Name in Literature
Related Components
Level
Approved Name(Name in Literature)
Type
Reference
Research Type
Statistical Result
Relation Description
All
suicidal phenotypes
rs3745406 (rs3745406)
SNP
Wang, 2010
patients and normal controls
chi(2) = 4.746, P-value = 0.0360
Further analyses revealed a significant association between ......
Further analyses revealed a significant association between rs3745406 locus and HAMD suicidal phenotypes (chi(2) = 4.746, P = 0.0360).
More...
suicide attempt
rs40184 (rs40184)
SNP
Haeffel, 2008
nomal people
As hypothesized, one of the polymorphisms (rs40184) moderate......
As hypothesized, one of the polymorphisms (rs40184) moderated the effect of perceived maternal rejection on the onset of major depressive disorder, as well as on suicidal ideation
More...
suicide attempt
rs11568817 (rs11568817)
SNP
Wang, 2009
patients and normal controls
An allele association study revealed a significant relations......
An allele association study revealed a significant relationship between rs11568817 and suicidal ideation
More...
suicide attempt
HTR2A (5-HT2A)
gene
Du, 2000
patients and normal controls
P-value<0.05
The major finding of this study was a significant associatio......
The major finding of this study was a significant association between the 102 C allele in 5-HT2A receptor gene and major depression, chi(2) = 4.5, df = 1, P = 0.03, particularly in patients with suicidal ideation, chi(2) = 8.5, df = 1, P < 0.005. Furthermore, we found that patients with a 102 C/C genotype had a significantly higher mean HAMD item 3 score (indication of suicidal ideation) than T/C or T/T genotype patients.
More...
suicidal behavior
TPH1 (TPH)
gene
Abbar M, 2001
nomal people
chi(2) = 11.2; df = 1; P< 0.0008
Significant associations were found between variants in intr......
Significant associations were found between variants in introns 7, 8 and 9 (chi(2) = 11.2, df = 1, P< 0.0008 for the allele distribution; these loci are in complete linkage disequilibrium) and in the 3' noncoding region (chi(2) = 30.94, P = 0.0014) and suicide attempt.
More...
suicide attempt
HTR1A (5-HT1A)
gene
Lemonde, 2003
patients and normal controls
genotype: P-value = 0.002 , allele: P-value= 0.00008
In depressed patients, the homozygous G(-1019) allele was en......
In depressed patients, the homozygous G(-1019) allele was enriched twofold versus controls (p = 0.0017 and 0.0006 for G/G genotype and G allele distribution, respectively), and in completed suicide cases the G(-1019) allele was enriched fourfold (p = 0.002 and 0.00008 for G/G genotype and G allele distribution, respectively).
More...
suicide attempt
SLC6A4 (5-HTT)
gene
Lopez de Lara, 2006
patients and normal controls
chi(2)(1) = 10.833; P-value = 0.002
We found a significant association of suicide completion wit......
We found a significant association of suicide completion with having at least one copy of the STin2 10 allele [chi(2)(1) = 10.833, p = .002]. No differences were found for the 5-HTTLPR variable number of tandem repeats.
More...
suicide
TPH2 (TPH2)
gene
Zhou, 2005
patients and normal controls
The yin haplotype, 212121,(in TPH2 gene) was increased in f......
The yin haplotype, 212121,(in TPH2 gene) was increased in frequency in suicide attempters in both populations tested (Finnish whites and African Americans)
More...
suicide attempt
SAT1 (SSAT)
gene
Sequeira, 2006
patients and normal controls
P-value
Twenty-six genes were selected because of the consistency of......
Twenty-six genes were selected because of the consistency of their expression pattern (fold change, >1.3 in either direction [P
More...
suicide attempt
TPH2 (TPH2)
gene
Lopez de Lara, 2007
patients only
We found two upstream and two intronic SNPs of this gene ass......
We found two upstream and two intronic SNPs of this gene associated with suicide.
More...
suicide attempt
BDNF (BDNF)
gene
Iga, 2007
patients and normal controls
The dose of Met allele had significant effects on psychotic ......
The dose of Met allele had significant effects on psychotic feature and suicidal behavior and family history
More...
suicide attempt
SAT1 (SAT1)
gene
Klempan, 2009
patients and normal controls
A reduction in SAT1 expression identified through multiple p......
A reduction in SAT1 expression identified through multiple probesets was observed across 12 cortical regions in depressed individuals who have died by suicide compared with controls.
More...
suicide attempt
TPH2 (TPH2)
gene
Yoon, 2009
patients only
There were statistically significant differences in the geno......
There were statistically significant differences in the genotype distributions and allele frequencies of TPH2 -703G/T between the suicidal depressive group and the normal control group
More...
suicide attempt
FADS1 (Fatty acid desaturase (FADS1))
gene
Lalovic, 2010
patients and normal controls
Fatty acid desaturase (FADS1), leptin receptor (LEPR), phosp......
Fatty acid desaturase (FADS1), leptin receptor (LEPR), phosphoinositide-3-kinase (class 2 alpha; PIK3C2A) and stearoyl-CoA desaturase (SCD) were consistently down-regulated in all three regions of the frontal cortex of depressed suicides compared to comparison subjects
More...
suicide attempt
LEPR (leptin receptor (LEPR))
gene
Lalovic, 2010
patients and normal controls
Fatty acid desaturase (FADS1), leptin receptor (LEPR), phosp......
Fatty acid desaturase (FADS1), leptin receptor (LEPR), phosphoinositide-3-kinase (class 2 alpha; PIK3C2A) and stearoyl-CoA desaturase (SCD) were consistently down-regulated in all three regions of the frontal cortex of depressed suicides compared to comparison subjects
More...
suicide attempt
PIK3C2A (phosphoinositide-3-kinase (class 2 alpha, PIK3C2A))
gene
Lalovic, 2010
patients and normal controls
Fatty acid desaturase (FADS1), leptin receptor (LEPR), phosp......
Fatty acid desaturase (FADS1), leptin receptor (LEPR), phosphoinositide-3-kinase (class 2 alpha; PIK3C2A) and stearoyl-CoA desaturase (SCD) were consistently down-regulated in all three regions of the frontal cortex of depressed suicides compared to comparison subjects
More...
suicide attempt
SCD (stearoyl-CoA desaturase (SCD))
gene
Lalovic, 2010
patients and normal controls
Fatty acid desaturase (FADS1), leptin receptor (LEPR), phosp......
Fatty acid desaturase (FADS1), leptin receptor (LEPR), phosphoinositide-3-kinase (class 2 alpha; PIK3C2A) and stearoyl-CoA desaturase (SCD) were consistently down-regulated in all three regions of the frontal cortex of depressed suicides compared to comparison subjects
More...
suicide
QKI (QKI)
gene
Klempan, 2009
patients and normal controls
The messenger RNA (mRNA) levels of multiple transcripts of Q......
The messenger RNA (mRNA) levels of multiple transcripts of QKI were revealing significant reduced in 11 cortical regions and the hippocampus and amygdala of suicide victims compared with control subjects.
More...
suicide attempt
HTR1B (HTR1B)
gene
Wang, 2009
patients and normal controls
An allele association study revealed a significant relations......
An allele association study revealed a significant relationship between rs11568817 and suicidal ideation
More...
suicide
NTRK2 (NTRK2)
gene
Kohli, 2010
patients and normal controls
SNPs within NTRK2 were associated with suicide attempt among......
SNPs within NTRK2 were associated with suicide attempt among depressed patients
More...
suicide attempt
TPH2 (TPH2)
gene
Zhang, 2010
patients only
OR 0.33, 95% CI 0.22-0.99
The multivariate logistic regression analysis indicated that......
The multivariate logistic regression analysis indicated that TPH2 rs7305115 AA (OR 0.33, 95% CI 0.22-0.99), family history of suicide (OR 2.98, 95% CI 1.17-5.04), negative life events half year ago (OR 6.64, 95% CI 2.48-11.04) and hopelessness (OR 7.68, 95% CI 5.79-13.74) were significantly associated with the suicide behaviors in MDD patients.
More...
suicide
ADAR (ADAR1)
gene
Simmons, 2010
patients and normal controls
ADAR1 expression was found to be significantly increased in ......
ADAR1 expression was found to be significantly increased in major depressive suicide victims compared with patients who did not commit suicide.
More...
suicide attempt
KIAA1244 (KIAA1244)
gene
Schosser A, 2011
patients only
P-value<5e-6
For the discrete trait of suicide attempt, SNPs in KIAA1244 ......
For the discrete trait of suicide attempt, SNPs in KIAA1244 and RGS18 attained p-values of <5e-6.
More...
suicide attempt
RGS18 (RGS18)
gene
Schosser A, 2011
patients only
P-value<5e-6
For the discrete trait of suicide attempt, SNPs in KIAA1244 ......
For the discrete trait of suicide attempt, SNPs in KIAA1244 and RGS18 attained p-values of <5e-6.
More...
suicide
C18ORF25 (C18orf25)
gene
Sequeira A, 2009
patients and nomal controls
Group: P-value=0.012, F=5.3; Substance: P-value=0.001, F=16
Genes differentially expressed after an ANCOVA analysis betw......
Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression).
More...
suicide
MBNL2 (MBNL2)
gene
Sequeira A, 2009
patients and nomal controls
Group: P-value=0.001, F=11.2; Substance: P-value=0.006, F=9.8
Genes differentially expressed after an ANCOVA analysis betw......
Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression).
More...
suicide
LTA4H (LTA4H)
gene
Sequeira A, 2009
patients and nomal controls
Group: P-value=0.001, F=10.1; Substance: P-value=0.003, F=12
Genes differentially expressed after an ANCOVA analysis betw......
Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression).
More...
suicide
ANKRD28 (ANKRD28)
gene
Sequeira A, 2009
patients and nomal controls
Group: P-value=0, F=18.4; Substance: P-value=0.006, F=10.2
Genes differentially expressed after an ANCOVA analysis betw......
Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression).
More...
suicide
PTPRB (PTPRB)
gene
Sequeira A, 2009
patients and nomal controls
Group: P-value=0.008, F=6.2; Substance: P-value=0.009, F=8.2
Genes differentially expressed after an ANCOVA analysis betw......
Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression).
More...
suicide
HADHA (HADHA)
gene
Sequeira A, 2009
patients and nomal controls
Group: P-value=0.001, F=11.6; Substance: P-value=0.006, F=10.4
Genes differentially expressed after an ANCOVA analysis betw......
Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression).
More...
suicide
TANC1 (KIAA1728)
gene
Sequeira A, 2009
patients and nomal controls
Group: P-value=0, F=13.5; Substance: P-value=0.004, F=11.3
Genes differentially expressed after an ANCOVA analysis betw......
Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression).
More...
suicide
TRPS1 (TRPS1)
gene
Sequeira A, 2009
patients and nomal controls
Group: P-value=0, F=10.8; Substance: P-value=0.005, F=9.3
Genes differentially expressed after an ANCOVA analysis betw......
Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression).
More...
suicide
ABCA8 (ABCA8)
gene
Sequeira A, 2009
patients and nomal controls
Group: P-value=0.006, F=6.5; Substance: P-value=0.009, F=8.3
Genes differentially expressed after an ANCOVA analysis betw......
Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression).
More...
suicide
IRF2 (IRF2)
gene
Sequeira A, 2009
patients and nomal controls
Group: P-value=0, F=16.1; Substance: P-value=0.001, F=14.4
Genes differentially expressed after an ANCOVA analysis betw......
Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression).
More...
suicide
VPS13A (VPS13A)
gene
Sequeira A, 2009
patients and nomal controls
Group: P-value=0.023, F=4.5; Substance: P-value=0.008, F=8.6
Genes differentially expressed after an ANCOVA analysis betw......
Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression).
More...
suicide
MAN2A1 (MAN2A1)
gene
Sequeira A, 2009
patients and nomal controls
Group: P-value=0.016, F=5; Substance: P-value=0.005, F=9.5
Genes differentially expressed after an ANCOVA analysis betw......
Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression).
More...
suicide
CPNE2 (CPNE2)
gene
Sequeira A, 2009
patients and nomal controls
Group: P-value=0.003, F=7.8; Substance: P-value=0.002, F=12.9
Genes differentially expressed after an ANCOVA analysis betw......
Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression).
More...
suicide
LAMP1 (LAMP1)
gene
Sequeira A, 2009
patients and nomal controls
Group: P-value=0.004, F=7.4; Substance: P-value=0.009, F=8.2
Genes differentially expressed after an ANCOVA analysis betw......
Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression).
More...
suicide
STON2 (STN2)
gene
Sequeira A, 2009
patients and nomal controls
Group: P-value=0, F=14.2; Substance: P-value=0.01, F=8
Genes differentially expressed after an ANCOVA analysis betw......
Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression).
More...
suicide
PREX1 (PREX1)
gene
Sequeira A, 2009
patients and nomal controls
Group: P-value=0, F=11; Substance: P-value=0.006, F=9.4
Genes differentially expressed after an ANCOVA analysis betw......
Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression).
More...
suicide
NHSL1 (NHSL1)
gene
Sequeira A, 2009
patients and nomal controls
Group: P-value=0.001, F=10.1; Substance: P-value=0.002, F=12
Genes differentially expressed after an ANCOVA analysis betw......
Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression).
More...
suicide
DYNC1LI1 (DNCLI1)
gene
Sequeira A, 2009
patients and nomal controls
Group: P-value=0.001, F=10.8; Substance: P-value=0.001, F=14.1
Genes differentially expressed after an ANCOVA analysis betw......
Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression).
More...
suicide
TOLLIP (TOLLIP)
gene
Sequeira A, 2009
patients and nomal controls
Group: P-value=0.001, F=10.9; Substance: P-value=0.007, F=8.9
Genes differentially expressed after an ANCOVA analysis betw......
Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression).
More...
suicide
DSTYK (DustyPK)
gene
Sequeira A, 2009
patients and nomal controls
Group: P-value=0, F=18.1; Substance: P-value=0.008, F=9.3
Genes differentially expressed after an ANCOVA analysis betw......
Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression).
More...
suicide
PUM1 (PUM1)
gene
Sequeira A, 2009
patients and nomal controls
Group: P-value=0.001, F=11.1; Substance: P-value=0.009, F=8.8
Genes differentially expressed after an ANCOVA analysis betw......
Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression).
More...
suicide
DDX25 (DDX25)
gene
Sequeira A, 2009
patients and nomal controls
Group: P-value=0, F=14.3; Substance: P-value=0.004, F=11.3
Genes differentially expressed after an ANCOVA analysis betw......
Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression).
More...
suicide
ARL4C (ARL7)
gene
Sequeira A, 2009
patients and nomal controls
Group: P-value=0.001, F=10.5; Substance: P-value=0.009, F=8.9
Genes differentially expressed after an ANCOVA analysis betw......
Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression).
More...
suicide
USP14 (USP14)
gene
Sequeira A, 2009
patients and nomal controls
Group: P-value=0.003, F=8.2; Substance: P-value=0.008, F=8.8
Genes differentially expressed after an ANCOVA analysis betw......
Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression).
More...
suicide
SF3B3 (SAP130)
gene
Sequeira A, 2009
patients and nomal controls
Group: P-value=0.002, F=9.2; Substance: P-value=0.006, F=9.6
Genes differentially expressed after an ANCOVA analysis betw......
Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression).
More...
suicide
KCNA4 (KCNA4)
gene
Sequeira A, 2009
patients and nomal controls
Group: P-value=0, F=13.7; Substance: P-value=0.008, F=8.7
Genes differentially expressed after an ANCOVA analysis betw......
Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression).
More...
suicide attempt
2p (2p)
region
Zubenko, 2004
patients and normal controls
P-value<0.001
Exceeded the criterion for highly-significant linkage (genom......
Exceeded the criterion for highly-significant linkage (genome-wide adjusted P < 0.001)
More...
suicide attempt
6q (6q)
region
Zubenko, 2004
patients and normal controls
P-value<0.001
Exceeded the criterion for highly-significant linkage (genom......
Exceeded the criterion for highly-significant linkage (genome-wide adjusted P < 0.001)
More...
suicide attempt
8p22-p21 (8p22-p21)
region
Zubenko, 2004
patients and normal controls
P-value<0.0001
P < 0.0001
P < 0.0001
suicide attempt
Xq (Xq)
region
Zubenko, 2004
patients and normal controls
LOD = 3.87, P-value < 0.0001
LOD = 3.87, P < 0.0001
LOD = 3.87, P < 0.0001
suicidality
18q22-q23 (18q22-q23)
region
Butler, 2010
patients and normal controls
LOD score > 1.5
LOD score > 1.5
LOD score > 1.5
suicidality
3p14 (3p14)
region
Butler, 2010
patients and normal controls
P-value=0.0017
This rigon achieved suggestive linkage and yielded a maximum......
This rigon achieved suggestive linkage and yielded a maximum LOD of 1.853 (P=0.0017)
More...
suicidality
9p24.3 (9p24.3)
region
Butler, 2010
patients and normal controls
LOD score > 1.5
LOD score > 1.5
LOD score > 1.5
suicide attempt
Cyclic AMP-responsive element-binding protein 1 (CREB)
protein
Dowlatshahi, 1999
patients and normal controls
We also detected a significant effect of suicide on temporal......
We also detected a significant effect of suicide on temporal cortex CREB levels in subjects that died as a result of suicide relative to those that did not, which was more evident in patients with major depressive disorder.
More...
suicide attempt
Calreticulin (calreticulin)
protein
Bown, 2000
patients and normal controls
Increased levels of GRP78, GRP94, and calreticulin, a third ......
Increased levels of GRP78, GRP94, and calreticulin, a third member of the ER stress protein family, were found in temporal cortex of subjects with major depressive disorder who died by suicide compared with controls and subjects who died by other means.
More...
suicide attempt
78 kDa glucose-regulated protein (GRP78)
protein
Bown, 2000
patients and normal controls
Increased levels of GRP78, GRP94, and calreticulin, a third ......
Increased levels of GRP78, GRP94, and calreticulin, a third member of the ER stress protein family, were found in temporal cortex of subjects with major depressive disorder who died by suicide compared with controls and subjects who died by other means.
More...
suicide attempt
Endoplasmin (GRP94)
protein
Bown, 2000
patients and normal controls
Increased levels of GRP78, GRP94, and calreticulin, a third ......
Increased levels of GRP78, GRP94, and calreticulin, a third member of the ER stress protein family, were found in temporal cortex of subjects with major depressive disorder who died by suicide compared with controls and subjects who died by other means.
More...
suicide
Corticoliberin (corticotropin-releasing hormone (CRH))
protein
Austin, 2003
patients and normal controls
The level of CRH-IR was increased by 30% in the locus coerul......
The level of CRH-IR was increased by 30% in the locus coeruleus, 39% in the median raphe and 45% in the caudal dorsal raphe in the depressed suicide subjects compared to controls.
More...
suicide
5-hydroxytryptamine receptor 1A (5-HT1A receptor)
protein
Hsiung, 2003
patients and normal controls
Measurements of [35S]GTPgammaS binding to Galphai/o in the o......
Measurements of [35S]GTPgammaS binding to Galphai/o in the occipital cortex of suicide victims and matched controls revealed a blunted response in suicide subjects and a decrease in the coupling of 5-HT1A receptor to adenylyl cyclase.
More...
suicide attempt
Brain-derived neurotrophic factor (BDNF)
protein
Kim, 2007
patients and normal controls
F=6.682, P-value=0.002
Plasma BDNF levels were measured by enzyme linked immunosorb......
Plasma BDNF levels were measured by enzyme linked immunosorbent assay. BDNF levels were significantly lower in suicidal MDD patients (430.5+/-397.0 pg/ml) than non-suicidal MDD patients (875.80+/-663.02 pg/ml) or normal controls (889.4+/-611.3 pg/ml) (F=6.682, p=0.002).
More...
suicide attempt
5-hydroxytryptamine receptor 2A (5HT(2A))
protein
Roggenbach, 2007
patients and normal controls
Mean K(D) for the platelet 5HT(2A) receptor and MAO-B activi......
Mean K(D) for the platelet 5HT(2A) receptor and MAO-B activity were significantly lower in suicidal patients as compared to nonsuicidal depressed patients and healthy controls
More...
suicide attempt
Amine oxidase [flavin-containing] B (MAO-B)
protein
Roggenbach, 2007
patients and normal controls
Mean K(D) for the platelet 5HT(2A) receptor and MAO-B activi......
Mean K(D) for the platelet 5HT(2A) receptor and MAO-B activity were significantly lower in suicidal patients as compared to nonsuicidal depressed patients and healthy controls
More...
suicide
Interleukin-2 (interleukin [IL]-2)
protein
Kim, 2008
patients and normal controls
P-value<0.001
Suicidal MDD patients had significantly lower IL-2 compared ......
Suicidal MDD patients had significantly lower IL-2 compared with non-suicidal patients and normal controls (p<0.001).
More...
suicide
Interleukin-6 (interleukin [IL]-6)
protein
Kim, 2008
patients and normal controls
P-value<0.001
Non-suicidal MDD patients had significantly higher IL-6 prod......
Non-suicidal MDD patients had significantly higher IL-6 production than suicidal MDD patients and normal controls (p<0.001).
More...
suicide attempt
Brain-derived neurotrophic factor (BDNF)
protein
Deveci, 2007
patients and normal controls
P-value = 0.004
Mean serum BDNF levels were significantly lower in the suici......
Mean serum BDNF levels were significantly lower in the suicide group (21.2 +/- 12.4 ng/ml) and the major depressive disorder group (21.2 +/- 11.3 ng/ml) than the control group (31.4 +/- 8.8 ng/ml; p = 0.004).
More...
suicide
Tumor necrosis factor (tumor necrosis factor-alpha (TNF-alpha))
protein
Gabbay, 2009
patients and normal controls
P-value = 0.03
suicidal adolescents with MDD had significantly decreased pl......
suicidal adolescents with MDD had significantly decreased plasma TNF-alpha concentrations compared to nonsuicidal adolescents with MDD (1.33 +/- 2.95 pg/mL versus 30.9 +/- 110.9 pg/mL; p = 0.03)
More...
suicidality
Tumor necrosis factor (tumor necrosis factor-alpha (TNFalpha))
protein
Eller, 2009
patients and normal controls
TNFalpha was associated with decreased activity and suicidal......
TNFalpha was associated with decreased activity and suicidality.
More...
suicide
Intercellular adhesion molecule 1 (intercellular adhesion molecule-1 (ICAM-1))
protein
Miguel-Hidalgo, 2011
patients and normal controls
Non-psychiatric comparison subjects older than 60 experience......
Non-psychiatric comparison subjects older than 60 experienced dramatic increase in extravascular ICAM-1 immunoreactivity, but this increase was attenuated in elderly subjects with MDD, particularly in those dying by suicide.
More...
suicide
Hydroxyindoleacetic Acid (5hydroxyindolacetic acid)
molecule
Placidi, 2001
patients only
Lower CSF(cerebrospinal fluid) 5-HIAA(5hydroxyindolacetic ac......
Lower CSF(cerebrospinal fluid) 5-HIAA(5hydroxyindolacetic acid) and greater suicidal intent were found in high-lethality suicide attempters compared with low-lethality suicide attempters.
More...
suicide
Serotonin (serotonin)
molecule
Austin, 2002
patients and normal controls
P-value < 0.01
The mean total length of serotonin transporter-immunoreactiv......
The mean total length of serotonin transporter-immunoreactive axons per unit area was unchanged in layers 2 and 4 of area 46 in the depressed suicide subjects compared to controls, but was significantly (P < 0.01) decreased by 24% in layer 6 in the depressed suicide group.
More...
suicide intent
Hydrocortisone (cortisol)
molecule
Mathew, 2003
patients and normal controls
Adolescents who are at risk to make suicide attempts appear ......
Adolescents who are at risk to make suicide attempts appear to display significant elevations of cortisol prior to sleep onset, a time when the hypothalamic-pituitary-adrenal (HPA) axis is normally most quiescent.
More...
suicide attempt
Cholesterol (cholesterol)
molecule
Kim, 2004
patients and normal controls
Significant differences in total serum cholesterol levels we......
Significant differences in total serum cholesterol levels were observed between the suicide patients and non-suicide depression patients and between violent suicide patients and non-violent suicide patients when age, sex, BMI and total serum protein levels were controlled.
More...
suicide attempt
Homovanillic Acid (homovanillic acid)
molecule
Sher, 2006
patients and normal controls
P-value < 0.0001
Depressed suicide attempters had lower cerebrospinal fluid H......
Depressed suicide attempters had lower cerebrospinal fluid HVA (homovanillic acid) levels compared to depressed non-attempters (t = 4.4, df = 56, p < 0.0001) and to controls (t = -4.09, df = 79, p < 0.0001).
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suicide
Nitric oxide (nitric oxide)
molecule
Lee, 2006
patients and normal controls
t=-3.090, d.f.=84, P-value=0.003
Among the patients with a diagnosis of major depression, sui......
Among the patients with a diagnosis of major depression, suicidal depressive patients had significantly higher plasma nitric oxide metabolites NO(x) levels than non-suicidal depressive patients (t=-3.090, d.f.=84, p=0.003).
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suicidal intents
Serotonin (serotonin (5-HT))
molecule
Hou, 2006
patients and normal controls
The patients with intense suicidal intents and suicidal atte......
The patients with intense suicidal intents and suicidal attempts had significantly lower CSF(cerebrospinal fluid) 5-HT compared to patients with nonsuicidal intents.
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suicide attempt
Serotonin (5HT)
molecule
Roggenbach, 2007
patients and normal controls
Mean platelet 5HT concentration was significantly lower in s......
Mean platelet 5HT concentration was significantly lower in suicidal inpatients when compared to nonsuicidal depressed patients
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suicidal intent
Hydrocortisone (cortisol)
molecule
Lindqvist, 2008
patients only
There was a significant negative correlation between suicida......
There was a significant negative correlation between suicidal intent and post Dexamethasone Suppression Test (DST) cortisol in patients with MDD.
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suicide attempters
Hydrocortisone (cortisol)
molecule
Lindqvist, 2008
patients and normal controls
At follow-up, evening salivary cortisol was lower in suicide......
At follow-up, evening salivary cortisol was lower in suicide attempters compared to controls.
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suicide
Methoxyhydroxyphenylglycol (3-methoxy-4-hydroxphenylglycol (MHPG))
molecule
Galfalvy, 2009
patients only
P-value=0.045
Lower cerebrospinal fluid MHPG(3-methoxy-4-hydroxphenylglyco......
Lower cerebrospinal fluid MHPG(3-methoxy-4-hydroxphenylglycol) predicted future suicide attempt or suicide (22% increase in hazard for each 10 pmol/ml lower MHPG, p=0.045). Lower CSF MHPG also correlated with higher medical lethality of future suicidal act (mean MHPG: 49+/-18 vs. 32+/-12 pmol/ml for low- vs. high-lethality, t=2.8, d.f.=25, p=0.009).
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suicide attempt
Kynurenine (kynurenine)
molecule
Sublette, 2011
patients and normal controls
t=0.418, df=58, and P-value=0.677
KYN was higher in the MDD suicide attempter subgroup compare......
KYN was higher in the MDD suicide attempter subgroup compared with MDD non-attempters (t=2.105, df=58, and p=0.040), who did not differ from healthy volunteers (t=0.418, df=58, and p=0.677).
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suicide
adenylate cyclase activity (adenylyl cyclase)
pathway
Hsiung, 2003
patients and normal controls
Measurements of [35S]GTPgammaS binding to Galphai/o in the o......
Measurements of [35S]GTPgammaS binding to Galphai/o in the occipital cortex of suicide victims and matched controls revealed a blunted response in suicide subjects and a decrease in the coupling of 5-HT1A receptor to adenylyl cyclase.
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suicide
DNA methyltransferase activity (DNA methyltransferase)
pathway
Poulter, 2008
patients only
The DNMT gene transcripts' expression was altered in several......
The DNMT gene transcripts' expression was altered in several brains regions of suicides, including frontopolar cortex, amygdala, and the paraventricular nucleus of the hypothalamus.
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suicidal intent
Hypothalamic-pituitary-adrenal axis (stress system (HPA))
neurobiological system
Lindqvist, 2008
patients only
Our findings may be attributed to pathophysiological process......
Our findings may be attributed to pathophysiological processes, where a high suicidal intent is revealed during a potential chronic course of MDD, which in turn results in a seemingly normal stress system.
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suicide intent
Hypothalamic-pituitary-adrenal axis (hypothalamic-pituitary-adrenal (HPA) axis)
neurobiological system
Mathew, 2003
patients and normal controls
Adolescents who are at risk to make suicide attempts appear ......
Adolescents who are at risk to make suicide attempts appear to display significant elevations of cortisol prior to sleep onset, a time when the hypothalamic-pituitary-adrenal (HPA) axis is normally most quiescent.
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suicide
Visually evoked potentials (VEPs) (visual evoked potential)
neurobiological system
Fountoulakis, 2004
patients only
The suicidal patients had a significantly prolonged pattern-......
The suicidal patients had a significantly prolonged pattern-reversal visual evoked potential latency in comparison with the other patients.
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suicidal ideation (SI)
Alpha wave (alpha)
neurobiological system
Iosifescu, 2008
patients only
Left-right asymmetry of combined theta + alpha power correla......
Left-right asymmetry of combined theta + alpha power correlated significantly with change in SI from baseline, even when adjusting for changes in depression severity (HAM-D-17) and for the SSRI utilized. Frontal QEEG parameters before treatment may predict worsening SI during SSRI treatment in MDD.
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suicidal ideation (SI)
Theta wave (theta)
neurobiological system
Iosifescu, 2008
patients only
Left-right asymmetry of combined theta + alpha power correla......
Left-right asymmetry of combined theta + alpha power correlated significantly with change in SI from baseline, even when adjusting for changes in depression severity (HAM-D-17) and for the SSRI utilized. Frontal QEEG parameters before treatment may predict worsening SI during SSRI treatment in MDD.
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suicidal behaviour
Hypothalamic-pituitary-adrenal axis (HPA axis)
neurobiological system
Jokinen, 2009
patients only
DST(dexamethasone suppression test) non-suppression was asso......
DST(dexamethasone suppression test) non-suppression was associated with suicide attempt and post-dexamethasone serum cortisol at 11:00 p.m. was significantly higher in suicide attempters compared to non-attempters. The DST non-suppressor rate was 39% in young adult suicide attempters compared with 11% in non-attempters. The results add to previous evidence in support of the role of HPA axis hyperactivity and suicidal behaviour.
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suicide intent
P300 (P3)
neurobiological system
Jandl, 2010
patients only
Decreases in P3 were also more pronounced in the HAS and SAS......
Decreases in P3 were also more pronounced in the HAS and SAS groups in study 1 and in the HAS group in study 2, 'novel' and 'target' condition. Both EDA an P3 habituated faster in MDD patients with a history of attempted suicide.
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suicide attempt
Temporo-parietal connection (temporal cortex)
brain morphology and function
Dowlatshahi, 1999
patients and normal controls
We also detected a significant effect of suicide on temporal......
We also detected a significant effect of suicide on temporal cortex CREB levels in subjects that died as a result of suicide relative to those that did not, which was more evident in patients with major depressive disorder.
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suicide attempt
Temporo-parietal connection (temporal cortex)
brain morphology and function
Bown, 2000
patients and normal controls
Increased levels of GRP78, GRP94, and calreticulin, a third ......
Increased levels of GRP78, GRP94, and calreticulin, a third member of the ER stress protein family, were found in temporal cortex of subjects with major depressive disorder who died by suicide compared with controls and subjects who died by other means.
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suicide attempt
Basal ganglia (basal ganglia)
brain morphology and function
Ahearn, 2001
patients only
Unipolar patients with a history of a suicide attempt demons......
Unipolar patients with a history of a suicide attempt demonstrated significantly more subcortical gray matter hyperintensities compared with patients without such a history. Gray matter hyperintensities in the basal ganglia may be especially associated with risk for suicide attempts.
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suicide
Prefrontal cortex (prefrontal cortex (PFC))
brain morphology and function
Oquendo, 2003
patients only
Depressed high-lethality suicide attempters had lower rCMRgl......
Depressed high-lethality suicide attempters had lower rCMRglu (relative regional cerebral uptake) in ventral, medial, and lateral PFC compared with low-lethality attempters. Lower ventromedial PFC activity was associated with lower lifetime impulsivity and higher-lethality suicide attempts.
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suicide attempt
White matter (white matter hyperintensities (WMH))
brain morphology and function
Ehrlich, 2005
patients only
P-value = 0.02
Bivariate analysis showed that the prevalence of periventric......
Bivariate analysis showed that the prevalence of periventricular WMH was significantly higher in subjects with past suicide attempts (Fisher's Exact Test, p=0.02).
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suicide
Orbitofrontal cortex (orbitofrontal cortex)
brain morphology and function
Monkul, 2007
patients and normal controls
Suicidal patients had smaller right and left orbitofrontal c......
Suicidal patients had smaller right and left orbitofrontal cortex gray matter volumes compared with healthy comparison subjects.
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suicide
Right amygdala (right amygdala)
brain morphology and function
Monkul, 2007
patients and normal controls
Suicidal patients had larger right amygdala volumes than non......
Suicidal patients had larger right amygdala volumes than non-suicidal patients.
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suicide attempt
White matter (white matter hyperintensities (WMH))
brain morphology and function
Pompili, 2007
patients only
Fisher's Exact Test, P-value = 0.01
Bivariate analysis showed that the prevalence of WMH was sig......
Bivariate analysis showed that the prevalence of WMH was significantly higher in subjects with past suicide attempts (Fisher's Exact Test, p = 0.01) and other clinical indicators of elevated suicide risk.
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suicide
Lacunar stroke (lacunar infarction)
brain morphology and function
Komaki, 2008
patients only
the suicide rate was significantly higher in the LI group th......
the suicide rate was significantly higher in the LI group than in the other two groups.
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suicide attempt
right anterior cingulate cortex (right anterior cingulate gyrus)
brain morphology and function
Jollant, 2008
patients and normal controls
Relative to affective comparison subjects, suicide attempter......
Relative to affective comparison subjects, suicide attempters showed greater activity in the right anterior cingulate gyrus (area 32 extending to area 10) to mild happy versus neutral faces
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suicide attempt
right cerebellum (right cerebellum)
brain morphology and function
Jollant, 2008
patients and normal controls
Relative to affective comparison subjects, suicide attempter......
Relative to affective comparison subjects, suicide attempters showed greater activity in the right cerebellum to mild angry versus neutral faces.
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suicide attempt
right lateral orbitofrontal cortex (right lateral orbitofrontal cortex)
brain morphology and function
Jollant, 2008
patients and normal controls
Relative to affective comparison subjects, suicide attempter......
Relative to affective comparison subjects, suicide attempters showed greater activity in the right lateral orbitofrontal cortex (Brodmann's area 47) and decreased activity in the right superior frontal gyrus (area 6) in response to prototypical angry versus neutral faces
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suicide attempt
right superior frontal gyrus (right superior frontal gyrus)
brain morphology and function
Jollant, 2008
patients and normal controls
Relative to affective comparison subjects, suicide attempter......
Relative to affective comparison subjects, suicide attempters showed greater activity in the right lateral orbitofrontal cortex (Brodmann's area 47) and decreased activity in the right superior frontal gyrus (area 6) in response to prototypical angry versus neutral faces
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suicidal behaviors
White matter (periventricular white matter hyperintensities (PVH))
brain morphology and function
Pompili, 2008
patients only
OR: 8.08
Attempters and nonattempters differed only in the presence o......
Attempters and nonattempters differed only in the presence of PVH--the former were more likely to have PVH. The logistic regression indicated that the presence of PVH was robustly associated with suicidal behaviors after controlling for age (OR: 8.08).
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suicide
Amygdala (amygdala)
brain morphology and function
Poulter, 2008
patients only
The DNMT gene transcripts' expression was altered in several......
The DNMT gene transcripts' expression was altered in several brains regions of suicides, including frontopolar cortex, amygdala, and the paraventricular nucleus of the hypothalamus.
More...
suicide
frontopolar regions (frontopolar cortex)
brain morphology and function
Poulter, 2008
patients only
The DNMT gene transcripts' expression was altered in several......
The DNMT gene transcripts' expression was altered in several brains regions of suicides, including frontopolar cortex, amygdala, and the paraventricular nucleus of the hypothalamus.Importantly, an increase of both mRNA and protein expression was found in the frontopolar cortex.
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suicide
Hypothalamus (hypothalamus)
brain morphology and function
Poulter, 2008
patients only
The DNMT gene transcripts' expression was altered in several......
The DNMT gene transcripts' expression was altered in several brains regions of suicides, including frontopolar cortex, amygdala, and the paraventricular nucleus of the hypothalamus.
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suicide attempt
Fronto-parietal connection (frontal cortex)
brain morphology and function
Lalovic, 2010
patients and normal controls
Fatty acid desaturase (FADS1), leptin receptor (LEPR), phosp......
Fatty acid desaturase (FADS1), leptin receptor (LEPR), phosphoinositide-3-kinase (class 2 alpha; PIK3C2A) and stearoyl-CoA desaturase (SCD) were consistently down-regulated in all three regions of the frontal cortex of depressed suicides compared to comparison subjects
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suicide
Amygdala (amygdala)
brain morphology and function
Klempan, 2009
patients and normal controls
The messenger RNA (mRNA) levels of multiple transcripts of Q......
The messenger RNA (mRNA) levels of multiple transcripts of QKI were revealing significant reduced in 11 cortical regions and the hippocampus and amygdala of suicide victims compared with control subjects.
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suicide
Hippocampus (hippocampus)
brain morphology and function
Klempan, 2009
patients and normal controls
The messenger RNA (mRNA) levels of multiple transcripts of Q......
The messenger RNA (mRNA) levels of multiple transcripts of QKI were revealing significant reduced in 11 cortical regions and the hippocampus and amygdala of suicide victims compared with control subjects.
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suicide
Cerebellum (cerebellum)
brain morphology and function
Hwang, 2010
patients and normal controls
Compared with nonsuicidal counterpart, suicidal depression w......
Compared with nonsuicidal counterpart, suicidal depression was associated with decreased GM(gray matter) and WM(white matter) volume in the cerebellum.
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suicide
Frontal Lobe (frontal regions)
brain morphology and function
Hwang, 2010
patients and normal controls
Compared with nonsuicidal counterpart, suicidal depression w......
Compared with nonsuicidal counterpart, suicidal depression was associated with decreased GM(gray matter) and WM(white matter) volume in the frontal regions
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suicide
Insula (insula)
brain morphology and function
Hwang, 2010
patients and normal controls
Compared with nonsuicidal counterpart, suicidal depression w......
Compared with nonsuicidal counterpart, suicidal depression was associated with decreased GM(gray matter) and WM(white matter) volume in the insula
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suicide
Lentiform nucleus (lentiform nucleus)
brain morphology and function
Hwang, 2010
patients and normal controls
Compared with nonsuicidal counterpart, suicidal depression w......
Compared with nonsuicidal counterpart, suicidal depression was associated with decreased GM(gray matter) and WM(white matter) volume in the lentiform nucleus
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suicide
Midbrain (midbrain)
brain morphology and function
Hwang, 2010
patients and normal controls
Compared with nonsuicidal counterpart, suicidal depression w......
Compared with nonsuicidal counterpart, suicidal depression was associated with decreased GM(gray matter) and WM(white matter) volume in the midbrain
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suicide
Parietal Lobe (parietal regions)
brain morphology and function
Hwang, 2010
patients and normal controls
Compared with nonsuicidal counterpart, suicidal depression w......
Compared with nonsuicidal counterpart, suicidal depression was associated with decreased GM(gray matter) and WM(white matter) volume in the parietal regions
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suicide
Temporal Lobe (temporal regions)
brain morphology and function
Hwang, 2010
patients and normal controls
Compared with nonsuicidal counterpart, suicidal depression w......
Compared with nonsuicidal counterpart, suicidal depression was associated with decreased GM(gray matter) and WM(white matter) volume in the temporal regions
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suicide attempters
Internal capsule (internal capsule)
brain morphology and function
Jia, 2010
patients and normal controls
Fractional anisotropy was decreased in the left anterior lim......
Fractional anisotropy was decreased in the left anterior limb of the internal capsule in suicide attempters relative to both nonattempters and healthy comparison subjects
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suicide attempters
right frontal cortex (right frontal lobe)
brain morphology and function
Jia, 2010
patients and normal controls
Fractional anisotropy was decreased in the left anterior lim......
Fractional anisotropy was decreased in the left anterior limb of the internal capsule in suicide attempters relative to both nonattempters and healthy comparison subjects, in the right frontal lobe relative to comparison subjects only
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suicide attempters
right lentiform nucleus (right lentiform nucleus)
brain morphology and function
Jia, 2010
patients and normal controls
Fractional anisotropy was decreased in the left anterior lim......
Fractional anisotropy was decreased in the left anterior limb of the internal capsule in suicide attempters relative to both nonattempters and healthy comparison subjects, and in the right lentiform nucleus relative to nonattempters only
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suicide attempters
right anterior cingulate cortex (right anterior cingulate gyrus)
brain morphology and function
Pan, 2011
patients and normal controls
P-value = .008
A 3 group by 2 condition (go-no-go response inhibition versu......
A 3 group by 2 condition (go-no-go response inhibition versus go motor control blocks) block-design whole-brain analysis (p < .05, corrected) showed that NATs (adolescents with a history of depressive disorder but no suicide attempt) showed greater activity than ATTs (adolescent suicide attempters with a history of major depressive disorder) in the right anterior cingulate gyrus (p = .008)
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suicide
Cognitive performance (cognitive functioning)
cognition and behavior
Conner, 2007
patients only
lower cognitive functioning was associated with lower levels......
lower cognitive functioning was associated with lower levels of (suicide)planning
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suicide intent
Irritability (aggressive)
symptoms
Horesh, 2003
patients only
Suicidal versus nonsuicidal adolescents were more depressed,......
Suicidal versus nonsuicidal adolescents were more depressed, hopeless, and aggressive, but not more angry or impulsive.
More...
suicide intent
Depressed mood (depressed mood)
symptoms
Horesh, 2003
patients only
Suicidal versus nonsuicidal adolescents were more depressed,......
Suicidal versus nonsuicidal adolescents were more depressed, hopeless, and aggressive, but not more angry or impulsive.
More...
suicide intent
Feelings of hopelessness, worthlessness, and guilt (hopeless)
symptoms
Horesh, 2003
patients only
Suicidal versus nonsuicidal adolescents were more depressed,......
Suicidal versus nonsuicidal adolescents were more depressed, hopeless, and aggressive, but not more angry or impulsive.
More...
suicide intent
Feelings of hopelessness, worthlessness, and guilt (hopelessness)
symptoms
Barbe, 2005
patients only
P-value = .001
Depressed suicidal youth were more hopeless (p = .001). Amon......
Depressed suicidal youth were more hopeless (p = .001). Among postpubertal depressed females, suicidal girls were more frequently hopeless (p = .008).
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suicide intent
Sleep disturbances (insomnia)
symptoms
Barbe, 2005
patients only
P-value = .011
Depressed suicidal youth presented more frequently with inso......
Depressed suicidal youth presented more frequently with insomnia (p = .011).
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suicidal behavior
Sleep disturbances (insomnia)
symptoms
McGirr, 2007
patients only
Inter-episode symptom concordance suggests that insomnia is ......
Inter-episode symptom concordance suggests that insomnia is an immediate indicator of suicide risk
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suicide intent
Depressed mood (depressed mood)
symptoms
Liu, 2006
patients only
Compared with nonsuicidal peers, suicidal children and adole......
Compared with nonsuicidal peers, suicidal children and adolescents were more severely depressed, had more depressive symptoms
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suicidal behavior
Feelings of hopelessness, worthlessness, and guilt (feelings of worthlessness)
symptoms
Liu, 2006
patients only
Only feelings of worthlessness was related to all 4 suicidal......
Only feelings of worthlessness was related to all 4 suicidal behaviors, after adjustment for other depressive symptoms, comorbid disorders, and demographics. Feelings of worthlessness may play a central role in the development of suicidal behavior.
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suicidal ideation
Sleep disturbances (insomnia)
symptoms
Chellappa, 2007
patients only
The results of multivariate analysis showed that only insomn......
The results of multivariate analysis showed that only insomnia had a significant association with suicidal ideation.
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suicidality
Psychotic symptoms (psychotic features)
symptoms
Gaudiano, 2008
patients only
Patients with PMD(patients with psychotic major depression) ......
Patients with PMD(patients with psychotic major depression) were more likely to endorse the presence of suicidality compared with NMD(nonpsychotic major depression) patients.
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suicidality
Irritability (irritability)
symptoms
Perlis, 2009
patients only
Irritable depression is not a distinct subtype of MDD, but i......
Irritable depression is not a distinct subtype of MDD, but irritability is associated with greater overall severity, anxiety comorbidity and suicidality.
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suicidal thoughts
Rhythm disturbances (rhythm disturbances(eveningness-type))
symptoms
Gaspar-Barba, 2009
patients only
The eveningness-type group showed higher scores in suicidal ......
The eveningness-type group showed higher scores in suicidal thoughts, more impaired work and activities, higher paranoid symptoms, higher scores on the anxiety cluster (HRSD)
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suicide attempt
Depressed mood (depressed mood)
symptoms
Liu, 2009
patients only
One of the pathways to suicide attempt in mood disorders may......
One of the pathways to suicide attempt in mood disorders may involve maladaptive responses to depressed mood.
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suicide
Depressed mood (depressive symptoms)
symptoms
Vitiello, 2009
patients only
P-value < .05
Severity of self-rated pretreatment suicidal ideation (Suici......
Severity of self-rated pretreatment suicidal ideation (Suicidal Ideation Questionnaire adapted for adolescents score > or = 31) and depressive symptoms (Reynolds Adolescent Depression Scale score > or = 91) predicted occurrence of suicidal events during treatment (P < .05).
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suicide attempt
Social network (current social adjustment)
environment
Lizardi, 2011
patients only
OR = 1.25; 95%CI = 1.019-1.540; P-value = 0.033
Among subtypes of social adjustment, work adjustment was ass......
Among subtypes of social adjustment, work adjustment was associated with past history of suicide attempt (OR = 1.25; 95%CI = 1.019-1.540; P = 0.033).
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