MK4MDD

Gene Report

Basic Information
Approved Symbol IL6
Approved Name interleukin 6 (interferon, beta 2)
Previous Symbol IFNB2
Symbol Alias IL-6, BSF2, HGF, HSF
Location 7p21-p15
Position chr7:22771193-22771621 (+)
External Links Entrez Gene: 3569
Ensembl: ENSG00000136244
UCSC: uc003svj.4
HGNC ID: 6018
No. of Studies (Positive/Negative) 2(1/1) Help
Type Literature-origin; Protein mapped

Positive relationships between IL6 and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description Help
IL6 Carvalho LA, 2014 patients and normal controls FC=7.9; P-value=0.016 Thirty-four of the 47 monocyte inflammatory-related genes w...... Thirty-four of the 47 monocyte inflammatory-related genes were significantly upregulated and 2 were significantly downregulated as compared to controls More...

Positive relationships between IL6 and other components at different levels (count: 0) Help
Positive relationship network of IL6 in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between IL6 and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description
IL6 Hong CJ, 2005 Patients and nomal controls No significant differences were demonstrated for the genoty...... No significant differences were demonstrated for the genotype or allele frequency of the IL-6 polymorphism when comparing the MDD and control groups More...

Negative relationships between IL6 and other components at different levels (count: 0) Help
IL6 related SNPs in MK4MDD (count: 0)
IL6 related proteins in MK4MDD (count: 1)
IL6 related GO terms (count: 104)
IL6 related KEGG pathways (count: 11)
IL6 related BioCarta pathways (count: 11)
IL6 related Reactome pathways (count: 0)
IL6 related interactors from protein-protein interaction data in HPRD (count: 5)