Study Report

Reference

Citation	Aston, 2005 PubMed
Full Info	Aston, C., Jiang, L. and Sokolov, B.P. (2005) Transcriptional profiling reveals evidence for signaling and oligodendroglial abnormalities in the temporal cortex from patients with major depressive disorder. Mol Psychiatry, 10, 309-322.

Study

Hypothesis or Background	Major depressive disorder is one of the most common and devastating psychiatric disorders.
Sample Information	12 patients with major depressive disorder and 14 matched controls
Method Detail	To identify candidate mechanisms for major depressive disorder, we compared gene expression in the temporal cortex from 12 patients with major depressive disorder and 14 matched controls using Affymetrix HgU95A microarrays.
Method Keywords	microarray
Result	Significant expression changes were revealed in families of genes involved in neurodevelopment, signal transduction and cell communication. Among these, the expression of 17 genes related to oligodendrocyte function was significantly (P < 0.05, fold change > 1.4) decreased in patients with major depressive disorder. Eight of these 17 genes encode structural components of myelin (CNP, MAG, MAL, MOG, MOBP, PMP22, PLLP, PLP1). Five other genes encode enzymes involved in the synthesis of myelin constituents (ASPA, UGT8), or are essential in regulation of myelin formation (ENPP2, EDG2, TF, KLK6). One gene, that is, SOX10, encodes a transcription factor regulating other myelination-related genes. OLIG2 is a transcription factor present exclusively in oligodendrocytes and oligodendrocyte precursors. Another gene, ERBB3, is involved in oligodendrocyte differentiation. In addition to myelination-related genes, there were significant changes in multiple genes involved in axonal growth/synaptic function.
Conclusions	These findings suggest that major depressive disorder may be associated with changes in cell communication and signal transduction mechanisms that contribute to abnormalities in oligodendroglia and synaptic function. Taken together with other studies, these findings indicate that major depressive disorder may share common oligodendroglial abnormalities with schizophrenia and bipolar disorder.

Relationships reported by Aston, 2005

Component A Approved Name (Name in Paper)	Component A Type	Component B Approved Name (Name in Paper)	Component B Type	Relationship Description	Result Category (Positive/Negative))
MDD	syndrome	VAMP3 (VAMP3)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	ZKSCAN1 (ZNF36)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	UBE2A (UBE2A)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	UGT8 (UGT8)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	TTR (TTR)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	DDX23 (U5-100K)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	TRIO (TRIO)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	TSBETA (TSBETA)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	TNFRSF25 (TNFRSF12)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	TPM2 (TPM2)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	PMP22 (PMP22)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	PLP1 (PLP1)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	PLLP (PLLP)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	PLAGL1 (PLAGL1)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	PPP2R3A (PPP2R3)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	PPFIBP2 (PPFIBP2)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	PPFIA4 (PPFIA4)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	PMS2P3 (PMS2L9)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	PDE8A (PDE8A)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	PDE6B (PDE6B)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	PCSK2 (PCSK2)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	PCM1 (PCM1)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	PIK3R1 (PIK3R1)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	LITAF (PIG7)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	PENK (PENK)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	PDK2 (PDK2)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	NPC1 (NPC1)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	NTRK2 (NTRK2)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	NKX2-2 (NKX2B)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	PRPF19 (NMP200)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	P2RX7 (P2RX7)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	PCBP2 (PCBP2)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	NUP88 (NUP88)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	OLIG2 (OLIG2)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	MTCP1 (MTCP1)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	MTHFD2 (MTHFD2)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	MOBP (MOBP)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	MOG (MOG)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	MYO9B (MYO9B)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	NAPA (NAPA)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	MX1 (MX1)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	MYO1C (MYO1C)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	SYNJ2 (SYNJ2)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	SYNGR2 (SYNGR2)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	SRSF10 (TASR)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	TAF11 (TAF2I)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	RRAS2 (TC21)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	CNTN2 (TAX1)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	TIAM1 (TIAM1)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	TF (TF)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	SLC31A2 (SLC31A2)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	SEMA3C (SEMAE)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	SNRPE (SNRPE)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	SLC4A2 (SLC4A2)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	SPOCK1 (SPOCK)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	SOX10 (SOX10)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	SRPK3 (STK23)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	STIP1 (STIP1)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	RAB2A (RAB2)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	RALA (RALA)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	RASGRF1 (RASGRF1)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	RBM8A (RBM8A)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	RDX (RDX)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	REV3L (REV3L)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	RNASE1 (RNASE1)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	RPS21 (RPS21)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	PRKCQ (PRKCQ)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	PROSC (PROSC)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	PSEN1 (PSEN1)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	PSMD11 (PSMD11)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	PTH1R (PTHR1)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	PTK2B (PTK2B)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	PTP4A2 (PTP4A2)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	PTPRT (PTPRT)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	CDKN1C (CDKN1C)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	CDK8 (CDK8)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	CNP (CNP)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	CEP250 (CEP2)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	CAPN3 (CAPN3)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	CAP2 (CAP2)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	CDH19 (CDH19)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	SCARB2 (CD36L2)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	CELF2 (CUGBP2)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	CTNNAL1 (CTNNAL1)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	SF1 (D26121)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	CYP19A1 (CYP19)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	COL4A5 (COL4A5)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	COL16A1 (COL16A1)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	COPA (COPA)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	COMP (COMP)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	DLGAP1 (DLGAP1)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	DYNC1LI2 (DNCLI2)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	DPH2 (DPH2L2)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	LPAR1 (EDG2)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	FADS1 (D5D)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	DFFA (DFFA)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	DGCR5 (DGCR5)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	DICER1 (DICER1)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	EPHA5 (EPHA5)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	ERBB3 (ERBB3)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	FGFR2 (FGFR2)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	FOLH1 (FOLH1)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	EEF1E1 (EEF1E1)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	EFS (EFS2)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	ENPP2 (ENPP2)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	EP300 (EP300)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	HEXA (HEXA)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	GSTM4 (GSTM4)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	GSTM3 (GSTM3)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	GPRC5B (GPRC5B)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	GPR37 (GPR37)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	GOLGA2 (GOLGA2)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	CCKBR (GASR)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	GABRB2 (GABRB2)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	KAL1 (KAL1)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	JUN (JUN)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	LILRA4 (ILT7)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	IGFBP7 (IGFBP7)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	LRP8 (HSZ75190)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	HSPA2 (HSPA2)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	SPOCK3 (HSAJ1454)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	DIMT1 (HSA9761)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	LIPA (LIPA)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	LIPE (LIPE)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	KLRC3 (KLRC3)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	LAMP2 (LAMP2)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	KLF4 (KLF4)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	KLK6 (KLK6)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	KIF13B (KIAA0639)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	ZNF423 (KIAA0760)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	MCM7 (MCM7)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	MN1 (MN1)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	MAN2A1 (MAN2A1)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	MAPK8 (MAPK8)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	MAG (MAG)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	MAL (MAL)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	LMO4 (LMO4)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	LTBP1 (LTBP1)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	HTR4 (5-HT4A)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	APC (APC)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	AMD1 (AMD1)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	AKAP2 (AKAP2)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	ABCA8 (ABCA8)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	SORBS2 (ARGBP2)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	ARHGEF2 (ARHGEF2)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	APLP1 (APLP1)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	APOD (APOD)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	ATP5F1 (ATP5F1)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	BCAT1 (BCAT1)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	ASPA (ASPA)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	ATM (ATM)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	BRF2 (BRF2)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	BTK (BTK)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	BIN1 (BIN1)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	BRD2 (BRD2)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	CALD1 (CALD1)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	BRD4 (CAP)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	MYRF (C11ORF9)	gene	Genes altered in major depressive disorder	Positive
MDD	syndrome	CACNG3 (CACNG3)	gene	Genes altered in major depressive disorder	Positive