Study Report
Reference
| Citation | Leo, 2006 PubMed |
| Full Info | Leo, R., Di Lorenzo, G., Tesauro, M., Razzini, C., Forleo, G.B., Chiricolo, G., Cola, C., Zanasi, M., Troisi, A., Siracusano, A. et al. (2006) Association between enhanced soluble CD40 ligand and proinflammatory and prothrombotic states in major depressive disorder: pilot observations on the effects of selective serotonin reuptake inhibitor therapy. J Clin Psychiatry, 67, 1760-1766.
|
Study
| Hypothesis or Background |
Major depressive disorder (MDD) is associated with low-grade inflammation, and it is considered a risk factor for coronary artery disease (CAD). CD40 ligand (CD40L) plays an important role in inflammation, platelet activation, and clotting system activation. We investigated soluble CD40L (sCD40L) expression in MDD and assessed whether it may represent a molecular mechanism that links inflammation and a prothrombotic state and whether this condition may be modified by selective serotonin reuptake inhibitor (SSRI) therapy.
|
| Sample Information | 46 drug-naive, first-episode MDD patients without conventional CAD risk factors and in 46 matched healthy controls |
|---|
| Method Detail | Levels of sCD40L, interleukin-1beta (IL-1beta), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), soluble P-selectin (sP-selectin), activated factor VII (FVIIa), and prothrombin fragment 1+2 (F1+2) were measured in 46 drug-naive, first-episode MDD patients without conventional CAD risk factors and in 46 matched healthy controls. Participants were screened between March 2002 and November 2005. Twenty of the 46 MDD patients were then randomly assigned to either sertraline 100 mg/day (N = 10) or citalopram 20 mg/day (N = 10); the aforementioned variables were measured at baseline and after 6 weeks of treatment. |
| Method Keywords | protein analysis |
| Result | Compared with control subjects, MDD patients had higher baseline levels of sCD40L, IL-1beta, IL-6, TNF-alpha, sP-selectin, FVIIa, and F1+2. In the clinical group, sCD40L levels, HAM-D total scores, and proinflammatory markers were strongly intercorrelated. In contrast, there were no significant correlations in the control group. Mood improvement achieved with SSRI therapy was associated with significant reduction in sCD40L, proinflammatory markers, and prothrombotic markers expression. (All p values < .0001.) |
| Conclusions | This pilot study shows that CD40/ CD40L pathway up-regulation in MDD patients relates increased levels of sCD40L to a prothrombotic state and, preliminarily, indicates that SSRI therapy may significantly reduce sCD40L and CD40L levels associated with proinflammatory and prothrombotic states. |
Relationships reported by
Leo, 2006
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
Prothrombin (prothrombin fragment 1+2 (F1+2)) |
protein |
|
Compared with control subjects, MDD patients had higher baseline levels of F1+2 |
Positive
|
|
MDD
|
syndrome |
Interleukin-6 (IL6) |
protein |
|
Compared with control subjects, MDD patients had higher baseline levels of IL6 |
Positive
|
|
MDD
|
syndrome |
Tumor necrosis factor (TNF-¦Á) |
protein |
|
Compared with control subjects, MDD patients had higher baseline levels of TNF-¦Á |
Positive
|
|
MDD
|
syndrome |
P-selectin (P-selectin) |
protein |
|
Compared with control subjects, MDD patients had higher baseline levels of soluble P-selectin |
Positive
|
|
MDD
|
syndrome |
Coagulation factor VII (activated factor VII (FVIIa)) |
protein |
|
Compared with control subjects, MDD patients had higher baseline levels of FVIIa |
Positive
|
|
MDD
|
syndrome |
Interleukin-1 beta (IL1-¦Â) |
protein |
|
Compared with control subjects, MDD patients had higher baseline levels of IL1-¦Â |
Positive
|
|
MDD
|
syndrome |
CD40 ligand (CD40L) |
protein |
|
Compared with control subjects, MDD patients had higher baseline levels of soluble CD40L |
Positive
|
