MK4MDD

Gene Report

Basic Information
Approved Symbol HTR2A
Approved Name 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
Previous Symbol HTR2
Previous Name "5-hydroxytryptamine (serotonin) receptor 2A"
Symbol Alias 5-HT2A
Location 13q14-q21
Position chr13:47470969-47471211 (-)
External Links Entrez Gene: 3356
Ensembl: ENSG00000102468
UCSC: uc010acr.4
HGNC ID: 5293
No. of Studies (Positive/Negative) 11(7/4) Help
Type Literature-origin; SNP mapped; Protein mapped

Positive relationships between HTR2A and MDD (count: 5)
Name in Literature Reference Research Type Statistical Result Relation Description Help
5-HT2A Du, 2000 patients and normal controls P-value=0.03 The major finding of this study was a significant associatio...... The major finding of this study was a significant association between the 102 C allele in 5-HT2A receptor gene and major depression, chi(2) = 4.5, df = 1, P = 0.03, particularly in patients with suicidal ideation, chi(2) = 8.5, df = 1, P < 0.005. More...
5-HT(2A) Arias B, 2001 Patients and nomal controls OR = 5.50; 95% CI = 1.18-35.20; P = 0.01 Significant differences in allele (chi-square = 4.13, df = 1...... Significant differences in allele (chi-square = 4.13, df = 1, P = 0.04) and genotype (chi-square = 6.19, df = 2, P = 0.04) distributions were found between non-suicide attempters and suicide attempters. Moreover, those patients carrying 5-HT(2A)-C allele had more than five times the risk for attempting suicide than noncarriers (OR = 5.50, 95% CI = 1.18-35.20, P = 0.01). More...
5-HTR2A Choi, 2004 patients and normal controls genotype: chi(2) = 10.78, d.f. = 2, P-value = 0.005; allele:chi(2) = 10.18, P-value = 0.001; OR = 2.46, 95% CI 1.40-4.32 This polymorphism was analyzed in 189 patients with MDD and ...... This polymorphism was analyzed in 189 patients with MDD and in 148 unrelated healthy controls using a case-control design, which revealed a significant difference in the genotype distributions (chi(2) = 10.78, d.f. = 2, p = 0.005). The frequency of the -1438G allele was also much higher in MDD patients than in normal controls (chi(2) = 7.20, p = 0.007; OR = 1.52, 95% CI 1.12-2.06). We also found significantly more carriers of the G allele (GG+AG genotypes) in MDD patients than in normal controls (chi(2) = 10.18, p = 0.001; OR = 2.46, 95% CI 1.40-4.32). More...
HTR2A Klempan, 2009 patients and normal controls Selected differentially expressed genes in BA44 to BA47 (ANO...... Selected differentially expressed genes in BA44 to BA47 (ANOVA and t-test P < 0.01, fold change 1.3t) More...
HTR2A Belzeaux, 2010 patients and normal controls We also observed that variations in other mRNA expression we...... We also observed that variations in other mRNA expression were associated with treatment efficacy or clinical improvement (CREB1, HDAC5, HSPA2, HTR1B, HTR2A, and SLC6A4/5HTT). More...

Positive relationships between HTR2A and other components at different levels (count: 4) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of HTR2A in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between HTR2A and MDD (count: 3)
Name in Literature Reference Research Type Statistical Result Relation Description
5HTR2A Yoon HK, 2008 Patients and nomal controls There were no significant differences in the genotype distri...... There were no significant differences in the genotype distributions or allelic frequencies in the two serotonergic polymorphisms between suicide attempters and normal controls. None of the two serotonergic polymorphisms was correlated with lethality. More...
HTR2A Kishi T, 2009 Patients and nomal controls We did not detect significant an association of HTR2A with M...... We did not detect significant an association of HTR2A with MDD and BP in allele/genotype-wise or haplotype-wise analysis More...
HTR2A Tan, 2014 Patients and nomal controls The current meta-analysis performed a systematic evaluation ...... The current meta-analysis performed a systematic evaluation between the T102C polymorphism and susceptibility to MDD, BPD, and SCZ based on a total of 97 independent studies containing 17,178 cases and 20,855 control subjects. However, no statistical significance was detected in the overall data analysis forMDD,BPD, or SCZ. More...

Negative relationships between HTR2A and other components at different levels (count: 1) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


HTR2A related SNPs in MK4MDD (count: 1)
HTR2A related proteins in MK4MDD (count: 1)
HTR2A related GO terms (count: 49)
HTR2A related KEGG pathways (count: 3)
HTR2A related BioCarta pathways (count: 0)
HTR2A related Reactome pathways (count: 6)
HTR2A related interactors from protein-protein interaction data in HPRD (count: 16)