Gene Report

Basic Information

Approved Symbol	SF3B3
Approved Name	splicing factor 3b, subunit 3, 130kDa
Previous Name	splicing factor 3b, subunit 3, 130kD
Symbol Alias	SAP130, SF3b130, RSE1, KIAA0017
Location	16q22
Position	chr16:70557691-70611571 (+)
External Links	Entrez Gene: 23450 Ensembl: ENSG00000189091 UCSC: uc002ezf.3 HGNC ID: 10770
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between SF3B3 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
SAP130	Sequeira A, 2009	patients and nomal controls	Group: P-value=0.002, F=9.2; Substance: P-value=0.006, F=9.6	Genes differentially expressed after an ANCOVA analysis betw...... Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). More...

Positive relationships between SF3B3 and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
SAP130		Suicide(suicide)	symptoms	Sequeira A, 2009	patients and nomal controls	Group: P-value=0.002, F=9.2; Substance: P-value=0.006, F=9.6	Genes differentially expressed after an ANCOVA analysis betw...... Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). More...

Positive relationship network of SF3B3 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between SF3B3 and MDD (count: 0)

Negative relationships between SF3B3 and other components at different levels (count: 0)

SF3B3 related SNPs in MK4MDD (count: 0)

SF3B3 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Splicing factor 3B subunit 3	Q15393	0(0/0)	Gene mapped

SF3B3 related GO terms (count: 12)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0071013	catalytic step 2 spliceosome	cellular component	IDA[11991638]
GO:0000398	mRNA splicing, via spliceosome	biological process	IC[11991638]; TAS
GO:0003676	nucleic acid binding	molecular function	IEA
GO:0006461	protein complex assembly	biological process	TAS[10490618]
GO:0006397	mRNA processing	biological process	TAS[10490618]
GO:0008380	RNA splicing	biological process	TAS
GO:0005689	U12-type spliceosomal complex	cellular component	IDA[15146077]
GO:0005654	nucleoplasm	cellular component	TAS
GO:0000375	RNA splicing, via transesterification reactions	biological process	TAS[10490618]
GO:0030532	small nuclear ribonucleoprotein complex	cellular component	TAS[10490618]
GO:0010467	gene expression	biological process	TAS
GO:0005681	spliceosomal complex	cellular component	TAS[10490618]

SF3B3 related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa03040	spliceosome	Spliceosome	After transcription, eukaryotic mRNA precursors contain prot...... After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified. More...

SF3B3 related BioCarta pathways (count: 0)

SF3B3 related Reactome pathways (count: 6)

ID	Name	Description
Gene mapped Reactome pathways
REACT_1735	mrna splicing	The process in which excision of introns from the primary tr...... The process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing. Most of the mRNA is spliced by the major pathway, involving the U1, U2, U4, U5 and U6 snRNPs. A minor fraction, about 1 %, of the mRNAs are spliced via the U12 dependent pathway. More...
REACT_1021	elongation and_processing_of_capped_transcripts
REACT_71	gene expression	Gene Expression covers the process of transcription of mRNA ...... Gene Expression covers the process of transcription of mRNA genes, the processing of pre-mRNA, and its subsequent translation to result in a protein. The expression of non-protein-coding genes is not included in this section yet. However, the transcription of RNAs other than mRNA is described in the section on transcription; in the sections 'RNA Polymerase I Transcription', and 'RNA Polymerase III Transcription'. More...
REACT_2039	formation and_maturation_of_mrna_transcript	Before a gene transcript is ready to be transported out of t...... Before a gene transcript is ready to be transported out of the nucleus, it has to undergo three major processing events to produce a fully translatable mRNA. These comprise capping, splicing out of introns from within the body of the pre-mRNA, and the generation of a 3' end, by cleavage, and except in the case of histone pre-mRNAs, polyadenylation. Although each of these reactions is a biochemically distinct process, these processes are interlinked and hence, influence one another's specificity and efficiency. On the other hand, most mRNA processing reactions occur co-transcriptionally. This is particularly important in very long genes where a strictly post-transcriptional processing would imply the existence of extremely long primary transcript molecules that would be susceptible to degradation. The co-transcriptional nature of pre-mRNA processing does not necessarily imply a functional coupling between the transcription and mRNA processing machineries. In some cases it may simply reflect that processing reactions occur during transcription because they are relatively fast compared with the time it takes to transcribe a gene to its end. In other cases a tight link exists between a particular processing reaction and the transcription process, due to the ability of the carboxy-terminal (CTD) of RNA polymerase II largest subunit to bind or recruit processing factors. The CTD consists of 52 heptad repeats (YSPTSPS). Specific phosphorylation/dephosphorylation patterns of serines 2 and 5 are critical for CTD function in coupling. CTD deletions that do not inactivate transcription significantly decrease the efficiency of capping, splicing and polyadenylation. The export of mRNA from the nucleus and mRNA splicing are also coupled. Mature mRNAs generated by splicing are more efficiently exported than their identical counterparts transcribed from a complementary DNA (cDNA). This effect of splicing on export is due to the recruitment of the mRNA export factor ALY to the mRNA during the splicing reaction, which in turn delivers the mRNP to the nuclear pore for export. More...
REACT_125	processing of_capped_intron_containing_pre_mrna	Any covalent change in a primary (nascent) mRNA transcript i...... Any covalent change in a primary (nascent) mRNA transcript is mRNA Processing. For successful gene expression, the primary mRNA transcript needs to be converted to a mature mRNA prior to its translation into polypeptide. Eucaryotic mRNAs undergo a series of complex processing reactions; these begin on nascent transcripts as soon as a few ribonucleotides have been synthesized during transcription by RNA Polymerase II, through the export of the mature mRNA to the cytoplasm, and culminate with mRNA turnover in the cytoplasm. More...
REACT_1753	mrna splicing_minor_pathway	The splicing of a subset of pre-mRNA introns occurs by a sec...... The splicing of a subset of pre-mRNA introns occurs by a second pathway, designated the AT-AC or U12-dependent splicing pathway. AT-AC introns have highly conserved, non-canonical splice sites that are removed by the AT-AC spliceosome, which contains distinct snRNAs (U11, U12, U4atac, U6atac) that are structurally and functionally analogous to the major spliceosome. U5 snRNA as well as many of the protein factors appear to be conserved between the two spliceosomes. More...

SF3B3 related interactors from protein-protein interaction data in HPRD (count: 7)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
SF3B3	HCK	No	in vitro	12029088
SF3B3	SF3B1	No	in vivo	10490618 , 11406595 , 12234937
SF3B3	MPP3	No	yeast 2-hybrid	16169070
SF3B3	YWHAG	No	in vivo	15324660
SF3B3	SFRS12	No	in vitro;in vivo;yeast 2-hybrid	14559993
SF3B3	TAF9	No	in vitro	11564863
SF3B3	NOL12	No	yeast 2-hybrid	16169070

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways