Study Report
Reference
| Citation | Everall, 2006 PubMed |
| Full Info | Everall, I.P., Salaria, S., Atkinson, J.H., Young, C., Corbeil, J., Grant, I. and Masliah, E. (2006) Diminished somatostatin gene expression in individuals with HIV and major depressive disorder. Neurology, 67, 1867-1869.
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Study
| Hypothesis or Background |
|
| Sample Information | 15 candidate genes for HIV encephalitis (HIVE) |
|---|
| Method Detail | |
| Method Keywords | |
| Result | |
| Conclusions | In analyzing the expression of 15 candidate genes for HIV encephalitis (HIVE) by the presence or absence of major depressive disorder (MDD), we noted significant reductions in the expression of four cytoskeletal genes and somatostatin. Whereas disruption of cytoskeletal genes has been noted in HIVE, dysregulation of somatostatin has not, indicating that dysregulation of somatostatin is part of the molecular pathologic process of MDD in the setting of HIV |
Relationships reported by
Everall, 2006
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
SSTR5 (somatostatin) |
gene |
|
In analyzing the expression of 15 candidate genes for HIV encephalitis (HIVE) by the presence or absence of major depressive disorder (MDD), we noted significant reductions in the expression of four cytoskeletal genes and somatostatin. Whereas disruption of cytoskeletal genes has been noted in HIVE, dysregulation of somatostatin has not, indicating that dysregulation of somatostatin is part of the molecular pathologic process of MDD in the setting of HIV. |
Positive
|
