Name in Literature  
                                Related Components  
                            
                                Level 
                                Approved Name(Name in Literature) 
                                Type 
                                Reference 
                                Research Type 
                                Statistical Result 
                                Relation Description 
                                 
                            
                            
                                
                                
                                    
                                    
                                        
                                    
                                
                                            suicidal phenotypes 
                                
                                    
                                            rs3745406 (rs3745406)SNP 
                                    Wang, 2010 patients and normal controls 
                                    chi(2) = 4.746, P-value = 0.0360 
                                    
                                        
                                                        
                                                                    
                                                                            Further analyses revealed a significant association between ......
                                                                    
                                                                    
                                                        
                                         
                                        Further analyses revealed a significant association between rs3745406 locus and HAMD suicidal phenotypes (chi(2) = 4.746, P = 0.0360). 
                                                    
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                                            suicide attempt 
                                
                                    
                                            rs40184 (rs40184)SNP 
                                    Haeffel, 2008 nomal people 
                                    
                                        
                                                        
                                                                    
                                                                            As hypothesized, one of the polymorphisms (rs40184) moderate......
                                                                    
                                                                    
                                                        
                                         
                                        As hypothesized, one of the polymorphisms (rs40184) moderated the effect of perceived maternal rejection on the onset of major depressive disorder, as well as on suicidal ideation 
                                                    
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                                            suicide attempt 
                                
                                    
                                            rs11568817 (rs11568817)SNP 
                                    Wang, 2009 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            An allele association study revealed a significant relations......
                                                                    
                                                                    
                                                        
                                         
                                        An allele association study revealed a significant relationship between rs11568817 and suicidal ideation 
                                                    
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                                            suicide attempt 
                                
                                    
                                            HTR2A (5-HT2A)gene 
                                    Du, 2000 patients and normal controls 
                                    P-value<0.05 
                                    
                                        
                                                        
                                                                    
                                                                            The major finding of this study was a significant associatio......
                                                                    
                                                                    
                                                        
                                         
                                        The major finding of this study was a significant association between the 102 C allele in 5-HT2A receptor gene and major depression, chi(2) = 4.5, df = 1, P = 0.03, particularly in patients with suicidal ideation, chi(2) = 8.5, df = 1, P < 0.005. Furthermore, we found that patients with a 102 C/C genotype had a significantly higher mean HAMD item 3 score (indication of suicidal ideation) than T/C or T/T genotype patients. 
                                                    
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                                            suicidal behavior 
                                
                                    
                                            TPH1 (TPH)gene 
                                    Abbar M, 2001 nomal people 
                                    chi(2) = 11.2; df = 1;  P< 0.0008 
                                    
                                        
                                                        
                                                                    
                                                                            Significant associations were found between variants in intr......
                                                                    
                                                                    
                                                        
                                         
                                        Significant associations were found between variants in introns 7, 8 and 9 (chi(2) = 11.2, df = 1, P< 0.0008 for the allele distribution; these loci are in complete linkage disequilibrium) and in the 3' noncoding region (chi(2) = 30.94, P = 0.0014) and suicide attempt. 
                                                    
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                                            suicide attempt 
                                
                                    
                                            HTR1A (5-HT1A)gene 
                                    Lemonde, 2003 patients and normal controls 
                                    genotype: P-value = 0.002 , allele: P-value= 0.00008 
                                    
                                        
                                                        
                                                                    
                                                                            In depressed patients, the homozygous G(-1019) allele was en......
                                                                    
                                                                    
                                                        
                                         
                                        In depressed patients, the homozygous G(-1019) allele was enriched twofold versus controls (p = 0.0017 and 0.0006 for G/G genotype and G allele distribution, respectively), and in completed suicide cases the G(-1019) allele was enriched fourfold (p = 0.002 and 0.00008 for G/G genotype and G allele distribution, respectively).  
                                                    
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                                            suicide attempt 
                                
                                    
                                            SLC6A4 (5-HTT)gene 
                                    Lopez de Lara, 2006 patients and normal controls 
                                    chi(2)(1) = 10.833;  P-value = 0.002 
                                    
                                        
                                                        
                                                                    
                                                                            We found a significant association of suicide completion wit......
                                                                    
                                                                    
                                                        
                                         
                                        We found a significant association of suicide completion with having at least one copy of the STin2 10 allele [chi(2)(1) = 10.833, p = .002]. No differences were found for the 5-HTTLPR variable number of tandem repeats.  
                                                    
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                                            suicide 
                                
                                    
                                            TPH2 (TPH2)gene 
                                    Zhou, 2005 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                             The yin haplotype, 212121,(in TPH2 gene) was increased in f......
                                                                    
                                                                    
                                                        
                                         
                                         The yin haplotype, 212121,(in TPH2 gene) was increased in frequency in suicide attempters in both populations tested (Finnish whites and African Americans) 
                                                    
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                                            suicide attempt 
                                
                                    
                                            SAT1 (SSAT)gene 
                                    Sequeira, 2006 patients and normal controls 
                                    P-value
                                    
                                        
                                                        
                                                                    
                                                                            Twenty-six genes were selected because of the consistency of......
                                                                    
                                                                    
                                                        
                                         
                                        Twenty-six genes were selected because of the consistency of their expression pattern (fold change, >1.3 in either direction [P
                                                    
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                                            suicide attempt 
                                
                                    
                                            TPH2 (TPH2)gene 
                                    Lopez de Lara, 2007 patients only 
                                    
                                        
                                                        
                                                                    
                                                                            We found two upstream and two intronic SNPs of this gene ass......
                                                                    
                                                                    
                                                        
                                         
                                        We found two upstream and two intronic SNPs of this gene associated with suicide. 
                                                    
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                                            suicide attempt 
                                
                                    
                                            BDNF (BDNF)gene 
                                    Iga, 2007 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            The dose of Met allele had significant effects on psychotic ......
                                                                    
                                                                    
                                                        
                                         
                                        The dose of Met allele had significant effects on psychotic feature and suicidal behavior and family history 
                                                    
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                                            suicide attempt 
                                
                                    
                                            SAT1 (SAT1)gene 
                                    Klempan, 2009 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            A reduction in SAT1 expression identified through multiple p......
                                                                    
                                                                    
                                                        
                                         
                                        A reduction in SAT1 expression identified through multiple probesets was observed across 12 cortical regions in depressed individuals who have died by suicide compared with controls. 
                                                    
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                                            suicide attempt 
                                
                                    
                                            TPH2 (TPH2)gene 
                                    Yoon, 2009 patients only 
                                    
                                        
                                                        
                                                                    
                                                                            There were statistically significant differences in the geno......
                                                                    
                                                                    
                                                        
                                         
                                        There were statistically significant differences in the genotype distributions and allele frequencies of TPH2 -703G/T between the suicidal depressive group and the normal control group 
                                                    
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                                            suicide attempt 
                                
                                    
                                            FADS1 (Fatty acid desaturase (FADS1))gene 
                                    Lalovic, 2010 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            Fatty acid desaturase (FADS1), leptin receptor (LEPR), phosp......
                                                                    
                                                                    
                                                        
                                         
                                        Fatty acid desaturase (FADS1), leptin receptor (LEPR), phosphoinositide-3-kinase (class 2 alpha; PIK3C2A) and stearoyl-CoA desaturase (SCD) were consistently down-regulated in all three regions of the frontal cortex of depressed suicides compared to comparison subjects 
                                                    
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                                            suicide attempt 
                                
                                    
                                            LEPR (leptin receptor (LEPR))gene 
                                    Lalovic, 2010 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            Fatty acid desaturase (FADS1), leptin receptor (LEPR), phosp......
                                                                    
                                                                    
                                                        
                                         
                                        Fatty acid desaturase (FADS1), leptin receptor (LEPR), phosphoinositide-3-kinase (class 2 alpha; PIK3C2A) and stearoyl-CoA desaturase (SCD) were consistently down-regulated in all three regions of the frontal cortex of depressed suicides compared to comparison subjects 
                                                    
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                                            suicide attempt 
                                
                                    
                                            PIK3C2A (phosphoinositide-3-kinase (class 2 alpha, PIK3C2A))gene 
                                    Lalovic, 2010 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            Fatty acid desaturase (FADS1), leptin receptor (LEPR), phosp......
                                                                    
                                                                    
                                                        
                                         
                                        Fatty acid desaturase (FADS1), leptin receptor (LEPR), phosphoinositide-3-kinase (class 2 alpha; PIK3C2A) and stearoyl-CoA desaturase (SCD) were consistently down-regulated in all three regions of the frontal cortex of depressed suicides compared to comparison subjects 
                                                    
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                                            suicide attempt 
                                
                                    
                                            SCD (stearoyl-CoA desaturase (SCD))gene 
                                    Lalovic, 2010 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            Fatty acid desaturase (FADS1), leptin receptor (LEPR), phosp......
                                                                    
                                                                    
                                                        
                                         
                                        Fatty acid desaturase (FADS1), leptin receptor (LEPR), phosphoinositide-3-kinase (class 2 alpha; PIK3C2A) and stearoyl-CoA desaturase (SCD) were consistently down-regulated in all three regions of the frontal cortex of depressed suicides compared to comparison subjects 
                                                    
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                                            suicide 
                                
                                    
                                            QKI (QKI)gene 
                                    Klempan, 2009 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            The messenger RNA (mRNA) levels of multiple transcripts of Q......
                                                                    
                                                                    
                                                        
                                         
                                        The messenger RNA (mRNA) levels of multiple transcripts of QKI were revealing significant reduced in 11 cortical regions and the hippocampus and amygdala of suicide victims compared with control subjects.  
                                                    
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                                            suicide attempt 
                                
                                    
                                            HTR1B (HTR1B)gene 
                                    Wang, 2009 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            An allele association study revealed a significant relations......
                                                                    
                                                                    
                                                        
                                         
                                        An allele association study revealed a significant relationship between rs11568817 and suicidal ideation 
                                                    
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                                            suicide 
                                
                                    
                                            NTRK2 (NTRK2)gene 
                                    Kohli, 2010 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            SNPs within NTRK2 were associated with suicide attempt among......
                                                                    
                                                                    
                                                        
                                         
                                        SNPs within NTRK2 were associated with suicide attempt among depressed patients 
                                                    
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                                            suicide attempt 
                                
                                    
                                            TPH2 (TPH2)gene 
                                    Zhang, 2010 patients only 
                                    OR 0.33, 95% CI 0.22-0.99 
                                    
                                        
                                                        
                                                                    
                                                                            The multivariate logistic regression analysis indicated that......
                                                                    
                                                                    
                                                        
                                         
                                        The multivariate logistic regression analysis indicated that TPH2 rs7305115 AA (OR 0.33, 95% CI 0.22-0.99), family history of suicide (OR 2.98, 95% CI 1.17-5.04), negative life events half year ago (OR 6.64, 95% CI 2.48-11.04) and hopelessness (OR 7.68, 95% CI 5.79-13.74) were significantly associated with the suicide behaviors in MDD patients. 
                                                    
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                                            suicide 
                                
                                    
                                            ADAR (ADAR1)gene 
                                    Simmons, 2010 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            ADAR1 expression was found to be significantly increased in ......
                                                                    
                                                                    
                                                        
                                         
                                        ADAR1 expression was found to be significantly increased in major depressive suicide victims compared with patients who did not commit suicide.  
                                                    
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                                            suicide attempt 
                                
                                    
                                            KIAA1244 (KIAA1244)gene 
                                    Schosser A, 2011 patients only 
                                    P-value<5e-6 
                                    
                                        
                                                        
                                                                    
                                                                            For the discrete trait of suicide attempt, SNPs in KIAA1244 ......
                                                                    
                                                                    
                                                        
                                         
                                        For the discrete trait of suicide attempt, SNPs in KIAA1244 and RGS18 attained p-values of <5e-6.  
                                                    
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                                            suicide attempt 
                                
                                    
                                            RGS18 (RGS18)gene 
                                    Schosser A, 2011 patients only 
                                    P-value<5e-6 
                                    
                                        
                                                        
                                                                    
                                                                            For the discrete trait of suicide attempt, SNPs in KIAA1244 ......
                                                                    
                                                                    
                                                        
                                         
                                        For the discrete trait of suicide attempt, SNPs in KIAA1244 and RGS18 attained p-values of <5e-6.  
                                                    
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                                            suicide 
                                
                                    
                                            C18ORF25 (C18orf25)gene 
                                    Sequeira A, 2009 patients and nomal controls 
                                    Group: P-value=0.012, F=5.3; Substance: P-value=0.001, F=16 
                                    
                                        
                                                        
                                                                    
                                                                            Genes differentially expressed after an ANCOVA analysis betw......
                                                                    
                                                                    
                                                        
                                         
                                        Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). 
                                                    
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                                            suicide 
                                
                                    
                                            MBNL2 (MBNL2)gene 
                                    Sequeira A, 2009 patients and nomal controls 
                                    Group: P-value=0.001, F=11.2; Substance: P-value=0.006, F=9.8 
                                    
                                        
                                                        
                                                                    
                                                                            Genes differentially expressed after an ANCOVA analysis betw......
                                                                    
                                                                    
                                                        
                                         
                                        Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                    
                                        
                                    
                                
                                            suicide 
                                
                                    
                                            LTA4H (LTA4H)gene 
                                    Sequeira A, 2009 patients and nomal controls 
                                    Group: P-value=0.001, F=10.1; Substance: P-value=0.003, F=12 
                                    
                                        
                                                        
                                                                    
                                                                            Genes differentially expressed after an ANCOVA analysis betw......
                                                                    
                                                                    
                                                        
                                         
                                        Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). 
                                                    
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                                            suicide 
                                
                                    
                                            ANKRD28 (ANKRD28)gene 
                                    Sequeira A, 2009 patients and nomal controls 
                                    Group: P-value=0, F=18.4; Substance: P-value=0.006, F=10.2 
                                    
                                        
                                                        
                                                                    
                                                                            Genes differentially expressed after an ANCOVA analysis betw......
                                                                    
                                                                    
                                                        
                                         
                                        Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). 
                                                    
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                                            suicide 
                                
                                    
                                            PTPRB (PTPRB)gene 
                                    Sequeira A, 2009 patients and nomal controls 
                                    Group: P-value=0.008, F=6.2; Substance: P-value=0.009, F=8.2 
                                    
                                        
                                                        
                                                                    
                                                                            Genes differentially expressed after an ANCOVA analysis betw......
                                                                    
                                                                    
                                                        
                                         
                                        Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                        
                                    
                                    
                                
                                            suicide 
                                
                                    
                                            HADHA (HADHA)gene 
                                    Sequeira A, 2009 patients and nomal controls 
                                    Group: P-value=0.001, F=11.6; Substance: P-value=0.006, F=10.4 
                                    
                                        
                                                        
                                                                    
                                                                            Genes differentially expressed after an ANCOVA analysis betw......
                                                                    
                                                                    
                                                        
                                         
                                        Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                    
                                        
                                    
                                
                                            suicide 
                                
                                    
                                            TANC1 (KIAA1728)gene 
                                    Sequeira A, 2009 patients and nomal controls 
                                    Group: P-value=0, F=13.5; Substance: P-value=0.004, F=11.3 
                                    
                                        
                                                        
                                                                    
                                                                            Genes differentially expressed after an ANCOVA analysis betw......
                                                                    
                                                                    
                                                        
                                         
                                        Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                        
                                    
                                    
                                
                                            suicide 
                                
                                    
                                            TRPS1 (TRPS1)gene 
                                    Sequeira A, 2009 patients and nomal controls 
                                    Group: P-value=0, F=10.8; Substance: P-value=0.005, F=9.3 
                                    
                                        
                                                        
                                                                    
                                                                            Genes differentially expressed after an ANCOVA analysis betw......
                                                                    
                                                                    
                                                        
                                         
                                        Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                    
                                        
                                    
                                
                                            suicide 
                                
                                    
                                            ABCA8 (ABCA8)gene 
                                    Sequeira A, 2009 patients and nomal controls 
                                    Group: P-value=0.006, F=6.5; Substance: P-value=0.009, F=8.3 
                                    
                                        
                                                        
                                                                    
                                                                            Genes differentially expressed after an ANCOVA analysis betw......
                                                                    
                                                                    
                                                        
                                         
                                        Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                        
                                    
                                    
                                
                                            suicide 
                                
                                    
                                            IRF2 (IRF2)gene 
                                    Sequeira A, 2009 patients and nomal controls 
                                    Group: P-value=0, F=16.1; Substance: P-value=0.001, F=14.4 
                                    
                                        
                                                        
                                                                    
                                                                            Genes differentially expressed after an ANCOVA analysis betw......
                                                                    
                                                                    
                                                        
                                         
                                        Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                    
                                        
                                    
                                
                                            suicide 
                                
                                    
                                            VPS13A (VPS13A)gene 
                                    Sequeira A, 2009 patients and nomal controls 
                                    Group: P-value=0.023, F=4.5; Substance: P-value=0.008, F=8.6 
                                    
                                        
                                                        
                                                                    
                                                                            Genes differentially expressed after an ANCOVA analysis betw......
                                                                    
                                                                    
                                                        
                                         
                                        Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                        
                                    
                                    
                                
                                            suicide 
                                
                                    
                                            MAN2A1 (MAN2A1)gene 
                                    Sequeira A, 2009 patients and nomal controls 
                                    Group: P-value=0.016, F=5; Substance: P-value=0.005, F=9.5 
                                    
                                        
                                                        
                                                                    
                                                                            Genes differentially expressed after an ANCOVA analysis betw......
                                                                    
                                                                    
                                                        
                                         
                                        Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                    
                                        
                                    
                                
                                            suicide 
                                
                                    
                                            CPNE2 (CPNE2)gene 
                                    Sequeira A, 2009 patients and nomal controls 
                                    Group: P-value=0.003, F=7.8; Substance: P-value=0.002, F=12.9 
                                    
                                        
                                                        
                                                                    
                                                                            Genes differentially expressed after an ANCOVA analysis betw......
                                                                    
                                                                    
                                                        
                                         
                                        Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                        
                                    
                                    
                                
                                            suicide 
                                
                                    
                                            LAMP1 (LAMP1)gene 
                                    Sequeira A, 2009 patients and nomal controls 
                                    Group: P-value=0.004, F=7.4; Substance: P-value=0.009, F=8.2 
                                    
                                        
                                                        
                                                                    
                                                                            Genes differentially expressed after an ANCOVA analysis betw......
                                                                    
                                                                    
                                                        
                                         
                                        Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                    
                                        
                                    
                                
                                            suicide 
                                
                                    
                                            STON2 (STN2)gene 
                                    Sequeira A, 2009 patients and nomal controls 
                                    Group: P-value=0, F=14.2; Substance: P-value=0.01, F=8 
                                    
                                        
                                                        
                                                                    
                                                                            Genes differentially expressed after an ANCOVA analysis betw......
                                                                    
                                                                    
                                                        
                                         
                                        Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                        
                                    
                                    
                                
                                            suicide 
                                
                                    
                                            PREX1 (PREX1)gene 
                                    Sequeira A, 2009 patients and nomal controls 
                                    Group: P-value=0, F=11; Substance: P-value=0.006, F=9.4 
                                    
                                        
                                                        
                                                                    
                                                                            Genes differentially expressed after an ANCOVA analysis betw......
                                                                    
                                                                    
                                                        
                                         
                                        Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                    
                                        
                                    
                                
                                            suicide 
                                
                                    
                                            NHSL1 (NHSL1)gene 
                                    Sequeira A, 2009 patients and nomal controls 
                                    Group: P-value=0.001, F=10.1; Substance: P-value=0.002, F=12 
                                    
                                        
                                                        
                                                                    
                                                                            Genes differentially expressed after an ANCOVA analysis betw......
                                                                    
                                                                    
                                                        
                                         
                                        Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                        
                                    
                                    
                                
                                            suicide 
                                
                                    
                                            DYNC1LI1 (DNCLI1)gene 
                                    Sequeira A, 2009 patients and nomal controls 
                                    Group: P-value=0.001, F=10.8; Substance: P-value=0.001, F=14.1 
                                    
                                        
                                                        
                                                                    
                                                                            Genes differentially expressed after an ANCOVA analysis betw......
                                                                    
                                                                    
                                                        
                                         
                                        Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                    
                                        
                                    
                                
                                            suicide 
                                
                                    
                                            TOLLIP (TOLLIP)gene 
                                    Sequeira A, 2009 patients and nomal controls 
                                    Group: P-value=0.001, F=10.9; Substance: P-value=0.007, F=8.9 
                                    
                                        
                                                        
                                                                    
                                                                            Genes differentially expressed after an ANCOVA analysis betw......
                                                                    
                                                                    
                                                        
                                         
                                        Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                        
                                    
                                    
                                
                                            suicide 
                                
                                    
                                            DSTYK (DustyPK)gene 
                                    Sequeira A, 2009 patients and nomal controls 
                                    Group: P-value=0, F=18.1; Substance: P-value=0.008, F=9.3 
                                    
                                        
                                                        
                                                                    
                                                                            Genes differentially expressed after an ANCOVA analysis betw......
                                                                    
                                                                    
                                                        
                                         
                                        Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                    
                                        
                                    
                                
                                            suicide 
                                
                                    
                                            PUM1 (PUM1)gene 
                                    Sequeira A, 2009 patients and nomal controls 
                                    Group: P-value=0.001, F=11.1; Substance: P-value=0.009, F=8.8 
                                    
                                        
                                                        
                                                                    
                                                                            Genes differentially expressed after an ANCOVA analysis betw......
                                                                    
                                                                    
                                                        
                                         
                                        Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                        
                                    
                                    
                                
                                            suicide 
                                
                                    
                                            DDX25 (DDX25)gene 
                                    Sequeira A, 2009 patients and nomal controls 
                                    Group: P-value=0, F=14.3; Substance: P-value=0.004, F=11.3 
                                    
                                        
                                                        
                                                                    
                                                                            Genes differentially expressed after an ANCOVA analysis betw......
                                                                    
                                                                    
                                                        
                                         
                                        Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                    
                                        
                                    
                                
                                            suicide 
                                
                                    
                                            ARL4C (ARL7)gene 
                                    Sequeira A, 2009 patients and nomal controls 
                                    Group: P-value=0.001, F=10.5; Substance: P-value=0.009, F=8.9 
                                    
                                        
                                                        
                                                                    
                                                                            Genes differentially expressed after an ANCOVA analysis betw......
                                                                    
                                                                    
                                                        
                                         
                                        Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                        
                                    
                                    
                                
                                            suicide 
                                
                                    
                                            USP14 (USP14)gene 
                                    Sequeira A, 2009 patients and nomal controls 
                                    Group: P-value=0.003, F=8.2; Substance: P-value=0.008, F=8.8 
                                    
                                        
                                                        
                                                                    
                                                                            Genes differentially expressed after an ANCOVA analysis betw......
                                                                    
                                                                    
                                                        
                                         
                                        Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                    
                                        
                                    
                                
                                            suicide 
                                
                                    
                                            SF3B3 (SAP130)gene 
                                    Sequeira A, 2009 patients and nomal controls 
                                    Group: P-value=0.002, F=9.2; Substance: P-value=0.006, F=9.6 
                                    
                                        
                                                        
                                                                    
                                                                            Genes differentially expressed after an ANCOVA analysis betw......
                                                                    
                                                                    
                                                        
                                         
                                        Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                        
                                    
                                    
                                
                                            suicide 
                                
                                    
                                            KCNA4 (KCNA4)gene 
                                    Sequeira A, 2009 patients and nomal controls 
                                    Group: P-value=0, F=13.7; Substance: P-value=0.008, F=8.7 
                                    
                                        
                                                        
                                                                    
                                                                            Genes differentially expressed after an ANCOVA analysis betw......
                                                                    
                                                                    
                                                        
                                         
                                        Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                    
                                        
                                    
                                
                                            suicide attempt 
                                
                                    
                                            2p (2p)region 
                                    Zubenko, 2004 patients and normal controls 
                                    P-value<0.001 
                                    
                                        
                                                        
                                                                    
                                                                            Exceeded the criterion for highly-significant linkage (genom......
                                                                    
                                                                    
                                                        
                                         
                                        Exceeded the criterion for highly-significant linkage (genome-wide adjusted P < 0.001) 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                        
                                    
                                    
                                
                                            suicide attempt 
                                
                                    
                                            6q (6q)region 
                                    Zubenko, 2004 patients and normal controls 
                                    P-value<0.001 
                                    
                                        
                                                        
                                                                    
                                                                            Exceeded the criterion for highly-significant linkage (genom......
                                                                    
                                                                    
                                                        
                                         
                                        Exceeded the criterion for highly-significant linkage (genome-wide adjusted P < 0.001) 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                    
                                        
                                    
                                
                                            suicide attempt 
                                
                                    
                                            8p22-p21 (8p22-p21)region 
                                    Zubenko, 2004 patients and normal controls 
                                    P-value<0.0001 
                                    
                                        
                                                        
                                                                    
                                                                    
                                                                             P < 0.0001
                                                                    
                                                        
                                         
                                         P < 0.0001 
                                                     
                                      
                                      
                                       
                            
                                
                                
                                    
                                        
                                    
                                    
                                
                                            suicide attempt 
                                
                                    
                                            Xq (Xq)region 
                                    Zubenko, 2004 patients and normal controls 
                                    LOD = 3.87, P-value < 0.0001 
                                    
                                        
                                                        
                                                                    
                                                                    
                                                                            LOD = 3.87, P < 0.0001
                                                                    
                                                        
                                         
                                        LOD = 3.87, P < 0.0001 
                                                     
                                      
                                      
                                       
                            
                                
                                
                                    
                                    
                                        
                                    
                                
                                            suicidality 
                                
                                    
                                            18q22-q23 (18q22-q23)region 
                                    Butler, 2010 patients and normal controls 
                                    LOD score > 1.5 
                                    
                                        
                                                        
                                                                    
                                                                    
                                                                            LOD score > 1.5
                                                                    
                                                        
                                         
                                        LOD score > 1.5 
                                                     
                                      
                                      
                                       
                            
                                
                                
                                    
                                        
                                    
                                    
                                
                                            suicidality 
                                
                                    
                                            3p14 (3p14)region 
                                    Butler, 2010 patients and normal controls 
                                    P-value=0.0017 
                                    
                                        
                                                        
                                                                    
                                                                            This rigon achieved suggestive linkage and yielded a maximum......
                                                                    
                                                                    
                                                        
                                         
                                        This rigon achieved suggestive linkage and yielded a maximum LOD of 1.853 (P=0.0017) 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                    
                                        
                                    
                                
                                            suicidality 
                                
                                    
                                            9p24.3 (9p24.3)region 
                                    Butler, 2010 patients and normal controls 
                                    LOD score > 1.5 
                                    
                                        
                                                        
                                                                    
                                                                    
                                                                            LOD score > 1.5
                                                                    
                                                        
                                         
                                        LOD score > 1.5 
                                                     
                                      
                                      
                                       
                            
                                
                                
                                    
                                        
                                    
                                    
                                
                                            suicide attempt 
                                
                                    
                                        
                                        Cyclic AMP-responsive element-binding protein 1 (CREB)protein 
                                    Dowlatshahi, 1999 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            We also detected a significant effect of suicide on temporal......
                                                                    
                                                                    
                                                        
                                         
                                        We also detected a significant effect of suicide on temporal cortex CREB levels in subjects that died as a result of suicide relative to those that did not, which was more evident in patients with major depressive disorder. 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                    
                                        
                                    
                                
                                            suicide attempt 
                                
                                    
                                        
                                        Calreticulin (calreticulin)protein 
                                    Bown, 2000 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            Increased levels of GRP78, GRP94, and calreticulin, a third ......
                                                                    
                                                                    
                                                        
                                         
                                        Increased levels of GRP78, GRP94, and calreticulin, a third member of the ER stress protein family, were found in temporal cortex of subjects with major depressive disorder who died by suicide compared with controls and subjects who died by other means. 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                        
                                    
                                    
                                
                                            suicide attempt 
                                
                                    
                                        
                                        78 kDa glucose-regulated protein (GRP78)protein 
                                    Bown, 2000 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            Increased levels of GRP78, GRP94, and calreticulin, a third ......
                                                                    
                                                                    
                                                        
                                         
                                        Increased levels of GRP78, GRP94, and calreticulin, a third member of the ER stress protein family, were found in temporal cortex of subjects with major depressive disorder who died by suicide compared with controls and subjects who died by other means. 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                    
                                        
                                    
                                
                                            suicide attempt 
                                
                                    
                                        
                                        Endoplasmin (GRP94)protein 
                                    Bown, 2000 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            Increased levels of GRP78, GRP94, and calreticulin, a third ......
                                                                    
                                                                    
                                                        
                                         
                                        Increased levels of GRP78, GRP94, and calreticulin, a third member of the ER stress protein family, were found in temporal cortex of subjects with major depressive disorder who died by suicide compared with controls and subjects who died by other means. 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                        
                                    
                                    
                                
                                            suicide 
                                
                                    
                                        
                                        Corticoliberin (corticotropin-releasing hormone (CRH))protein 
                                    Austin, 2003 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            The level of CRH-IR was increased by 30% in the locus coerul......
                                                                    
                                                                    
                                                        
                                         
                                        The level of CRH-IR was increased by 30% in the locus coeruleus, 39% in the median raphe and 45% in the caudal dorsal raphe in the depressed suicide subjects compared to controls.  
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                    
                                        
                                    
                                
                                            suicide 
                                
                                    
                                        
                                        5-hydroxytryptamine receptor 1A (5-HT1A receptor)protein 
                                    Hsiung, 2003 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            Measurements of [35S]GTPgammaS binding to Galphai/o in the o......
                                                                    
                                                                    
                                                        
                                         
                                        Measurements of [35S]GTPgammaS binding to Galphai/o in the occipital cortex of suicide victims and matched controls revealed a blunted response in suicide subjects and a decrease in the coupling of 5-HT1A receptor to adenylyl cyclase.  
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                        
                                    
                                    
                                
                                            suicide attempt 
                                
                                    
                                        
                                        Brain-derived neurotrophic factor (BDNF)protein 
                                    Kim, 2007 patients and normal controls 
                                    F=6.682, P-value=0.002 
                                    
                                        
                                                        
                                                                    
                                                                            Plasma BDNF levels were measured by enzyme linked immunosorb......
                                                                    
                                                                    
                                                        
                                         
                                        Plasma BDNF levels were measured by enzyme linked immunosorbent assay. BDNF levels were significantly lower in suicidal MDD patients (430.5+/-397.0 pg/ml) than non-suicidal MDD patients (875.80+/-663.02 pg/ml) or normal controls (889.4+/-611.3 pg/ml) (F=6.682, p=0.002). 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                    
                                        
                                    
                                
                                            suicide attempt 
                                
                                    
                                        
                                        5-hydroxytryptamine receptor 2A (5HT(2A))protein 
                                    Roggenbach, 2007 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            Mean K(D) for the platelet 5HT(2A) receptor and MAO-B activi......
                                                                    
                                                                    
                                                        
                                         
                                        Mean K(D) for the platelet 5HT(2A) receptor and MAO-B activity were significantly lower in suicidal patients as compared to nonsuicidal depressed patients and healthy controls 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                        
                                    
                                    
                                
                                            suicide attempt 
                                
                                    
                                        
                                        Amine oxidase [flavin-containing] B (MAO-B)protein 
                                    Roggenbach, 2007 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            Mean K(D) for the platelet 5HT(2A) receptor and MAO-B activi......
                                                                    
                                                                    
                                                        
                                         
                                        Mean K(D) for the platelet 5HT(2A) receptor and MAO-B activity were significantly lower in suicidal patients as compared to nonsuicidal depressed patients and healthy controls 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                    
                                        
                                    
                                
                                            suicide 
                                
                                    
                                        
                                        Interleukin-2 (interleukin [IL]-2)protein 
                                    Kim, 2008 patients and normal controls 
                                    P-value<0.001 
                                    
                                        
                                                        
                                                                    
                                                                            Suicidal MDD patients had significantly lower IL-2 compared ......
                                                                    
                                                                    
                                                        
                                         
                                        Suicidal MDD patients had significantly lower IL-2 compared with non-suicidal patients and normal controls (p<0.001). 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                        
                                    
                                    
                                
                                            suicide 
                                
                                    
                                        
                                        Interleukin-6 (interleukin [IL]-6)protein 
                                    Kim, 2008 patients and normal controls 
                                    P-value<0.001 
                                    
                                        
                                                        
                                                                    
                                                                            Non-suicidal MDD patients had significantly higher IL-6 prod......
                                                                    
                                                                    
                                                        
                                         
                                        Non-suicidal MDD patients had significantly higher IL-6 production than suicidal MDD patients and normal controls (p<0.001).  
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                    
                                        
                                    
                                
                                            suicide attempt 
                                
                                    
                                        
                                        Brain-derived neurotrophic factor (BDNF)protein 
                                    Deveci, 2007 patients and normal controls 
                                    P-value = 0.004 
                                    
                                        
                                                        
                                                                    
                                                                            Mean serum BDNF levels were significantly lower in the suici......
                                                                    
                                                                    
                                                        
                                         
                                        Mean serum BDNF levels were significantly lower in the suicide group (21.2 +/- 12.4 ng/ml) and the major depressive disorder group (21.2 +/- 11.3 ng/ml) than the control group (31.4 +/- 8.8 ng/ml; p = 0.004).  
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                        
                                    
                                    
                                
                                            suicide 
                                
                                    
                                        
                                        Tumor necrosis factor (tumor necrosis factor-alpha (TNF-alpha))protein 
                                    Gabbay, 2009 patients and normal controls 
                                    P-value = 0.03 
                                    
                                        
                                                        
                                                                    
                                                                            suicidal adolescents with MDD had significantly decreased pl......
                                                                    
                                                                    
                                                        
                                         
                                        suicidal adolescents with MDD had significantly decreased plasma TNF-alpha concentrations compared to nonsuicidal adolescents with MDD (1.33 +/- 2.95 pg/mL versus 30.9 +/- 110.9 pg/mL; p = 0.03) 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                    
                                        
                                    
                                
                                            suicidality 
                                
                                    
                                        
                                        Tumor necrosis factor (tumor necrosis factor-alpha (TNFalpha))protein 
                                    Eller, 2009 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            TNFalpha was associated with decreased activity and suicidal......
                                                                    
                                                                    
                                                        
                                         
                                        TNFalpha was associated with decreased activity and suicidality. 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                        
                                    
                                    
                                
                                            suicide 
                                
                                    
                                        
                                        Intercellular adhesion molecule 1 (intercellular adhesion molecule-1 (ICAM-1))protein 
                                    Miguel-Hidalgo, 2011 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            Non-psychiatric comparison subjects older than 60 experience......
                                                                    
                                                                    
                                                        
                                         
                                        Non-psychiatric comparison subjects older than 60 experienced dramatic increase in extravascular ICAM-1 immunoreactivity, but this increase was attenuated in elderly subjects with MDD, particularly in those dying by suicide.  
                                                    
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                                            suicide 
                                
                                    
                                        
                                        Hydroxyindoleacetic Acid (5hydroxyindolacetic acid)molecule 
                                    Placidi, 2001 patients only 
                                    
                                        
                                                        
                                                                    
                                                                            Lower CSF(cerebrospinal fluid) 5-HIAA(5hydroxyindolacetic ac......
                                                                    
                                                                    
                                                        
                                         
                                        Lower CSF(cerebrospinal fluid) 5-HIAA(5hydroxyindolacetic acid) and greater suicidal intent were found in high-lethality suicide attempters compared with low-lethality suicide attempters. 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                        
                                    
                                    
                                
                                            suicide 
                                
                                    
                                        
                                        Serotonin (serotonin)molecule 
                                    Austin, 2002 patients and normal controls 
                                    P-value < 0.01 
                                    
                                        
                                                        
                                                                    
                                                                            The mean total length of serotonin transporter-immunoreactiv......
                                                                    
                                                                    
                                                        
                                         
                                        The mean total length of serotonin transporter-immunoreactive axons per unit area was unchanged in layers 2 and 4 of area 46 in the depressed suicide subjects compared to controls, but was significantly (P < 0.01) decreased by 24% in layer 6 in the depressed suicide group. 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                    
                                        
                                    
                                
                                            suicide intent 
                                
                                    
                                        
                                        Hydrocortisone (cortisol)molecule 
                                    Mathew, 2003 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            Adolescents who are at risk to make suicide attempts appear ......
                                                                    
                                                                    
                                                        
                                         
                                        Adolescents who are at risk to make suicide attempts appear to display significant elevations of cortisol prior to sleep onset, a time when the hypothalamic-pituitary-adrenal (HPA) axis is normally most quiescent.  
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                        
                                    
                                    
                                
                                            suicide attempt 
                                
                                    
                                        
                                        Cholesterol (cholesterol)molecule 
                                    Kim, 2004 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            Significant differences in total serum cholesterol levels we......
                                                                    
                                                                    
                                                        
                                         
                                        Significant differences in total serum cholesterol levels were observed between the suicide patients and non-suicide depression patients and between violent suicide patients and non-violent suicide patients when age, sex, BMI and total serum protein levels were controlled. 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                    
                                        
                                    
                                
                                            suicide attempt 
                                
                                    
                                        
                                        Homovanillic Acid (homovanillic acid)molecule 
                                    Sher, 2006 patients and normal controls 
                                    P-value < 0.0001 
                                    
                                        
                                                        
                                                                    
                                                                            Depressed suicide attempters had lower cerebrospinal fluid H......
                                                                    
                                                                    
                                                        
                                         
                                        Depressed suicide attempters had lower cerebrospinal fluid HVA (homovanillic acid) levels compared to depressed non-attempters (t = 4.4, df = 56, p < 0.0001) and to controls (t = -4.09, df = 79, p < 0.0001).  
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                        
                                    
                                    
                                
                                            suicide 
                                
                                    
                                        
                                        Nitric oxide (nitric oxide)molecule 
                                    Lee, 2006 patients and normal controls 
                                    t=-3.090, d.f.=84, P-value=0.003 
                                    
                                        
                                                        
                                                                    
                                                                            Among the patients with a diagnosis of major depression, sui......
                                                                    
                                                                    
                                                        
                                         
                                        Among the patients with a diagnosis of major depression, suicidal depressive patients had significantly higher plasma nitric oxide metabolites NO(x) levels than non-suicidal depressive patients (t=-3.090, d.f.=84, p=0.003).  
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                    
                                        
                                    
                                
                                            suicidal intents 
                                
                                    
                                        
                                        Serotonin (serotonin (5-HT))molecule 
                                    Hou, 2006 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            The patients with intense suicidal intents and suicidal atte......
                                                                    
                                                                    
                                                        
                                         
                                        The patients with intense suicidal intents and suicidal attempts had significantly lower CSF(cerebrospinal fluid) 5-HT compared to patients with nonsuicidal intents.  
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                        
                                    
                                    
                                
                                            suicide attempt 
                                
                                    
                                        
                                        Serotonin (5HT)molecule 
                                    Roggenbach, 2007 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            Mean platelet 5HT concentration was significantly lower in s......
                                                                    
                                                                    
                                                        
                                         
                                        Mean platelet 5HT concentration was significantly lower in suicidal inpatients when compared to nonsuicidal depressed patients 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                    
                                        
                                    
                                
                                            suicidal intent 
                                
                                    
                                        
                                        Hydrocortisone (cortisol)molecule 
                                    Lindqvist, 2008 patients only 
                                    
                                        
                                                        
                                                                    
                                                                            There was a significant negative correlation between suicida......
                                                                    
                                                                    
                                                        
                                         
                                        There was a significant negative correlation between suicidal intent and post Dexamethasone Suppression Test (DST) cortisol in patients with MDD. 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                        
                                    
                                    
                                
                                            suicide attempters 
                                
                                    
                                        
                                        Hydrocortisone (cortisol)molecule 
                                    Lindqvist, 2008 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            At follow-up, evening salivary cortisol was lower in suicide......
                                                                    
                                                                    
                                                        
                                         
                                        At follow-up, evening salivary cortisol was lower in suicide attempters compared to controls.  
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                    
                                        
                                    
                                
                                            suicide 
                                
                                    
                                        
                                        Methoxyhydroxyphenylglycol (3-methoxy-4-hydroxphenylglycol (MHPG))molecule 
                                    Galfalvy, 2009 patients only 
                                    P-value=0.045 
                                    
                                        
                                                        
                                                                    
                                                                            Lower cerebrospinal fluid MHPG(3-methoxy-4-hydroxphenylglyco......
                                                                    
                                                                    
                                                        
                                         
                                        Lower cerebrospinal fluid MHPG(3-methoxy-4-hydroxphenylglycol) predicted future suicide attempt or suicide (22% increase in hazard for each 10 pmol/ml lower MHPG, p=0.045). Lower CSF MHPG also correlated with higher medical lethality of future suicidal act (mean MHPG: 49+/-18 vs. 32+/-12 pmol/ml for low- vs. high-lethality, t=2.8, d.f.=25, p=0.009). 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                        
                                    
                                    
                                
                                            suicide attempt 
                                
                                    
                                        
                                        Kynurenine (kynurenine)molecule 
                                    Sublette, 2011 patients and normal controls 
                                    t=0.418, df=58, and P-value=0.677 
                                    
                                        
                                                        
                                                                    
                                                                            KYN was higher in the MDD suicide attempter subgroup compare......
                                                                    
                                                                    
                                                        
                                         
                                        KYN was higher in the MDD suicide attempter subgroup compared with MDD non-attempters (t=2.105, df=58, and p=0.040), who did not differ from healthy volunteers (t=0.418, df=58, and p=0.677). 
                                                    
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                                            suicide 
                                
                                    
                                        
                                        
                                        adenylate cyclase activity (adenylyl cyclase)pathway 
                                    Hsiung, 2003 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            Measurements of [35S]GTPgammaS binding to Galphai/o in the o......
                                                                    
                                                                    
                                                        
                                         
                                        Measurements of [35S]GTPgammaS binding to Galphai/o in the occipital cortex of suicide victims and matched controls revealed a blunted response in suicide subjects and a decrease in the coupling of 5-HT1A receptor to adenylyl cyclase.  
                                                    
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                                            suicide 
                                
                                    
                                        
                                        
                                        DNA methyltransferase activity (DNA methyltransferase)pathway 
                                    Poulter, 2008 patients only 
                                    
                                        
                                                        
                                                                    
                                                                            The DNMT gene transcripts' expression was altered in several......
                                                                    
                                                                    
                                                        
                                         
                                        The DNMT gene transcripts' expression was altered in several brains regions of suicides, including frontopolar cortex, amygdala, and the paraventricular nucleus of the hypothalamus. 
                                                    
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                                            suicidal intent 
                                
                                    
                                        
                                        
                                        
                                        Hypothalamic-pituitary-adrenal axis (stress system (HPA))neurobiological system 
                                    Lindqvist, 2008 patients only 
                                    
                                        
                                                        
                                                                    
                                                                            Our findings may be attributed to pathophysiological process......
                                                                    
                                                                    
                                                        
                                         
                                        Our findings may be attributed to pathophysiological processes, where a high suicidal intent is revealed during a potential chronic course of MDD, which in turn results in a seemingly normal stress system. 
                                                    
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                                            suicide intent 
                                
                                    
                                        
                                        
                                        
                                        Hypothalamic-pituitary-adrenal axis (hypothalamic-pituitary-adrenal (HPA) axis)neurobiological system 
                                    Mathew, 2003 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            Adolescents who are at risk to make suicide attempts appear ......
                                                                    
                                                                    
                                                        
                                         
                                        Adolescents who are at risk to make suicide attempts appear to display significant elevations of cortisol prior to sleep onset, a time when the hypothalamic-pituitary-adrenal (HPA) axis is normally most quiescent.  
                                                    
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                                            suicide 
                                
                                    
                                        
                                        
                                        
                                        Visually evoked potentials (VEPs) (visual evoked potential)neurobiological system 
                                    Fountoulakis, 2004 patients only 
                                    
                                        
                                                        
                                                                    
                                                                            The suicidal patients had a significantly prolonged pattern-......
                                                                    
                                                                    
                                                        
                                         
                                        The suicidal patients had a significantly prolonged pattern-reversal visual evoked potential latency in comparison with the other patients.  
                                                    
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                                            suicidal ideation (SI) 
                                
                                    
                                        
                                        
                                        
                                        Alpha wave (alpha)neurobiological system 
                                    Iosifescu, 2008 patients only 
                                    
                                        
                                                        
                                                                    
                                                                            Left-right asymmetry of combined theta + alpha power correla......
                                                                    
                                                                    
                                                        
                                         
                                        Left-right asymmetry of combined theta + alpha power correlated significantly with change in SI from baseline, even when adjusting for changes in depression severity (HAM-D-17) and for the SSRI utilized. Frontal QEEG parameters before treatment may predict worsening SI during SSRI treatment in MDD. 
                                                    
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                                            suicidal ideation (SI) 
                                
                                    
                                        
                                        
                                        
                                        Theta wave (theta)neurobiological system 
                                    Iosifescu, 2008 patients only 
                                    
                                        
                                                        
                                                                    
                                                                            Left-right asymmetry of combined theta + alpha power correla......
                                                                    
                                                                    
                                                        
                                         
                                        Left-right asymmetry of combined theta + alpha power correlated significantly with change in SI from baseline, even when adjusting for changes in depression severity (HAM-D-17) and for the SSRI utilized. Frontal QEEG parameters before treatment may predict worsening SI during SSRI treatment in MDD. 
                                                    
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                                            suicidal behaviour 
                                
                                    
                                        
                                        
                                        
                                        Hypothalamic-pituitary-adrenal axis (HPA axis)neurobiological system 
                                    Jokinen, 2009 patients only 
                                    
                                        
                                                        
                                                                    
                                                                            DST(dexamethasone suppression test) non-suppression was asso......
                                                                    
                                                                    
                                                        
                                         
                                        DST(dexamethasone suppression test) non-suppression was associated with suicide attempt and post-dexamethasone serum cortisol at 11:00 p.m. was significantly higher in suicide attempters compared to non-attempters. The DST non-suppressor rate was 39% in young adult suicide attempters compared with 11% in non-attempters. The results add to previous evidence in support of the role of HPA axis hyperactivity and suicidal behaviour. 
                                                    
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                                            suicide intent 
                                
                                    
                                        
                                        
                                        
                                        P300 (P3)neurobiological system 
                                    Jandl, 2010 patients only 
                                    
                                        
                                                        
                                                                    
                                                                            Decreases in P3 were also more pronounced in the HAS and SAS......
                                                                    
                                                                    
                                                        
                                         
                                        Decreases in P3 were also more pronounced in the HAS and SAS groups in study 1 and in the HAS group in study 2, 'novel' and 'target' condition. Both EDA an P3 habituated faster in MDD patients with a history of attempted suicide. 
                                                    
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                                            suicide attempt 
                                
                                    
                                        
                                        
                                        
                                        Temporo-parietal connection (temporal cortex)brain morphology and function 
                                    Dowlatshahi, 1999 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            We also detected a significant effect of suicide on temporal......
                                                                    
                                                                    
                                                        
                                         
                                        We also detected a significant effect of suicide on temporal cortex CREB levels in subjects that died as a result of suicide relative to those that did not, which was more evident in patients with major depressive disorder. 
                                                    
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                                            suicide attempt 
                                
                                    
                                        
                                        
                                        
                                        Temporo-parietal connection (temporal cortex)brain morphology and function 
                                    Bown, 2000 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            Increased levels of GRP78, GRP94, and calreticulin, a third ......
                                                                    
                                                                    
                                                        
                                         
                                        Increased levels of GRP78, GRP94, and calreticulin, a third member of the ER stress protein family, were found in temporal cortex of subjects with major depressive disorder who died by suicide compared with controls and subjects who died by other means. 
                                                    
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                                            suicide attempt 
                                
                                    
                                        
                                        
                                        
                                        Basal ganglia (basal ganglia)brain morphology and function 
                                    Ahearn, 2001 patients only 
                                    
                                        
                                                        
                                                                    
                                                                            Unipolar patients with a history of a suicide attempt demons......
                                                                    
                                                                    
                                                        
                                         
                                        Unipolar patients with a history of a suicide attempt demonstrated significantly more subcortical gray matter hyperintensities compared with patients without such a history. Gray matter hyperintensities in the basal ganglia may be especially associated with risk for suicide attempts. 
                                                    
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                                            suicide 
                                
                                    
                                        
                                        
                                        
                                        Prefrontal cortex (prefrontal cortex (PFC))brain morphology and function 
                                    Oquendo, 2003 patients only 
                                    
                                        
                                                        
                                                                    
                                                                            Depressed high-lethality suicide attempters had lower rCMRgl......
                                                                    
                                                                    
                                                        
                                         
                                        Depressed high-lethality suicide attempters had lower rCMRglu (relative regional cerebral uptake) in ventral, medial, and lateral PFC compared with low-lethality attempters. Lower ventromedial PFC activity was associated with lower lifetime impulsivity and higher-lethality suicide attempts.  
                                                    
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                                            suicide attempt 
                                
                                    
                                        
                                        
                                        
                                        White matter (white matter hyperintensities (WMH))brain morphology and function 
                                    Ehrlich, 2005 patients only 
                                    P-value = 0.02  
                                    
                                        
                                                        
                                                                    
                                                                            Bivariate analysis showed that the prevalence of periventric......
                                                                    
                                                                    
                                                        
                                         
                                        Bivariate analysis showed that the prevalence of periventricular WMH was significantly higher in subjects with past suicide attempts (Fisher's Exact Test, p=0.02).  
                                                    
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                                            suicide 
                                
                                    
                                        
                                        
                                        
                                        Orbitofrontal cortex (orbitofrontal cortex)brain morphology and function 
                                    Monkul, 2007 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            Suicidal patients had smaller right and left orbitofrontal c......
                                                                    
                                                                    
                                                        
                                         
                                        Suicidal patients had smaller right and left orbitofrontal cortex gray matter volumes compared with healthy comparison subjects.  
                                                    
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                                            suicide 
                                
                                    
                                        
                                        
                                        
                                        Right amygdala (right amygdala)brain morphology and function 
                                    Monkul, 2007 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            Suicidal patients had larger right amygdala volumes than non......
                                                                    
                                                                    
                                                        
                                         
                                        Suicidal patients had larger right amygdala volumes than non-suicidal patients. 
                                                    
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                                            suicide attempt 
                                
                                    
                                        
                                        
                                        
                                        White matter (white matter hyperintensities (WMH))brain morphology and function 
                                    Pompili, 2007 patients only  
                                    Fisher's Exact Test, P-value = 0.01 
                                    
                                        
                                                        
                                                                    
                                                                            Bivariate analysis showed that the prevalence of WMH was sig......
                                                                    
                                                                    
                                                        
                                         
                                        Bivariate analysis showed that the prevalence of WMH was significantly higher in subjects with past suicide attempts (Fisher's Exact Test, p = 0.01) and other clinical indicators of elevated suicide risk.  
                                                    
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                                            suicide 
                                
                                    
                                        
                                        
                                        
                                        Lacunar stroke (lacunar infarction)brain morphology and function 
                                    Komaki, 2008 patients only 
                                    
                                        
                                                        
                                                                    
                                                                            the suicide rate was significantly higher in the LI group th......
                                                                    
                                                                    
                                                        
                                         
                                        the suicide rate was significantly higher in the LI group than in the other two groups.  
                                                    
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                                            suicide attempt 
                                
                                    
                                        
                                        
                                        
                                        right anterior cingulate cortex (right anterior cingulate gyrus)brain morphology and function 
                                    Jollant, 2008 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            Relative to affective comparison subjects, suicide attempter......
                                                                    
                                                                    
                                                        
                                         
                                        Relative to affective comparison subjects, suicide attempters showed greater activity in the right anterior cingulate gyrus (area 32 extending to area 10) to mild happy versus neutral faces 
                                                    
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                                            suicide attempt 
                                
                                    
                                        
                                        
                                        
                                        right cerebellum (right cerebellum)brain morphology and function 
                                    Jollant, 2008 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            Relative to affective comparison subjects, suicide attempter......
                                                                    
                                                                    
                                                        
                                         
                                        Relative to affective comparison subjects, suicide attempters showed greater activity in the right cerebellum to mild angry versus neutral faces. 
                                                    
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                                            suicide attempt 
                                
                                    
                                        
                                        
                                        
                                        right lateral orbitofrontal cortex (right lateral orbitofrontal cortex)brain morphology and function 
                                    Jollant, 2008 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            Relative to affective comparison subjects, suicide attempter......
                                                                    
                                                                    
                                                        
                                         
                                        Relative to affective comparison subjects, suicide attempters showed greater activity in the right lateral orbitofrontal cortex (Brodmann's area 47) and decreased activity in the right superior frontal gyrus (area 6) in response to prototypical angry versus neutral faces 
                                                    
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                                            suicide attempt 
                                
                                    
                                        
                                        
                                        
                                        right superior frontal gyrus (right superior frontal gyrus)brain morphology and function 
                                    Jollant, 2008 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            Relative to affective comparison subjects, suicide attempter......
                                                                    
                                                                    
                                                        
                                         
                                        Relative to affective comparison subjects, suicide attempters showed greater activity in the right lateral orbitofrontal cortex (Brodmann's area 47) and decreased activity in the right superior frontal gyrus (area 6) in response to prototypical angry versus neutral faces 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                    
                                        
                                    
                                
                                            suicidal behaviors 
                                
                                    
                                        
                                        
                                        
                                        White matter (periventricular white matter hyperintensities (PVH))brain morphology and function 
                                    Pompili, 2008 patients only 
                                    OR: 8.08 
                                    
                                        
                                                        
                                                                    
                                                                            Attempters and nonattempters differed only in the presence o......
                                                                    
                                                                    
                                                        
                                         
                                        Attempters and nonattempters differed only in the presence of PVH--the former were more likely to have PVH. The logistic regression indicated that the presence of PVH was robustly associated with suicidal behaviors after controlling for age (OR: 8.08). 
                                                    
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                                            suicide 
                                
                                    
                                        
                                        
                                        
                                        Amygdala (amygdala)brain morphology and function 
                                    Poulter, 2008 patients only 
                                    
                                        
                                                        
                                                                    
                                                                            The DNMT gene transcripts' expression was altered in several......
                                                                    
                                                                    
                                                        
                                         
                                        The DNMT gene transcripts' expression was altered in several brains regions of suicides, including frontopolar cortex, amygdala, and the paraventricular nucleus of the hypothalamus. 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                    
                                        
                                    
                                
                                            suicide 
                                
                                    
                                        
                                        
                                        
                                        frontopolar regions (frontopolar cortex)brain morphology and function 
                                    Poulter, 2008 patients only 
                                    
                                        
                                                        
                                                                    
                                                                            The DNMT gene transcripts' expression was altered in several......
                                                                    
                                                                    
                                                        
                                         
                                        The DNMT gene transcripts' expression was altered in several brains regions of suicides, including frontopolar cortex, amygdala, and the paraventricular nucleus of the hypothalamus.Importantly, an increase of both mRNA and protein expression was found in the frontopolar cortex. 
                                                    
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                                            suicide 
                                
                                    
                                        
                                        
                                        
                                        Hypothalamus (hypothalamus)brain morphology and function 
                                    Poulter, 2008 patients only 
                                    
                                        
                                                        
                                                                    
                                                                            The DNMT gene transcripts' expression was altered in several......
                                                                    
                                                                    
                                                        
                                         
                                        The DNMT gene transcripts' expression was altered in several brains regions of suicides, including frontopolar cortex, amygdala, and the paraventricular nucleus of the hypothalamus. 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                    
                                        
                                    
                                
                                            suicide attempt 
                                
                                    
                                        
                                        
                                        
                                        Fronto-parietal connection (frontal cortex)brain morphology and function 
                                    Lalovic, 2010 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            Fatty acid desaturase (FADS1), leptin receptor (LEPR), phosp......
                                                                    
                                                                    
                                                        
                                         
                                        Fatty acid desaturase (FADS1), leptin receptor (LEPR), phosphoinositide-3-kinase (class 2 alpha; PIK3C2A) and stearoyl-CoA desaturase (SCD) were consistently down-regulated in all three regions of the frontal cortex of depressed suicides compared to comparison subjects 
                                                    
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                                            suicide 
                                
                                    
                                        
                                        
                                        
                                        Amygdala (amygdala)brain morphology and function 
                                    Klempan, 2009 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            The messenger RNA (mRNA) levels of multiple transcripts of Q......
                                                                    
                                                                    
                                                        
                                         
                                        The messenger RNA (mRNA) levels of multiple transcripts of QKI were revealing significant reduced in 11 cortical regions and the hippocampus and amygdala of suicide victims compared with control subjects.  
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                    
                                        
                                    
                                
                                            suicide 
                                
                                    
                                        
                                        
                                        
                                        Hippocampus (hippocampus)brain morphology and function 
                                    Klempan, 2009 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            The messenger RNA (mRNA) levels of multiple transcripts of Q......
                                                                    
                                                                    
                                                        
                                         
                                        The messenger RNA (mRNA) levels of multiple transcripts of QKI were revealing significant reduced in 11 cortical regions and the hippocampus and amygdala of suicide victims compared with control subjects.  
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                        
                                    
                                    
                                
                                            suicide 
                                
                                    
                                        
                                        
                                        
                                        Cerebellum (cerebellum)brain morphology and function 
                                    Hwang, 2010 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            Compared with nonsuicidal counterpart, suicidal depression w......
                                                                    
                                                                    
                                                        
                                         
                                        Compared with nonsuicidal counterpart, suicidal depression was associated with decreased GM(gray matter) and WM(white matter) volume in the cerebellum.  
                                                    
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                                            suicide 
                                
                                    
                                        
                                        
                                        
                                        Frontal Lobe (frontal regions)brain morphology and function 
                                    Hwang, 2010 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            Compared with nonsuicidal counterpart, suicidal depression w......
                                                                    
                                                                    
                                                        
                                         
                                        Compared with nonsuicidal counterpart, suicidal depression was associated with decreased GM(gray matter) and WM(white matter) volume in the frontal regions 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                        
                                    
                                    
                                
                                            suicide 
                                
                                    
                                        
                                        
                                        
                                        Insula (insula)brain morphology and function 
                                    Hwang, 2010 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            Compared with nonsuicidal counterpart, suicidal depression w......
                                                                    
                                                                    
                                                        
                                         
                                        Compared with nonsuicidal counterpart, suicidal depression was associated with decreased GM(gray matter) and WM(white matter) volume in the insula 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                    
                                        
                                    
                                
                                            suicide 
                                
                                    
                                        
                                        
                                        
                                        Lentiform nucleus (lentiform nucleus)brain morphology and function 
                                    Hwang, 2010 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            Compared with nonsuicidal counterpart, suicidal depression w......
                                                                    
                                                                    
                                                        
                                         
                                        Compared with nonsuicidal counterpart, suicidal depression was associated with decreased GM(gray matter) and WM(white matter) volume in the lentiform nucleus 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                        
                                    
                                    
                                
                                            suicide 
                                
                                    
                                        
                                        
                                        
                                        Midbrain (midbrain)brain morphology and function 
                                    Hwang, 2010 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            Compared with nonsuicidal counterpart, suicidal depression w......
                                                                    
                                                                    
                                                        
                                         
                                        Compared with nonsuicidal counterpart, suicidal depression was associated with decreased GM(gray matter) and WM(white matter) volume in the midbrain 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                    
                                        
                                    
                                
                                            suicide 
                                
                                    
                                        
                                        
                                        
                                        Parietal Lobe (parietal regions)brain morphology and function 
                                    Hwang, 2010 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            Compared with nonsuicidal counterpart, suicidal depression w......
                                                                    
                                                                    
                                                        
                                         
                                        Compared with nonsuicidal counterpart, suicidal depression was associated with decreased GM(gray matter) and WM(white matter) volume in the parietal regions 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                        
                                    
                                    
                                
                                            suicide 
                                
                                    
                                        
                                        
                                        
                                        Temporal Lobe (temporal regions)brain morphology and function 
                                    Hwang, 2010 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            Compared with nonsuicidal counterpart, suicidal depression w......
                                                                    
                                                                    
                                                        
                                         
                                        Compared with nonsuicidal counterpart, suicidal depression was associated with decreased GM(gray matter) and WM(white matter) volume in the temporal regions 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                    
                                        
                                    
                                
                                            suicide attempters 
                                
                                    
                                        
                                        
                                        
                                        Internal capsule (internal capsule)brain morphology and function 
                                    Jia, 2010 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            Fractional anisotropy was decreased in the left anterior lim......
                                                                    
                                                                    
                                                        
                                         
                                        Fractional anisotropy was decreased in the left anterior limb of the internal capsule in suicide attempters relative to both nonattempters and healthy comparison subjects 
                                                    
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                                            suicide attempters 
                                
                                    
                                        
                                        
                                        
                                        right frontal cortex (right frontal lobe)brain morphology and function 
                                    Jia, 2010 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            Fractional anisotropy was decreased in the left anterior lim......
                                                                    
                                                                    
                                                        
                                         
                                        Fractional anisotropy was decreased in the left anterior limb of the internal capsule in suicide attempters relative to both nonattempters and healthy comparison subjects, in the right frontal lobe relative to comparison subjects only 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                    
                                        
                                    
                                
                                            suicide attempters 
                                
                                    
                                        
                                        
                                        
                                        right lentiform nucleus (right lentiform nucleus)brain morphology and function 
                                    Jia, 2010 patients and normal controls 
                                    
                                        
                                                        
                                                                    
                                                                            Fractional anisotropy was decreased in the left anterior lim......
                                                                    
                                                                    
                                                        
                                         
                                        Fractional anisotropy was decreased in the left anterior limb of the internal capsule in suicide attempters relative to both nonattempters and healthy comparison subjects, and in the right lentiform nucleus relative to nonattempters only 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                        
                                    
                                    
                                
                                            suicide attempters 
                                
                                    
                                        
                                        
                                        
                                        right anterior cingulate cortex (right anterior cingulate gyrus)brain morphology and function 
                                    Pan, 2011 patients and normal controls 
                                    P-value = .008 
                                    
                                        
                                                        
                                                                    
                                                                            A 3 group by 2 condition (go-no-go response inhibition versu......
                                                                    
                                                                    
                                                        
                                         
                                        A 3 group by 2 condition (go-no-go response inhibition versus go motor control blocks) block-design whole-brain analysis (p < .05, corrected) showed that NATs (adolescents with a history of depressive disorder but no suicide attempt) showed greater activity than ATTs (adolescent suicide attempters with a history of major depressive disorder) in the right anterior cingulate gyrus (p = .008) 
                                                    
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                                            suicide 
                                
                                    
                                        
                                        
                                        
                                        
                                        Cognitive performance (cognitive functioning)cognition and behavior 
                                    Conner, 2007 patients only 
                                    
                                        
                                                        
                                                                    
                                                                            lower cognitive functioning was associated with lower levels......
                                                                    
                                                                    
                                                        
                                         
                                        lower cognitive functioning was associated with lower levels of (suicide)planning 
                                                    
                                                    More...   
                                      
                                      
                                       
                            
                                
                                
                                    
                                        
                                    
                                    
                                
                                            suicide intent 
                                
                                    
                                        
                                        
                                        
                                        
                                        
                                        Irritability (aggressive)symptoms 
                                    Horesh, 2003 patients only 
                                    
                                        
                                                        
                                                                    
                                                                            Suicidal versus nonsuicidal adolescents were more depressed,......
                                                                    
                                                                    
                                                        
                                         
                                        Suicidal versus nonsuicidal adolescents were more depressed, hopeless, and aggressive, but not more angry or impulsive.  
                                                    
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                                            suicide intent 
                                
                                    
                                        
                                        
                                        
                                        
                                        
                                        Depressed mood (depressed mood)symptoms 
                                    Horesh, 2003 patients only 
                                    
                                        
                                                        
                                                                    
                                                                            Suicidal versus nonsuicidal adolescents were more depressed,......
                                                                    
                                                                    
                                                        
                                         
                                        Suicidal versus nonsuicidal adolescents were more depressed, hopeless, and aggressive, but not more angry or impulsive.  
                                                    
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                                            suicide intent 
                                
                                    
                                        
                                        
                                        
                                        
                                        
                                        Feelings of hopelessness, worthlessness, and guilt (hopeless)symptoms 
                                    Horesh, 2003 patients only 
                                    
                                        
                                                        
                                                                    
                                                                            Suicidal versus nonsuicidal adolescents were more depressed,......
                                                                    
                                                                    
                                                        
                                         
                                        Suicidal versus nonsuicidal adolescents were more depressed, hopeless, and aggressive, but not more angry or impulsive.  
                                                    
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                                            suicide intent 
                                
                                    
                                        
                                        
                                        
                                        
                                        
                                        Feelings of hopelessness, worthlessness, and guilt (hopelessness)symptoms 
                                    Barbe, 2005 patients only 
                                    P-value = .001 
                                    
                                        
                                                        
                                                                    
                                                                            Depressed suicidal youth were more hopeless (p = .001). Amon......
                                                                    
                                                                    
                                                        
                                         
                                        Depressed suicidal youth were more hopeless (p = .001). Among postpubertal depressed females, suicidal girls were more frequently hopeless (p = .008).  
                                                    
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                                            suicide intent 
                                
                                    
                                        
                                        
                                        
                                        
                                        
                                        Sleep disturbances (insomnia)symptoms 
                                    Barbe, 2005 patients only 
                                    P-value = .011 
                                    
                                        
                                                        
                                                                    
                                                                            Depressed suicidal youth presented more frequently with inso......
                                                                    
                                                                    
                                                        
                                         
                                        Depressed suicidal youth presented more frequently with insomnia (p = .011). 
                                                    
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                                            suicidal behavior 
                                
                                    
                                        
                                        
                                        
                                        
                                        
                                        Sleep disturbances (insomnia)symptoms 
                                    McGirr, 2007 patients only 
                                    
                                        
                                                        
                                                                    
                                                                            Inter-episode symptom concordance suggests that insomnia is ......
                                                                    
                                                                    
                                                        
                                         
                                        Inter-episode symptom concordance suggests that insomnia is an immediate indicator of suicide risk 
                                                    
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                                            suicide intent 
                                
                                    
                                        
                                        
                                        
                                        
                                        
                                        Depressed mood (depressed mood)symptoms 
                                    Liu, 2006 patients only 
                                    
                                        
                                                        
                                                                    
                                                                            Compared with nonsuicidal peers, suicidal children and adole......
                                                                    
                                                                    
                                                        
                                         
                                        Compared with nonsuicidal peers, suicidal children and adolescents were more severely depressed, had more depressive symptoms 
                                                    
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                                            suicidal behavior 
                                
                                    
                                        
                                        
                                        
                                        
                                        
                                        Feelings of hopelessness, worthlessness, and guilt (feelings of worthlessness)symptoms 
                                    Liu, 2006 patients only 
                                    
                                        
                                                        
                                                                    
                                                                            Only feelings of worthlessness was related to all 4 suicidal......
                                                                    
                                                                    
                                                        
                                         
                                        Only feelings of worthlessness was related to all 4 suicidal behaviors, after adjustment for other depressive symptoms, comorbid disorders, and demographics. Feelings of worthlessness may play a central role in the development of suicidal behavior.  
                                                    
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                                            suicidal ideation 
                                
                                    
                                        
                                        
                                        
                                        
                                        
                                        Sleep disturbances (insomnia)symptoms 
                                    Chellappa, 2007 patients only  
                                    
                                        
                                                        
                                                                    
                                                                            The results of multivariate analysis showed that only insomn......
                                                                    
                                                                    
                                                        
                                         
                                        The results of multivariate analysis showed that only insomnia had a significant association with suicidal ideation.  
                                                    
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                                            suicidality 
                                
                                    
                                        
                                        
                                        
                                        
                                        
                                        Psychotic symptoms (psychotic features)symptoms 
                                    Gaudiano, 2008 patients only 
                                    
                                        
                                                        
                                                                    
                                                                            Patients with PMD(patients with psychotic major depression) ......
                                                                    
                                                                    
                                                        
                                         
                                        Patients with PMD(patients with psychotic major depression) were more likely to endorse the presence of suicidality compared with NMD(nonpsychotic major depression) patients.  
                                                    
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                                            suicidality 
                                
                                    
                                        
                                        
                                        
                                        
                                        
                                        Irritability (irritability)symptoms 
                                    Perlis, 2009 patients only 
                                    
                                        
                                                        
                                                                    
                                                                            Irritable depression is not a distinct subtype of MDD, but i......
                                                                    
                                                                    
                                                        
                                         
                                        Irritable depression is not a distinct subtype of MDD, but irritability is associated with greater overall severity, anxiety comorbidity and suicidality. 
                                                    
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                                            suicidal thoughts 
                                
                                    
                                        
                                        
                                        
                                        
                                        
                                        Rhythm disturbances (rhythm disturbances(eveningness-type))symptoms 
                                    Gaspar-Barba, 2009 patients only 
                                    
                                        
                                                        
                                                                    
                                                                            The eveningness-type group showed higher scores in suicidal ......
                                                                    
                                                                    
                                                        
                                         
                                        The eveningness-type group showed higher scores in suicidal thoughts, more impaired work and activities, higher paranoid symptoms, higher scores on the anxiety cluster (HRSD) 
                                                    
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                                            suicide attempt 
                                
                                    
                                        
                                        
                                        
                                        
                                        
                                        Depressed mood (depressed mood)symptoms 
                                    Liu, 2009 patients only 
                                    
                                        
                                                        
                                                                    
                                                                            One of the pathways to suicide attempt in mood disorders may......
                                                                    
                                                                    
                                                        
                                         
                                        One of the pathways to suicide attempt in mood disorders may involve maladaptive responses to depressed mood. 
                                                    
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                                            suicide 
                                
                                    
                                        
                                        
                                        
                                        
                                        
                                        Depressed mood (depressive symptoms)symptoms 
                                    Vitiello, 2009 patients only 
                                    P-value < .05 
                                    
                                        
                                                        
                                                                    
                                                                            Severity of self-rated pretreatment suicidal ideation (Suici......
                                                                    
                                                                    
                                                        
                                         
                                        Severity of self-rated pretreatment suicidal ideation (Suicidal Ideation Questionnaire adapted for adolescents score > or = 31) and depressive symptoms (Reynolds Adolescent Depression Scale score > or = 91) predicted occurrence of suicidal events during treatment (P < .05).  
                                                    
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                                            suicide attempt 
                                
                                    
                                        
                                        
                                        
                                        
                                        
                                        
                                        Social network (current social adjustment)environment 
                                    Lizardi, 2011 patients only   
                                    OR = 1.25; 95%CI = 1.019-1.540; P-value = 0.033 
                                    
                                        
                                                        
                                                                    
                                                                            Among subtypes of social adjustment, work adjustment was ass......
                                                                    
                                                                    
                                                        
                                         
                                        Among subtypes of social adjustment, work adjustment was associated with past history of suicide attempt (OR = 1.25; 95%CI = 1.019-1.540; P = 0.033). 
                                                    
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