Reactome Pathway Report

Basic Information

ID
Name	slc mediated_transmembrane_transport
Description	Proteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the movement of the substrates across the membrane, against their electrochemical gradient. Channels at the open state can transfer the substrates. At least 20-25% amino-acid sequence identity is shared by members belonging to the same SLC family. No homology is shared between different SLC families. While the HUGO nomenclature system by definition only includes human genes, the nomenclature system has been informally extended to include rodent species through the use of lower cases letters (e.g., Slc1a1 denotes the rodent ortholog of the human SLC1A1 gene). And it's worthwhile to mention that pumps, channels and aquporins are not included in SLC superfamily.

REACT_19118 related genes in MK4MDD (count: 17)

Approved Symbol	Approved Name	Type	No. of Studies (Positive/Negative)
SLC3A2	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2	Protein mapped	0(0/0)
SLC32A1	solute carrier family 32 (GABA vesicular transporter), member 1	Literature-origin; Protein mapped	1(1/0)
SLC18A2	solute carrier family 18 (vesicular monoamine), member 2	Literature-origin; Protein mapped	1(1/0)
SLC17A7	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7	Literature-origin; Protein mapped	4(4/0)
RHCG	Rh family, C glycoprotein	Literature-origin	1(1/0)
SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	Literature-origin; SNP mapped; Protein mapped	3(3/0)
SLC17A6	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6	Literature-origin	1(1/0)
SLC30A3	solute carrier family 30 (zinc transporter), member 3	Literature-origin	1(1/0)
SLC4A2	solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)	Literature-origin	1(1/0)
SLC6A1	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	Literature-origin	1(1/0)
SLC1A3	solute carrier family 1 (glial high affinity glutamate transporter), member 3	Literature-origin; Protein mapped	3(3/0)
SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	Literature-origin; Protein mapped	3(3/0)
SLC6A15	solute carrier family 6 (neutral amino acid transporter), member 15	Literature-origin	2(2/0)
SLC1A6	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	Protein mapped	0(0/0)
SLC1A4	solute carrier family 1 (glutamate/neutral amino acid transporter), member 4	Protein mapped	0(0/0)
SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Literature-origin; SNP mapped; Protein mapped	3(2/1)
SLC4A4	solute carrier family 4, sodium bicarbonate cotransporter, member 4	Literature-origin	1(1/0)