Reactome Pathway Report

Basic Information
Name downstream events_in_gpcr_signaling
Description G protein-coupled receptors. The beta:gamma G-protein dimer is also involved in downstream signaling , and some receptors form part of metastable complexes of receptor and accessory proteins such as the arrestins. GPCRs are involved in many diverse signaling events , using a variety of pathways that include modulation of adenylyl cyclase, phospholipase C, the mitogen activated protein kinases (MAPKs), extracellular signal regulated kinase (ERK) c-Jun-NH2-terminal kinase (JNK) and p38 MAPK.

REACT_19184 related genes in MK4MDD (count: 100)
Approved Symbol Approved Name Type No. of Studies (Positive/Negative)
HCRTR1 hypocretin (orexin) receptor 1 Literature-origin; SNP mapped 2(2/0)
CRHR2 corticotropin releasing hormone receptor 2 Literature-origin; SNP mapped 1(0/1)
CCKAR cholecystokinin A receptor Literature-origin 1(1/0)
CHRM2 cholinergic receptor, muscarinic 2 Literature-origin; Protein mapped 2(1/1)
CRHR1 corticotropin releasing hormone receptor 1 Literature-origin; SNP mapped; Protein mapped 7(6/1)
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled Literature-origin; SNP mapped; Protein mapped 11(7/4)
S1PR1 sphingosine-1-phosphate receptor 1 Literature-origin 1(1/0)
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) Literature-origin 1(1/0)
AVPR1B arginine vasopressin receptor 1B Literature-origin; Protein mapped 1(1/0)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 Literature-origin 2(2/0)
PDE10A phosphodiesterase 10A Literature-origin 1(1/0)
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 Literature-origin; Protein mapped 1(1/0)
SSTR5 somatostatin receptor 5 Literature-origin 1(1/0)
DRD3 dopamine receptor D3 SNP mapped; Protein mapped 0(0/0)
POMC proopiomelanocortin Protein mapped 0(0/0)
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled Literature-origin; Protein mapped 5(4/1)
DRD1 dopamine receptor D1 Literature-origin; Protein mapped 2(2/0)
HRH1 histamine receptor H1 Protein mapped 0(0/0)
OXTR oxytocin receptor Literature-origin 1(1/0)
ADCY3 adenylate cyclase 3 Literature-origin 2(1/1)
DGKA diacylglycerol kinase, alpha 80kDa Literature-origin 1(1/0)
PDE4A phosphodiesterase 4A, cAMP-specific Literature-origin 1(1/0)
GNG3 guanine nucleotide binding protein (G protein), gamma 3 Literature-origin 1(1/0)
CCR6 chemokine (C-C motif) receptor 6 Literature-origin 1(1/0)
NTSR2 neurotensin receptor 2 Literature-origin 1(1/0)
GNAS GNAS complex locus Literature-origin 1(0/1)
ADRA2A adrenoceptor alpha 2A Literature-origin; Protein mapped 2(2/0)
TSHB thyroid stimulating hormone, beta Protein mapped 0(0/0)
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 Literature-origin; SNP mapped 2(2/0)
BDKRB2 bradykinin receptor B2 SNP mapped 0(0/0)
CXCL2 chemokine (C-X-C motif) ligand 2 Literature-origin 1(1/0)
NPY1R neuropeptide Y receptor Y1 Literature-origin 1(1/0)
TRIO trio Rho guanine nucleotide exchange factor Literature-origin 1(1/0)
C3 complement component 3 Protein mapped 0(0/0)
DGKH diacylglycerol kinase, eta Literature-origin 2(1/1)
TIAM1 T-cell lymphoma invasion and metastasis 1 Literature-origin 1(1/0)
PDE4B phosphodiesterase 4B, cAMP-specific Literature-origin 2(2/0)
DRD2 dopamine receptor D2 Literature-origin; Protein mapped 5(3/2)
PDE11A phosphodiesterase 11A Literature-origin 2(2/0)
EDNRB endothelin receptor type B Literature-origin 1(1/0)
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 Literature-origin 1(1/0)
RHOC ras homolog family member C Protein mapped 0(0/0)
PTH parathyroid hormone Protein mapped 0(0/0)
PDE1B phosphodiesterase 1B, calmodulin-dependent Literature-origin 1(1/0)
PENK proenkephalin Literature-origin 1(1/0)
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 Literature-origin 1(1/0)
PROK2 prokineticin 2 Literature-origin 1(1/0)
ADM adrenomedullin Literature-origin 2(2/0)
PDE3A phosphodiesterase 3A, cGMP-inhibited Literature-origin 1(1/0)
CDC42 cell division cycle 42 Literature-origin 1(1/0)
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) Literature-origin; SNP mapped 1(1/0)
CNR2 cannabinoid receptor 2 (macrophage) Literature-origin 1(1/0)
PDYN prodynorphin Protein mapped 0(0/0)
OPRM1 opioid receptor, mu 1 Literature-origin; SNP mapped; Protein mapped 2(1/1)
PTH1R parathyroid hormone 1 receptor Literature-origin 1(1/0)
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 Literature-origin 1(1/0)
PDE8A phosphodiesterase 8A Literature-origin 2(2/0)
CCKBR cholecystokinin B receptor Literature-origin 2(2/0)
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) Literature-origin 1(1/0)
PROKR2 prokineticin receptor 2 Literature-origin 1(1/0)
SST somatostatin Literature-origin; Protein mapped 3(3/0)
TAC1 tachykinin, precursor 1 Literature-origin; Protein mapped 2(2/0)
ADCY8 adenylate cyclase 8 (brain) Literature-origin 2(2/0)
DGKG diacylglycerol kinase, gamma 90kDa Literature-origin 1(1/0)
CCL20 chemokine (C-C motif) ligand 20 Literature-origin 1(1/0)
CXCL3 chemokine (C-X-C motif) ligand 3 Literature-origin 1(1/0)
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled Literature-origin; Protein mapped 15(11/4)
PDE1A phosphodiesterase 1A, calmodulin-dependent Literature-origin 2(2/0)
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled Literature-origin 1(1/0)
GAL galanin/GMAP prepropeptide Literature-origin 2(1/1)
VIP vasoactive intestinal peptide Protein mapped 0(0/0)
LPAR1 lysophosphatidic acid receptor 1 Literature-origin 2(2/0)
P2RY12 purinergic receptor P2Y, G-protein coupled, 12 Literature-origin 1(1/0)
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 Protein mapped 0(0/0)
F2 coagulation factor II (thrombin) Protein mapped 0(0/0)
IL8 interleukin 8 Literature-origin; Protein mapped 2(2/0)
BDKRB1 bradykinin receptor B1 Protein mapped 0(0/0)
OXT oxytocin/neurophysin I prepropeptide Protein mapped 0(0/0)
FSHB follicle stimulating hormone, beta polypeptide Protein mapped 0(0/0)
CRH corticotropin releasing hormone SNP mapped; Protein mapped 0(0/0)
ADRA2C adrenoceptor alpha 2C Protein mapped 0(0/0)
DRD4 dopamine receptor D4 Literature-origin 2(0/2)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 Literature-origin 1(1/0)
ADRB2 adrenoceptor beta 2, surface Literature-origin 1(1/0)
CALCA calcitonin-related polypeptide alpha Protein mapped 0(0/0)
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled Literature-origin 1(1/0)
EDN1 endothelin 1 Literature-origin 1(1/0)
CNR1 cannabinoid receptor 1 (brain) Literature-origin; SNP mapped; Protein mapped 4(3/1)
RHOA ras homolog family member A Literature-origin 1(1/0)
ADCY7 adenylate cyclase 7 Literature-origin 2(2/0)
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 Literature-origin 1(1/0)
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled Literature-origin 2(0/2)
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 Literature-origin; Protein mapped 1(1/0)
NPY neuropeptide Y Literature-origin; SNP mapped; Protein mapped 7(6/1)
CALCB calcitonin-related polypeptide beta Protein mapped 0(0/0)
ADRBK1 adrenergic, beta, receptor kinase 1 Protein mapped 0(0/0)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) Literature-origin 1(1/0)
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled Literature-origin; SNP mapped 4(3/1)
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Protein mapped 0(0/0)
GALR2 galanin receptor 2 Literature-origin 1(1/0)