Study Report
Reference
| Citation | Duric, 2010 PubMed |
| Full Info | Duric, V., Banasr, M., Licznerski, P., Schmidt, H.D., Stockmeier, C.A., Simen, A.A., Newton, S.S. and Duman, R.S. (2010) A negative regulator of MAP kinase causes depressive behavior. Nat Med, 16, 1328-1332.
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Study
| Hypothesis or Background |
The lifetime prevalence ( approximately 16%) and the economic burden ($100 billion annually) associated with major depressive disorder (MDD) make it one of the most common and debilitating neurobiological illnesses. To date, the exact cellular and molecular mechanisms underlying the pathophysiology of MDD have not been identified
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| Sample Information | subjects with MDD compared to matched controls |
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| Method Detail | We use whole-genome expression profiling of postmortem tissue; we tested the role of altered MKP-1 expression in rat and mouse models of depression |
| Method Keywords | whole-genome expression profiling; transgenic method; sucrose preference test; active avoidance test; novelty suppressed feeding test; sucrose consumption test; elevated plus maze; open field test; forced swimming test |
| Result | Here we use whole-genome expression profiling of postmortem tissue and show significantly increased expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1, encoded by DUSP1, but hereafter called MKP-1) in the hippocampal subfields of subjects with MDD compared to matched controls. We tested the role of altered MKP-1 expression in rat and mouse models of depression and found that increased hippocampal MKP-1 expression, as a result of stress or viral-mediated gene transfer, causes depressive behaviors. |
Relationships reported by
Duric, 2010
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
Depression-like behaviors from animal model (depressive-like behavior)
|
cognition and behavior |
DUSP14 (MKP-1) |
gene |
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Increased hippocampal MKP-1 expression in rat causes depressive behaviors |
Positive
|
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MDD
|
syndrome |
MAPK1 (mitogen-activated protein kinase (MAPK) phosphatase-1) |
gene |
|
Whole-genome expression profiling of postmortem tissue shows significantly increased expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1, encoded by DUSP1, but hereafter called MKP-1) in the hippocampal subfields of subjects with MDD compared to matched controls. |
Positive
|
