Gene Report

Basic Information

Approved Symbol	IL20
Approved Name	interleukin 20
Symbol Alias	ZCYTO10, IL10D, IL-20
Location	1q32
Position	chr1:207039154-207042568 (+)
External Links	Entrez Gene: 50604 Ensembl: ENSG00000162891 UCSC: uc001her.3 HGNC ID: 6002
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between IL20 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
IL20	Traks, 2008	patients and normal controls	P-value = 0.0097; OR 3.45; 95% CI 1.28¨C9.32	The rs1518108-rs1150253-rs1150258 haplotype TGC frequency wa...... The rs1518108-rs1150253-rs1150258 haplotype TGC frequency was significantly higher in patients with MDD compared to the control group (P = 0.0097; OR 3.45; 95% CI 1.28¨C9.32) and the result remained statistically significant after permutations (Padj= 0.042). More...

Positive relationships between IL20 and other components at different levels (count: 0)

Positive relationship network of IL20 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between IL20 and MDD (count: 0)

Negative relationships between IL20 and other components at different levels (count: 0)

IL20 related SNPs in MK4MDD (count: 0)

IL20 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Interleukin-20	Q9NYY1	0(0/0)	Gene mapped

IL20 related GO terms (count: 8)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0045618	positive regulation of keratinocyte differentiation	biological process	TAS[11470428]
GO:0045517	interleukin-20 receptor binding	molecular function	TAS[11470428]
GO:0005125	cytokine activity	molecular function	IEA
GO:0050727	regulation of inflammatory response	biological process	TAS[11470428]
GO:0045606	positive regulation of epidermal cell differentiation	biological process	TAS[11470428]
GO:0005615	extracellular space	cellular component	IEA
GO:0005576	extracellular region	cellular component	TAS[11470428]
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein	biological process	TAS[11470428]

IL20 related KEGG pathways (count: 2)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04630	jak stat_signaling_pathway	Jak-STAT signaling pathway	The Janus kinase/signal transducers and activators of transc...... The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors. More...
hsa04060	cytokine cytokine_receptor_interaction	Cytokine-cytokine receptor interaction	Cytokines are soluble extracellular proteins or glycoprotein...... Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped. More...

IL20 related BioCarta pathways (count: 0)

IL20 related Reactome pathways (count: 0)

IL20 related interactors from protein-protein interaction data in HPRD (count: 2)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
IL20	IL20RA	No	in vivo	11163236 , 12351624 , 14580208
IL20	FNDC6	No	in vivo	11163236 , 12351624 , 14580208

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways