Gene Report

Basic Information

Approved Symbol	SLC4A2
Approved Name	solute carrier family 4 (anion exchanger), member 2
Previous Symbol	EPB3L1, AE2
Previous Name	"erythrocyte membrane protein band 3-like 1", "solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)"
Symbol Alias	HKB3, BND3L, NBND3
Name Alias	"anion exchanger 2 type a", "anion exchanger 2 type b1", "anion exchanger 2 type b2"
Location	7q36.1
Position	chr7:150773455-150773614 (+)
External Links	Entrez Gene: 6522 Ensembl: ENSG00000164889 UCSC: uc003wit.4 HGNC ID: 11028
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between SLC4A2 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
SLC4A2	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between SLC4A2 and other components at different levels (count: 0)

Positive relationship network of SLC4A2 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between SLC4A2 and MDD (count: 0)

Negative relationships between SLC4A2 and other components at different levels (count: 0)

SLC4A2 related SNPs in MK4MDD (count: 0)

SLC4A2 related proteins in MK4MDD (count: 0)

SLC4A2 related GO terms (count: 16)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0016323	basolateral plasma membrane	cellular component	IEA
GO:0055085	transmembrane transport	biological process	TAS
GO:0016020	membrane	cellular component	IDA[19946888]
GO:0008509	anion transmembrane transporter activity	molecular function	TAS[3015590]
GO:0048565	digestive tract development	biological process	IEA
GO:0007283	spermatogenesis	biological process	IEA
GO:0006820	anion transport	biological process	TAS[3015590]
GO:0016021	integral component of membrane	cellular component	IEA
GO:0016324	apical plasma membrane	cellular component	IEA
GO:0005886	plasma membrane	cellular component	TAS
GO:0006811	ion transport	biological process	TAS
GO:0005925	focal adhesion	cellular component	IDA[21423176]
GO:0005452	inorganic anion exchanger activity	molecular function	IEA
GO:0015701	bicarbonate transport	biological process	TAS
GO:0019899	enzyme binding	molecular function	IEA
GO:1902476	chloride transmembrane transport	biological process	IBA

SLC4A2 related KEGG pathways (count: 0)

SLC4A2 related BioCarta pathways (count: 0)

SLC4A2 related Reactome pathways (count: 3)

ID	Name	Description
Gene mapped Reactome pathways
REACT_19118	slc mediated_transmembrane_transport	Proteins with transporting functions can be roughly classifi...... Proteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the movement of the substrates across the membrane, against their electrochemical gradient. Channels at the open state can transfer the substrates. At least 20-25% amino-acid sequence identity is shared by members belonging to the same SLC family. No homology is shared between different SLC families. While the HUGO nomenclature system by definition only includes human genes, the nomenclature system has been informally extended to include rodent species through the use of lower cases letters (e.g., Slc1a1 denotes the rodent ortholog of the human SLC1A1 gene). And it's worthwhile to mention that pumps, channels and aquporins are not included in SLC superfamily. More...
REACT_15518	transmembrane transport_of_small_molecules
REACT_19397	inorganic cation_anion_slc_transporters	Teleologically, one might argue that inorganic cation and an...... Teleologically, one might argue that inorganic cation and anion transport would be evolutionarily among the oldest transport functions. Eight families comprise the group that transports exclusively inorganic cations and anions across membranes : SLC4 plays a pivotal role in mediating Na+- and/or Cl-dependent transport of basic anions [e.g. HCO3, ; SLC8 is a group of Na+/Ca2+ exchangers ; SLC24 is a group of Na+/Ca2+ or Na+/K+ exchangers ; SLC9 comprises Na+/H+ exchanger proteins involved in the electroneutral exchange of sodium ion and protons ; SLC12 functions as Na+, K+ and Cl ion electroneutral symporters ; SLC26 is the trans-epithelial multifunctional anion. SLC34 is an important Type II Na+/; SLC20 was originally identified as a viral receptor, and functions as a Type III Na+/. Eight SLC gene families are involved in the transport of amino acids and oligopeptides. More...

SLC4A2 related interactors from protein-protein interaction data in HPRD (count: 2)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
SLC4A2	CA2	No	in vitro	10820026
SLC4A2	EPB42	No	in vitro	2968981 , 7626035

Gene Report

Gene mapped GO terms

Gene mapped Reactome pathways