Gene Report

Basic Information

Approved Symbol	VCAN
Approved Name	versican
Previous Symbol	CSPG2
Previous Name	chondroitin sulfate proteoglycan 2
Symbol Alias	PG-M
Name Alias	versican proteoglycan
Location	5q12-q14
Position	chr5:82767493-82878122 (+)
External Links	Entrez Gene: 1462 Ensembl: ENSG00000038427 UCSC: uc003kii.3 HGNC ID: 2464
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between VCAN and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
VCAN	Lewis, 2010	patients and normal controls	P-value <10 -5	associated with MDD(P <10 -5) associated with MDD(P <10 -5)

Positive relationships between VCAN and other components at different levels (count: 0)

Positive relationship network of VCAN in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between VCAN and MDD (count: 0)

Negative relationships between VCAN and other components at different levels (count: 0)

VCAN related SNPs in MK4MDD (count: 0)

VCAN related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Versican core protein	P13611	0(0/0)	Gene mapped

VCAN related GO terms (count: 22)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0030203	glycosaminoglycan metabolic process	biological process	TAS
GO:0005576	extracellular region	cellular component	TAS
GO:0008347	glial cell migration	biological process	IDA[18431253]
GO:0043202	lysosomal lumen	cellular component	TAS
GO:0005540	hyaluronic acid binding	molecular function	IEA
GO:0030246	carbohydrate binding	molecular function	IEA
GO:0005615	extracellular space	cellular component	IDA
GO:0005509	calcium ion binding	molecular function	IEA
GO:0030207	chondroitin sulfate catabolic process	biological process	TAS
GO:0031012	extracellular matrix	cellular component	IDA; ISS
GO:0030208	dermatan sulfate biosynthetic process	biological process	TAS
GO:0007507	heart development	biological process	IEA
GO:0030204	chondroitin sulfate metabolic process	biological process	TAS
GO:0005539	glycosaminoglycan binding	molecular function	TAS[7528742]
GO:0044281	small molecule metabolic process	biological process	TAS
GO:0030206	chondroitin sulfate biosynthetic process	biological process	TAS
GO:0008037	cell recognition	biological process	TAS[2583089]
GO:0005578	proteinaceous extracellular matrix	cellular component	IEA
GO:0005796	Golgi lumen	cellular component	TAS
GO:0007155	cell adhesion	biological process	IEA
GO:0005975	carbohydrate metabolic process	biological process	TAS
GO:0007275	multicellular organismal development	biological process	TAS[2583089]

VCAN related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Literature-origin KEGG pathway
hsa04514	cell adhesion_molecules_cams	Cell adhesion molecules (CAMs)	Cell adhesion molecules are (glyco)proteins expressed on the...... Cell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cellcell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes. More...

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways

VCAN related BioCarta pathways (count: 0)

VCAN related Reactome pathways (count: 0)

VCAN related interactors from protein-protein interaction data in HPRD (count: 20)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
VCAN	ITGB1	No	in vivo	11805102
VCAN	ADAMTS1	No	in vitro;in vivo	11278559 , 12907688
VCAN	FBLN1	No	in vitro	10400671
VCAN	PLA2G2A	No	in vitro	9848887 , 8824283
VCAN	FBN1	No	in vitro	11726670
VCAN	CCL8	No	in vitro	11083865
VCAN	HAPLN1	No	in vitro	12888576
VCAN	VCAN	Yes	in vitro	11083865
VCAN	CCL5	No	in vitro	11083865
VCAN	SELP	No	in vitro	10950950
VCAN	FBLN2	No	in vitro	11038354
VCAN	CCL2	Yes	in vitro	11083865
VCAN	CCL21	No	in vitro	11083865
VCAN	CXCL10	No	in vitro	11083865
VCAN	CCL20	No	in vitro	11083865
VCAN	XCL1	No	in vitro	11083865
VCAN	ITGA4	No	in vitro	11083865
VCAN	SELPLG	No	in vitro;in vivo;yeast 2-hybrid	15522894
VCAN	TNR	No	in vivo	9294172
VCAN	CD44	No	in vitro	10950950

Gene Report

Gene mapped GO terms

Literature-origin KEGG pathway

Gene mapped KEGG pathways