Gene Report

Basic Information

Approved Symbol	PTH1R
Approved Name	parathyroid hormone 1 receptor
Previous Symbol	PTHR, PTHR1
Previous Name	parathyroid hormone receptor 1
Location	3p22-p21.1
Position	chr3:46919236-46945289 (+)
External Links	Entrez Gene: 5745 Ensembl: ENSG00000160801 UCSC: uc021wxg.1 HGNC ID: 9608
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between PTH1R and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
PTHR1	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between PTH1R and other components at different levels (count: 0)

Positive relationship network of PTH1R in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between PTH1R and MDD (count: 0)

Negative relationships between PTH1R and other components at different levels (count: 0)

PTH1R related SNPs in MK4MDD (count: 0)

PTH1R related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Parathyroid hormone/parathyroid hormone-related peptide receptor	Q03431	0(0/0)	Gene mapped

PTH1R related GO terms (count: 27)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway	biological process	IC[19608645]
GO:0030282	bone mineralization	biological process	IEA
GO:0045453	bone resorption	biological process	IEA
GO:0001501	skeletal system development	biological process	TAS[9745456]
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	biological process	IDA[19674967]
GO:0007204	elevation of cytosolic calcium ion concentration	biological process	IEA
GO:0004991	parathyroid hormone receptor activity	molecular function	IDA[19674967]
GO:0002076	osteoblast development	biological process	IEA
GO:0031526	brush border membrane	cellular component	IEA
GO:0002062	chondrocyte differentiation	biological process	IEA
GO:0008284	positive regulation of cell proliferation	biological process	IEA
GO:0016323	basolateral plasma membrane	cellular component	ISS
GO:0043621	protein self-association	molecular function	IDA[19674967]
GO:0005886	plasma membrane	cellular component	TAS
GO:0048469	cell maturation	biological process	IEA
GO:0005634	nucleus	cellular component	IEA
GO:0005887	integral to plasma membrane	cellular component	IDA[19674967]
GO:0007186	G-protein coupled receptor signaling pathway	biological process	TAS[9745456]
GO:0060732	positive regulation of inositol phosphate biosynthetic process	biological process	ISS
GO:0017046	peptide hormone binding	molecular function	IDA[19674967]
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway	biological process	ISS
GO:0016324	apical plasma membrane	cellular component	ISS
GO:0005737	cytoplasm	cellular component	IEA
GO:0008285	negative regulation of cell proliferation	biological process	IEA
GO:0043235	receptor complex	cellular component	ISS
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	biological process	TAS[9927325]
GO:0007568	aging	biological process	IEA

PTH1R related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa04080	neuroactive ligand_receptor_interaction	Neuroactive ligand-receptor interaction

PTH1R related BioCarta pathways (count: 0)

PTH1R related Reactome pathways (count: 4)

ID	Name	Description
Gene mapped Reactome pathways
REACT_21340	gpcr ligand_binding	There are more than 800 G-protein coupled receptor. GPCRs ar...... There are more than 800 G-protein coupled receptor. GPCRs are receptors for a diverse range of ligands from large proteins to photons and have an equal diverstiy of ligand-binding mechanisms. Classical GPCR signaling involves signal transduction via heterotrimeric G-proteins, however many G-protein independent mechanisms have been reported. More...
REACT_18372	class b2_secretin_family_receptors	This family is known as Family B. This family is known as Family B.
REACT_19327	g alpha_s_signalling_events	The general function of the G alpha (s) subunit (Gs) is to a...... The general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to collectively as Protein Kinase A). The signal from the ligand-stimulated GPCR is amplified because the receptor can activate several Gs heterotrimers before it is inactivated. More...
REACT_19184	downstream events_in_gpcr_signaling	G protein-coupled receptors. The beta:gamma G-protein dimer ...... G protein-coupled receptors. The beta:gamma G-protein dimer is also involved in downstream signaling , and some receptors form part of metastable complexes of receptor and accessory proteins such as the arrestins. GPCRs are involved in many diverse signaling events , using a variety of pathways that include modulation of adenylyl cyclase, phospholipase C, the mitogen activated protein kinases (MAPKs), extracellular signal regulated kinase (ERK) c-Jun-NH2-terminal kinase (JNK) and p38 MAPK. More...

PTH1R related interactors from protein-protein interaction data in HPRD (count: 7)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
PTH1R	SLC9A3R2	No	in vivo	12075354
PTH1R	PTHLH	No	in vivo	9108031
PTH1R	PTH	No	in vivo	9108031
PTH1R	ARRB1	No	in vitro;in vivo;yeast 2-hybrid	12220636
PTH1R	GNB1	No	in vitro	16099817
PTH1R	YWHAH	No	in vitro;in vivo	12595070
PTH1R	SLC9A3R1	No	in vitro;in vivo	12075354

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways