Reactome Pathway Report

Basic Information
Name peptide ligand_binding_receptors
Description These receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.

REACT_14819 related genes in MK4MDD (count: 35)
Approved Symbol Approved Name Type No. of Studies (Positive/Negative)
PENK proenkephalin Literature-origin 1(1/0)
PROK2 prokineticin 2 Literature-origin 1(1/0)
NTSR2 neurotensin receptor 2 Literature-origin 1(1/0)
HCRTR1 hypocretin (orexin) receptor 1 Literature-origin; SNP mapped 2(2/0)
CCKAR cholecystokinin A receptor Literature-origin 1(1/0)
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) Literature-origin; SNP mapped 1(1/0)
F2 coagulation factor II (thrombin) Protein mapped 0(0/0)
BDKRB1 bradykinin receptor B1 Protein mapped 0(0/0)
IL8 interleukin 8 Literature-origin; Protein mapped 2(2/0)
OXT oxytocin/neurophysin I prepropeptide Protein mapped 0(0/0)
CCL7 chemokine (C-C motif) ligand 7 Literature-origin 1(1/0)
PDYN prodynorphin Protein mapped 0(0/0)
AVPR1B arginine vasopressin receptor 1B Literature-origin; Protein mapped 1(1/0)
OPRM1 opioid receptor, mu 1 Literature-origin; SNP mapped; Protein mapped 2(1/1)
BDKRB2 bradykinin receptor B2 SNP mapped 0(0/0)
CCKBR cholecystokinin B receptor Literature-origin 2(2/0)
SSTR5 somatostatin receptor 5 Literature-origin 1(1/0)
CXCL2 chemokine (C-X-C motif) ligand 2 Literature-origin 1(1/0)
POMC proopiomelanocortin Protein mapped 0(0/0)
PROKR2 prokineticin receptor 2 Literature-origin 1(1/0)
SST somatostatin Literature-origin; Protein mapped 3(3/0)
NPY1R neuropeptide Y receptor Y1 Literature-origin 1(1/0)
TAC1 tachykinin, precursor 1 Literature-origin; Protein mapped 2(2/0)
EDN1 endothelin 1 Literature-origin 1(1/0)
C3 complement component 3 Protein mapped 0(0/0)
CCL20 chemokine (C-C motif) ligand 20 Literature-origin 1(1/0)
CXCL3 chemokine (C-X-C motif) ligand 3 Literature-origin 1(1/0)
OXTR oxytocin receptor Literature-origin 1(1/0)
NPY neuropeptide Y Literature-origin; SNP mapped; Protein mapped 7(6/1)
CCL2 chemokine (C-C motif) ligand 2 Literature-origin; Protein mapped 3(2/1)
EDNRB endothelin receptor type B Literature-origin 1(1/0)
GAL galanin/GMAP prepropeptide Literature-origin 2(1/1)
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Protein mapped 0(0/0)
GALR2 galanin receptor 2 Literature-origin 1(1/0)
CCR6 chemokine (C-C motif) receptor 6 Literature-origin 1(1/0)