Protein Report

Protein Name	Interleukin-6
UniPortKB	P05231
No. of Studies (Positive/Negative)	17 (15/2)
Type	Literature-origin

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
IL-6	Alesci, 2005	patients and normal controls	P-value<0.05	MDD patients had significant mean IL-6 elevations from 1000-...... MDD patients had significant mean IL-6 elevations from 1000-1200 h and at 1500 h (P ranging from <0.05 to <0.01) vs. controls. More...
interleukin-6 (IL-6)	Motivala, 2005	patients and normal controls	P-value<0.05	As compared with matched controls, depressed patients showed...... As compared with matched controls, depressed patients showed significant (p <.05) nocturnal elevations of circulating levels of IL-6 and sICAM. More...
IL-6	Pike, 2006	patients and normal controls	P-value<0.05	As compared to controls, patients with major depressive diso...... As compared to controls, patients with major depressive disorder showed lower NK activity (p = .05) and higher circulating levels of IL-6 (p < .05). More...
IL-6	Marques-Deak, 2007	patients and normal controls		Evaluations of serum IL-1beta, IL-6, IFN-gamma and cortisol ...... Evaluations of serum IL-1beta, IL-6, IFN-gamma and cortisol were performed on both groups. Patients were evaluated prior and after antidepressant treatment. After remission of the symptoms, patients with MDD evolved with enhancement of cytokine levels, but no differences were observed in cortisol levels. More...
interleukin-6	Wichers, 2006	high-risk people		Baseline soluble interleukin-2 receptor (sIL-2r), interleuki...... Baseline soluble interleukin-2 receptor (sIL-2r), interleukin-6 (IL-6), and interleukin-10 (IL-10) concentrations were significantly increased in the five subjects that developed MDD during treatment compared with those that did not, with standardized effect sizes of 1.08, 1.16, and 1.25, respectively, controlling for marijuana use, cigarette smoking, and baseline level of depressive symptoms. More...
IL-6	Pace, 2006	patients and normal controls		Trier Social Stress Test-induced increases in IL-6 and NF-ka...... Trier Social Stress Test-induced increases in IL-6 and NF-kappaB DNA-binding were greater in major depression patients with increased early life stress and independently correlated with depression severity, but not early life stress. More...
IL6	Leo, 2006	patients and normal controls		Compared with control subjects, MDD patients had higher base...... Compared with control subjects, MDD patients had higher baseline levels of IL6 More...
interleukin [IL]-6	Kim, 2007	patients and normal controls		At admission, IL-6, TNF-alpha, TGF-beta1 production, and IFN...... At admission, IL-6, TNF-alpha, TGF-beta1 production, and IFN-gamma/IL-4 ratio were significantly higher in MDD patients. After treatment, IL-6 and TGF-beta1 production were significantly lower than before treatment. More...
interleukin-6	Soygur, 2007	patients and normal controls		Breast cancer patients with major depression had markedly hi...... Breast cancer patients with major depression had markedly higher plasma levels of interleukin-6 than the other group More...
interleukin [IL]-6	Kim, 2008	patients and normal controls	P-value<0.001	Non-suicidal MDD patients had significantly higher IL-6 prod...... Non-suicidal MDD patients had significantly higher IL-6 production than suicidal MDD patients and normal controls (p<0.001). HDRS(Hamilton's depression rating scale) scores had significant positive correlations with IL-6. More...
IL-6	Su, 2009	high-risk people	P-value<0.001	An association was observed between severity of current depr...... An association was observed between severity of current depressive symptoms and increased levels of inflammatory markers (p < .001 for IL-6 and p = .005 for CRP). More...
IL-6	Dhabhar, 2009	patients and normal controls	P-value=0.05, Cohen's d=0.50	Depressed subjects showed significantly lower IL-10 (p=0.03,...... Depressed subjects showed significantly lower IL-10 (p=0.03, Cohen's d=-0.96), non-significantly higher IL-6, and significantly higher IL-6/IL-10 ratios (p=0.05, Cohen's d=0.50). More...
IL-6	Yoshimura, 2010	patients and normal controls		The plasma IL-6 levels in the dysthymic group and major depr...... The plasma IL-6 levels in the dysthymic group and major depression group were significantly higher than those in the control group. More...
IL-6	Hughes MM, 2012	patients and normal controls		Whilst no changes in TNF-alpha or IL-1beta were observed, pl...... Whilst no changes in TNF-alpha or IL-1beta were observed, plasma concentrations of IL-6, IFN-gamma and CRP were increased in the depressed cohort. More...
interleukin-6	Crnkovic D, 2012	patients and normal controls		Study results showed a statistically significant difference ...... Study results showed a statistically significant difference in the concentrations of inflammatory markers (C-reactive protein (CRP), interleukin-6 and tumor necrosis factor alpha) between the group of MDD subjects and control group of healthy subjects. These concentrations were higher in MDD subjects. More...

Name in Literature	Related Components
	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
interleukin-6 (IL-6)		Rapid eye movement (REM) sleep(rapid eye movement (REM) sleep)	neurobiological system	Motivala, 2005	patients and normal controls	P-value<0.05	Both sleep latency and rapid eye movement (REM) density had ...... Both sleep latency and rapid eye movement (REM) density had moderate correlations with IL-6 and sICAM (r's > or = 0.30). Backward regression analyses indicated that sleep latency (beta = 0.34, p <.05) and REM density (beta = 0.27, p = .09) were better predictors of IL-6 than depressive status. More...
interleukin [IL]-6		Suicide(suicide)	symptoms	Kim, 2008	patients and normal controls	P-value<0.001	Non-suicidal MDD patients had significantly higher IL-6 prod...... Non-suicidal MDD patients had significantly higher IL-6 production than suicidal MDD patients and normal controls (p<0.001). More...

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Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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Name in Literature	Reference	Research Type	Statistical Result	Relation Description
interleukin [IL]-6	Gabbay, 2009	patients and normal controls	P-value=0.09	A trend for IL-6 to be elevated in the MDD group was also ob...... A trend for IL-6 to be elevated in the MDD group was also observed (1.52+/-2.88 pg/ml versus 0.49+/-0.90 pg/ml; p=0.09). More...
interleukin-6	Einvik G, 2012	patients and normal controls		Group comparisons revealed no significant difference in the ...... Group comparisons revealed no significant difference in the levels of 17 cytokines [interleukin-1beta, -2,-4, -5, -6, -7, -8, -10, -12(p70), -13 and -17; tumor necrosis factor-alpha; interferon-gamma; granulocyte colony-stimulating factor; granulocyte-monocyte colony-stimulating factor; macrophage chemoattractant protein-1 and monocyte inhibitory protein-1beta] between persons with (n=34) and without MDD (n=68) More...

Gene Symbol	Gene Name	Type	No. of Studies (Positive/Negative)	Add to Relationship Set
IL6	interleukin 6 (interferon, beta 2)	Literature-origin; Protein mapped	1 (0/1)