MK4MDD

Gene Report

Basic Information
Approved Symbol MAPK1
Approved Name mitogen-activated protein kinase 1
Previous Symbol PRKM2, PRKM1
Symbol Alias ERK, ERK2, p41mapk, MAPK2
Location 22q11.2
Position chr22:22221731-22221970 (-)
External Links Entrez Gene: 5594
Ensembl: ENSG00000100030
UCSC: uc002zvn.3
HGNC ID: 6871
No. of Studies (Positive/Negative) 2(2/0) Help
Type Literature-origin

Positive relationships between MAPK1 and MDD (count: 2)
Name in Literature Reference Research Type Statistical Result Relation Description Help
mitogen-activated protein kinase (MAPK) phosphatase-1 Duric, 2010 patients and normal controls Whole-genome expression profiling of postmortem tissue shows...... Whole-genome expression profiling of postmortem tissue shows significantly increased expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1, encoded by DUSP1, but hereafter called MKP-1) in the hippocampal subfields of subjects with MDD compared to matched controls. More...
MAPK1 Sibille E, 2009 animal model; patients and nomal controls R=0.88, P-value<5E-6; y slope=1.14 Downregulated in MDD patients Downregulated in MDD patients

Positive relationships between MAPK1 and other components at different levels (count: 0) Help
Positive relationship network of MAPK1 in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between MAPK1 and MDD (count: 0)
Negative relationships between MAPK1 and other components at different levels (count: 0) Help
MAPK1 related SNPs in MK4MDD (count: 0)
MAPK1 related proteins in MK4MDD (count: 0)
MAPK1 related GO terms (count: 118)
MAPK1 related KEGG pathways (count: 46)
MAPK1 related BioCarta pathways (count: 40)
MAPK1 related Reactome pathways (count: 32)
MAPK1 related interactors from protein-protein interaction data in HPRD (count: 161)