MK4MDD

Full List of Potential Biomarkers of MDD

Total count: 534

Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment

Level Name Type No. of Studies Evidence from Studies
Reference Description Test method
Gene rs2715148 SNP 2
Sullivan, 2009 Of the top 200, 11 signals localized to ...... Of the top 200, 11 signals localized to a 167 kb region overlapping the gene piccolo (PCLO, whose protein product localizes to the cytomatrix of the presynaptic active zone and is important in monoaminergic neurotransmission in the brain) with P-values of 7.7 x 10(-7) for rs2715148 and 1.2 x 10(-6) for rs2522833. More... genotyping
Aragam, 2011 We identified 40 male-specific and 56 fe...... We identified 40 male-specific and 56 female-specific MDD associated SNPs with P-values less than 10(-4). The best male-specific SNP was rs9352774 (P=2.26x10(-6)) within LGSN gene while the best female-specific SNP was rs2715148 (P=5.64x10(-7)) within PCLO gene. More... genotyping
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Gene rs1513105 SNP 1
Shi C, 2012 Of the 16 SNPs selected, rs1513105 was t...... Of the 16 SNPs selected, rs1513105 was the only one showing allelic association (chi2=9.019, p=0.0027) and genotypic association (chi2=8.813, df=2, p=0.012), of which the rs1513105(C) allele was associated with an increased risk of MDD (OR=1.331, 95% CI 1.104-1.604), but the rs1513105 association resulted mainly from female subjects (chi2=12.35, p=0.00044 for allelic association; chi2=11.26, df=2, p=0.0036 for genotypic association). More... genotyping
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Gene rs2710102 SNP 1
Ji W, 2012 We found that the genotypes of rs1723623...... We found that the genotypes of rs17236239 were significantly associated with schizophrenia (P=0.0026), and the alleles of rs2710102 (P=0.0031) and rs2710117 (P=0.0031) were significantly associated with major depression. More... genotyping
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Gene rs13074924 SNP 1
Lewis, 2010 associated with MDD(P <10 -5) associated with MDD(P <10 -5) genotyping
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Gene rs619002 SNP 1
Shi C, 2012 The conditional test showed disease asso...... The conditional test showed disease association for the rs619002(EHD3)-rs1112714(FREM3) combination (P = 0.0059) and for the rs644926(EHD3)-rs13130123(FREM3) combination (P = 0.007), of which a reduced risk was found for the rs619002(G)-rs1112714(T) combination (OR = 0, P = 4.02 x 10(-6) ) and for the rs644926(A)-rs11938298(G) combination (OR = 0.12, 95% CI = 0.035-0.39, P = 3.85 x 10(-6) ). Quantitative trait analysis revealed that rs13130123 in the FREM3 locus was strongly associated with the insomnia early symptom in patients carrying the rs619002(G) allele (P = 0.001) and those carrying the rs644926(A) allele (P = 0.00077). More... genotyping
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Gene rs2710117 SNP 1
Ji W, 2012 We found that the genotypes of rs1723623...... We found that the genotypes of rs17236239 were significantly associated with schizophrenia (P=0.0026), and the alleles of rs2710102 (P=0.0031) and rs2710117 (P=0.0031) were significantly associated with major depression. More... genotyping
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Gene rs310501 SNP 1
Lewis, 2010 associated with MDD(P <10 -5) associated with MDD(P <10 -5) genotyping
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Gene rs1112714 SNP 1
Shi C, 2012 The conditional test showed disease asso...... The conditional test showed disease association for the rs619002(EHD3)-rs1112714(FREM3) combination (P = 0.0059) and for the rs644926(EHD3)-rs13130123(FREM3) combination (P = 0.007), of which a reduced risk was found for the rs619002(G)-rs1112714(T) combination (OR = 0, P = 4.02 x 10(-6) ) and for the rs644926(A)-rs11938298(G) combination (OR = 0.12, 95% CI = 0.035-0.39, P = 3.85 x 10(-6) ). Quantitative trait analysis revealed that rs13130123 in the FREM3 locus was strongly associated with the insomnia early symptom in patients carrying the rs619002(G) allele (P = 0.001) and those carrying the rs644926(A) allele (P = 0.00077). More... genotyping
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Gene rs9939609 SNP 1
Samaan Z, 2012 A meta-analysis of the four studies show...... A meta-analysis of the four studies showed a significant inverse association between the obesity risk FTO rs9939609 A variant and depression (odds ratio=0.92 (0.89, 0.97), P=3 x 10(-4)) adjusted for age, sex, ethnicity/population structure and body-mass index (BMI) with no significant between-study heterogeneity (I(2)=0%, P=0.63). More... genotyping
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Gene rs4709845 SNP 1
Lewis, 2010 associated with MDD(P <10 -5) associated with MDD(P <10 -5) genotyping
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Gene rs644926 SNP 1
Shi C, 2012 The conditional test showed disease asso...... The conditional test showed disease association for the rs619002(EHD3)-rs1112714(FREM3) combination (P = 0.0059) and for the rs644926(EHD3)-rs13130123(FREM3) combination (P = 0.007), of which a reduced risk was found for the rs619002(G)-rs1112714(T) combination (OR = 0, P = 4.02 x 10(-6) ) and for the rs644926(A)-rs11938298(G) combination (OR = 0.12, 95% CI = 0.035-0.39, P = 3.85 x 10(-6) ). Quantitative trait analysis revealed that rs13130123 in the FREM3 locus was strongly associated with the insomnia early symptom in patients carrying the rs619002(G) allele (P = 0.001) and those carrying the rs644926(A) allele (P = 0.00077). More... genotyping
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Gene rs606149 SNP 1
Lewis, 2010 associated with MDD(P <10 -5) associated with MDD(P <10 -5) genotyping
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Gene rs13130123 SNP 1
Shi C, 2012 The conditional test showed disease asso...... The conditional test showed disease association for the rs619002(EHD3)-rs1112714(FREM3) combination (P = 0.0059) and for the rs644926(EHD3)-rs13130123(FREM3) combination (P = 0.007), of which a reduced risk was found for the rs619002(G)-rs1112714(T) combination (OR = 0, P = 4.02 x 10(-6) ) and for the rs644926(A)-rs11938298(G) combination (OR = 0.12, 95% CI = 0.035-0.39, P = 3.85 x 10(-6) ). Quantitative trait analysis revealed that rs13130123 in the FREM3 locus was strongly associated with the insomnia early symptom in patients carrying the rs619002(G) allele (P = 0.001) and those carrying the rs644926(A) allele (P = 0.00077). More... genotyping
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Gene rs7713917 SNP 1
Rietschel, 2010 rs7713917 showed nominally significant a...... rs7713917 showed nominally significant association in both the genome-wide association study and the replication samples(p(combined) = 1.48E-6). More... genotyping
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Gene rs10447760 SNP 1
Li T, 2012 We found rs10447760 was significantly as...... We found rs10447760 was significantly associated with schizophrenia (allelic P = 0.00069) and major depression (allelic P = 0.0011) More... genotyping
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Gene rs9943849 SNP 1
Rietschel, 2010 rs9943849 showed nominally significant a...... rs9943849 showed nominally significant association in both the genome-wide association study and the replication samples (p(combined) = 3.24E-6). More... genotyping
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Gene rs110402 SNP 1
Ishitobi Y, 2012 The SNP rs110402 and rs242924 in the CRH...... The SNP rs110402 and rs242924 in the CRHR1 gene and the rs3779250 in the CRHR2 gene were associated with MDD More... genotyping
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Gene rs2522833 SNP 1
Sullivan, 2009 Of the top 200, 11 signals localized to ...... Of the top 200, 11 signals localized to a 167 kb region overlapping the gene piccolo (PCLO, whose protein product localizes to the cytomatrix of the presynaptic active zone and is important in monoaminergic neurotransmission in the brain) with P-values of 7.7 x 10(-7) for rs2715148 and 1.2 x 10(-6) for rs2522833. More... genotyping
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Gene rs242924 SNP 1
Ishitobi Y, 2012 The SNP rs110402 and rs242924 in the CRH...... The SNP rs110402 and rs242924 in the CRHR1 gene and the rs3779250 in the CRHR2 gene were associated with MDD More... genotyping
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Gene rs3779250 SNP 1
Ishitobi Y, 2012 The SNP rs110402 and rs242924 in the CRH...... The SNP rs110402 and rs242924 in the CRHR1 gene and the rs3779250 in the CRHR2 gene were associated with MDD More... genotyping
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Gene rs12692709 SNP 1
Aragam, 2011 We also found 38 SNPs showing genexgende...... We also found 38 SNPs showing genexgender interactions in influencing MDD (P<10(-4)). The best SNP was rs12692709 (P=5.75x10(-6)) near FIGN gene at 2q24.3 while the next best SNP was rs11039588 (P=1.16x10(-5)) within OR4B1 gene. More... genotyping
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Gene rs2464805 SNP 1
Yang Z, 2012 Two SNPs (rs2464805 and rs563556) within...... Two SNPs (rs2464805 and rs563556) within the APC gene exhibited a statistically significant association with MDD when analyzed by genotype and allele frequencies More... genotyping
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Gene rs9352774 SNP 1
Aragam, 2011 We identified 40 male-specific and 56 fe...... We identified 40 male-specific and 56 female-specific MDD associated SNPs with P-values less than 10(-4). The best male-specific SNP was rs9352774 (P=2.26x10(-6)) within LGSN gene while the best female-specific SNP was rs2715148 (P=5.64x10(-7)) within PCLO gene. More... genotyping
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Gene rs563556 SNP 1
Yang Z, 2012 Two SNPs (rs2464805 and rs563556) within...... Two SNPs (rs2464805 and rs563556) within the APC gene exhibited a statistically significant association with MDD when analyzed by genotype and allele frequencies More... genotyping
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Gene SLC6A4 gene 4
Garriock, 2006 A statistically significant difference i...... A statistically significant difference in genotype frequency for the SLC6A4 intron 2 VNTR was detected between the subjects with a history of depression and controls (p = 0.004). More... genotyping
Sarosi, 2011 We found a significantly higher frequenc...... We found a significantly higher frequency of the STin2 10/10 genotype in the MDD patient group compared to controls. More... genotyping; neuropsychological test
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Gene CREB1 gene 2
Liu, 2010 There was strong positive association be...... There was strong positive association between the rs10932201-rs6740584 haplotype of the CREB1 and MDD (P=0.00003241), and both haplotypes of A-C and A-T were significantly associated with MDD (P=0.020 and P=0.00022) More... genotyping; transmission disequilibrium test (TDT)
Zubenko, 2003 The highest maximum LOD score observed, ...... The highest maximum LOD score observed, 8.19 (genome-wide adjusted P << 0.0001), occurred for Recurrent Major Depressive Disorder (R-MDD) at D2S2321 (205 cM), located 121 kb proximal to CREB1 More... linkage analysis
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Gene MLC1 gene 1
Spijker, 2010 Based on LPS-stimulated blood gene expre...... Based on LPS-stimulated blood gene expression using whole-genome microarrays, this gene serves as a molecular signature of MDD More... microarray
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Gene NPY gene 1
Mickey, 2011 Low-expression NPY genotypes were overre...... Low-expression NPY genotypes were overrepresented in subjects with MDD after controlling for age and sex (P = .004). More... functional magnetic resonance imaging (fMRI); genotyping
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Gene SLC18A2 gene 1
Christiansen, 2007 A specific haplotype in VMAT2, the gene ...... A specific haplotype in VMAT2, the gene encoding the vesicular monoamine transporter, was significantly associated with depression symptoms in men (p= .007). More... genotyping
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Gene PLSCR1 gene 1
Spijker, 2010 Based on LPS-stimulated blood gene expre...... Based on LPS-stimulated blood gene expression using whole-genome microarrays, this gene serves as a molecular signature of MDD More... microarray
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Gene CRHR1 gene 1
Hsu, 2012 Among GG-homozygotes, BOLD signal in the...... Among GG-homozygotes, BOLD signal in the subgenual cingulate was greater in MDD participants (n = 9) compared with controls (n = 33). More... functional magnetic resonance imaging (fMRI); genotyping
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Gene BDNF gene 1
Lau, 2010 Significant effects of diagnosis and dia...... Significant effects of diagnosis and diagnosis-by-genotype interactions (F's>4, p's<0.05) characterized activations in amygdala and anterior hippocampal regions. Greater activations in patients than healthy adolescents were found. Critically, these hyperactivations were modulated by BDNF genotype: Met-carriers showed greater neural responses of emotional faces than Val/Val homozygotes in patients only. More... functional magnetic resonance imaging (fMRI); genotyping
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Gene PROK2 gene 1
Spijker, 2010 Based on LPS-stimulated blood gene expre...... Based on LPS-stimulated blood gene expression using whole-genome microarrays, this gene serves as a molecular signature of MDD More... microarray
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Gene SYNE1 gene 1
Green EK, 2012 We have also examined the polymorphism i...... We have also examined the polymorphism in our recurrent unipolar depression cases (n=1159) and control (n=2592) sample, and found that the risk allele was associated with risk for recurrent major depression (P=0.032, OR=1.118) More... genotyping
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Gene FGFR3 gene 1
Bernard, 2010 The expression of this gene was altered ...... The expression of this gene was altered in the locus coeruleus of MDD More... laser-capture microdissection (LCM); microarray; Q-PCR
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Gene ZBTB16 gene 1
Spijker, 2010 Based on LPS-stimulated blood gene expre...... Based on LPS-stimulated blood gene expression using whole-genome microarrays, this gene serves as a molecular signature of MDD More... microarray
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Gene CYP2C9 gene 1
A, 2003 The CYP2C9*3 allele frequency was higher...... The CYP2C9*3 allele frequency was higher (P<0.01) among the patients suffering from major depression than in a population of 89 schizophrenic patients (odds ratio=3.3) and 138 healthy volunteers (odds ratio=2.8). More... genotyping
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Gene GLUL gene 1
Bernard, 2010 The expression of this gene was altered ...... The expression of this gene was altered in the locus coeruleus of MDD More... laser-capture microdissection (LCM); microarray; Q-PCR
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Gene MAPK1 gene 1
Duric, 2010 Whole-genome expression profiling of pos...... Whole-genome expression profiling of postmortem tissue shows significantly increased expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1, encoded by DUSP1, but hereafter called MKP-1) in the hippocampal subfields of subjects with MDD compared to matched controls. More... whole-genome expression profiling; transgenic method; sucrose preference test; active avoidance test; novelty suppressed feeding test; sucrose consumption test; elevated plus maze; open field test; forced swimming test
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Gene SLC1A2 gene 1
Bernard, 2010 The expression of this gene was altered ...... The expression of this gene was altered in the locus coeruleus of MDD More... laser-capture microdissection (LCM); microarray; Q-PCR
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Gene RORC gene 1
Chen, 2010 A higher level of RORgammat (retinoic ac...... A higher level of RORgammat (retinoic acid-related orphan receptor-gammat, the specific transcription factor of Th17 cell) mRNA expression in peripheral blood lymphocytes was found in patient. More... immunocytochemical analysis; flow cytometric analysis; RT-PCR; Enzyme-linked immunosorbent assay (ELISA)
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Gene CCBL2 gene 1
Claes, 2011 The frequencies of SNP haplotype CGCTCT ...... The frequencies of SNP haplotype CGCTCT of KAT III gene in patients with major depression showed significantly higher than the control population (p<0.001) More... genotyping
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Gene SLC1A3 gene 1
Bernard, 2010 The expression of this gene was altered ...... The expression of this gene was altered in the locus coeruleus of MDD More... laser-capture microdissection (LCM); microarray; Q-PCR
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Gene EMP1 gene 1
Nakataki, 2011 The level of expression of the EMP1 mRNA...... The level of expression of the EMP1 mRNA was significantly lower in medication-free patients compared with control subjects (P<0.001). More... Q-PCR
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Gene NTRK2 gene 1
Bernard, 2010 The expression of this gene was altered ...... The expression of this gene was altered in the locus coeruleus of MDD More... laser-capture microdissection (LCM); microarray; Q-PCR
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Gene SST gene 1
Sibille, 2011 MDD subjects demonstrated reduced SST mR...... MDD subjects demonstrated reduced SST mRNA expression in the dorsolateral prefrontal cortex. More... Q-PCR
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Gene LOC647167 gene 1
Lewis, 2010 associated with MDD(P <10 -5) associated with MDD(P <10 -5) genotyping
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Gene CAPRIN1 gene 1
Spijker, 2010 Based on LPS-stimulated blood gene expre...... Based on LPS-stimulated blood gene expression using whole-genome microarrays, this gene serves as a molecular signature of MDD More... microarray
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Gene CSF2RB gene 1
Chen, 2011 Haplotype association analysis revealed ...... Haplotype association analysis revealed one protective haplotype in CSF2RB (P value = 0.0004 for MDD) and one risk haplotype in CSF2RB (P value = 0.001 for MDD) More... genotyping
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Gene LOC728275 gene 1
Lewis, 2010 associated with MDD(P <10 -5) associated with MDD(P <10 -5) genotyping
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Gene CLEC4A gene 1
Spijker, 2010 Based on LPS-stimulated blood gene expre...... Based on LPS-stimulated blood gene expression using whole-genome microarrays, this gene serves as a molecular signature of MDD More... microarray
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Gene HTR1A gene 1
Lopez-Figueroa, 2004 In the DLPFC(dorsolateral prefrontal cor...... In the DLPFC(dorsolateral prefrontal cortex), there is a significant decrease in 5-HT(1A) mRNA of subjects with MDD More... in situ hybridization
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Gene NLGN1 gene 1
Lewis, 2010 associated with MDD(P <10 -5) associated with MDD(P <10 -5) genotyping
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Gene KRT23 gene 1
Spijker, 2010 Based on LPS-stimulated blood gene expre...... Based on LPS-stimulated blood gene expression using whole-genome microarrays, this gene serves as a molecular signature of MDD More... microarray
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Gene PCLO gene 1
Sullivan, 2009 Of the top 200, 11 signals localized to ...... Of the top 200, 11 signals localized to a 167 kb region overlapping the gene piccolo (PCLO, whose protein product localizes to the cytomatrix of the presynaptic active zone and is important in monoaminergic neurotransmission in the brain) with P-values of 7.7 x 10(-7) for rs2715148 and 1.2 x 10(-6) for rs2522833. More... genotyping
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Gene VCAN gene 1
Lewis, 2010 associated with MDD(P <10 -5) associated with MDD(P <10 -5) genotyping
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Molecule Pro-opiomelanocortin protein 9
Kennedy, 2006 Comparisons between patients with MDD an...... Comparisons between patients with MDD and controls showed significantly lower neutral-state mu-opioid receptor BP in patients with MDD in the posterior thalamus, correlating with corticotropin and cortisol plasma levels. More... positron emission tomography (PET)
Appelhof, 2006 Posttreatment maximal adrenocorticotropi...... Posttreatment maximal adrenocorticotropic hormone (ACTH) and maximal cortisol levels, as well as delta ACTH and delta cortisol levels, were significantly higher (all p < .05) among patients who relapsed (n = 22) compared with patients in whom no relapse occurred (n = 23). More... blood analysis
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Molecule Sodium-dependent serotonin transporter protein 8
Staley, 2006 Diencephalon 5-HT transporter availabili...... Diencephalon 5-HT transporter availability is decreased in depressed patients. More... single photon emission computed tomography (SPECT); magnetic resonance imaging (MRI)
Selvaraj, 2011 The depressed patients had lowered 5-HTT...... The depressed patients had lowered 5-HTT binding in several brain regions including brain stem, thalamus, caudate, putamen, anterior cingulate cortex and frontal cortex. More... positron emission tomography (PET)
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Molecule 5-hydroxytryptamine receptor 1A protein 7
Meltzer, 2004 We used [11C]WAY 100635 and positron emi...... We used [11C]WAY 100635 and positron emission tomography (PET) to test our hypothesis that 5-HT(1A) receptor binding, We observed significantly diminished [11C]WAY 100635 binding in the DRN (dorsal raphe nucleus) in depressed (BP = 2.31+/-0.90) relative to control (BP = 3.69+/-1.56) subjects (p = 0.0016). More... positron emission tomography (PET)
Drevets, 1999 The mean 5HT1A receptor BP was reduced 4...... The mean 5HT1A receptor BP was reduced 41.5% in the raphe (p < .02) and 26.8% in the mesiotemporal cortex (p < .025) in the depressives relative to the controls. More... positron emission tomography (PET)
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Molecule Interleukin-6 protein 6
Kim, 2008 Non-suicidal MDD patients had significan...... Non-suicidal MDD patients had significantly higher IL-6 production than suicidal MDD patients and normal controls (p<0.001). More... immunocytochemical analysis
Motivala, 2005 As compared with matched controls, depre...... As compared with matched controls, depressed patients showed significant (p <.05) nocturnal elevations of circulating levels of IL-6 and sICAM. More... electroencephalogram (EEG); blood analysis
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Molecule D(2) dopamine receptor protein 5
D'Haenen H, 1994 The basal ganglia/cerebellum 123I-iodobe...... The basal ganglia/cerebellum 123I-iodobenzamide (a high-affinity ligand for D2 receptors) uptake ratio was higher in depressed patients than controls. More... single photon emission computed tomography (SPECT); psychometric method
Montgomery, 2007 [(11)C]raclopride binding was reduced in...... [(11)C]raclopride binding was reduced in the dorsal striatum of people taking antidepressants suggesting that D(2/3) expression was reduced compared to untreated controls. More... positron emission tomography (PET)
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Molecule Sodium-dependent dopamine transporter protein 5
Yang, 2008 DAT binding in the patient group were si...... DAT binding in the patient group were significantly higher than in control group. More... single photon emission computed tomography (SPECT)
Meyer, 2001 Low striatal dopamine transporter bindin...... Low striatal dopamine transporter binding potential (DAT BP) in major depressive episodes is consistent with a downregulation of DAT (dopamine transporter) . More... positron emission tomography (PET); neuropsychological test
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Molecule Brain-derived neurotrophic factor protein 4
Shi, 2010 Baseline plasma BDNF and tPA levels were...... Baseline plasma BDNF and tPA levels were significantly lower in LGD(late-onset geriatric depression) patients compared to controls (P = 0.037 and P = 0.000, respectively). There was a heightening tendency of plasma BDNF level after treatment. More... blood analysis
Lee, 2007 Plasma BDNF levels were significantly lo...... Plasma BDNF levels were significantly lower in MDD patients than in normal control subjects (p<0.001). More... protein analysis; cognitive test
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Molecule Interferon gamma protein 4
Kim, 2007 At admission IFN-gamma, IL-2, and IL-4 w...... At admission IFN-gamma, IL-2, and IL-4 were significantly lower in MDD patients. More... immunocytochemical analysis
Gabbay, 2009 IFN-gamma was increased in both suicidal...... IFN-gamma was increased in both suicidal and nonsuicidal adolescents with MDD compared to controls (2.14 +/- 6.22 and 4.20 +/- 14.48 versus 0.37 +/- 0.64; p < 0.02, p = 0.005). More... immunocytochemical analysis
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Molecule Interleukin-4 protein 3
Kim, 2008 Both MDD groups, with or without attempt...... Both MDD groups, with or without attempted suicide, had significantly lower IFN-gamma and IL-4 and higher TGF-beta1 production. More... immunocytochemical analysis
Kim, 2007 At admission, IL-6, TNF-alpha, TGF-beta1...... At admission, IL-6, TNF-alpha, TGF-beta1 production, and IFN-gamma/IL-4 ratio were significantly higher and IL-4 were significantly lower in MDD patients. More... immunocytochemical analysis
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Molecule Amine oxidase [flavin-containing] A protein 3
Zhang, 2010 quantity of MAOA messenger RNA was signi...... quantity of MAOA messenger RNA was significantly higher in patients with MDD than in control subjects (fold change = 5.28, p = 1.7 ¡Á 10-7) More... genotyping; Q-PCR
Meyer, 2006 The MAO-A DVS (specific distribution vol...... The MAO-A DVS (specific distribution volume) was highly significantly elevated in every brain region assessed (t test; P=.001 to 3x10(-7)). The MAO-A DVS was elevated on average by 34% (2 SDs) throughout the brain during major depression. More... positron emission tomography (PET)
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Molecule Transforming growth factor beta-1 protein 3
Kim, 2008 Both MDD groups, with or without attempt...... Both MDD groups, with or without attempted suicide, had significantly lower IFN-gamma and IL-4 and higher TGF-beta1 production. More... immunocytochemical analysis
Musil, 2011 Depressed patients showed significantly ...... Depressed patients showed significantly elevated MIF (p < 0.001) and reduced TGF-beta (p = 0.006) concentrations at baseline. More... blood analysis
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Molecule Thyrotropin subunit beta protein 3
Duval, 2006 Compared with controls, patients showed ...... Compared with controls, patients showed lower responses to TRH: 2300 h maximum increment in serum thyrotropin (TSH) level (p=0.006) and the difference between 2300 and 0800 h maximum increment in serum TSH values (p=0.0001). More... dose administration; blood analysis
Sarandol, 2003 Thyroid Stimulating Hormone (TSH) respon...... Thyroid Stimulating Hormone (TSH) responses to TRH(Thyroid Releasing Hormone test), maximal TSH responses, change in maximal TSH level were significantly lower in the patient group compared with the controls. More... blood analysis
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Molecule Amyloid beta A4 protein protein 3
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
Kita, 2009 Abeta40/42 ratio was significantly highe...... Abeta40/42 ratio was significantly higher in both young (P < 0.001) and elderly (P < 0.001) patients with MDD compared to controls. More... Enzyme-linked immunosorbent assay (ELISA)
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Molecule D(3) dopamine receptor protein 3
Shah, 1997 Right striatal 123I-IBZM (dopamine D2/3 ...... Right striatal 123I-IBZM (dopamine D2/3 ligand) uptake ratios were significantly higher in depressed patients than controls. More... single photon emission computed tomography (SPECT); psychometric method
Montgomery, 2007 [(11)C]raclopride binding was reduced in...... [(11)C]raclopride binding was reduced in the dorsal striatum of people taking antidepressants suggesting that D(2/3) expression was reduced compared to untreated controls. More... positron emission tomography (PET)
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Molecule 5-hydroxytryptamine receptor 2A protein 3
Yatham, 1999 Depressed patients showed a significant ...... Depressed patients showed a significant decrease in 5-HT2 receptor binding as measured by setoperone binding in frontal, temporal, parietal, and occipital cortical regions following desipramine treatment. More... positron emission tomography (PET)
Sheline, 2004 Depressed subjects had less hippocampal ...... Depressed subjects had less hippocampal 5-HT(2A) receptor binding than controls (p = 0.05). More... positron emission tomography (PET)
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Molecule Tumor necrosis factor protein 3
Leo, 2006 Compared with control subjects, MDD pati...... Compared with control subjects, MDD patients had higher baseline levels of TNFalpha More... protein analysis
Piletz, 2010 Compared to controls, patients with MDD ...... Compared to controls, patients with MDD had significantly higher baseline levels of tumour necrosis factor-alpha (TNFalpha, P=0.04) in the blood. More... protein analysis
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Molecule Cystatin-C protein 2
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule Leptin protein 2
Westling, 2004 women in the MDD group had lower CSF(cer...... women in the MDD group had lower CSF(cerebrospinal fluid) leptin than those in the non-MDD group (P < 0.01). More... cerebrospinal fluid analysis
Cizza, 2010 mean nocturnal leptin concentration was ...... mean nocturnal leptin concentration was higher in the MDD versus control groups More... blood analysis
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Molecule Interleukin-1 beta protein 2
Leo, 2006 Compared with control subjects, MDD pati...... Compared with control subjects, MDD patients had higher baseline levels of IL1-¦Â More... protein analysis
Piletz, 2010 Compared to controls, patients with MDD ...... Compared to controls, patients with MDD had significantly higher baseline levels of interleukin-1beta (IL1beta, P=0.03) in the blood. More... protein analysis
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Molecule C-reactive protein protein 2
Surtees, 2008 Past-year MDD was associated with increa...... Past-year MDD was associated with increased CRP concentration levels (4.31 mg/L for participants who reported episodes of MDD in the past year versus 3.65 mg/L for those who did not; p = .003) More... protein analysis
Su, 2009 An association was observed between seve...... An association was observed between severity of current depressive symptoms and increased levels of inflammatory markers (p < .001 for IL-6 and p = .005 for CRP). More... protein analysis
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Molecule Prolactin protein 2
Koenigsberg, 2004 The depressed patients had phase advance...... The depressed patients had phase advanced circadian rhythms for cortisol, norepinephrine and MHPG, phase advanced hemicircadian rhythms for cortisol and prolactin, and a phase advanced ultradian rhythm for prolactin compared to healthy control subjects. More... blood analysis
Kiive, 2004 prolactin levels increased only in the d...... prolactin levels increased only in the depressed patients group during the exercise More... blood analysis
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Molecule Prothrombin protein 2
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
Leo, 2006 Compared with control subjects, MDD pati...... Compared with control subjects, MDD patients had higher baseline levels of F1+2 More... protein analysis
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Molecule Interleukin-7 protein 2
Lehto, 2010 The MDD subjects had lowered serum level...... The MDD subjects had lowered serum levels of IL-7 More... blood analysis; protein analysis
Lehto, 2010 The MDD subjects had lowered levels of I...... The MDD subjects had lowered levels of IL-7. More... blood analysis; protein analysis
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Molecule Intercellular adhesion molecule 1 protein 2
Motivala, 2005 As compared with matched controls, depre...... As compared with matched controls, depressed patients showed significant (p <.05) nocturnal elevations of circulating levels of IL-6 and sICAM. More... electroencephalogram (EEG); blood analysis
Miguel-Hidalgo, 2011 Vascular and extravascular fractions of ...... Vascular and extravascular fractions of ICAM-1 immunoreactivity were lower in subjects with MDD than in non-psychiatric comparison subjects. More... postmortem study
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Molecule D(1A) dopamine receptor protein 2
Cannon, 2009 The mean D(1) receptor BP(ND) was reduce...... The mean D(1) receptor BP(ND) was reduced (14%) in the left middle caudate of the MDD group relative to control group. More... positron emission tomography (PET)
Dougherty, 2006 [(11)C]SCH 23,390 binding in bilateral s...... [(11)C]SCH 23,390 binding in bilateral striata was significantly lower in the MDD+A group when compared to healthy volunteers. These results implicate striatal D1 receptor dysfunction in MDD+A and further suggest an association between dopaminergic transmission and anger or aggression. More... positron emission tomography (PET)
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Molecule Apolipoprotein E protein 2
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
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Molecule Oxytocin-neurophysin 1 protein 1
Parker, 2010 Results indicated that depressed subject...... Results indicated that depressed subjects exhibit increased OT (oxytocin) levels compared to healthy control subjects, and this difference is most apparent during the nocturnal peak. More... blood analysis
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Molecule Beta-2-microglobulin protein 1
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
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Molecule Fatty acid-binding protein, heart protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule Somatotropin protein 1
Duval, 2006 Compared with controls, patients showed ...... Compared with controls, patients showed lower growth hormone response to clonidine (p=0.001) More... dose administration; blood analysis
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Molecule Glial cell line-derived neurotrophic factor protein 1
Xiaoquan, 2011 The plasma GDNF levels in late-onset dep...... The plasma GDNF levels in late-onset depression(LOD) patients were significantly increased compared to control subjects (P<0.05). More... neuropsychological test; psychometric method; blood analysis
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Molecule Neuronal cell adhesion molecule protein 1
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
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Molecule Histidine triad nucleotide-binding protein 1 protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule Interleukin-2 protein 1
Kim, 2007 At admission IFN-gamma, IL-2, and IL-4 w...... At admission IFN-gamma, IL-2, and IL-4 were significantly lower in MDD patients. More... immunocytochemical analysis
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Molecule Disks large homolog 4 protein 1
Feyissa, 2009 The results revealed that there was a re...... The results revealed that there was a reduced expression of the NMDA (N-methyl-d-aspartate) receptor subunits NR2A (-54%) and NR2B (-48%), and PSD-95 protein level (-40%) in the PFC of depressed subjects relative to controls More... postmortem study; immunoblotting
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Molecule Hemopexin protein 1
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
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Molecule Cytochrome c oxidase subunit 5B, mitochondrial protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule Single-stranded DNA-binding protein, mitochondrial protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule Alpha-2A adrenergic receptor protein 1
Ordway, 2003 The specific binding of p-[125I]iodoclon...... The specific binding of p-[125I]iodoclonidine to alpha2-adrenoceptors was significantly elevated throughout the LC (locus coeruleus) from MD (major depression) compared with matched control subjects. More... postmortem study
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Molecule Excitatory amino acid transporter 1 protein 1
Miguel-Hidalgo, 2010 EAAT1 levels were lower in MDA(comorbid ...... EAAT1 levels were lower in MDA(comorbid alcoholism plus MDD) and MDD subjects as compared to controls. More... postmortem study; immunoblotting; immunocytochemical analysis
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Molecule CD44 antigen protein 1
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
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Molecule Fatty acid-binding protein, brain protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule Mu-type opioid receptor protein 1
Kennedy, 2006 The sustained sadness condition was asso...... The sustained sadness condition was associated with a statistically significant decrease in mu-opioid receptor BP in the left inferior temporal cortex of patients with MDD. More... positron emission tomography (PET)
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Molecule Macrophage migration inhibitory factor protein 1
Musil, 2011 Depressed patients showed significantly ...... Depressed patients showed significantly elevated MIF (p < 0.001) and reduced TGF-beta (p = 0.006) concentrations at baseline. More... blood analysis
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Molecule Peroxisomal targeting signal 1 receptor protein 1
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
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Molecule Rho-related GTP-binding protein RhoC protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule C-C motif chemokine 2 protein 1
Piletz, 2010 Compared to controls, patients with MDD ...... Compared to controls, patients with MDD had significantly higher baseline levels of monocyte chemotactic protein-1 (MCP-1; P=0.02) in the blood. More... protein analysis
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Molecule Cytochrome c oxidase subunit 7A2, mitochondrial protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule CDGSH iron-sulfur domain-containing protein 1 protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule Corticoliberin protein 1
Austin, 2003 The level of CRH-IR was increased by 30%...... The level of CRH-IR was increased by 30% in the locus coeruleus, 39% in the median raphe and 45% in the caudal dorsal raphe in the depressed suicide subjects compared to controls. More... postmortem study
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Molecule Excitatory amino acid transporter 2 protein 1
Miguel-Hidalgo, 2010 EAAT2 immunoreactivity was significantly...... EAAT2 immunoreactivity was significantly lower in MDD and MDA(comorbid alcoholism plus MDD) subjects than in controls. More... postmortem study; immunoblotting; immunocytochemical analysis
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Molecule Clusterin protein 1
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
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Molecule FXYD domain-containing ion transport regulator 6 protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule Beta-2-glycoprotein 1 protein 1
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
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Molecule Plasma protease C1 inhibitor protein 1
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
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Molecule Microtubule-associated proteins 1A/1B light chain 3A protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule Metabotropic glutamate receptor 2 protein 1
Feyissa, 2010 There was a robust (+67%) increase in th...... There was a robust (+67%) increase in the expression of the mGlu2 protein in the PFC of depressed subjects relative to healthy controls. More... postmortem study; immunoblotting
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Molecule Fructose-bisphosphate aldolase C protein 1
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
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Molecule Cytochrome c protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule Glial fibrillary acidic protein protein 1
Miguel-Hidalgo, 2010 Area fraction of GFAP was lower in MDD, ...... Area fraction of GFAP was lower in MDD, but not in MDA subjects as compared to controls or alcoholics. More... postmortem study; immunoblotting; immunocytochemical analysis
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Molecule Collagen alpha-1(VI) chain protein 1
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
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Molecule Gamma-aminobutyric acid receptor-associated protein-like 2 protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule Vitamin D-binding protein protein 1
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
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Molecule Platelet-activating factor acetylhydrolase protein 1
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
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Molecule Profilin-1 protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule Metabotropic glutamate receptor 3 protein 1
Feyissa, 2010 There was a robust (+67%) increase in th...... There was a robust (+67%) increase in the expression of the mGlu3 protein in the PFC of depressed subjects relative to healthy controls. More... postmortem study; immunoblotting
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Molecule cAMP-dependent protein kinase catalytic subunit alpha protein 1
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
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Molecule NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule Glutamine synthetase protein 1
Miguel-Hidalgo, 2010 GS levels in MDA(comorbid alcoholism plu...... GS levels in MDA(comorbid alcoholism plus MDD) were significantly lower than in alcoholics and controls, and lower in MDD subjects than in alcoholics More... postmortem study; immunoblotting; immunocytochemical analysis
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Molecule Complement C3 protein 1
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
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Molecule Ribonuclease UK114 protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule Coagulation factor VII protein 1
Leo, 2006 Compared with control subjects, MDD pati...... Compared with control subjects, MDD patients had higher baseline levels of FVIIa More... protein analysis
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Molecule Transthyretin protein 1
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
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Molecule Secretogranin-1 protein 1
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
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Molecule Profilin-2 protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule Serum albumin protein 1
Gudmundsson, 2007 Compared to women without depression, wo...... Compared to women without depression, women with MDD had higher levels of Abeta42 and the CSF/serum albumin ratio. More... cerebrospinal fluid analysis; blood analysis
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Molecule Neurofilament light polypeptide protein 1
Gudmundsson, 2010 Women had MDD have higher levels of NFL ...... Women had MDD have higher levels of NFL compared with women without depression More... cerebrospinal fluid analysis; blood analysis
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Molecule Alpha-1-acid glycoprotein 1 protein 1
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
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Molecule NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule Nitric oxide synthase, endothelial protein 1
Chrapko, 2004 The levels of both plasma Nox(NO metabol...... The levels of both plasma Nox(NO metabolite) and platelet eNOS(endothelial NO synthase) activity were significantly lower in subjects with major depression compared with healthy control subjects. More... blood analysis
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Molecule Tissue-type plasminogen activator protein 1
Shi, 2010 Baseline plasma BDNF and tPA levels were...... Baseline plasma BDNF and tPA levels were significantly lower in LGD(late-onset geriatric depression) patients compared to controls (P = 0.037 and P = 0.000, respectively). More... blood analysis
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Molecule Epididymal secretory protein E1 protein 1
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
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Molecule Synaptosomal-associated protein 25 protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule CD40 ligand protein 1
Leo, 2006 Compared with control subjects, MDD pati...... Compared with control subjects, MDD patients had higher baseline levels of soluble CD40L More... protein analysis
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Molecule Prostaglandin-H2 D-isomerase protein 1
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
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Molecule Superoxide dismutase [Cu-Zn] protein 1
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
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Molecule Putative tubulin-like protein alpha-4B protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule Myeloperoxidase protein 1
Vaccarino, 2008 Twins with a history of MDD had 32% high...... Twins with a history of MDD had 32% higher levels of MPO (p < .0001); twins with MDD had 77% higher MPO than their brothers without MDD, after adjusting for other factors (p < .0001) More... blood analysis
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Molecule Interleukin-2 receptor subunit alpha protein 1
Eller, 2009 The results showed that the level of sIL...... The results showed that the level of sIL-2R (soluble interleukin-2 receptor) was significantly lower in depressed patients in remission phase compared to the healthy controls and subjects with recurrent depression. Drug-nalve patients with major depressive disorder with recurrent episode had higher levels of sIL-2R than previously treated or patients with the first episode. More... blood analysis
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Molecule Alpha-2-macroglobulin protein 1
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
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Molecule NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule Histamine H1 receptor protein 1
Kano, 2004 Binding (histamine H1 receptor (H(1)R) b...... Binding (histamine H1 receptor (H(1)R) binding) potential values for [(11)C]-doxepin binding in the frontal and prefrontal cortices, and cingulate gyrus were significantly lower in the depressed patients than those in the normal control subjects. More... positron emission tomography (PET)
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Molecule Natriuretic peptides A protein 1
Wisen, 2011 The MDD group showed significantly lower...... The MDD group showed significantly lower levels of ANP than the controls at rest, at maximal work rate and post exercise. The dynamic changes of ANP, respectively, from baseline to maximal work rate were significantly lower in the MDD group. More... blood analysis
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Molecule Gelsolin protein 1
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
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Molecule Amphiphysin protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule Alpha-1B-glycoprotein protein 1
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
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Molecule Vitronectin protein 1
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
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Molecule Cystatin-B protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule BDNF/NT-3 growth factors receptor protein 1
Hung, 2010 The serum TrkB protein level was signifi...... The serum TrkB protein level was significantly higher in depressive patients than in healthy controls (F((1,107))=4.043, p=0.047) More... Enzyme-linked immunosorbent assay (ELISA)
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Molecule Angiotensinogen protein 1
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
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Molecule NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule Natriuretic peptides B protein 1
Wisen, 2011 The MDD group showed significantly lower...... The MDD group showed significantly lower levels of BNP at rest and at maximal work rate. The dynamic changes of BNP, respectively, from baseline to maximal work rate were significantly lower in the MDD group. More... blood analysis
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Molecule Beta-Ala-His dipeptidase protein 1
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
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Molecule Dihydropyrimidinase-related protein 2 protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule Interleukin-10 protein 1
Hernandez, 2008 Before treatment we found high levels of...... Before treatment we found high levels of cortisol, IL-4, IL-13 (Th2) and IL-10 in MDD patients when compared with healthy volunteers. More... blood analysis
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Molecule Heterogeneous nuclear ribonucleoprotein H protein 1
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
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Molecule Interleukin-5 protein 1
Elomaa AP, 2012 In our basic multivariate model controll...... In our basic multivariate model controlling for the effects of potential confounders on the associations between MDD and the examined cytokines, each 1-unit increase in the serum IL-5 level increased the likelihood of belonging to the MDD group by 76% (OR 1.76, 95% CI 1.03-2.99, p = 0.04; model covariates: age, gender, marital status, daily smoking and alcohol use). More... blood analysis
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Molecule Alpha-synuclein protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule Apolipoprotein A-I protein 1
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
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Molecule Putative cytochrome b-c1 complex subunit Rieske-like protein 1 protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule Interleukin-17A protein 1
Chen, 2010 A higher level of serum concentration of...... A higher level of serum concentration of IL-17 was found in patient. More... immunocytochemical analysis; flow cytometric analysis; RT-PCR; Enzyme-linked immunosorbent assay (ELISA)
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Molecule Histidine-rich glycoprotein protein 1
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
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Molecule Dihydropyrimidinase-related protein 3 protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule P-selectin protein 1
Leo, 2006 Compared with control subjects, MDD pati...... Compared with control subjects, MDD patients had higher baseline levels of soluble P-selectin More... protein analysis
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Molecule Interleukin-13 protein 1
Hernandez, 2008 Before treatment we found high levels of...... Before treatment we found high levels of cortisol, IL-4, IL-13 (Th2) and IL-10 in MDD patients when compared with healthy volunteers. More... blood analysis
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Molecule Pigment epithelium-derived factor protein 1
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
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Molecule Acyl-coenzyme A thioesterase 13 protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule Gamma-synuclein protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule 5-hydroxytryptamine receptor 1B protein 1
Murrough, 2011 Within the ventral striatum/ventral pall...... Within the ventral striatum/ventral pallidum region of interest, 5-HT(1B) receptor radioligand [(11)C]P943 BP (ND) was significantly reduced in the MDD group compared with the healthy control group (1.37 +/- 0.13 and 1.68 +/- 0.16, respectively; 18.7% between-group difference; p < 0.001). More... positron emission tomography (PET)
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Molecule Apolipoprotein A-II protein 1
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
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Molecule ATP synthase subunit e, mitochondrial protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule Transcription factor PU.1 protein 1
Weigelt, 2011 In MDD patients, PU.1 gene expression wa...... In MDD patients, PU.1 gene expression was increased with a tendency for TREM-1 gene over expression. More... Q-PCR; Chromatin immunoprecipitation (ChIP)
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Molecule Homeobox protein Hox-D12 protein 1
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
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Molecule Peptidyl-prolyl cis-trans isomerase FKBP2 protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule Glutamate receptor ionotropic, NMDA 2A protein 1
Feyissa, 2009 The results revealed that there was a re...... The results revealed that there was a reduced expression of the NMDA (N-methyl-d-aspartate) receptor subunits NR2A (-54%) and NR2B (-48%), and PSD-95 protein level (-40%) in the PFC of depressed subjects relative to controls More... postmortem study; immunoblotting
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Molecule Heat shock cognate 71 kDa protein protein 1
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
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Molecule Acylphosphatase-2 protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule Histone H4 protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule Adiponectin protein 1
Cizza, 2010 Women with MDD had approximately 30% low...... Women with MDD had approximately 30% lower mean 24-hour concentration of adiponectin than did control subjects. More... blood analysis
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Molecule Apolipoprotein D protein 1
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
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Molecule ATP synthase subunit g, mitochondrial protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule Metabotropic glutamate receptor 5 protein 1
Deschwanden, 2011 The PET study revealed lower levels of r...... The PET study revealed lower levels of regional mGluR5 binding in the prefrontal cortex, the cingulate cortex, the insula, the thalamus, and the hippocampus in the depression group relative to the comparison group. More... positron emission tomography (PET); immunoblotting
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Molecule Neurofilament heavy polypeptide protein 1
Ditzen C, 2012 Regulated Protein in Cerebrospinal Fluid...... Regulated Protein in Cerebrospinal Fluid of Depressed Patients More... two-dimensional electrophoresis (2-DE); spectrophotometric analysis; immunoblotting
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Molecule Neuromodulin protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule Glutamate receptor ionotropic, NMDA 2B protein 1
Feyissa, 2009 The results revealed that there was a re...... The results revealed that there was a reduced expression of the NMDA (N-methyl-d-aspartate) receptor subunits NR2A (-54%) and NR2B (-48%), and PSD-95 protein level (-40%) in the PFC of depressed subjects relative to controls More... postmortem study; immunoblotting
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Molecule Cytochrome c oxidase subunit 4 isoform 1, mitochondrial protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule DNA-binding protein SATB2 protein 1
Martins-de-Souza D, 2012 Differentially expressed proteins in all...... Differentially expressed proteins in all post mortem brains from MDD patients compared with controls More... gel electrophoresis; shotgun data-independent label-free liquid chromatography-mass spectrometry; Western blot ; selected reaction monitoring mass spectrometry
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Molecule Synaptic vesicular amine transporter protein 1
Zucker, 2002 A significant elevation in the VMAT2 den...... A significant elevation in the VMAT2 density (B(max)) was observed in the platelets of untreated MDD patients (+24%) compared to healthy control subjects. More... blood analysis
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Molecule Hydrocortisone molecule 27
Hernandez, 2008 Before treatment we found high levels of...... Before treatment we found high levels of cortisol, IL-4, IL-13 (Th2) and IL-10 in MDD patients when compared with healthy volunteers. More... blood analysis
Sarandol, 2003 All cortisol responses were found to be ...... All cortisol responses were found to be significantly higher in the patient group during depression period compared to the control group except at 16:00 before dexamethasone. More... blood analysis
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Molecule Glutamates molecule 12
Rosenberg, 2005 Reduced anterior cingulate glutamate was...... Reduced anterior cingulate glutamate was observed in MDD patients versus control subjects (8.79 +/- 1.68 vs. 11.46 +/- 1.55, respectively, p = .0002; 23% decrease). More... spectrophotometric analysis
Sanacora, 2004 mean glutamate levels were significantly...... mean glutamate levels were significantly increased in depressed subjects compared with healthy controls (P<.001). More... spectrophotometric analysis
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Molecule Creatine molecule 8
Kusumakar, 2001 Subjects with depression demonstrated lo...... Subjects with depression demonstrated lower left amygdala Cho-Cr ratios, compared with control subjects (paired t = 2.624, df 10, P = 0.025). More... spectrophotometric analysis
Horn, 2010 Creatine in the pgACC were lowest in sev...... Creatine in the pgACC were lowest in severely depressed patients. More... functional magnetic resonance imaging (fMRI); spectrophotometric analysis; psychometric method
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Molecule Glutamine molecule 7
Bhagwagar, 2007 Occipital levels of GABA and NAA were si...... Occipital levels of GABA and NAA were significantly lower in recovered depressed and bipolar subjects than in healthy controls, whereas Glu +Gln concentrations were higher. More... spectrophotometric analysis
Horn, 2010 the sum of Glutamine (Glx) in the pgACC ...... the sum of Glutamine (Glx) in the pgACC predicted the resting-state functional connectivity between the two regions exclusively in depressed patients. More... functional magnetic resonance imaging (fMRI); spectrophotometric analysis; psychometric method
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Molecule N-acetylaspartate molecule 7
Vythilingam, 2003 Compared with control subjects, MDD pati...... Compared with control subjects, MDD patients had a significantly lower mean NAA/Cr amplitude in the caudate and a significantly higher mean Cho/Cr amplitude in the putamen, particularly on the right side. More... spectrophotometric analysis
Jarnum, 2011 significantly reduced N-acetylaspartate ...... significantly reduced N-acetylaspartate levels in MDD patients compared with healthy controls at baseline. More... magnetic resonance imaging (MRI)
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Molecule gamma-Aminobutyric Acid molecule 7
Sanacora, 2004 Depressed subjects had significantly low...... Depressed subjects had significantly lower occipital cortex GABA concentrations compared with healthy controls (P =.01). More... spectrophotometric analysis
Gabbay, 2012 Compared with control subjects, adolesce...... Compared with control subjects, adolescents with MDD had significantly decreased ACC GABA/w (t = 3.2; P < .003). More... spectrophotometric analysis
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Molecule Inositol molecule 7
Taylor, 2009 myo-inositol concentrations were signifi...... myo-inositol concentrations were significantly higher in those with a history of depression than in controls. More... spectrophotometric analysis
Kumar, 2002 myo-Inositol/creatine and choline/creati...... myo-Inositol/creatine and choline/creatine ratios were significantly higher in the frontal white matter in the major depression group than in the comparison group. More... spectrophotometric analysis
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Molecule Choline molecule 6
Kumar, 2002 myo-Inositol/creatine and choline/creati...... myo-Inositol/creatine and choline/creatine ratios were significantly higher in the frontal white matter in the major depression group than in the comparison group. More... spectrophotometric analysis
Vythilingam, 2003 Compared with control subjects, MDD pati...... Compared with control subjects, MDD patients had a significantly lower mean NAA/Cr amplitude in the caudate and a significantly higher mean Cho/Cr amplitude in the putamen, particularly on the right side. More... spectrophotometric analysis
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Molecule Nitric oxide molecule 5
Lee, 2006 Among the patients with a diagnosis of m...... Among the patients with a diagnosis of major depression, suicidal depressive patients had significantly higher plasma nitric oxide metabolites NO(x) levels than non-suicidal depressive patients (t=-3.090, d.f.=84, p=0.003). More... blood analysis
Arslan, 2008 MD (major depression) group had signific...... MD (major depression) group had significantly lower plasma NO levels compared to healthy women (12.7 +/- 1.4 vs. 21.82 +/- 3.5 microM, respectively, p < 0.05). More... spectrophotometric analysis
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Molecule Serotonin molecule 4
Ljubicic, 2007 The significant increase in platelet 5-H...... The significant increase in platelet 5-HT values were found in female (p=0.01) and male (p=0.029) depressed patients during long compared to short period. More... blood analysis
Hou, 2006 significantly lower CSF(cerebrospinal fl...... significantly lower CSF(cerebrospinal fluid) NPY was found in first episode depressed patients compared with recurrent depressed patients More... cerebrospinal fluid analysis
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Molecule Dopamine molecule 3