Gene Report

Basic Information

Approved Symbol	SSTR5
Approved Name	somatostatin receptor 5
Location	16p13.3
Position	chr16:1129964-1131454 (+)
External Links	Entrez Gene: 6755 Ensembl: ENSG00000162009 UCSC: uc021taf.1 HGNC ID: 11334
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between SSTR5 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
somatostatin	Everall, 2006	high-risk people		In analyzing the expression of 15 candidate genes for HIV en...... In analyzing the expression of 15 candidate genes for HIV encephalitis (HIVE) by the presence or absence of major depressive disorder (MDD), we noted significant reductions in the expression of four cytoskeletal genes and somatostatin. Whereas disruption of cytoskeletal genes has been noted in HIVE, dysregulation of somatostatin has not, indicating that dysregulation of somatostatin is part of the molecular pathologic process of MDD in the setting of HIV. More...

Positive relationships between SSTR5 and other components at different levels (count: 0)

Positive relationship network of SSTR5 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between SSTR5 and MDD (count: 0)

Negative relationships between SSTR5 and other components at different levels (count: 0)

SSTR5 related SNPs in MK4MDD (count: 0)

SSTR5 related proteins in MK4MDD (count: 0)

SSTR5 related GO terms (count: 16)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0004994	somatostatin receptor activity	molecular function	IEA
GO:0008285	negative regulation of cell proliferation	biological process	TAS[9892014]
GO:0071385	cellular response to glucocorticoid stimulus	biological process	IBA
GO:0038170	somatostatin signaling pathway	biological process	IEA; TAS[9892014]
GO:0007186	G-protein coupled receptor signaling pathway	biological process	TAS[9892014]
GO:0043005	neuron projection	cellular component	IBA
GO:0042593	glucose homeostasis	biological process	IEA
GO:0050796	regulation of insulin secretion	biological process	IBA
GO:0042923	neuropeptide binding	molecular function	IBA
GO:0005737	cytoplasm	cellular component	IEA
GO:0005887	integral component of plasma membrane	cellular component	TAS[7908405]
GO:0005886	plasma membrane	cellular component	IDA; TAS
GO:0005634	nucleus	cellular component	IDA
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	biological process	TAS[7908405]
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	biological process	IEA
GO:0032467	positive regulation of cytokinesis	biological process	IMP[22888021]

SSTR5 related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa04080	neuroactive ligand_receptor_interaction	Neuroactive ligand-receptor interaction

SSTR5 related BioCarta pathways (count: 0)

SSTR5 related Reactome pathways (count: 5)

ID	Name	Description
Gene mapped Reactome pathways
REACT_14819	peptide ligand_binding_receptors	These receptors, a subset of the Class A/1 (Rhodopsin-like) ...... These receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins. More...
REACT_21340	gpcr ligand_binding	There are more than 800 G-protein coupled receptor. GPCRs ar...... There are more than 800 G-protein coupled receptor. GPCRs are receptors for a diverse range of ligands from large proteins to photons and have an equal diverstiy of ligand-binding mechanisms. Classical GPCR signaling involves signal transduction via heterotrimeric G-proteins, however many G-protein independent mechanisms have been reported. More...
REACT_19184	downstream events_in_gpcr_signaling	G protein-coupled receptors. The beta:gamma G-protein dimer ...... G protein-coupled receptors. The beta:gamma G-protein dimer is also involved in downstream signaling , and some receptors form part of metastable complexes of receptor and accessory proteins such as the arrestins. GPCRs are involved in many diverse signaling events , using a variety of pathways that include modulation of adenylyl cyclase, phospholipase C, the mitogen activated protein kinases (MAPKs), extracellular signal regulated kinase (ERK) c-Jun-NH2-terminal kinase (JNK) and p38 MAPK. More...
REACT_14828	class a1_rhodopsin_like_receptors	Rhodopsin-like receptors. They represent members which inclu...... Rhodopsin-like receptors. They represent members which include hormone, light and neurotransmitter receptors and encompass a wide range of functions including many autocrine, paracrine and endocrine processes. More...
REACT_19231	g alpha_i_signalling_events	The classical signalling mechanism for G alpha (i) is inhibi...... The classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased activity of cAMP-dependent protein kinases. More...

SSTR5 related interactors from protein-protein interaction data in HPRD (count: 9)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
SSTR5	SST	Yes	in vivo	7908405
SSTR5	PDZK1	No	in vitro;in vivo;yeast 2-hybrid	16012170
SSTR5	ADCY10	No	in vivo	9694905
SSTR5	SSTR1	No	in vitro	10713101
SSTR5	GOPC	No	in vitro;in vivo;yeast 2-hybrid	16012170
SSTR5	DRD2	Yes	in vivo	10753124
SSTR5	SSTR5	Yes	in vivo	9694905
SSTR5	CORT	Yes	in vivo	9205124 , 9125122
SSTR5	PEX5	No	in vitro;in vivo;yeast 2-hybrid	16012170

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways