Gene Report

Basic Information

Approved Symbol	BMP7
Approved Name	bone morphogenetic protein 7
Symbol Alias	OP-1
Name Alias	osteogenic protein 1
Location	20q13
Position	chr20:55743809-55841707 (-)
External Links	Entrez Gene: 655 Ensembl: ENSG00000101144 UCSC: uc010gip.1 HGNC ID: 1074
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between BMP7 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
BMP7	Ordway GA, 2011	patients and normal controls		Real-time PCR of reversed transcribed RNA isolated from homo...... Real-time PCR of reversed transcribed RNA isolated from homogenates of LC tissue from 12 matched pairs of MDD subjects and psychiatrically normal control subjects revealed low levels of BMP7 gene expression in MDD. More...

Positive relationships between BMP7 and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
BMP7		Astrocytes(astrocyte)	cell	Ordway GA, 2011	patients and normal controls		Laser capture microdissection of noradrenergic neurons, astr...... Laser capture microdissection of noradrenergic neurons, astrocytes, and oligodendrocytes from the LC revealed that BMP7 gene expression was highest in LC astrocytes relative to the other cell types, and that the MDD-associated reduction in BMP7 gene expression was limited to astrocytes. More...

Positive relationship network of BMP7 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between BMP7 and MDD (count: 0)

Negative relationships between BMP7 and other components at different levels (count: 0)

BMP7 related SNPs in MK4MDD (count: 0)

BMP7 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Bone morphogenetic protein 7	P18075	0(0/0)	Gene mapped

BMP7 related GO terms (count: 64)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0001707	mesoderm formation	biological process	IEA
GO:0008083	growth factor activity	molecular function	IEA
GO:0048812	neuron projection morphogenesis	biological process	IDA[16325379]
GO:0043065	positive regulation of apoptotic process	biological process	IEA
GO:0060445	branching involved in salivary gland morphogenesis	biological process	IEA
GO:0042326	negative regulation of phosphorylation	biological process	IDA[17244894]
GO:0001657	ureteric bud development	biological process	ISS
GO:0001837	epithelial to mesenchymal transition	biological process	TAS[14679171]
GO:0042347	negative regulation of NF-kappaB import into nucleus	biological process	ISS
GO:0043407	negative regulation of MAP kinase activity	biological process	IDA[17244894]
GO:0001656	metanephros development	biological process	IEP[18437684]
GO:0050768	negative regulation of neurogenesis	biological process	IEA
GO:0030326	embryonic limb morphogenesis	biological process	IEA
GO:0030501	positive regulation of bone mineralization	biological process	IDA[18436533]
GO:0010800	positive regulation of peptidyl-threonine phosphorylation	biological process	IDA[19736306]
GO:0048762	mesenchymal cell differentiation	biological process	IDA[9693150]
GO:0060272	embryonic skeletal joint morphogenesis	biological process	IEA
GO:0030855	epithelial cell differentiation	biological process	IEA
GO:0045786	negative regulation of cell cycle	biological process	IDA[11502704]
GO:0001501	skeletal system development	biological process	TAS[2357959]
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	biological process	IDA[19736306]; TAS[11580864]
GO:0048754	branching morphogenesis of a tube	biological process	IEA
GO:0034116	positive regulation of heterotypic cell-cell adhesion	biological process	IDA[15100360]
GO:0072133	metanephric mesenchyme morphogenesis	biological process	IEA
GO:0048596	embryonic camera-type eye morphogenesis	biological process	IEA
GO:1900006	positive regulation of dendrite development	biological process	IDA[11580864]
GO:0030509	BMP signaling pathway	biological process	IDA[18436533]
GO:0001823	mesonephros development	biological process	IEP[18437684]
GO:0005515	protein binding	molecular function	IPI[18184661]; IPI[9872992]
GO:0045666	positive regulation of neuron differentiation	biological process	IEA
GO:0045893	positive regulation of transcription, DNA-dependent	biological process	IDA[16049014]
GO:0034504	protein localization to nucleus	biological process	IDA[17244894]
GO:0045892	negative regulation of transcription, DNA-dependent	biological process	IDA[15100360]
GO:0060485	mesenchyme development	biological process	ISS
GO:0040007	growth	biological process	IEA
GO:0060393	regulation of pathway-restricted SMAD protein phosphorylation	biological process	IDA[16049014]
GO:0045746	negative regulation of Notch signaling pathway	biological process	IEA
GO:0005125	cytokine activity	molecular function	IEA
GO:0060686	negative regulation of prostatic bud formation	biological process	IEA
GO:0043401	steroid hormone mediated signaling pathway	biological process	IMP[17244894]
GO:0072125	negative regulation of glomerular mesangial cell proliferation	biological process	IDA[17244894]
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IEA
GO:0045665	negative regulation of neuron differentiation	biological process	IDA[16325379]
GO:0071456	cellular response to hypoxia	biological process	ISS
GO:0016358	dendrite development	biological process	TAS[11580864]
GO:0009880	embryonic pattern specification	biological process	IEA
GO:0051216	cartilage development	biological process	IEA
GO:0032088	negative regulation of NF-kappaB transcription factor activity	biological process	ISS
GO:0005615	extracellular space	cellular component	IDA[17977014]
GO:0060687	regulation of branching involved in prostate gland morphogenesis	biological process	IEA
GO:1900106	positive regulation of hyaluranon cable assembly	biological process	IDA[15100360]
GO:0042475	odontogenesis of dentin-containing tooth	biological process	IEA
GO:0060395	SMAD protein signal transduction	biological process	IDA[17244894]
GO:0072040	negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis	biological process	IEA
GO:0072134	nephrogenic mesenchyme morphogenesis	biological process	IEA
GO:0070487	monocyte aggregation	biological process	IDA[15100360]
GO:0010664	negative regulation of striated muscle cell apoptotic process	biological process	ISS
GO:0045839	negative regulation of mitosis	biological process	IDA[17244894]
GO:0072136	metanephric mesenchymal cell proliferation involved in metanephros development	biological process	IEA
GO:0007411	axon guidance	biological process	IEA
GO:0001503	ossification	biological process	IEA
GO:2000121	regulation of removal of superoxide radicals	biological process	ISS
GO:0060548	negative regulation of cell death	biological process	IDA[12631064]
GO:0045669	positive regulation of osteoblast differentiation	biological process	IDA[18436533]

BMP7 related KEGG pathways (count: 3)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04350	tgf beta_signaling_pathway	TGF-beta signaling pathway	The transforming growth factor-beta (TGF-beta) family member...... The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins. More...
hsa04060	cytokine cytokine_receptor_interaction	Cytokine-cytokine receptor interaction	Cytokines are soluble extracellular proteins or glycoprotein...... Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped. More...
hsa04340	hedgehog signaling_pathway	Hedgehog signaling pathway	The Hedgehog (Hh) family of secreted signaling proteins play...... The Hedgehog (Hh) family of secreted signaling proteins plays a crucial role in development of diverse animal phyla, from Drosophila to humans, regulating morphogenesis of a variety of tissues and organs. Hh signaling is also involved in control of stem cell proliferation in adult tissues and aberrant activation of the Hh pathway has been linked to multiple types of human cancer. Members of the Hh family bind to patched (ptc), thus releasing smoothened (smo) to transduce a signal. Transcriptional activation occurs through the GLI family of proteins resulting in activation of target genes. More...

BMP7 related BioCarta pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped BioCarta pathways
ALK_PATHWAY	alk pathway	ALK in cardiac myocytes	Heart formation is cued by a combination of positive and neg...... Heart formation is cued by a combination of positive and negative signals from surrounding tissues. Inhibitory signals that block heart formation in anterior paraxial mesoderm include Wnt family members expressed in dorsal neural tube and anti-BMPs expressed in the axial tissues (i.e., noggin in the notochord). Wnt signalling pathway, which is essential for setting up the entire body pattern during embryonic development involves glycogen synthase kinase-3 (GSK3). In the absence of Wnt signaling, GSK3 is active and phosphorylates b-catenin resulting in its degradation by ubiquitin-mediated proteolysis. Activation of Wnt signaling inhibits GSK3, thereby preventing phosphorylation of b-catenin, which is then able to move to the nucleus. There it associates with members of the LEF-1/TCF family of transcription factors, which activate the transcription of genes like cyclin-D1, myc, and MMPs. The Wnt signaling pathway is blocked by a family of secreted proteins such as crescent and Dkk-1 sufficient for induction of heart formation in posterior mesoderm. BMP signaling can also be blocked by the BMP antagonists noggin and chordin, which are secreted from the notochord and cooperate with Wnts to prevent cardiogenesis. Receptors for BMPs, members of the transforming growth factor-beta (TGFb) superfamily, are persistently expressed during cardiac development, yet mice lacking type II or type IA BMP receptors die at gastrulation and cannot be used to assess potential later roles in creation of the heart. Activin receptor-like kinase 3 (ALK3) is specifically required at mid-gestation for normal development of the trabeculae, compact myocardium, interventricular septum, and endocardial cushion. Cardiac muscle lacking ALK3 is specifically deficient in expressing TGFb2, an established paracrine mediator of cushion morphogenesis. In humans, congenital heart defects occur with a prevalence of at least 1% in newborns, and are even more common in death before term. Most frequent are defects in septation and the cardiac valves, and few single gene etiologies are known. The invariable defects in myocardium and AV cushion resulting from congenital deletion of ALK3 provide strong support for its assessment as a candidate gene in human congenital heart disease. More...

BMP7 related Reactome pathways (count: 0)

BMP7 related interactors from protein-protein interaction data in HPRD (count: 12)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
BMP7	ACVR2A	No	in vitro;in vivo	9748228 , 12667445
BMP7	CHRDL2	No	in vivo	14660436
BMP7	BMPR1A	No	in vivo	7791754 , 8605097
BMP7	NCOA3	No	in vivo	7791754
BMP7	BMPR2	No	in vivo;yeast 2-hybrid	7791754
BMP7	SOSTDC1	Yes	in vitro;in vivo	15020244 , 14623234
BMP7	ACVR2B	No	in vivo	9748228
BMP7	ENG	No	in vitro	9872992
BMP7	GDF7	No	in vitro	12741987
BMP7	BMPR1B	No	in vivo	8605097
BMP7	NOG	No	in vitro	12478285
BMP7	ACVR1	No	in vivo	8006002

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped BioCarta pathways