MK4MDD

Gene Report

Basic Information
Approved Symbol IL8
Approved Name interleukin 8
Symbol Alias SCYB8, LUCT, LECT, MDNCF, TSG-1, CXCL8, IL-8, NAP-1, 3-10C, MONAP, AMCF-I, LYNAP, NAF, b-ENAP, GCP-1, K60, GCP1, NAP1
Name Alias "chemokine (C-X-C motif) ligand 8", "neutrophil-activating peptide 1", "granulocyte chemotactic protein 1", "monocyte-derived neutrophil chemotactic factor", "lung giant cell carcinoma-derived chemotactic protein", "tumor necrosis factor-induced gene 1", "monocyte-derived neutrophil-activating peptide", "lymphocyte derived neutrophil activating peptide", "beta endothelial cell-derived neutrophil activating peptide", "alveolar macrophage chemotactic factor I"
Location 4q13-q21
Position chr4:74608182-74609433 (+)
External Links Entrez Gene: 3576
Ensembl: ENSG00000169429
UCSC: uc003hhe.3
HGNC ID: 6025
No. of Studies (Positive/Negative) 2(2/0) Help
Type Literature-origin; Protein mapped

Positive relationships between IL8 and MDD (count: 2)
Name in Literature Reference Research Type Statistical Result Relation Description Help
IL-8 Shelton, 2011 patients and normal controls Gene set analysis suggested up-regulation of a variety of pr...... Gene set analysis suggested up-regulation of a variety of pro- and anti-inflammatory cytokines, including interleukin 1alpha (IL-1alpha), IL-2, IL-3, IL-5, IL-8, IL-9, IL-10, IL-12A, IL-13, IL-15, IL-18, interferon gamma (IFNgamma), and lymphotoxin alpha (TNF superfamily member 1). More...
IL8 Carvalho LA, 2014 patients and normal controls FC=2.7; P-value=0.004 Thirty-four of the 47 monocyte inflammatory-related genes w...... Thirty-four of the 47 monocyte inflammatory-related genes were significantly upregulated and 2 were significantly downregulated as compared to controls More...

Positive relationships between IL8 and other components at different levels (count: 0) Help
Positive relationship network of IL8 in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between IL8 and MDD (count: 0)
Negative relationships between IL8 and other components at different levels (count: 0) Help
IL8 related SNPs in MK4MDD (count: 0)
IL8 related proteins in MK4MDD (count: 1)
IL8 related GO terms (count: 37)
IL8 related KEGG pathways (count: 8)
IL8 related BioCarta pathways (count: 9)
IL8 related Reactome pathways (count: 6)
IL8 related interactors from protein-protein interaction data in HPRD (count: 12)