Gene Report

Basic Information

Approved Symbol	TNFRSF25
Approved Name	tumor necrosis factor receptor superfamily, member 25
Previous Symbol	TNFRSF12
Previous Name	tumor necrosis factor receptor superfamily, member 12 (translocating chain-association membrane protein)
Symbol Alias	DR3, TRAMP, WSL-1, LARD, WSL-LR, DDR3, TR3, APO-3
Location	1p36.2
Position	chr1:6521211-6526255 (-)
External Links	Entrez Gene: 8718 Ensembl: ENSG00000215788 UCSC: uc001ane.3 HGNC ID: 11910
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between TNFRSF25 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
TNFRSF12	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between TNFRSF25 and other components at different levels (count: 0)

Positive relationship network of TNFRSF25 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between TNFRSF25 and MDD (count: 0)

Negative relationships between TNFRSF25 and other components at different levels (count: 0)

TNFRSF25 related SNPs in MK4MDD (count: 0)

TNFRSF25 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Tumor necrosis factor receptor superfamily member 25	Q93038	0(0/0)	Gene mapped

TNFRSF25 related GO terms (count: 13)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0006915	apoptotic process	biological process	NAS[9114039]

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0007165	signal transduction	biological process	TAS[8994832]
GO:0004872	receptor activity	molecular function	NAS[9114039]
GO:0097190	apoptotic signaling pathway	biological process	TAS[8994832]
GO:0006917	induction of apoptosis	biological process	TAS[8875942]
GO:0005887	integral to plasma membrane	cellular component	TAS[9052839]
GO:0042981	regulation of apoptotic process	biological process	NAS[9114039]
GO:0033209	tumor necrosis factor-mediated signaling pathway	biological process	TAS[9052839]
GO:0005886	plasma membrane	cellular component	IDA[11911831]
GO:0005031	tumor necrosis factor-activated receptor activity	molecular function	TAS[9052839]
GO:0005576	extracellular region	cellular component	IEA
GO:0007166	cell surface receptor signaling pathway	biological process	TAS[9052839]
GO:0005829	cytosol	cellular component	NAS[9114039]

TNFRSF25 related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04060	cytokine cytokine_receptor_interaction	Cytokine-cytokine receptor interaction	Cytokines are soluble extracellular proteins or glycoprotein...... Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped. More...

TNFRSF25 related BioCarta pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped BioCarta pathways
DEATH_PATHWAY	death pathway	Induction of apoptosis through DR3 and DR4/5 Death Receptors	Apoptosis is specifically induced via signaling through a fa...... Apoptosis is specifically induced via signaling through a family of receptors known collectively as 'death receptors' including Fas, TNFR, DR3, -4 and -5. Death receptor ligands characteristically initiate signaling via receptor oligomerization, recruitment of specialized adaptor proteins and activation of caspase cascades. Apo3L recruits initiator caspase 8 via the adapter protein FADD. Caspase 8 then oligomerizes and is activated via autocatalysis. Activated caspase 8 stimulates apoptosis via two parallel cascades: it directly cleaves and activates caspase-3, and it cleaves Bid (a Bcl-2 family protein). Truncated Bid (tBid) translocates to mitochondria, inducing cytochrome C release, which sequentially activates caspases 9 and 3. DR-3L can deliver pro- or anti-apoptotic signals. DR-3 promote apoptosis via the adaptor proteins TRADD/FADD and the activation of caspase 8. Alternatively, apoptosis inhibited via an adaptor protein complex including RIP which activates NF-kB and induces survival genes including IAP. Induction of apoptosis via Apo2L requires caspase activity, but the adaptor requirement is unclear. More...

TNFRSF25 related Reactome pathways (count: 0)

TNFRSF25 related interactors from protein-protein interaction data in HPRD (count: 7)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
TNFRSF25	MAPK1	Yes	in vitro;in vivo	11606045
TNFRSF25	TRAF2	No	in vivo	8875942
TNFRSF25	TNFRSF1A	Yes	yeast 2-hybrid	8934525
TNFRSF25	TRADD	No	in vivo;yeast 2-hybrid	8934525
TNFRSF25	TNFSF12	No	in vivo	11094155
TNFRSF25	BAG4	No	in vivo;yeast 2-hybrid	9915703
TNFRSF25	TNFSF15	No	in vivo	11911831

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped BioCarta pathways