MK4MDD

Gene Report

Basic Information
Approved Symbol GLUL
Approved Name glutamate-ammonia ligase
Previous Symbol GLNS
Previous Name "glutamate-ammonia ligase (glutamine synthase)"
Name Alias "glutamine synthetase"
Location 1q31
Position chr1:182360814-182361341 (-)
External Links Entrez Gene: 2752
Ensembl: ENSG00000135821
UCSC: uc001gpa.2
HGNC ID: 4341
No. of Studies (Positive/Negative) 4(3/1) Help
Type Literature-origin; Protein mapped

Positive relationships between GLUL and MDD (count: 3)
Name in Literature Reference Research Type Statistical Result Relation Description Help
GLUL Bernard, 2010 patients and normal controls The expression of this gene was altered in the locus coerule...... The expression of this gene was altered in the locus coeruleus of MDD More...
L-glutamate-ammonia ligase Choudary, 2005 patients and normal controls Microarray analysis of specific areas of cerebral cortex fro...... Microarray analysis of specific areas of cerebral cortex from individuals who had suffered from major depressive disorder demonstrated significant down-regulation of SLC1A2 and SLC1A3, two key members of the glutamate/neutral amino acid transporter protein family, SLC1. Similarly, expression of L-glutamate-ammonia ligase, the enzyme that converts glutamate to nontoxic glutamine was significantly decreased. More...
GLUL Klempan, 2009 patients and normal controls Selected differentially expressed genes in BA44 to BA47 (ANO...... Selected differentially expressed genes in BA44 to BA47 (ANOVA and t-test P < 0.01, fold change 1.3t) More...

Positive relationships between GLUL and other components at different levels (count: 0) Help
Positive relationship network of GLUL in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between GLUL and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description
GLUL Chandley MJ, 2013 patients and normal controls

Negative relationships between GLUL and other components at different levels (count: 0) Help
GLUL related SNPs in MK4MDD (count: 0)
GLUL related proteins in MK4MDD (count: 1)
GLUL related GO terms (count: 34)
GLUL related KEGG pathways (count: 3)
GLUL related BioCarta pathways (count: 0)
GLUL related Reactome pathways (count: 3)
GLUL related interactors from protein-protein interaction data in HPRD (count: 6)