MK4MDD

Gene Report

Basic Information
Approved Symbol CCL2
Approved Name chemokine (C-C motif) ligand 2
Previous Symbol SCYA2
Previous Name "small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je)"
Symbol Alias MCP1, MCP-1, MCAF, SMC-CF, GDCF-2, HC11, MGC9434
Name Alias "monocyte chemotactic protein 1, homologous to mouse Sig-je", "monocyte chemoattractant protein-1", "monocyte chemotactic and activating factor", "monocyte secretory protein JE", "small inducible cytokine subfamily A (Cys-Cys), member 2"
Location 17q11.2-q21.1
Position chr17:32583847-32584222 (+)
External Links Entrez Gene: 6347
Ensembl: ENSG00000108691
UCSC: uc002hhy.3
HGNC ID: 10618
No. of Studies (Positive/Negative) 3(2/1) Help
Type Literature-origin; Protein mapped

Positive relationships between CCL2 and MDD (count: 2)
Name in Literature Reference Research Type Statistical Result Relation Description Help
MCP1 Pae, 2004 patients and normal controls We found significant differences in genotype and allele freq...... We found significant differences in genotype and allele frequencies. More...
CCL2 Carvalho LA, 2014 patients and normal controls FC=1.1; P-value=0.018 Thirty-four of the 47 monocyte inflammatory-related genes w...... Thirty-four of the 47 monocyte inflammatory-related genes were significantly upregulated and 2 were significantly downregulated as compared to controls More...

Positive relationships between CCL2 and other components at different levels (count: 0) Help
Positive relationship network of CCL2 in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between CCL2 and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description
MCP-1 Altamura AC, 2010 Patients and nomal controls chi(2) = 8.215; d.f. = 6; p = 0.223 No genotypic (chi(2) = 8.215, d.f. = 6, p = 0.223) or alleli...... No genotypic (chi(2) = 8.215, d.f. = 6, p = 0.223) or allelic (chi(2) = 5.058, d.f. = 3, p = 0.168) association for the A-2518G polymorphism of SCYA2 was found considering cases and controls. More...

Negative relationships between CCL2 and other components at different levels (count: 0) Help
CCL2 related SNPs in MK4MDD (count: 0)
CCL2 related proteins in MK4MDD (count: 1)
CCL2 related GO terms (count: 102)
CCL2 related KEGG pathways (count: 3)
CCL2 related BioCarta pathways (count: 1)
CCL2 related Reactome pathways (count: 4)
CCL2 related interactors from protein-protein interaction data in HPRD (count: 12)