Potential Biomarkers of MDD
MK4MDD provides a list of potential biomarkers by analyzing the current research data. There are several principles applied to the analysis to ensure the reliability of all candidates: 1) directly related to MDD and reflected differences between patients and normal controls; 2) measured from peripheral blood, cerebrospinal fluid or other clinical samples, or recorded from imaging methods; and 3) shown in an evaluable way (such as protein concentration, SNP genotype and brain volume). There are a total of 532 components across six research levels (except environment level from the seven research levels in MK4MDD), which will provide new clues in looking for biomarkers1 for MDD early detection, diagnosis and treatment.
1. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther 2001; 69(3): 89-95.