Gene Report

Basic Information

Approved Symbol	SLC6A2
Approved Name	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
Previous Symbol	NET1, NAT1, SLC6A5
Symbol Alias	NET
Location	16q12.2
Position	chr16:55689542-55740104 (+)
External Links	Entrez Gene: 6530 Ensembl: ENSG00000103546 UCSC: uc021tio.1 HGNC ID: 11048
No. of Studies (Positive/Negative)	3(3/0)
Type	Literature-origin; SNP mapped; Protein mapped

Positive relationships between SLC6A2 and MDD (count: 2)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
SLC6A2	Bosker, 2010	patients and normal controls	P-value = 0.039	significantly more SNPs (19 out of 100; P = 0.039)than expec...... significantly more SNPs (19 out of 100; P = 0.039)than expected were associated while accounting for the linkage disequilibrium (LD) structure. More...
SLC6A2	Hahn, 2008	patients and normal controls	OR = 4.15 (1.91-9.02)	MPT analyses show significant associations of the norepineph...... MPT analyses show significant associations of the norepinephrine transporter (NET, SLC6A2) -182 T/C (rs2242446) with recurrent depression [odds ratio, OR = 4.15 (1.91-9.02)] More...

Positive relationships between SLC6A2 and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
norepinephrine transporter (NET)		Residency(residency)	environment	Xu, 2009	patients and normal controls		A gene-environment interaction between the G1287A polymorphi...... A gene-environment interaction between the G1287A polymorphism and residency was found in the female sample. More...

Positive relationship network of SLC6A2 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between SLC6A2 and MDD (count: 0)

Negative relationships between SLC6A2 and other components at different levels (count: 0)

SLC6A2 related SNPs in MK4MDD (count: 2)

#rs	Location	Annotation	No. of Studies (Positive/Negative)
rs2242446	chr16:55690425(Forward)	5_prime_UTR_variant; intron_variant; upstream_gene_variant	2(2/0)
rs5569	chr16:55731835(Forward)	downstream_gene_variant; synonymous_variant; upstream_gene_variant	1(0/1)

SLC6A2 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Sodium-dependent noradrenaline transporter	P23975	1(1/0)	Literature-origin

SLC6A2 related GO terms (count: 10)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0007268	synaptic transmission	biological process	TAS[2008212]

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0006810	transport	biological process	TAS[2008212]
GO:0005886	plasma membrane	cellular component	TAS
GO:0015844	monoamine transport	biological process	IDA[16024787]
GO:0008504	monoamine transmembrane transporter activity	molecular function	IDA[16024787]
GO:0005887	integral to plasma membrane	cellular component	IEA
GO:0005334	norepinephrine:sodium symporter activity	molecular function	TAS[2008212]
GO:0016020	membrane	cellular component	TAS[2008212]
GO:0055085	transmembrane transport	biological process	TAS
GO:0005515	protein binding	molecular function	IPI[17156375]

SLC6A2 related KEGG pathways (count: 0)

SLC6A2 related BioCarta pathways (count: 0)

SLC6A2 related Reactome pathways (count: 5)

ID	Name	Description
Gene mapped Reactome pathways
REACT_15518	transmembrane transport_of_small_molecules
REACT_19118	slc mediated_transmembrane_transport	Proteins with transporting functions can be roughly classifi...... Proteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the movement of the substrates across the membrane, against their electrochemical gradient. Channels at the open state can transfer the substrates. At least 20-25% amino-acid sequence identity is shared by members belonging to the same SLC family. No homology is shared between different SLC families. While the HUGO nomenclature system by definition only includes human genes, the nomenclature system has been informally extended to include rodent species through the use of lower cases letters (e.g., Slc1a1 denotes the rodent ortholog of the human SLC1A1 gene). And it's worthwhile to mention that pumps, channels and aquporins are not included in SLC superfamily. More...
REACT_20679	amine compound_slc_transporters	Five SLC gene families encode proteins that mediate transpor...... Five SLC gene families encode proteins that mediate transport of amines. More...
REACT_20506	na cl_dependent_neurotransmitter_transporters	The SLC6 gene family encodes proteins that mediate neurotran...... The SLC6 gene family encodes proteins that mediate neurotransmitter uptake thus terminating a synaptic signal. The proteins mediate transport of GABA. More...
REACT_19305	glucose and_other_sugar_slc_transporters	Hexoses like glucose, galactose and fructose serve as basic ...... Hexoses like glucose, galactose and fructose serve as basic fuel molecules for eukaryotic cells. Indeed, glucose is the main energy source for mammalian cells. These sugars are unable to diffuse across cellular membranes, and require transporter proteins for entry into and exit out of cells. Four gene families encode hexose transporter proteins. SLC2 family contains 14 genes and encode facilitative glucose transporters. SLC5 family contains 12 genes and encode Na+/glucose symporters. SLC37 family contains 4 members and encode sugar-phosphate/phosphate exchangers. SLC45 family has 4 members and encode putative sugar/H+ symporters. More...

SLC6A2 related interactors from protein-protein interaction data in HPRD (count: 2)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
SLC6A2	PPP2R1A	No	in vivo	15963952
SLC6A2	STX1A	Yes	in vivo	12629174

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped Reactome pathways