KEGG Pathway Report

Basic Information

ID	hsa04060
Name	cytokine cytokine_receptor_interaction
Brief Description	Cytokine-cytokine receptor interaction
Full Description	Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.

hsa04060 related genes in MK4MDD (count: 43)

Approved Symbol	Approved Name	Type	No. of Studies (Positive/Negative)
IL13	interleukin 13	Literature-origin; Protein mapped	1(1/0)
BMP7	bone morphogenetic protein 7	Literature-origin	1(1/0)
IL4	interleukin 4	Protein mapped	0(0/0)
IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	Literature-origin; Protein mapped	1(1/0)
NGFR	nerve growth factor receptor	Literature-origin; SNP mapped	1(0/1)
LTA	lymphotoxin alpha (TNF superfamily, member 1)	Literature-origin; SNP mapped	2(1/1)
CCL2	chemokine (C-C motif) ligand 2	Literature-origin; SNP mapped; Protein mapped	2(1/1)
IL1A	interleukin 1, alpha	Literature-origin	2(2/0)
PRLR	prolactin receptor	Literature-origin	1(1/0)
EGF	epidermal growth factor	Literature-origin; SNP mapped; Protein mapped	1(0/1)
IL2RA	interleukin 2 receptor, alpha	Protein mapped	0(0/0)
TNF	tumor necrosis factor	Literature-origin; SNP mapped; Protein mapped	5(5/0)
IL5	interleukin 5 (colony-stimulating factor, eosinophil)	Literature-origin; Protein mapped	1(1/0)
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	Literature-origin; Protein mapped	1(1/0)
PRL	prolactin	Protein mapped	0(0/0)
IL3	interleukin 3 (colony-stimulating factor, multiple)	Literature-origin	1(1/0)
IL2	interleukin 2	Literature-origin; Protein mapped	1(1/0)
IL6	interleukin 6 (interferon, beta 2)	Literature-origin; Protein mapped	1(0/1)
IL17A	interleukin 17A	Protein mapped	0(0/0)
IL7	interleukin 7	Protein mapped	0(0/0)
IL10	interleukin 10	Literature-origin; Protein mapped	4(2/2)
VEGFA	vascular endothelial growth factor A	Literature-origin	1(1/0)
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	Literature-origin	1(1/0)
IL8	interleukin 8	Literature-origin	1(1/0)
TGFB1	transforming growth factor, beta 1	Protein mapped	0(0/0)
CD40LG	CD40 ligand	Protein mapped	0(0/0)
CSF3	colony stimulating factor 3 (granulocyte)	Protein mapped	0(0/0)
IL18	interleukin 18 (interferon-gamma-inducing factor)	Literature-origin; Protein mapped	1(1/0)
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	Protein mapped	0(0/0)
IL9	interleukin 9	Literature-origin	1(1/0)
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	Literature-origin; Protein mapped	2(2/0)
TNFRSF25	tumor necrosis factor receptor superfamily, member 25	Literature-origin	1(1/0)
IFNG	interferon, gamma	Literature-origin; Protein mapped	1(1/0)
IL1B	interleukin 1, beta	Literature-origin; SNP mapped; Protein mapped	3(2/1)
IL15	interleukin 15	Literature-origin	2(2/0)
CXCR1	chemokine (C-X-C motif) receptor 1	Protein mapped	0(0/0)
IL24	interleukin 24	Literature-origin	1(1/0)
LEPR	leptin receptor	Literature-origin; SNP mapped; Protein mapped	3(3/0)
IL20	interleukin 20	Literature-origin	1(1/0)
GH1	growth hormone 1	Protein mapped	0(0/0)
EPO	erythropoietin	Protein mapped	0(0/0)
TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	Protein mapped	0(0/0)
LEP	leptin	Protein mapped	0(0/0)