MK4MDD

Genetic/Epigenetic Locus Search Cross Data Search

Study Report

Reference

Citation	Chen, 2011 PubMed
Full Info	Chen, P., Huang, K., Zhou, G., Zeng, Z., Wang, T., Li, B., Wang, Y., He, L., Feng, G. and Shi, Y. (2011) Common SNPs in CSF2RB are associated with major depression and schizophrenia in the Chinese Han population. World J Biol Psychiatry, 12, 233-238.

Study

Hypothesis or Background	Colony stimulating factor 2 receptor beta (CSF2RB) encodes the protein which is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. It locates in the linkage region 22q12.3 of both bipolar disorder and schizophrenia, and is expressed in most cells.
Sample Information	1140 bipolar affective disorder patients (including 645 type I bipolar affective disorder patients), 1140 schizophrenia patients, 1139 major depressive disorder patients and 1140 healthy controls
Method Detail	We carried out a large scale case-control study to test the association between CSF2RB and three major mental disorders in the Chinese Han population. Seven single nucleotide polymorphisms were genotyped in 1140 bipolar affective disorder patients (including 645 type I bipolar affective disorder patients), 1140 schizophrenia patients, 1139 major depressive disorder patients and 1140 healthy controls.
Method Keywords	genotyping
Result	Three SNPs were found to be associated with both schizophrenia and major depressive disorder. Haplotype association analysis revealed one protective haplotype (P value = 0.014 for SCZ and 0.0004 for MDD) and one risk haplotype (P value = 0.006 for SCZ and 0.001 for MDD). Additional 52 SNPs were analyzed for population stratification, which demonstrated that our positive results were not caused by population stratification.
Conclusions	Our results support CSF2RB as a risk factor common to both schizophrenia and major depression in the Chinese Han population.

Relationships reported by Chen, 2011