein phosphorylation	biological process	IDA[11577348]
GO:0051209	release of sequestered calcium ion into cytosol	biological process	IDA[11577348]
GO:0005737	cytoplasm	cellular component	IDA[11577348]

IBTK related KEGG pathways (count: 0)

IBTK related BioCarta pathways (count: 0)

IBTK related Reactome pathways (count: 0)

IBTK related interactors from protein-protein interaction data in HPRD (count: 1)

Gene Report

Gene mapped GO terms