BioCarta Pathway Report
Basic Information
| ID |
IL17_PATHWAY
|
| Name |
il17 pathway
|
| Brief Description |
IL 17 Signaling Pathway
|
| Full Description |
Inflammation is a complex response involving many different cells and signaling molecules, including the secretion of the cytokine IL-17 by activated T cells. IL-17 secretion is restricted to specific subsets of T cells but the receptor for IL-17 is widely expressed throughout the body, including fibroblasts and epithelial cells. Inflammatory responses involving IL-17 probably contribute to arthritis, asthma, skin immune reactions and autoimmune disorders. Fibroblasts and other cells stimulated by IL-17 are induced themselves to secrete inflammatory and hematopoietic cytokines, including IL-6, IL-8, G-CSF and Stem Cell Factor (SCF). These cytokines in turn provoke a range of activities, including the stimulation of neutrophil proliferation and differentiation. |
IL17_PATHWAY related genes in MK4MDD (count: 5)
| Approved Symbol |
Approved Name |
Type |
No. of Studies (Positive/Negative) |
| IL8 |
interleukin 8 |
Literature-origin
|
1(1/0) |
| CSF3 |
colony stimulating factor 3 (granulocyte) |
Protein mapped
|
0(0/0) |
| IL3 |
interleukin 3 (colony-stimulating factor, multiple) |
Literature-origin
|
1(1/0) |
| IL6 |
interleukin 6 (interferon, beta 2) |
Literature-origin; Protein mapped
|
1(0/1) |
| IL17A |
interleukin 17A |
Protein mapped
|
0(0/0) |
