Protein Report

Protein Name	Corticoliberin
UniPortKB	P06850
No. of Studies (Positive/Negative)	4 (4/0)
Type	Literature-origin

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
corticotropin-releasing hormone (CRH)	Austin, 2003	patients and normal controls		The level of CRH-IR (CRH-immunoreactivity) was increased by ...... The level of CRH-IR (CRH-immunoreactivity) was increased by 30% in the locus coeruleus, 39% in the median raphe and 45% in the caudal dorsal raphe in the depressed suicide subjects compared to controls. More...

Name in Literature	Related Components
	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
CRH, corticosteron releasing hormone		TAC1(tac1)	gene	Frisch, 2010	animal model		Our results show a strong induction of CRH expression in the...... Our results show a strong induction of CRH expression in the cortex of tac1(-/-) animals. More...
corticotropin-releasing factor (CRF)		Hypothalamic-pituitary-adrenal axis(hypothalamic-pituitary-adrenal axis)	neurobiological system	Heim, 2000	patients and normal controls		Our findings suggest that hypothalamic-pituitary-adrenal axi...... Our findings suggest that hypothalamic-pituitary-adrenal axis and autonomic nervous system hyperreactivity, presumably due to CRF hypersecretion, is a persistent consequence of childhood abuse that may contribute to the diathesis for adulthood psychopathological conditions. More...
corticotropin-releasing factor (CRF)		Autonomic nervous system(autonomic nervous system)	brain morphology and function	Heim, 2000	patients and normal controls		Our findings suggest that hypothalamic-pituitary-adrenal axi...... Our findings suggest that hypothalamic-pituitary-adrenal axis and autonomic nervous system hyperreactivity, presumably due to CRF hypersecretion, is a persistent consequence of childhood abuse that may contribute to the diathesis for adulthood psychopathological conditions. More...
corticotropin-releasing hormone (CRH)		Suicide(suicide)	symptoms	Austin, 2003	patients and normal controls		The level of CRH-IR was increased by 30% in the locus coerul...... The level of CRH-IR was increased by 30% in the locus coeruleus, 39% in the median raphe and 45% in the caudal dorsal raphe in the depressed suicide subjects compared to controls. More...
corticotropin-releasing factor		Stress(early-life stress)	environment	Carpenter, 2004	patients and normal controls		perceived early-life stress was a significant predictor of c...... perceived early-life stress was a significant predictor of cerebrospinal fluid (CSF) corticotropin-releasing factor More...

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Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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Gene Symbol	Gene Name	Type	No. of Studies (Positive/Negative)	Add to Relationship Set
CRH	corticotropin releasing hormone	Protein mapped	0 (0/0)