MK4MDD

KEGG Pathway Report

Basic Information
ID hsa05221
Name acute myeloid_leukemia
Brief Description Acute myeloid leukemia
Full Description Two major types of genetic events are crucial for the molecular pathogenesis of acute myeloid leukemias (AML) : activating mutations of signal transduction intermediates and alterations in myeloid transcription factors governing hematopoietic differentiation. Both aberrant and constitutive activation of signal transduction molecules are found in about 50% of primary AML bone marrow samples, and seem to contribute to the increased proliferation and apoptosis resistance. The most common of these activating events were observed in the RTK Flt3, in N-Ras and K-Ras, in Kit, and sporadically in other RTKs. Specific haematopoietic transcription factors are crucial for differentiation to particular lineages during normal differentiation, but are frequently disrupted in AML. Some mechanisms of disruption involve the effect of fusion proteins that are generated by chromosomal translocations on haematopoietic transcription factors. In other cases, the transcription factors themselves are mutated.

hsa05221 related genes in MK4MDD (count: 11)
Approved Symbol Approved Name Type No. of Studies (Positive/Negative)
ZBTB16 zinc finger and BTB domain containing 16 Literature-origin 1(1/0)
CCND1 cyclin D1 Literature-origin 1(1/0)
MTOR mechanistic target of rapamycin (serine/threonine kinase) Protein mapped 0(0/0)
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog Protein mapped 0(0/0)
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) Literature-origin 1(1/0)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Protein mapped 0(0/0)
MAPK1 mitogen-activated protein kinase 1 Literature-origin 2(2/0)
SPI1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 Protein mapped 0(0/0)
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 Protein mapped 0(0/0)
KRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog Protein mapped 0(0/0)
HRAS v-Ha-ras Harvey rat sarcoma viral oncogene homolog Protein mapped 0(0/0)