Gene Report

Basic Information

Approved Symbol	BCL6
Approved Name	B-cell CLL/lymphoma 6
Previous Symbol	ZNF51
Previous Name	"zinc finger protein 51"
Symbol Alias	ZBTB27, LAZ3, BCL5, BCL6A
Location	3q27
Position	chr3:187463198-187463513 (-)
External Links	Entrez Gene: 604 Ensembl: ENSG00000113916 UCSC: uc003frq.2 HGNC ID: 1001
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between BCL6 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
B-cell lymphoma 6 protein	Tochigi, 2008	patients and normal controls		Genes differentially expressed in major depression Genes differentially expressed in major depression

Positive relationships between BCL6 and other components at different levels (count: 0)

Positive relationship network of BCL6 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between BCL6 and MDD (count: 0)

Negative relationships between BCL6 and other components at different levels (count: 0)

BCL6 related SNPs in MK4MDD (count: 0)

BCL6 related proteins in MK4MDD (count: 0)

BCL6 related GO terms (count: 48)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0006954	inflammatory response	biological process	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:2000773	negative regulation of cellular senescence	biological process	IEA
GO:0043565	sequence-specific DNA binding	molecular function	IDA[15577913]
GO:0007266	Rho protein signal transduction	biological process	IEA
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IDA[11929873\|15577913]
GO:0002467	germinal center formation	biological process	IEA
GO:0032764	negative regulation of mast cell cytokine production	biological process	IEA
GO:0035024	negative regulation of Rho protein signal transduction	biological process	IEA
GO:0030036	actin cytoskeleton organization	biological process	IEA
GO:0045746	negative regulation of Notch signaling pathway	biological process	IEA
GO:0043380	regulation of memory T cell differentiation	biological process	IEA
GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding	molecular function	IEA
GO:0043087	regulation of GTPase activity	biological process	IEA
GO:0043065	positive regulation of apoptotic process	biological process	IDA[10490843]
GO:0003700	transcription factor activity, sequence-specific DNA binding	molecular function	IMP[15577913]
GO:0050727	regulation of inflammatory response	biological process	IBA
GO:0006351	transcription, DNA-templated	biological process	IEA
GO:0005515	protein binding	molecular function	IPI[10898795\|12590135\|16147992\|16819511\|25416956]
GO:0000902	cell morphogenesis	biological process	IEA
GO:0048821	erythrocyte development	biological process	IEA
GO:0001161	intronic transcription regulatory region sequence-specific DNA binding	molecular function	IEA
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	molecular function	IEA
GO:0008285	negative regulation of cell proliferation	biological process	IEA
GO:0003682	chromatin binding	molecular function	IDA[12097386]
GO:0005634	nucleus	cellular component	IDA[10898795\|11929873]
GO:0007283	spermatogenesis	biological process	IEA
GO:0006974	cellular response to DNA damage stimulus	biological process	IDA[15577913]
GO:0001953	negative regulation of cell-matrix adhesion	biological process	IEA
GO:0002903	negative regulation of B cell apoptotic process	biological process	NAS[15577913]
GO:0030308	negative regulation of cell growth	biological process	IDA[10490843]
GO:0002634	regulation of germinal center formation	biological process	NAS[7795255]
GO:0030890	positive regulation of B cell proliferation	biological process	IEA
GO:0031490	chromatin DNA binding	molecular function	IEA
GO:0030099	myeloid cell differentiation	biological process	IBA
GO:0030183	B cell differentiation	biological process	IEA
GO:0046872	metal ion binding	molecular function	IEA
GO:0045629	negative regulation of T-helper 2 cell differentiation	biological process	IEA
GO:0000060	protein import into nucleus, translocation	biological process	IGI[11821949]
GO:0048294	negative regulation of isotype switching to IgE isotypes	biological process	IEA
GO:0042127	regulation of cell proliferation	biological process	IBA
GO:0050767	regulation of neurogenesis	biological process	IBA
GO:0042092	type 2 immune response	biological process	IBA
GO:0031065	positive regulation of histone deacetylation	biological process	IEA
GO:0045666	positive regulation of neuron differentiation	biological process	IEA
GO:0045892	negative regulation of transcription, DNA-templated	biological process	IMP[15577913]; NAS[9135990]
GO:0050776	regulation of immune response	biological process	NAS[16455075]
GO:0005657	replication fork	cellular component	IDA[10490843]
GO:0051272	positive regulation of cellular component movement	biological process	IEA

BCL6 related KEGG pathways (count: 0)

BCL6 related BioCarta pathways (count: 0)

BCL6 related Reactome pathways (count: 0)

BCL6 related interactors from protein-protein interaction data in HPRD (count: 23)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
BCL6	JUNB	No	in vitro;in vivo	12165517
BCL6	HDAC7	No	in vitro;in vivo	11929873
BCL6	EP300	Yes	in vitro;in vivo	12402037
BCL6	BCL6	Yes	in vitro;in vivo	11929873 , 10898795
BCL6	NCOR1	No	in vitro;in vivo	10898795
BCL6	MAPK1	Yes	in vitro	9649500
BCL6	PRKD3	No	in vivo	16147992
BCL6	RUNX1T1	No	in vitro;in vivo	14551142
BCL6	JUN	Yes	in vitro;in vivo	12165517
BCL6	JUND	No	in vitro;in vivo	12165517
BCL6	NCOR2	No	in vitro;in vivo	9765306 , 16147992
BCL6	IRF4	No	in vitro;in vivo	10601358
BCL6	ZBTB7A	No	in vivo;yeast 2-hybrid	9927193
BCL6	HDAC4	No	in vitro;in vivo	11929873 , 16147992
BCL6	HDAC5	Yes	in vitro;in vivo	11929873
BCL6	HDAC9	No	in vitro;in vivo	12590135
BCL6	BCOR	No	in vitro;in vivo	10898795
BCL6	PPARD	No	in vitro;in vivo	12970571
BCL6	SP1	No	in vitro;in vivo	12004059
BCL6	WNK4	No	in vivo	16147992
BCL6	BCL6B	No	in vitro;in vivo	9632807
BCL6	SIN3A	No	in vitro;in vivo	9765306
BCL6	ZBTB16	Yes	in vitro;in vivo;yeast 2-hybrid	11175338

Gene Report

Literature-origin GO terms

Gene mapped GO terms