Pathway Report

Name	synaptic transmission
GO Link	ID: GO:0007268 Name: synaptic transmission Type: biological process
Description	"Genes annotated by the GO term GO:0007268. The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse."
No. of Studies (Positive/Negative)	1 (1/0)

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Synaptic transmission		SLC17A7(vesicular glutamate transporter 1 (VGLUT1))	gene	Tordera RM, 2011	animal model		genes invovled in this pathwy were regulated in frontal cort...... genes invovled in this pathwy were regulated in frontal cortex of VGLUT1(+/-) mice More...

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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Approved Symbol	Approved Name	Type	No. of Studies (Positive/Negative)
ADCY3	adenylate cyclase 3	Literature-origin	2(1/1)
DBH	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	Literature-origin; SNP mapped; Protein mapped	1(1/0)
GABRG2	gamma-aminobutyric acid (GABA) A receptor, gamma 2	Literature-origin	3(2/1)
GRIK2	glutamate receptor, ionotropic, kainate 2	Literature-origin	1(0/1)
PLP1	proteolipid protein 1	Literature-origin	1(1/0)
SLC6A3	solute carrier family 6 (neurotransmitter transporter), member 3	Literature-origin; Protein mapped	3(2/1)
SLC18A2	solute carrier family 18 (vesicular monoamine transporter), member 2	Literature-origin; Protein mapped	1(1/0)
PMP22	peripheral myelin protein 22	Literature-origin	1(1/0)
PRKCB	protein kinase C, beta	Literature-origin; Protein mapped	1(1/0)
CALM1	calmodulin 1 (phosphorylase kinase, delta)	Literature-origin	1(1/0)
GRIA2	glutamate receptor, ionotropic, AMPA 2	Literature-origin	1(1/0)
GRIK3	glutamate receptor, ionotropic, kainate 3	Literature-origin	1(1/0)
GABRR1	gamma-aminobutyric acid (GABA) A receptor, rho 1	Literature-origin	1(1/0)
GRM1	glutamate receptor, metabotropic 1	Literature-origin	2(2/0)
SYN2	synapsin II	Literature-origin; Protein mapped	3(1/2)
GRIA3	glutamate receptor, ionotropic, AMPA 3	Literature-origin; Protein mapped	3(2/1)
HTR4	5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled	Literature-origin	1(1/0)
CACNA1C	calcium channel, voltage-dependent, L type, alpha 1C subunit	Literature-origin	2(1/1)
GNAL	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type	Literature-origin; Protein mapped	1(0/1)
RAB3A	RAB3A, member RAS oncogene family	Literature-origin	1(1/0)
AMPH	amphiphysin	Literature-origin; Protein mapped	1(1/0)
SYPL1	synaptophysin-like 1	Literature-origin	1(1/0)
TAC1	tachykinin, precursor 1	Literature-origin; Protein mapped	2(2/0)
DLG4	discs, large homolog 4 (Drosophila)	Literature-origin; Protein mapped	1(1/0)
HTR1D	5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled	Literature-origin	1(1/0)
SLC32A1	solute carrier family 32 (GABA vesicular transporter), member 1	Literature-origin; Protein mapped	1(1/0)
GLRB	glycine receptor, beta	Literature-origin	1(1/0)
SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	Literature-origin; Protein mapped	6(3/3)
GNB3	guanine nucleotide binding protein (G protein), beta polypeptide 3	Literature-origin; SNP mapped	2(2/0)
HTR2A	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	Literature-origin; SNP mapped; Protein mapped	11(7/4)
USP14	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)	Literature-origin	1(1/0)
MBP	myelin basic protein	Literature-origin; Protein mapped	2(2/0)
DLGAP1	discs, large (Drosophila) homolog-associated protein 1	Literature-origin	1(1/0)
HTR2C	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	Literature-origin; SNP mapped	4(3/1)
MAPK1	mitogen-activated protein kinase 1	Literature-origin	2(2/0)
CALM2	calmodulin 2 (phosphorylase kinase, delta)	Literature-origin	1(1/0)
CAMK2A	calcium/calmodulin-dependent protein kinase II alpha	Literature-origin; Protein mapped	1(1/0)
CACNG3	calcium channel, voltage-dependent, gamma subunit 3	Literature-origin	1(1/0)
HCRTR1	hypocretin (orexin) receptor 1	Literature-origin; SNP mapped	2(2/0)
GABBR2	gamma-aminobutyric acid (GABA) B receptor, 2	Literature-origin; Protein mapped	1(1/0)
NCALD	neurocalcin delta	Literature-origin	1(1/0)
GNG3	guanine nucleotide binding protein (G protein), gamma 3	Literature-origin	1(1/0)
GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	Literature-origin; Protein mapped	2(2/0)
CORT	cortistatin	Literature-origin	1(1/0)
PPFIA4	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	Literature-origin	1(1/0)
KCND2	potassium voltage-gated channel, Shal-related subfamily, member 2	Literature-origin	1(1/0)
CNP	2',3'-cyclic nucleotide 3' phosphodiesterase	Literature-origin; Protein mapped	2(2/0)
ADCY8	adenylate cyclase 8 (brain)	Literature-origin	2(2/0)
DLG2	discs, large homolog 2 (Drosophila)	Literature-origin	1(1/0)
GLUL	glutamate-ammonia ligase	Literature-origin; Protein mapped	4(3/1)
GABRA3	gamma-aminobutyric acid (GABA) A receptor, alpha 3	Literature-origin	2(2/0)
GABRG1	gamma-aminobutyric acid (GABA) A receptor, gamma 1	Literature-origin	1(1/0)
GNAI1	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	Literature-origin	1(1/0)
GABRA5	gamma-aminobutyric acid (GABA) A receptor, alpha 5	Literature-origin	1(1/0)
STX1A	syntaxin 1A (brain)	Literature-origin	2(2/0)
SLC1A3	solute carrier family 1 (glial high affinity glutamate transporter), member 3	Literature-origin; Protein mapped	4(3/1)
KCNJ2	potassium inwardly-rectifying channel, subfamily J, member 2	Literature-origin	1(1/0)
HTR1B	5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled	Literature-origin; Protein mapped	5(4/1)
GRIN2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	Literature-origin; Protein mapped	2(2/0)
GAD1	glutamate decarboxylase 1 (brain, 67kDa)	Literature-origin; Protein mapped	3(2/1)
SLC6A2	solute carrier family 6 (neurotransmitter transporter), member 2	Literature-origin; SNP mapped; Protein mapped	3(3/0)
GABRD	gamma-aminobutyric acid (GABA) A receptor, delta	Literature-origin	1(1/0)
SLC6A4	solute carrier family 6 (neurotransmitter transporter), member 4	Literature-origin; Protein mapped	56(44/12)
KCNN3	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	Literature-origin	1(1/0)
CHRNA7	cholinergic receptor, nicotinic, alpha 7 (neuronal)	Literature-origin	1(1/0)
CPLX1	complexin 1	Literature-origin; Protein mapped	1(0/1)
KCNA4	potassium voltage-gated channel, shaker-related subfamily, member 4	Literature-origin	1(1/0)
GRIA1	glutamate receptor, ionotropic, AMPA 1	Literature-origin; Protein mapped	1(1/0)
SLC17A7	solute carrier family 17 (vesicular glutamate transporter), member 7	Literature-origin; Protein mapped	4(4/0)
SYN1	synapsin I	Literature-origin; Protein mapped	2(2/0)
COMT	catechol-O-methyltransferase	Literature-origin; SNP mapped	11(8/3)
HTR3B	5-hydroxytryptamine (serotonin) receptor 3B, ionotropic	Literature-origin; SNP mapped	1(1/0)
GRM3	glutamate receptor, metabotropic 3	Literature-origin; Protein mapped	4(3/1)
CREB1	cAMP responsive element binding protein 1	Literature-origin; Protein mapped	12(10/2)
SNAP25	synaptosomal-associated protein, 25kDa	Literature-origin; Protein mapped	1(1/0)
GALR2	galanin receptor 2	Literature-origin	1(1/0)
SLC6A1	solute carrier family 6 (neurotransmitter transporter), member 1	Literature-origin	1(1/0)
NPY	neuropeptide Y	Literature-origin; SNP mapped; Protein mapped	7(6/1)
GRIK5	glutamate receptor, ionotropic, kainate 5	Literature-origin	1(1/0)
RASGRF1	Ras protein-specific guanine nucleotide-releasing factor 1	Literature-origin	1(1/0)
SST	somatostatin	Literature-origin; Protein mapped	3(3/0)
KCNK2	potassium channel, subfamily K, member 2	Literature-origin	2(2/0)
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	Literature-origin; Protein mapped	2(2/0)
MAOA	monoamine oxidase A	Literature-origin; SNP mapped; Protein mapped	13(9/4)
GABRA1	gamma-aminobutyric acid (GABA) A receptor, alpha 1	Literature-origin	1(1/0)
GABRB2	gamma-aminobutyric acid (GABA) A receptor, beta 2	Literature-origin	2(2/0)
ADCY7	adenylate cyclase 7	Literature-origin	2(2/0)
GABRA2	gamma-aminobutyric acid (GABA) A receptor, alpha 2	Literature-origin; Protein mapped	1(1/0)
GABRB1	gamma-aminobutyric acid (GABA) A receptor, beta 1	Literature-origin; Protein mapped	2(2/0)
GABBR1	gamma-aminobutyric acid (GABA) B receptor, 1	Literature-origin; Protein mapped	1(1/0)