MK4MDD

Protein Report

Basic Information
Protein Name Interleukin-6
UniPortKB P05231
No. of Studies (Positive/Negative) 18 (16/2) Help
Type Literature-origin
Positive relationship between Interleukin-6 and MDD (count: 15)
Name in Literature Reference Research Type Statistical Result Relation Description Help
IL-6 Alesci, 2005 patients and normal controls P-value<0.05 MDD patients had significant mean IL-6 elevations from 1000-...... MDD patients had significant mean IL-6 elevations from 1000-1200 h and at 1500 h (P ranging from <0.05 to <0.01) vs. controls. More...
interleukin-6 (IL-6) Motivala, 2005 patients and normal controls P-value<0.05 As compared with matched controls, depressed patients showed...... As compared with matched controls, depressed patients showed significant (p <.05) nocturnal elevations of circulating levels of IL-6 and sICAM. More...
IL-6 Pike, 2006 patients and normal controls P-value<0.05 As compared to controls, patients with major depressive diso...... As compared to controls, patients with major depressive disorder showed lower NK activity (p = .05) and higher circulating levels of IL-6 (p < .05). More...
IL-6 Marques-Deak, 2007 patients and normal controls Evaluations of serum IL-1beta, IL-6, IFN-gamma and cortisol ...... Evaluations of serum IL-1beta, IL-6, IFN-gamma and cortisol were performed on both groups. Patients were evaluated prior and after antidepressant treatment. After remission of the symptoms, patients with MDD evolved with enhancement of cytokine levels, but no differences were observed in cortisol levels. More...
interleukin-6 Wichers, 2006 high-risk people Baseline soluble interleukin-2 receptor (sIL-2r), interleuki...... Baseline soluble interleukin-2 receptor (sIL-2r), interleukin-6 (IL-6), and interleukin-10 (IL-10) concentrations were significantly increased in the five subjects that developed MDD during treatment compared with those that did not, with standardized effect sizes of 1.08, 1.16, and 1.25, respectively, controlling for marijuana use, cigarette smoking, and baseline level of depressive symptoms. More...
IL-6 Pace, 2006 patients and normal controls Trier Social Stress Test-induced increases in IL-6 and NF-ka...... Trier Social Stress Test-induced increases in IL-6 and NF-kappaB DNA-binding were greater in major depression patients with increased early life stress and independently correlated with depression severity, but not early life stress. More...
IL6 Leo, 2006 patients and normal controls Compared with control subjects, MDD patients had higher base...... Compared with control subjects, MDD patients had higher baseline levels of IL6 More...
interleukin [IL]-6 Kim, 2007 patients and normal controls At admission, IL-6, TNF-alpha, TGF-beta1 production, and IFN...... At admission, IL-6, TNF-alpha, TGF-beta1 production, and IFN-gamma/IL-4 ratio were significantly higher in MDD patients. After treatment, IL-6 and TGF-beta1 production were significantly lower than before treatment. More...
interleukin-6 Soygur, 2007 patients and normal controls Breast cancer patients with major depression had markedly hi...... Breast cancer patients with major depression had markedly higher plasma levels of interleukin-6 than the other group More...
interleukin [IL]-6 Kim, 2008 patients and normal controls P-value<0.001 Non-suicidal MDD patients had significantly higher IL-6 prod...... Non-suicidal MDD patients had significantly higher IL-6 production than suicidal MDD patients and normal controls (p<0.001). HDRS(Hamilton's depression rating scale) scores had significant positive correlations with IL-6. More...
IL-6 Su, 2009 high-risk people P-value<0.001 An association was observed between severity of current depr...... An association was observed between severity of current depressive symptoms and increased levels of inflammatory markers (p < .001 for IL-6 and p = .005 for CRP). More...
IL-6 Dhabhar, 2009 patients and normal controls P-value=0.05, Cohen's d=0.50 Depressed subjects showed significantly lower IL-10 (p=0.03,...... Depressed subjects showed significantly lower IL-10 (p=0.03, Cohen's d=-0.96), non-significantly higher IL-6, and significantly higher IL-6/IL-10 ratios (p=0.05, Cohen's d=0.50). More...
IL-6 Yoshimura, 2010 patients and normal controls The plasma IL-6 levels in the dysthymic group and major depr...... The plasma IL-6 levels in the dysthymic group and major depression group were significantly higher than those in the control group. More...
IL-6 Hughes MM, 2012 patients and normal controls Whilst no changes in TNF-alpha or IL-1beta were observed, pl...... Whilst no changes in TNF-alpha or IL-1beta were observed, plasma concentrations of IL-6, IFN-gamma and CRP were increased in the depressed cohort. More...
interleukin-6 Crnkovic D, 2012 patients and normal controls Study results showed a statistically significant difference ...... Study results showed a statistically significant difference in the concentrations of inflammatory markers (C-reactive protein (CRP), interleukin-6 and tumor necrosis factor alpha) between the group of MDD subjects and control group of healthy subjects. These concentrations were higher in MDD subjects. More...

Positive relationships between Interleukin-6 and other components at different levels (count: 3) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment

Positive relationship network of Interleukin-6 in MK4MDD
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1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Interleukin-6 and MDD (count: 2)
Name in Literature Reference Research Type Statistical Result Relation Description
interleukin [IL]-6 Gabbay, 2009 patients and normal controls P-value=0.09 A trend for IL-6 to be elevated in the MDD group was also ob...... A trend for IL-6 to be elevated in the MDD group was also observed (1.52+/-2.88 pg/ml versus 0.49+/-0.90 pg/ml; p=0.09). More...
interleukin-6 Einvik G, 2012 patients and normal controls Group comparisons revealed no significant difference in the ...... Group comparisons revealed no significant difference in the levels of 17 cytokines [interleukin-1beta, -2,-4, -5, -6, -7, -8, -10, -12(p70), -13 and -17; tumor necrosis factor-alpha; interferon-gamma; granulocyte colony-stimulating factor; granulocyte-monocyte colony-stimulating factor; macrophage chemoattractant protein-1 and monocyte inhibitory protein-1beta] between persons with (n=34) and without MDD (n=68) More...

Negative relationships between Interleukin-6 and other components at different levels (count: 0) Help
Related Gene Info
Gene Symbol Gene Name Type No. of Studies (Positive/Negative) Add to Relationship Set
IL6 interleukin 6 (interferon, beta 2) Literature-origin; Protein mapped 2 (1/1)