Reactome Pathway Report

Basic Information

ID
Name	g alpha_s_signalling_events
Description	The general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to collectively as Protein Kinase A). The signal from the ligand-stimulated GPCR is amplified because the receptor can activate several Gs heterotrimers before it is inactivated.

REACT_19327 related genes in MK4MDD (count: 33)

Approved Symbol	Approved Name	Type	No. of Studies (Positive/Negative)
CALCB	calcitonin-related polypeptide beta	Protein mapped	0(0/0)
PDE8A	phosphodiesterase 8A	Literature-origin	1(1/0)
PDE3A	phosphodiesterase 3A, cGMP-inhibited	Literature-origin	1(1/0)
DRD1	dopamine receptor D1	Literature-origin; Protein mapped	2(2/0)
GNAI3	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	SNP mapped	0(0/0)
CRHR2	corticotropin releasing hormone receptor 2	Literature-origin; SNP mapped	1(0/1)
ADRB2	adrenoceptor beta 2, surface	Literature-origin	1(1/0)
GNB3	guanine nucleotide binding protein (G protein), beta polypeptide 3	Literature-origin; SNP mapped	2(2/0)
VIP	vasoactive intestinal peptide	Protein mapped	0(0/0)
PDE1B	phosphodiesterase 1B, calmodulin-dependent	Literature-origin	1(1/0)
PDE4B	phosphodiesterase 4B, cAMP-specific	Literature-origin; SNP mapped	1(1/0)
PTH	parathyroid hormone	Protein mapped	0(0/0)
FSHB	follicle stimulating hormone, beta polypeptide	Protein mapped	0(0/0)
ADCY7	adenylate cyclase 7	Literature-origin; SNP mapped	2(2/0)
PDE11A	phosphodiesterase 11A	Literature-origin; SNP mapped	2(2/0)
ADCY8	adenylate cyclase 8 (brain)	Literature-origin	2(2/0)
ADCY3	adenylate cyclase 3	Literature-origin; SNP mapped	1(0/1)
ADCYAP1	adenylate cyclase activating polypeptide 1 (pituitary)	Literature-origin	1(1/0)
TSHB	thyroid stimulating hormone, beta	Protein mapped	0(0/0)
PDE1A	phosphodiesterase 1A, calmodulin-dependent	Literature-origin	1(1/0)
GNB1	guanine nucleotide binding protein (G protein), beta polypeptide 1	Protein mapped	0(0/0)
CRH	corticotropin releasing hormone	Protein mapped	0(0/0)
CALCA	calcitonin-related polypeptide alpha	Protein mapped	0(0/0)
POMC	proopiomelanocortin	Protein mapped	0(0/0)
GNG3	guanine nucleotide binding protein (G protein), gamma 3	Literature-origin	1(1/0)
PDE4A	phosphodiesterase 4A, cAMP-specific	Literature-origin	1(1/0)
PTH1R	parathyroid hormone 1 receptor	Literature-origin	1(1/0)
MC1R	melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)	Literature-origin; SNP mapped	1(1/0)
GNAS	GNAS complex locus	Literature-origin	1(0/1)
HTR4	5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled	Literature-origin	1(1/0)
PDE10A	phosphodiesterase 10A	Literature-origin; SNP mapped	1(1/0)
CRHR1	corticotropin releasing hormone receptor 1	Literature-origin; SNP mapped; Protein mapped	6(6/0)
ADCY9	adenylate cyclase 9	SNP mapped	0(0/0)