MK4MDD

BioCarta Pathway Report

Basic Information
ID BAD_PATHWAY
Name bad pathway
Brief Description Regulation of BAD phosphorylation
Full Description The function of the pro-apoptotic molecule BAD is regulated by phosphorylation of three sites (ser 112,136 and 155). Phosphorylation at these sites results in loss of the ability of BAD to heterodimerize with the survival proteins BCL-XL or BCL-2. Phosphorylated BAD binds to 14-3-3 and is sequestered in the cytoplasm. While ser-136 phosphorylation is concordant with the activation of Akt, Ser-112 phosphorylation requires activation of the Ras-MAPK pathway. BAD Ser 155 was found to be a major site of phosphorylation induced following stimulation by growth factors and prevented by protein kinase A inhibitors.

BAD_PATHWAY related genes in MK4MDD (count: 10)
Approved Symbol Approved Name Type No. of Studies (Positive/Negative)
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) Literature-origin 1(1/0)
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha Literature-origin 1(1/0)
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) Literature-origin 1(1/0)
BAX BCL2-associated X protein Literature-origin 1(1/0)
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha Literature-origin; Protein mapped 1(1/0)
PRKACB protein kinase, cAMP-dependent, catalytic, beta Protein mapped 0(0/0)
MAPK1 mitogen-activated protein kinase 1 Literature-origin 2(2/0)
IL3 interleukin 3 (colony-stimulating factor, multiple) Literature-origin 1(1/0)
BCL2L1 BCL2-like 1 Literature-origin 1(1/0)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta Literature-origin 1(1/0)