Gene Report

Basic Information

Approved Symbol	PRLR
Approved Name	prolactin receptor
Location	5p14-p13
Position	chr5:35048861-35230823 (-)
External Links	Entrez Gene: 5618 Ensembl: ENSG00000113494 UCSC: uc003jjm.3 HGNC ID: 9446
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between PRLR and MDD (count: 0)

Positive relationships between PRLR and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
PRLR		Depression-like behaviors from animal model(depressive-like behavior)	cognition and behavior	Andrus, 2010	animal model		Differentially expressed depression genes hippocampus, (fold...... Differentially expressed depression genes hippocampus, (fold change > 2). More...

Positive relationship network of PRLR in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between PRLR and MDD (count: 0)

Negative relationships between PRLR and other components at different levels (count: 0)

PRLR related SNPs in MK4MDD (count: 0)

PRLR related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Prolactin receptor	P16471	0(0/0)	Gene mapped

PRLR related GO terms (count: 20)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005886	plasma membrane	cellular component	TAS
GO:0042110	T cell activation	biological process	NAS[10585417]
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway	biological process	TAS
GO:0006694	steroid biosynthetic process	biological process	NAS[10585417]
GO:0009986	cell surface	cellular component	IDA[10585417]
GO:0042978	ornithine decarboxylase activator activity	molecular function	NAS[10585417]
GO:0007595	lactation	biological process	NAS[10585417]
GO:0007566	embryo implantation	biological process	TAS[9009200]
GO:0038161	prolactin signaling pathway	biological process	NAS[10585417]; TAS[2558309]
GO:0043066	negative regulation of apoptotic process	biological process	NAS[10585417]
GO:0017046	peptide hormone binding	molecular function	IPI[7984244]
GO:0046872	metal ion binding	molecular function	IEA
GO:0005576	extracellular region	cellular component	IEA
GO:0042803	protein homodimerization activity	molecular function	NAS[10585417]
GO:0042977	activation of JAK2 kinase activity	biological process	NAS[10585417]
GO:0031904	endosome lumen	cellular component	TAS
GO:0007166	cell surface receptor signaling pathway	biological process	NAS[10585417]
GO:0016021	integral to membrane	cellular component	IEA
GO:0004925	prolactin receptor activity	molecular function	NAS[10585417]
GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity	biological process	IDA[10585417]

PRLR related KEGG pathways (count: 3)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04060	cytokine cytokine_receptor_interaction	Cytokine-cytokine receptor interaction	Cytokines are soluble extracellular proteins or glycoprotein...... Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped. More...
hsa04080	neuroactive ligand_receptor_interaction	Neuroactive ligand-receptor interaction
hsa04630	jak stat_signaling_pathway	Jak-STAT signaling pathway	The Janus kinase/signal transducers and activators of transc...... The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors. More...

PRLR related BioCarta pathways (count: 0)

PRLR related Reactome pathways (count: 0)

PRLR related interactors from protein-protein interaction data in HPRD (count: 17)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
PRLR	NEK3	No	in vivo	15618286
PRLR	GH1	No	in vitro	9556914
PRLR	SOCS3	No	in vivo	11713228
PRLR	PPIA	No	in vitro;in vivo	12668872
PRLR	YWHAG	No	in vitro;in vivo	12819209
PRLR	YWHAZ	No	in vitro;in vivo	12819209
PRLR	VAV1	No	in vivo	7768923
PRLR	PRL	No	in vitro;in vivo	9626554 , 10966654 , 7984244
PRLR	PRLR	Yes	in vitro	10966654
PRLR	PTPN11	No	in vitro	10991949 , 14522994
PRLR	ZAP70	No	in vitro	10221598
PRLR	CISH	No	in vivo	11713228
PRLR	TEC	No	in vitro;in vivo	11328862
PRLR	CSH1	No	in vitro	10966654
PRLR	SOCS2	No	in vitro;in vivo	10455112 , 9202403
PRLR	JAK2	No	in vivo	10772872
PRLR	VAV2	No	in vivo	15618286

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways