Reactome Pathway Report

Basic Information

ID
Name	transmission across_chemical_synapses
Description	Chemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron, muscle cell or glad cell. The pre and the post-synaptic cell are separated by a gap of 20nm called the synaptic cleft. The signals pass in a unidirection from pre-synaptic to post-synaptic. The pre-synaptic neuron communicates via the release of neurotransmitter which bind the receptors on the post-synaptic cell.

REACT_13477 related genes in MK4MDD (count: 47)

Approved Symbol	Approved Name	Type	No. of Studies (Positive/Negative)
MAOA	monoamine oxidase A	Literature-origin; SNP mapped; Protein mapped	12(9/3)
AP2A2	adaptor-related protein complex 2, alpha 2 subunit	Protein mapped	0(0/0)
SLC18A3	solute carrier family 18 (vesicular acetylcholine), member 3	SNP mapped	0(0/0)
SYN2	synapsin II	Literature-origin; Protein mapped	1(1/0)
CALM2	calmodulin 2 (phosphorylase kinase, delta)	Literature-origin	1(1/0)
RASGRF1	Ras protein-specific guanine nucleotide-releasing factor 1	Literature-origin	1(1/0)
PRKCG	protein kinase C, gamma	SNP mapped	0(0/0)
GRIA1	glutamate receptor, ionotropic, AMPA 1	Literature-origin; Protein mapped	1(1/0)
GLUL	glutamate-ammonia ligase	Literature-origin; Protein mapped	3(3/0)
TPH1	tryptophan hydroxylase 1	Literature-origin; SNP mapped	11(9/2)
GNB3	guanine nucleotide binding protein (G protein), beta polypeptide 3	Literature-origin; SNP mapped	2(2/0)
CREB1	cAMP responsive element binding protein 1	Literature-origin; Protein mapped	12(10/2)
NSF	N-ethylmaleimide-sensitive factor	Protein mapped	0(0/0)
STX1A	syntaxin 1A (brain)	Literature-origin	1(1/0)
DLG4	discs, large homolog 4 (Drosophila)	Literature-origin; Protein mapped	1(1/0)
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	Literature-origin; Protein mapped	2(2/0)
GRIK5	glutamate receptor, ionotropic, kainate 5	Literature-origin	1(1/0)
MAPK1	mitogen-activated protein kinase 1	Literature-origin	2(2/0)
DBH	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	Literature-origin; Protein mapped	1(1/0)
SYN1	synapsin I	Literature-origin; Protein mapped	1(1/0)
ADCY8	adenylate cyclase 8 (brain)	Literature-origin	2(2/0)
ADCY3	adenylate cyclase 3	Literature-origin; SNP mapped	1(0/1)
GRIN1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	Protein mapped	0(0/0)
SNAP25	synaptosomal-associated protein, 25kDa	Literature-origin; Protein mapped	1(1/0)
COMT	catechol-O-methyltransferase	Literature-origin; SNP mapped	6(6/0)
SLC18A2	solute carrier family 18 (vesicular monoamine), member 2	Literature-origin; Protein mapped	1(1/0)
SLC17A7	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7	Literature-origin; Protein mapped	4(4/0)
GRIA2	glutamate receptor, ionotropic, AMPA 2	Literature-origin	1(1/0)
GRIN2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	Literature-origin; Protein mapped	2(2/0)
GNB1	guanine nucleotide binding protein (G protein), beta polypeptide 1	Protein mapped	0(0/0)
CHAT	choline O-acetyltransferase	SNP mapped	0(0/0)
PRKCB	protein kinase C, beta	Protein mapped	0(0/0)
GRIA3	glutamate receptor, ionotropic, AMPA 3	Literature-origin; Protein mapped	1(1/0)
GNG3	guanine nucleotide binding protein (G protein), gamma 3	Literature-origin	1(1/0)
SLC1A3	solute carrier family 1 (glial high affinity glutamate transporter), member 3	Literature-origin; Protein mapped	3(3/0)
CPLX1	complexin 1	Protein mapped	0(0/0)
SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	Literature-origin; Protein mapped	3(3/0)
ACHE	acetylcholinesterase	Protein mapped	0(0/0)
RAB3A	RAB3A, member RAS oncogene family	Literature-origin	1(1/0)
SLC1A6	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	Protein mapped	0(0/0)
PRKACB	protein kinase, cAMP-dependent, catalytic, beta	Protein mapped	0(0/0)
NEFL	neurofilament, light polypeptide	Protein mapped	0(0/0)
CACNG3	calcium channel, voltage-dependent, gamma subunit 3	Literature-origin	1(1/0)
SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Literature-origin; SNP mapped; Protein mapped	3(2/1)
GRIK3	glutamate receptor, ionotropic, kainate 3	Literature-origin	1(1/0)
HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	Protein mapped	0(0/0)
CAMK2A	calcium/calmodulin-dependent protein kinase II alpha	Literature-origin; Protein mapped	1(1/0)