
Gene Report
Approved Symbol | CSF2RB |
---|---|
Approved Name | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) |
Previous Symbol | IL3RB |
Symbol Alias | IL5RB, CD131 |
Location | 22q12.2-q13.1 |
Position | chr22:37309675-37336481 (+) |
External Links |
Entrez Gene: 1439 Ensembl: ENSG00000100368 UCSC: uc003aqa.4 HGNC ID: 2436 |
No. of Studies (Positive/Negative) | 1(1/0)
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Type | Literature-origin |
Name in Literature | Reference | Research Type | Statistical Result | Relation Description | ![]() |
---|---|---|---|---|---|
CSF2RB | Chen, 2011 | patients and normal controls | P-value<0.01 | Haplotype association analysis revealed one protective haplo...... Haplotype association analysis revealed one protective haplotype in CSF2RB (P value = 0.0004 for MDD) and one risk haplotype in CSF2RB (P value = 0.001 for MDD) More... |
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus | Protein and Other Molecule | Cell and Molecular Pathway | Neural System | Cognition and Behavior | Symptoms and Signs | Environment | MDD |
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2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Approved Name | UniportKB | No. of Studies (Positive/Negative) | Source | |
---|---|---|---|---|
Cytokine receptor common subunit beta | P32927 | 0(0/0) | Gene mapped |
Gene mapped GO terms | ||||
ID | Name | Type | Evidence | |
---|---|---|---|---|
GO:0005887 | integral to plasma membrane | cellular component | NAS[1702217] | |
GO:0007165 | signal transduction | biological process | NAS[1702217] | |
GO:0038156 | interleukin-3-mediated signaling pathway | biological process | TAS[9410898] | |
GO:0038043 | interleukin-5-mediated signaling pathway | biological process | TAS[9410898] | |
GO:0004914 | interleukin-5 receptor activity | molecular function | TAS[9410898] | |
GO:0004912 | interleukin-3 receptor activity | molecular function | TAS[9410898] | |
GO:0030526 | granulocyte macrophage colony-stimulating factor receptor complex | cellular component | TAS[9410898] | |
GO:0005515 | protein binding | molecular function | IPI | |
GO:0036016 | cellular response to interleukin-3 | biological process | TAS[9410898] | |
GO:0004872 | receptor activity | molecular function | TAS[9410898] | |
GO:0007585 | respiratory gaseous exchange | biological process | TAS[9410898] | |
GO:0005886 | plasma membrane | cellular component | TAS |
Gene mapped KEGG pathways | ||||
ID | Name | Brief Description | Full Description | |
---|---|---|---|---|
hsa04210 | apoptosis | Apoptosis | Apoptosis is a genetically controlled mechanisms of cell dea...... Apoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily members and ligands) and the intrinsic (mitochondria-associated) pathways, both of which are found in the cytoplasm. The extrinsic pathway is triggered by death receptor engagement, which initiates a signaling cascade mediated by caspase-8 activation. Caspase-8 both feeds directly into caspase-3 activation and stimulates the release of cytochrome c by the mitochondria. Caspase-3 activation leads to the degradation of cellular proteins necessary to maintain cell survival and integrity. The intrinsic pathway occurs when various apoptotic stimuli trigger the release of cytochrome c from the mitochondria (independently of caspase-8 activation). Cytochrome c interacts with Apaf-1 and caspase-9 to promote the activation of caspase-3. Recent studies point to the ER as a third subcellular compartment implicated in apoptotic execution. Alterations in Ca2+ homeostasis and accumulation of misfolded proteins in the ER cause ER stress. Prolonged ER stress can result in the activation of BAD and/or caspase-12, and execute apoptosis. More... | |
hsa04630 | jak stat_signaling_pathway | Jak-STAT signaling pathway | The Janus kinase/signal transducers and activators of transc...... The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors. More... | |
hsa04060 | cytokine cytokine_receptor_interaction | Cytokine-cytokine receptor interaction | Cytokines are soluble extracellular proteins or glycoprotein...... Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped. More... |
Gene mapped BioCarta pathways | ||||
ID | Name | Brief Description | Full Description | |
---|---|---|---|---|
BAD_PATHWAY | bad pathway | Regulation of BAD phosphorylation | The function of the pro-apoptotic molecule BAD is regulated ...... The function of the pro-apoptotic molecule BAD is regulated by phosphorylation of three sites (ser 112,136 and 155). Phosphorylation at these sites results in loss of the ability of BAD to heterodimerize with the survival proteins BCL-XL or BCL-2. Phosphorylated BAD binds to 14-3-3 and is sequestered in the cytoplasm. While ser-136 phosphorylation is concordant with the activation of Akt, Ser-112 phosphorylation requires activation of the Ras-MAPK pathway. BAD Ser 155 was found to be a major site of phosphorylation induced following stimulation by growth factors and prevented by protein kinase A inhibitors. More... | |
IL3_PATHWAY | il3 pathway | IL 3 signaling pathway | Interleukin-3 promotes the proliferation and differentiation...... Interleukin-3 promotes the proliferation and differentiation of hematopoietic cells through binding to its receptor. The receptor for IL-3 is a heterodimer with a ligand-specific alpha chain (70 kD, CD123) and a common beta chain (shared with IL-5 and GM-CSF). Signaling is believed to be primarily through Stat5 and the MAPK pathways. More... |

Gene | Interactor | Interactor in MK4MDD? | Experiment Type | PMID | |
---|---|---|---|---|---|
CSF2RB | STAT3 | No | in vivo | 8631962 | |
CSF2RB | MAD2L1 | No | in vitro;in vivo | 11551900 | |
CSF2RB | IL3 | Yes | in vitro;in vivo | 9278420 | |
CSF2RB | CISH | No | in vitro | 7796808 | |
CSF2RB | JAK1 | No | in vivo | 11557047 | |
CSF2RB | PTPN11 | No | in vitro;in vivo | 9162089 , 9254654 | |
CSF2RB | SYK | No | in vivo | 8666899 | |
CSF2RB | IL3RA | No | in vitro | 8649415 | |
CSF2RB | CSF2 | No | in vitro;in vivo | 8278375 , 2645577 | |
CSF2RB | EPOR | No | in vitro;in vivo | 12488507 | |
CSF2RB | CSF2RB | Yes | in vitro;in vivo | 10753826 , 11207369 , 8666948 | |
CSF2RB | FES | No | in vivo | 8631962 | |
CSF2RB | FYN | No | in vitro;in vivo | 9195918 | |
CSF2RB | STAT1 | No | in vivo | 8631962 | |
CSF2RB | CSF2RA | No | in vitro;in vivo | 9211889 | |
CSF2RB | IL5RA | No | in vivo | 9516124 | |
CSF2RB | SHC1 | No | in vitro | 10704825 , 10477722 | |
CSF2RB | HCK | No | in vitro;in vivo | 9195918 | |
CSF2RB | KIT | No | in vivo | 15308671 | |
CSF2RB | PTPN6 | Yes | in vitro;in vivo | 8246974 , 9162089 , 9254654 | |
CSF2RB | YWHAZ | No | in vitro;in vivo | 8278375 , 10477722 | |
CSF2RB | LCK | No | in vitro | 1638019 , 7896837 | |
CSF2RB | JAK2 | No | in vivo | 10772872 | |
CSF2RB | GNB2L1 | No | in vivo;yeast 2-hybrid | 10490850 | |
CSF2RB | PRKCB | No | in vitro | 10490850 | |
CSF2RB | KDR | No | in vitro | 16007196 | |
CSF2RB | LYN | No | in vitro;in vivo | 9973406 , 7636265 |