
Gene Report
Approved Symbol | CCL2 |
---|---|
Approved Name | chemokine (C-C motif) ligand 2 |
Previous Symbol | SCYA2 |
Previous Name | small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je) |
Symbol Alias | MCP1, MCP-1, MCAF, SMC-CF, GDCF-2, HC11, MGC9434 |
Name Alias | monocyte chemotactic protein 1, homologous to mouse Sig-je, "monocyte chemoattractant protein-1", "monocyte chemotactic and activating factor", "monocyte secretory protein JE", "small inducible cytokine subfamily A (Cys-Cys), member 2" |
Location | 17q11.2-q21.1 |
Position | chr17:32582296-32584222 (+) |
External Links |
Entrez Gene: 6347 Ensembl: ENSG00000108691 UCSC: uc002hhy.3 HGNC ID: 10618 |
No. of Studies (Positive/Negative) | 2(1/1)
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Type | Literature-origin; SNP mapped; Protein mapped |
Name in Literature | Reference | Research Type | Statistical Result | Relation Description | ![]() |
---|---|---|---|---|---|
MCP1 | Pae, 2004 | patients and normal controls | We found significant differences in genotype and allele freq...... We found significant differences in genotype and allele frequencies. More... |
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1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus | Protein and Other Molecule | Cell and Molecular Pathway | Neural System | Cognition and Behavior | Symptoms and Signs | Environment | MDD |
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Name in Literature | Reference | Research Type | Statistical Result | Relation Description |
---|---|---|---|---|
MCP-1 | Altamura AC, 2010 | Patients and nomal controls | chi(2) = 8.215; d.f. = 6; p = 0.223 | No genotypic (chi(2) = 8.215, d.f. = 6, p = 0.223) or alleli...... No genotypic (chi(2) = 8.215, d.f. = 6, p = 0.223) or allelic (chi(2) = 5.058, d.f. = 3, p = 0.168) association for the A-2518G polymorphism of SCYA2 was found considering cases and controls. More... |
#rs | Location | Annotation | No. of Studies (Positive/Negative) | |
---|---|---|---|---|
rs1024611 | chr17:32579788(Forward) | downstream_gene_variant; upstream_gene_variant | 1(1/0) |
Approved Name | UniportKB | No. of Studies (Positive/Negative) | Source | |
---|---|---|---|---|
C-C motif chemokine 2 | P13500 | 2(1/1) | Literature-origin |
Literature-origin GO terms | ||||
ID | Name | Type | Evidence | |
---|---|---|---|---|
GO:0000165 | MAPK cascade | biological process | IMP | |
GO:0006954 | inflammatory response | biological process | IDA | |
GO:0043491 | protein kinase B signaling cascade | biological process | IMP |
Gene mapped GO terms | ||||
ID | Name | Type | Evidence | |
---|---|---|---|---|
GO:0009408 | response to heat | biological process | IEA | |
GO:0048246 | macrophage chemotaxis | biological process | IDA[12207323] | |
GO:0008009 | chemokine activity | molecular function | IEA | |
GO:0007165 | signal transduction | biological process | NAS[10770925] | |
GO:0005737 | cytoplasm | cellular component | IEA | |
GO:0019221 | cytokine-mediated signaling pathway | biological process | IDA[12207323] | |
GO:0005102 | receptor binding | molecular function | TAS[10542238] | |
GO:0071346 | cellular response to interferon-gamma | biological process | IEP[9407497]; ISS | |
GO:0046677 | response to antibiotic | biological process | IEA | |
GO:0006935 | chemotaxis | biological process | TAS[10623817] | |
GO:0001938 | positive regulation of endothelial cell proliferation | biological process | IEA | |
GO:0008201 | heparin binding | molecular function | IEA | |
GO:0050870 | positive regulation of T cell activation | biological process | ISS | |
GO:0009612 | response to mechanical stimulus | biological process | IEA | |
GO:0030968 | endoplasmic reticulum unfolded protein response | biological process | TAS | |
GO:0007010 | cytoskeleton organization | biological process | IDA[10072545] | |
GO:0044344 | cellular response to fibroblast growth factor stimulus | biological process | IEP[9407497] | |
GO:0050806 | positive regulation of synaptic transmission | biological process | IEA | |
GO:0019725 | cellular homeostasis | biological process | TAS[18334747] | |
GO:0005576 | extracellular region | cellular component | IDA; TAS | |
GO:0071356 | cellular response to tumor necrosis factor | biological process | IEP[9407497]; ISS | |
GO:0010759 | positive regulation of macrophage chemotaxis | biological process | IEA | |
GO:0048010 | vascular endothelial growth factor receptor signaling pathway | biological process | IEA | |
GO:0071222 | cellular response to lipopolysaccharide | biological process | ISS | |
GO:0006468 | protein phosphorylation | biological process | TAS[9670957] | |
GO:0009887 | organ morphogenesis | biological process | TAS[9364936] | |
GO:0031663 | lipopolysaccharide-mediated signaling pathway | biological process | IDA | |
GO:0006987 | activation of signaling protein activity involved in unfolded protein response | biological process | TAS | |
GO:0043025 | neuronal cell body | cellular component | IEA | |
GO:0007166 | cell surface receptor signaling pathway | biological process | TAS[9548499] | |
GO:0051384 | response to glucocorticoid stimulus | biological process | IEA | |
GO:0043200 | response to amino acid stimulus | biological process | IEA | |
GO:0007179 | transforming growth factor beta receptor signaling pathway | biological process | IEA | |
GO:0071347 | cellular response to interleukin-1 | biological process | IEP[9407497]; ISS | |
GO:0008360 | regulation of cell shape | biological process | IDA[10072545] | |
GO:0030593 | neutrophil chemotaxis | biological process | IEA | |
GO:0043066 | negative regulation of apoptotic process | biological process | IDA[12753088] | |
GO:0016525 | negative regulation of angiogenesis | biological process | IEA | |
GO:0048247 | lymphocyte chemotaxis | biological process | IEA | |
GO:0001666 | response to hypoxia | biological process | IEA | |
GO:0090265 | positive regulation of immune complex clearance by monocytes and macrophages | biological process | IEA | |
GO:0035684 | helper T cell extravasation | biological process | ISS | |
GO:0045471 | response to ethanol | biological process | IEA | |
GO:0007259 | JAK-STAT cascade | biological process | TAS[9670957] | |
GO:0019079 | viral genome replication | biological process | TAS[10985244] | |
GO:0006959 | humoral immune response | biological process | TAS[9548499] | |
GO:0007187 | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | biological process | TAS[10770925] | |
GO:0006874 | cellular calcium ion homeostasis | biological process | IEA | |
GO:0010574 | regulation of vascular endothelial growth factor production | biological process | IEA | |
GO:0051770 | positive regulation of nitric-oxide synthase biosynthetic process | biological process | ISS | |
GO:0032570 | response to progesterone stimulus | biological process | IEA | |
GO:0042493 | response to drug | biological process | IEA | |
GO:0004672 | protein kinase activity | molecular function | TAS[9973507] | |
GO:0014823 | response to activity | biological process | IEA | |
GO:0007155 | cell adhesion | biological process | TAS[10198043] | |
GO:2000427 | positive regulation of apoptotic cell clearance | biological process | ISS | |
GO:0070098 | chemokine-mediated signaling pathway | biological process | IEA | |
GO:0007568 | aging | biological process | IEA | |
GO:0031727 | CCR2 chemokine receptor binding | molecular function | ISS; TAS[18021937] | |
GO:0001525 | angiogenesis | biological process | TAS[18334747] | |
GO:0007186 | G-protein coupled receptor signaling pathway | biological process | TAS[10542238] | |
GO:0002548 | monocyte chemotaxis | biological process | IDA[12207323] | |
GO:0043615 | astrocyte cell migration | biological process | IDA[12271471] | |
GO:0009617 | response to bacterium | biological process | IEP[16034137] | |
GO:2000502 | negative regulation of natural killer cell chemotaxis | biological process | IDA[7545673] | |
GO:0031100 | organ regeneration | biological process | IEA | |
GO:0005615 | extracellular space | cellular component | IEA | |
GO:0010332 | response to gamma radiation | biological process | IEA | |
GO:0060137 | maternal process involved in parturition | biological process | IEA | |
GO:0071407 | cellular response to organic cyclic compound | biological process | IDA | |
GO:0033552 | response to vitamin B3 | biological process | IEA |
Gene mapped KEGG pathways | ||||
ID | Name | Brief Description | Full Description | |
---|---|---|---|---|
hsa04062 | chemokine signaling_pathway | Chemokine signaling pathway | Inflammatory immune response requires the recruitment of leu...... Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival. The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production. More... | |
hsa04621 | nod like_receptor_signaling_pathway | NOD-like receptor signaling pathway | Specific families of pattern recognition receptors are respo...... Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. These NLRs include NALP1, NALP3 and Ipaf. The inflammasomes are critical for generating mature proinflammatory cytokines in concert with Toll-like receptor signaling pathway. More... | |
hsa04060 | cytokine cytokine_receptor_interaction | Cytokine-cytokine receptor interaction | Cytokines are soluble extracellular proteins or glycoprotein...... Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped. More... |
Gene mapped BioCarta pathways | ||||
ID | Name | Brief Description | Full Description | |
---|---|---|---|---|
CCR5_PATHWAY | ccr5 pathway | Pertussis toxin-insensitive CCR5 Signaling in Macrophage | The chemokine receptors CCR5 and CXCR4 in macrophages are ac...... The chemokine receptors CCR5 and CXCR4 in macrophages are activated by their peptide ligands and also by the HIV envelope protein GP120 during HIV infection. One mechanism of signaling by these GPCRs is through activation of Gi signaling. These chemokine receptors can also signal through a Gi-independent pertussis toxin-insensitive pathway. This pathway elevates calcium influx into the cell through CRAC channels, ion channels that are activated by calcium release. Elevated calcium from CRAC is required for downstream activation of Pyk2, a focal adhesion-associated protein kinase. Non Gi signaling by these chemokine receptors also involves the Jnk and p38 Map kinase pathways leading to AP-1 activation and activation of genes such as MIP-1 and MCP-1. This pathway may be involved in the role of macrophages in the pathogenesis of AIDS. More... |
Gene mapped Reactome pathways | |||
ID | Name | Description | |
---|---|---|---|
REACT_14819 | peptide ligand_binding_receptors | These receptors, a subset of the Class A/1 (Rhodopsin-like) ...... These receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins. More... | |
REACT_14828 | class a1_rhodopsin_like_receptors | Rhodopsin-like receptors. They represent members which inclu...... Rhodopsin-like receptors. They represent members which include hormone, light and neurotransmitter receptors and encompass a wide range of functions including many autocrine, paracrine and endocrine processes. More... | |
REACT_15344 | chemokine receptors_bind_chemokines | Chemokine receptors are cytokine receptors found on the surf...... Chemokine receptors are cytokine receptors found on the surface of certain cells, which interact with a type of cytokine called a chemokine. Following interaction, these receptors trigger a flux of intracellular calcium which leads to chemotaxis. Chemokine receptors are divided into different families, CXC chemokine receptors, CC chemokine receptors, CX3C chemokine receptors and XC chemokine receptors that correspond to the 4 distinct subfamilies of chemokines they bind. More... | |
REACT_21340 | gpcr ligand_binding | There are more than 800 G-protein coupled receptor. GPCRs ar...... There are more than 800 G-protein coupled receptor. GPCRs are receptors for a diverse range of ligands from large proteins to photons and have an equal diverstiy of ligand-binding mechanisms. Classical GPCR signaling involves signal transduction via heterotrimeric G-proteins, however many G-protein independent mechanisms have been reported. More... |

Gene | Interactor | Interactor in MK4MDD? | Experiment Type | PMID | |
---|---|---|---|---|---|
CCL2 | CCRL1 | No | in vitro | 10734104 | |
CCL2 | CCBP2 | No | in vivo | 9364936 , 9405404 | |
CCL2 | CCR2 | No | in vitro;in vivo | 10529171 , 9287323 | |
CCL2 | CCR5 | No | in vivo | 10477718 | |
CCL2 | MMP3 | No | in vitro;in vivo | 12149192 , 9558113 | |
CCL2 | CCR10 | No | in vitro;in vivo | 9364936 , 10706668 | |
CCL2 | MMP1 | No | in vitro;in vivo | 12149192 , 9558113 | |
CCL2 | CCL2 | Yes | in vitro | 8639605 , 8989326 , 7651403 | |
CCL2 | DARC | No | in vitro;in vivo | 13679391 , 17416748 | |
CCL2 | MMP8 | No | in vitro;in vivo | 12149192 , 9558113 | |
CCL2 | VCAN | Yes | in vitro | 11083865 | |
CCL2 | CCR1 | No | in vitro | 8631787 |