Gene Report

Basic Information

Approved Symbol	ZBTB16
Approved Name	zinc finger and BTB domain containing 16
Previous Symbol	ZNF145
Previous Name	"zinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia)"
Symbol Alias	PLZF
Name Alias	"promyelocytic leukaemia zinc finger"
Location	11q23
Position	chr11:114121278-114121398 (+)
External Links	Entrez Gene: 7704 Ensembl: ENSG00000109906 UCSC: uc001poq.3 HGNC ID: 12930
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between ZBTB16 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
ZBTB16	Spijker, 2010	patients and normal controls		Based on LPS-stimulated blood gene expression using whole-ge...... Based on LPS-stimulated blood gene expression using whole-genome microarrays, this gene serves as a molecular signature of MDD More...

Positive relationships between ZBTB16 and other components at different levels (count: 0)

Positive relationship network of ZBTB16 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between ZBTB16 and MDD (count: 0)

Negative relationships between ZBTB16 and other components at different levels (count: 0)

ZBTB16 related SNPs in MK4MDD (count: 0)

ZBTB16 related proteins in MK4MDD (count: 0)

ZBTB16 related GO terms (count: 43)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0006915	apoptotic process	biological process	NAS[9294197]

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0042802	identical protein binding	molecular function	IPI[9294197\|25416956]
GO:0001823	mesonephros development	biological process	ISS[8541544]
GO:0019904	protein domain specific binding	molecular function	IEA
GO:0005829	cytosol	cellular component	IEA
GO:0035116	embryonic hindlimb morphogenesis	biological process	IEA
GO:0016567	protein ubiquitination	biological process	IEA
GO:0001206	transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding	molecular function	IDA[12802276]
GO:0017053	transcriptional repressor complex	cellular component	IDA[12802276]
GO:0008022	protein C-terminus binding	molecular function	IEA
GO:0009880	embryonic pattern specification	biological process	IEA
GO:0046872	metal ion binding	molecular function	IEA
GO:0045778	positive regulation of ossification	biological process	IDA[21547890]
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	molecular function	IDA[12802276]
GO:0005634	nucleus	cellular component	IDA[9294197\|11929873\|21547890]
GO:0007417	central nervous system development	biological process	ISS[8541544]
GO:0051138	positive regulation of NK T cell differentiation	biological process	IEA
GO:0005515	protein binding	molecular function	IPI[9294197\|16169070\|16189514\|16828757\|17118363\|19648967\|21988832\|23088713\|25241761\|25416956]
GO:0061036	positive regulation of cartilage development	biological process	IDA[21547890]
GO:0016604	nuclear body	cellular component	IDA[19648967]
GO:0030099	myeloid cell differentiation	biological process	TAS[9294197]
GO:0030097	hemopoiesis	biological process	IDA[8541544]; TAS[9294197]
GO:0006351	transcription, DNA-templated	biological process	IEA
GO:0042803	protein homodimerization activity	molecular function	IDA[8622986]
GO:0005886	plasma membrane	cellular component	IEA
GO:0045892	negative regulation of transcription, DNA-templated	biological process	IDA[12802276]; NAS[9294197]
GO:0034504	protein localization to nucleus	biological process	IEA
GO:0032332	positive regulation of chondrocyte differentiation	biological process	IMP[21547890]
GO:0035136	forelimb morphogenesis	biological process	IEA
GO:0005730	nucleolus	cellular component	IDA
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IDA[12802276]
GO:0045893	positive regulation of transcription, DNA-templated	biological process	IDA[21547890]
GO:0045638	negative regulation of myeloid cell differentiation	biological process	ISS[8541544]
GO:0042733	embryonic digit morphogenesis	biological process	IEA
GO:0003677	DNA binding	molecular function	IDA[12802276]; NAS[9294197]
GO:0043065	positive regulation of apoptotic process	biological process	IEA
GO:0016605	PML body	cellular component	IDA[9294197]
GO:0051216	cartilage development	biological process	IDA[21547890]
GO:0008285	negative regulation of cell proliferation	biological process	IEA
GO:0009952	anterior/posterior pattern specification	biological process	IEA
GO:0045600	positive regulation of fat cell differentiation	biological process	IMP[21547890]
GO:0048133	male germ-line stem cell asymmetric division	biological process	IEA
GO:0016607	nuclear speck	cellular component	IDA[8541544]

ZBTB16 related KEGG pathways (count: 2)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa05200	pathways in_cancer	Pathways in cancer
hsa05221	acute myeloid_leukemia	Acute myeloid leukemia	Two major types of genetic events are crucial for the molecu...... Two major types of genetic events are crucial for the molecular pathogenesis of acute myeloid leukemias (AML) : activating mutations of signal transduction intermediates and alterations in myeloid transcription factors governing hematopoietic differentiation. Both aberrant and constitutive activation of signal transduction molecules are found in about 50% of primary AML bone marrow samples, and seem to contribute to the increased proliferation and apoptosis resistance. The most common of these activating events were observed in the RTK Flt3, in N-Ras and K-Ras, in Kit, and sporadically in other RTKs. Specific haematopoietic transcription factors are crucial for differentiation to particular lineages during normal differentiation, but are frequently disrupted in AML. Some mechanisms of disruption involve the effect of fusion proteins that are generated by chromosomal translocations on haematopoietic transcription factors. In other cases, the transcription factors themselves are mutated. More...

ZBTB16 related BioCarta pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped BioCarta pathways
EGFR_SMRTE_PATHWAY	egfr smrte_pathway	Map Kinase Inactivation of SMRT Corepressor	Corepressors are coregulators that interact with transcripti...... Corepressors are coregulators that interact with transcriptional silencers in a variety of pathways such as cell proliferation, differentiation and apoptosis. Abnormal corepressor-silencer interactions have been implicated in a variety of human disease pathways including several types of leukemia. The regulation of the SMRT corepressor via the p38 and Mek-1 Kinase pathway is shown in this diagram. The EFG receptor represents one mechanism by which SMRT function is inhibited by the tyrosine kinase signaling pathway. The MEKK1 and p38 pathways are activated by EGF resulting in cross-regulation of SMRT. The induction of SMRT phosphorylation by each pathway is shown, causing SMRT to unbind from the transcription factor complexes represented by RXR, RAR, T3R and PLZF. More...

ZBTB16 related Reactome pathways (count: 0)

ZBTB16 related interactors from protein-protein interaction data in HPRD (count: 84)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
ZBTB16	CDK1	No	in vitro;in vivo	10497277
ZBTB16	TERF1	No	yeast 2-hybrid	16169070
ZBTB16	PAFAH1B3	No	yeast 2-hybrid	16169070
ZBTB16	GATA2	No	in vitro;in vivo	11964310
ZBTB16	EP300	Yes	in vitro;in vivo	15964811
ZBTB16	FCHO1	No	yeast 2-hybrid	16169070
ZBTB16	GSTM4	Yes	yeast 2-hybrid	16169070
ZBTB16	GATA1	Yes	in vitro;in vivo	12242665
ZBTB16	HDAC6	No	in vitro;in vivo	15467736
ZBTB16	FAM101B	No	yeast 2-hybrid	16169070
ZBTB16	TXNIP	No	in vitro;in vivo;yeast 2-hybrid	12821938
ZBTB16	RUNX1T1	No	in vitro;in vivo;yeast 2-hybrid	10688654 , 11090081
ZBTB16	PMAIP1	No	yeast 2-hybrid	16169070
ZBTB16	MAP3K3	No	yeast 2-hybrid	16169070
ZBTB16	BMI1	No	in vitro;in vivo	12408802
ZBTB16	RB1	No	yeast 2-hybrid	15949438
ZBTB16	HDAC7	No	in vitro	11929873
ZBTB16	ESR1	Yes	in vitro	14521715
ZBTB16	HDAC4	No	in vitro;in vivo	15467736 , 11929873
ZBTB16	EEF1A1	No	in vitro;in vivo;yeast 2-hybrid	16828757
ZBTB16	GNE	No	in vitro;yeast 2-hybrid	17118363
ZBTB16	HEATR2	No	yeast 2-hybrid	16169070
ZBTB16	ZBTB32	No	in vivo;yeast 2-hybrid	10572087
ZBTB16	BCL6	Yes	in vitro;in vivo;yeast 2-hybrid	11175338
ZBTB16	PML	No	in vitro;in vivo;yeast 2-hybrid	9294197 , 11175338
ZBTB16	PGAM5	No	yeast 2-hybrid	16169070
ZBTB16	KRTAP4-12	No	yeast 2-hybrid	16189514
ZBTB16	PLSCR1	Yes	yeast 2-hybrid	16189514
ZBTB16	ICAM3	No	yeast 2-hybrid	16169070
ZBTB16	VTA1	No	yeast 2-hybrid	16189514
ZBTB16	KIAA1549	No	yeast 2-hybrid	16169070
ZBTB16	TRAF2	No	yeast 2-hybrid	16189514
ZBTB16	TOLLIP	Yes	yeast 2-hybrid	16169070
ZBTB16	SPOP	No	yeast 2-hybrid	16189514
ZBTB16	VDR	No	in vitro;in vivo	12460926 , 11719366 , 14521715
ZBTB16	PSMD2	No	yeast 2-hybrid	16169070
ZBTB16	RXRA	Yes	in vitro	8622986
ZBTB16	WDR33	No	yeast 2-hybrid	16169070
ZBTB16	FSHR	No	yeast 2-hybrid	15196694
ZBTB16	PSMD11	Yes	yeast 2-hybrid	16169070
ZBTB16	HDAC5	Yes	in vitro;in vivo	15467736 , 11929873
ZBTB16	RARA	No	in vitro;yeast 2-hybrid	14521715
ZBTB16	ATP7B	No	in vitro;yeast 2-hybrid	16676348
ZBTB16	SMAD3	No	yeast 2-hybrid	15231748
ZBTB16	CD81	No	yeast 2-hybrid	16169070
ZBTB16	AGTR2	No	in vitro;yeast 2-hybrid	14657020
ZBTB16	DPM1	No	yeast 2-hybrid	16169070
ZBTB16	ACP5	No	yeast 2-hybrid	16169070
ZBTB16	NCOR2	No	in vitro;in vivo;yeast 2-hybrid	9256429 , 14982881
ZBTB16	CCDC85B	No	yeast 2-hybrid	16189514
ZBTB16	NCOR1	No	in vitro;in vivo;yeast 2-hybrid	9531570
ZBTB16	HDAC1	No	in vitro;in vivo	9627120 , 15467736
ZBTB16	PNRC2	No	yeast 2-hybrid	16169070
ZBTB16	THNSL2	No	yeast 2-hybrid	16169070
ZBTB16	NR3C1	Yes	in vitro	14521715
ZBTB16	GCSH	No	yeast 2-hybrid	16169070
ZBTB16	TRIM27	No	yeast 2-hybrid	16189514
ZBTB16	HBXIP	No	yeast 2-hybrid	16169070
ZBTB16	IL6	Yes	yeast 2-hybrid	16169070
ZBTB16	CEP72	No	yeast 2-hybrid	16189514
ZBTB16	EIF2S2	No	yeast 2-hybrid	16169070
ZBTB16	CCDC109B	No	yeast 2-hybrid	16169070
ZBTB16	CIDEA	No	yeast 2-hybrid	16169070
ZBTB16	HDAC9	No	in vitro	12590135
ZBTB16	HBEGF	No	in vitro;in vivo;yeast 2-hybrid	14597771 , 15219838
ZBTB16	COQ6	No	yeast 2-hybrid	16169070
ZBTB16	LYAR	No	yeast 2-hybrid	16169070
ZBTB16	LDOC1	No	yeast 2-hybrid	16189514
ZBTB16	CEP70	No	yeast 2-hybrid	16189514
ZBTB16	DLST	No	yeast 2-hybrid	16169070
ZBTB16	QTRT1	No	yeast 2-hybrid	16169070
ZBTB16	MAGEA11	No	yeast 2-hybrid	16189514
ZBTB16	SIN3A	No	in vitro;in vivo	9627120 , 11719366
ZBTB16	ENOX1	No	yeast 2-hybrid	16189514
ZBTB16	SP1	No	in vitro;in vivo	12004059
ZBTB16	ANAPC5	No	yeast 2-hybrid	16169070
ZBTB16	SIN3B	No	in vitro;in vivo	9627120
ZBTB16	LSM2	No	yeast 2-hybrid	16169070
ZBTB16	ZBTB16	Yes	in vitro;in vivo;yeast 2-hybrid	11929873 , 8622986
ZBTB16	ZNF24	No	yeast 2-hybrid	16169070
ZBTB16	EPN1	No	in vitro;in vivo;yeast 2-hybrid	10791968
ZBTB16	CCDC130	No	yeast 2-hybrid	16169070
ZBTB16	FHL2	No	in vitro;in vivo;yeast 2-hybrid	12145280
ZBTB16	RAB27A	No	yeast 2-hybrid	16169070

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped BioCarta pathways