MK4MDD

Protein Report

Basic Information
Protein Name Interleukin-10
UniPortKB P22301
No. of Studies (Positive/Negative) 5 (3/2) Help
Type Literature-origin
Positive relationship between Interleukin-10 and MDD (count: 3)
Name in Literature Reference Research Type Statistical Result Relation Description Help
interleukin-10 Wichers, 2006 high-risk people Baseline soluble interleukin-2 receptor (sIL-2r), interleuki...... Baseline soluble interleukin-2 receptor (sIL-2r), interleukin-6 (IL-6), and interleukin-10 (IL-10) concentrations were significantly increased in the five subjects that developed MDD during treatment compared with those that did not, with standardized effect sizes of 1.08, 1.16, and 1.25, respectively, controlling for marijuana use, cigarette smoking, and baseline level of depressive symptoms. More...
IL-10 Hernandez, 2008 patients and normal controls Before treatment we found high levels of cortisol, IL-4, IL-...... Before treatment we found high levels of cortisol, IL-4, IL-13 (Th2) and IL-10 in MDD patients when compared with healthy volunteers. More...
IL-10 Dhabhar, 2009 patients and normal controls P-value=0.03, Cohen's d=-0.96 Depressed subjects showed significantly lower IL-10 (p=0.03,...... Depressed subjects showed significantly lower IL-10 (p=0.03, Cohen's d=-0.96), non-significantly higher IL-6, and significantly higher IL-6/IL-10 ratios (p=0.05, Cohen's d=0.50). More...

Positive relationships between Interleukin-10 and other components at different levels (count: 0) Help
Positive relationship network of Interleukin-10 in MK4MDD
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network_footer.jsp Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Interleukin-10 and MDD (count: 2)
Name in Literature Reference Research Type Statistical Result Relation Description
IL-10 Farid Hosseini R, 2007 patients and nomal controls We found no significant differences in plasma concentration ...... We found no significant differences in plasma concentration of IL-4, IL-10, TNF-alpha, IFN-gamma, and immunoglobulins as well as total number of NK cells, B cells, and T cells between major depressed patients and healthy control subjects. More...
interleukin-10 Einvik G, 2012 patients and normal controls Group comparisons revealed no significant difference in the ...... Group comparisons revealed no significant difference in the levels of 17 cytokines [interleukin-1beta, -2,-4, -5, -6, -7, -8, -10, -12(p70), -13 and -17; tumor necrosis factor-alpha; interferon-gamma; granulocyte colony-stimulating factor; granulocyte-monocyte colony-stimulating factor; macrophage chemoattractant protein-1 and monocyte inhibitory protein-1beta] between persons with (n=34) and without MDD (n=68) More...

Negative relationships between Interleukin-10 and other components at different levels (count: 0) Help
Related Gene Info
Gene Symbol Gene Name Type No. of Studies (Positive/Negative) Add to Relationship Set
IL10 interleukin 10 Literature-origin; Protein mapped 4 (2/2)