
Gene Report
Approved Symbol | BCL6 |
---|---|
Approved Name | B-cell CLL/lymphoma 6 |
Previous Symbol | ZNF51 |
Previous Name | zinc finger protein 51 |
Symbol Alias | ZBTB27, LAZ3, BCL5, BCL6A |
Location | 3q27 |
Position | chr3:187439165-187463513 (-) |
External Links |
Entrez Gene: 604 Ensembl: ENSG00000113916 UCSC: uc003frq.2 HGNC ID: 1001 |
No. of Studies (Positive/Negative) | 1(1/0)
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Type | Literature-origin |
Name in Literature | Reference | Research Type | Statistical Result | Relation Description | ![]() |
---|---|---|---|---|---|
B-cell lymphoma 6 protein | Tochigi, 2008 | patients and normal controls | Genes differentially expressed in major depression Genes differentially expressed in major depression |
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus | Protein and Other Molecule | Cell and Molecular Pathway | Neural System | Cognition and Behavior | Symptoms and Signs | Environment | MDD |
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2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Approved Name | UniportKB | No. of Studies (Positive/Negative) | Source | |
---|---|---|---|---|
B-cell lymphoma 6 protein | P41182 | 0(0/0) | Gene mapped |
Gene mapped GO terms | ||||
ID | Name | Type | Evidence | |
---|---|---|---|---|
GO:0003682 | chromatin binding | molecular function | IDA[12097386] | |
GO:0035024 | negative regulation of Rho protein signal transduction | biological process | IEA | |
GO:0043065 | positive regulation of apoptotic process | biological process | IDA[10490843] | |
GO:0008270 | zinc ion binding | molecular function | IEA | |
GO:0008285 | negative regulation of cell proliferation | biological process | IEA | |
GO:0030890 | positive regulation of B cell proliferation | biological process | IEA | |
GO:0005730 | nucleolus | cellular component | IDA | |
GO:0048821 | erythrocyte development | biological process | IEA | |
GO:0045629 | negative regulation of T-helper 2 cell differentiation | biological process | IEA | |
GO:0050727 | regulation of inflammatory response | biological process | IEA | |
GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | biological process | IDA[11929873] | |
GO:0030308 | negative regulation of cell growth | biological process | IDA[10490843] | |
GO:0051272 | positive regulation of cellular component movement | biological process | IEA | |
GO:0002467 | germinal center formation | biological process | IEA | |
GO:0043565 | sequence-specific DNA binding | molecular function | IDA[15577913] | |
GO:0032764 | negative regulation of mast cell cytokine production | biological process | IEA | |
GO:0005634 | nucleus | cellular component | IDA | |
GO:0007266 | Rho protein signal transduction | biological process | IEA | |
GO:0031490 | chromatin DNA binding | molecular function | IEA | |
GO:0050776 | regulation of immune response | biological process | NAS[16455075] | |
GO:0032319 | regulation of Rho GTPase activity | biological process | IEA | |
GO:0043380 | regulation of memory T cell differentiation | biological process | IEA | |
GO:0005657 | replication fork | cellular component | IDA[10490843] | |
GO:0002634 | regulation of germinal center formation | biological process | NAS[7795255] | |
GO:0001953 | negative regulation of cell-matrix adhesion | biological process | IEA | |
GO:0000902 | cell morphogenesis | biological process | IEA | |
GO:0003700 | sequence-specific DNA binding transcription factor activity | molecular function | IMP[15577913] | |
GO:0007283 | spermatogenesis | biological process | IEA | |
GO:0002903 | negative regulation of B cell apoptotic process | biological process | NAS[15577913] | |
GO:0002829 | negative regulation of type 2 immune response | biological process | IEA | |
GO:0006351 | transcription, DNA-dependent | biological process | IEA | |
GO:0045749 | negative regulation of S phase of mitotic cell cycle | biological process | NAS[10490843] | |
GO:0005515 | protein binding | molecular function | IPI[16147992] | |
GO:0030036 | actin cytoskeleton organization | biological process | IEA | |
GO:0042092 | type 2 immune response | biological process | IEA | |
GO:0045892 | negative regulation of transcription, DNA-dependent | biological process | IMP[15577913]; NAS[9135990] | |
GO:0006974 | response to DNA damage stimulus | biological process | IDA[15577913] | |
GO:0000060 | protein import into nucleus, translocation | biological process | IGI[11821949] | |
GO:0030183 | B cell differentiation | biological process | IEA | |
GO:0048294 | negative regulation of isotype switching to IgE isotypes | biological process | IEA |

Gene | Interactor | Interactor in MK4MDD? | Experiment Type | PMID | |
---|---|---|---|---|---|
BCL6 | ZBTB7A | No | in vivo;yeast 2-hybrid | 9927193 | |
BCL6 | JUN | Yes | in vitro;in vivo | 12165517 | |
BCL6 | BCOR | No | in vitro;in vivo | 10898795 | |
BCL6 | RUNX1T1 | No | in vitro;in vivo | 14551142 | |
BCL6 | NCOR1 | No | in vitro;in vivo | 10898795 | |
BCL6 | PPARD | No | in vitro;in vivo | 12970571 | |
BCL6 | IRF4 | No | in vitro;in vivo | 10601358 | |
BCL6 | SIN3A | No | in vitro;in vivo | 9765306 | |
BCL6 | HDAC4 | No | in vitro;in vivo | 11929873 , 16147992 | |
BCL6 | EP300 | Yes | in vitro;in vivo | 12402037 | |
BCL6 | JUNB | No | in vitro;in vivo | 12165517 | |
BCL6 | SP1 | No | in vitro;in vivo | 12004059 | |
BCL6 | BCL6B | No | in vitro;in vivo | 9632807 | |
BCL6 | PRKD3 | No | in vivo | 16147992 | |
BCL6 | WNK4 | No | in vivo | 16147992 | |
BCL6 | HDAC7 | No | in vitro;in vivo | 11929873 | |
BCL6 | HDAC5 | Yes | in vitro;in vivo | 11929873 | |
BCL6 | MAPK1 | Yes | in vitro | 9649500 | |
BCL6 | JUND | No | in vitro;in vivo | 12165517 | |
BCL6 | NCOR2 | No | in vitro;in vivo | 9765306 , 16147992 | |
BCL6 | ZBTB16 | Yes | in vitro;in vivo;yeast 2-hybrid | 11175338 | |
BCL6 | HDAC9 | No | in vitro;in vivo | 12590135 | |
BCL6 | BCL6 | Yes | in vitro;in vivo | 11929873 , 10898795 |