Cell Report

Name	Astrocytes
Description	A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury
No. of Studies (Positive/Negative)	3(2/1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
astrocytes	Weis, 2007	patients and normal controls		A significant decrease in ASCT-1 immunoreactivity in neurons...... A significant decrease in ASCT-1 immunoreactivity in neurons in the cingulate cortex as well as astrocytes of the white matter was seen in schizophrenia. In bipolar disorder and major depression, similar results were seen for neurons. More...
astrocyte	Ordway GA, 2011	patients and normal controls		Laser capture microdissection of noradrenergic neurons, astr...... Laser capture microdissection of noradrenergic neurons, astrocytes, and oligodendrocytes from the LC revealed that BMP7 gene expression was highest in LC astrocytes relative to the other cell types, and that the MDD-associated reduction in BMP7 gene expression was limited to astrocytes. More...

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
astrocyte		BMP7(BMP7)	gene	Ordway GA, 2011	patients and normal controls		Laser capture microdissection of noradrenergic neurons, astr...... Laser capture microdissection of noradrenergic neurons, astrocytes, and oligodendrocytes from the LC revealed that BMP7 gene expression was highest in LC astrocytes relative to the other cell types, and that the MDD-associated reduction in BMP7 gene expression was limited to astrocytes. More...

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
astrocyte	Hamidi, 2004	patients and normal controls		There was no significant decrease in astrocyte or microglia ...... There was no significant decrease in astrocyte or microglia density in MDD or BD subjects. More...