MK4MDD

Gene Report

Basic Information
Approved Symbol IL10
Approved Name interleukin 10
Symbol Alias CSIF, TGIF, IL10A, IL-10
Name Alias "cytokine synthesis inhibitory factor", "T-cell growth inhibitory factor"
Location 1q31-q32
Position chr1:206945781-206945839 (-)
External Links Entrez Gene: 3586
Ensembl: ENSG00000136634
UCSC: uc001hen.1
HGNC ID: 5962
No. of Studies (Positive/Negative) 4(2/2) Help
Type Literature-origin; Protein mapped

Positive relationships between IL10 and MDD (count: 2)
Name in Literature Reference Research Type Statistical Result Relation Description Help
IL10 Belzeaux, 2010 patients and normal controls We also found a state-independent marker, IL10 We also found a state-independent marker, IL10
IL-10 Shelton, 2011 patients and normal controls Gene set analysis suggested up-regulation of a variety of pr...... Gene set analysis suggested up-regulation of a variety of pro- and anti-inflammatory cytokines, including interleukin 1alpha (IL-1alpha), IL-2, IL-3, IL-5, IL-8, IL-9, IL-10, IL-12A, IL-13, IL-15, IL-18, interferon gamma (IFNgamma), and lymphotoxin alpha (TNF superfamily member 1). More...

Positive relationships between IL10 and other components at different levels (count: 0) Help
Positive relationship network of IL10 in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between IL10 and MDD (count: 2)
Name in Literature Reference Research Type Statistical Result Relation Description
IL10 Jun TY, 2002 Patients and nomal controls There were no significant differences in genotype frequencie...... There were no significant differences in genotype frequencies of IL-10*T/T, IL-10*T/C, and IL-10*C/C as well as allelic frequencies of IL-10*T and IL-10*C between patients with major depression and controls in the Korean population. More...
IL10 Koido K, 2010 Patients and nomal controls We found no significant associations of the SNPs in IL10 fam...... We found no significant associations of the SNPs in IL10 family genes with either diagnostic group. Haplotype analysis revealed seven haplotype blocks, but their frequencies did not differ between patients and controls More...

Negative relationships between IL10 and other components at different levels (count: 0) Help
IL10 related SNPs in MK4MDD (count: 0)
IL10 related proteins in MK4MDD (count: 1)
IL10 related GO terms (count: 61)
IL10 related KEGG pathways (count: 9)
IL10 related BioCarta pathways (count: 5)
IL10 related Reactome pathways (count: 0)
IL10 related interactors from protein-protein interaction data in HPRD (count: 4)