Gene Report

Basic Information

Approved Symbol	CORT
Approved Name	cortistatin
Symbol Alias	MGC32686
Name Alias	prepro-cortistatin
Location	1p36.22
Position	chr1:10509776-10512060 (+)
External Links	Entrez Gene: 1325 Ensembl: ENSG00000241563 HGNC ID: 2257
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between CORT and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
CORT	Guilloux JP, 2012	patients and normal controls		genes significantly affected in female MDD subjects genes significantly affected in female MDD subjects

Positive relationships between CORT and other components at different levels (count: 0)

Positive relationship network of CORT in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between CORT and MDD (count: 0)

Negative relationships between CORT and other components at different levels (count: 0)

CORT related SNPs in MK4MDD (count: 0)

CORT related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Cortistatin	O00230	0(0/0)	Gene mapped

CORT related GO terms (count: 5)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0007268	synaptic transmission	biological process	NAS[9125122]

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005184	neuropeptide hormone activity	molecular function	IDA[9125122]
GO:0001664	G-protein coupled receptor binding	molecular function	IPI[12915402]
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	biological process	IDA[9125122]
GO:0005615	extracellular space	cellular component	NAS[9125122]

CORT related KEGG pathways (count: 0)

CORT related BioCarta pathways (count: 0)

CORT related Reactome pathways (count: 0)

CORT related interactors from protein-protein interaction data in HPRD (count: 7)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
CORT	SSTR1	No	in vivo	9205124 , 9125122
CORT	SSTR4	No	in vivo	9125122 , 9205124
CORT	SSTR2	No	in vivo	9125122
CORT	GHSR	No	in vivo	11227737
CORT	SSTR3	No	in vivo	9125122 , 9205124
CORT	MRGPRX2	No	in vivo	12915402
CORT	SSTR5	Yes	in vivo	9205124 , 9125122

Gene Report

Literature-origin GO terms

Gene mapped GO terms