Gene Report

Basic Information

Approved Symbol	CSF2RB
Approved Name	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
Previous Symbol	IL3RB
Symbol Alias	IL5RB, CD131
Location	22q12.2-q13.1
Position	chr22:37309675-37336481 (+)
External Links	Entrez Gene: 1439 Ensembl: ENSG00000100368 UCSC: uc003aqa.4 HGNC ID: 2436
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between CSF2RB and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
CSF2RB	Chen, 2011	patients and normal controls	P-value<0.01	Haplotype association analysis revealed one protective haplo...... Haplotype association analysis revealed one protective haplotype in CSF2RB (P value = 0.0004 for MDD) and one risk haplotype in CSF2RB (P value = 0.001 for MDD) More...

Positive relationships between CSF2RB and other components at different levels (count: 0)

Positive relationship network of CSF2RB in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between CSF2RB and MDD (count: 0)

Negative relationships between CSF2RB and other components at different levels (count: 0)

CSF2RB related SNPs in MK4MDD (count: 0)

CSF2RB related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Cytokine receptor common subunit beta	P32927	0(0/0)	Gene mapped

CSF2RB related GO terms (count: 12)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005887	integral to plasma membrane	cellular component	NAS[1702217]
GO:0007165	signal transduction	biological process	NAS[1702217]
GO:0038156	interleukin-3-mediated signaling pathway	biological process	TAS[9410898]
GO:0038043	interleukin-5-mediated signaling pathway	biological process	TAS[9410898]
GO:0004914	interleukin-5 receptor activity	molecular function	TAS[9410898]
GO:0004912	interleukin-3 receptor activity	molecular function	TAS[9410898]
GO:0030526	granulocyte macrophage colony-stimulating factor receptor complex	cellular component	TAS[9410898]
GO:0005515	protein binding	molecular function	IPI
GO:0036016	cellular response to interleukin-3	biological process	TAS[9410898]
GO:0004872	receptor activity	molecular function	TAS[9410898]
GO:0007585	respiratory gaseous exchange	biological process	TAS[9410898]
GO:0005886	plasma membrane	cellular component	TAS

CSF2RB related KEGG pathways (count: 3)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04630	jak stat_signaling_pathway	Jak-STAT signaling pathway	The Janus kinase/signal transducers and activators of transc...... The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors. More...
hsa04060	cytokine cytokine_receptor_interaction	Cytokine-cytokine receptor interaction	Cytokines are soluble extracellular proteins or glycoprotein...... Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped. More...
hsa04210	apoptosis	Apoptosis	Apoptosis is a genetically controlled mechanisms of cell dea...... Apoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily members and ligands) and the intrinsic (mitochondria-associated) pathways, both of which are found in the cytoplasm. The extrinsic pathway is triggered by death receptor engagement, which initiates a signaling cascade mediated by caspase-8 activation. Caspase-8 both feeds directly into caspase-3 activation and stimulates the release of cytochrome c by the mitochondria. Caspase-3 activation leads to the degradation of cellular proteins necessary to maintain cell survival and integrity. The intrinsic pathway occurs when various apoptotic stimuli trigger the release of cytochrome c from the mitochondria (independently of caspase-8 activation). Cytochrome c interacts with Apaf-1 and caspase-9 to promote the activation of caspase-3. Recent studies point to the ER as a third subcellular compartment implicated in apoptotic execution. Alterations in Ca2+ homeostasis and accumulation of misfolded proteins in the ER cause ER stress. Prolonged ER stress can result in the activation of BAD and/or caspase-12, and execute apoptosis. More...

CSF2RB related BioCarta pathways (count: 2)

ID	Name	Brief Description	Full Description
Gene mapped BioCarta pathways
BAD_PATHWAY	bad pathway	Regulation of BAD phosphorylation	The function of the pro-apoptotic molecule BAD is regulated ...... The function of the pro-apoptotic molecule BAD is regulated by phosphorylation of three sites (ser 112,136 and 155). Phosphorylation at these sites results in loss of the ability of BAD to heterodimerize with the survival proteins BCL-XL or BCL-2. Phosphorylated BAD binds to 14-3-3 and is sequestered in the cytoplasm. While ser-136 phosphorylation is concordant with the activation of Akt, Ser-112 phosphorylation requires activation of the Ras-MAPK pathway. BAD Ser 155 was found to be a major site of phosphorylation induced following stimulation by growth factors and prevented by protein kinase A inhibitors. More...
IL3_PATHWAY	il3 pathway	IL 3 signaling pathway	Interleukin-3 promotes the proliferation and differentiation...... Interleukin-3 promotes the proliferation and differentiation of hematopoietic cells through binding to its receptor. The receptor for IL-3 is a heterodimer with a ligand-specific alpha chain (70 kD, CD123) and a common beta chain (shared with IL-5 and GM-CSF). Signaling is believed to be primarily through Stat5 and the MAPK pathways. More...

CSF2RB related Reactome pathways (count: 0)

CSF2RB related interactors from protein-protein interaction data in HPRD (count: 27)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
CSF2RB	MAD2L1	No	in vitro;in vivo	11551900
CSF2RB	FYN	No	in vitro;in vivo	9195918
CSF2RB	STAT3	No	in vivo	8631962
CSF2RB	FES	No	in vivo	8631962
CSF2RB	PRKCB	No	in vitro	10490850
CSF2RB	CSF2RA	No	in vitro;in vivo	9211889
CSF2RB	KIT	No	in vivo	15308671
CSF2RB	LYN	No	in vitro;in vivo	9973406 , 7636265
CSF2RB	LCK	No	in vitro	1638019 , 7896837
CSF2RB	PTPN11	No	in vitro;in vivo	9162089 , 9254654
CSF2RB	IL5RA	No	in vivo	9516124
CSF2RB	STAT1	No	in vivo	8631962
CSF2RB	SYK	No	in vivo	8666899
CSF2RB	PTPN6	Yes	in vitro;in vivo	8246974 , 9162089 , 9254654
CSF2RB	YWHAZ	No	in vitro;in vivo	8278375 , 10477722
CSF2RB	KDR	No	in vitro	16007196
CSF2RB	CSF2RB	Yes	in vitro;in vivo	10753826 , 11207369 , 8666948
CSF2RB	JAK1	No	in vivo	11557047
CSF2RB	SHC1	No	in vitro	10704825 , 10477722
CSF2RB	IL3RA	No	in vitro	8649415
CSF2RB	JAK2	No	in vivo	10772872
CSF2RB	EPOR	No	in vitro;in vivo	12488507
CSF2RB	GNB2L1	No	in vivo;yeast 2-hybrid	10490850
CSF2RB	CSF2	No	in vitro;in vivo	8278375 , 2645577
CSF2RB	HCK	No	in vitro;in vivo	9195918
CSF2RB	IL3	Yes	in vitro;in vivo	9278420
CSF2RB	CISH	No	in vitro	7796808

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped BioCarta pathways