Reactome Pathway Report

Basic Information
Name g alpha_s_signalling_events
Description The general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to collectively as Protein Kinase A). The signal from the ligand-stimulated GPCR is amplified because the receptor can activate several Gs heterotrimers before it is inactivated.

REACT_19327 related genes in MK4MDD (count: 33)
Approved Symbol Approved Name Type No. of Studies (Positive/Negative)
VIP vasoactive intestinal peptide Protein mapped 0(0/0)
ADM adrenomedullin Literature-origin 2(2/0)
PDE3A phosphodiesterase 3A, cGMP-inhibited Literature-origin 1(1/0)
CRHR2 corticotropin releasing hormone receptor 2 Literature-origin; SNP mapped 1(0/1)
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 Protein mapped 0(0/0)
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) Literature-origin; SNP mapped 1(1/0)
GNAS GNAS complex locus Literature-origin 1(0/1)
CRHR1 corticotropin releasing hormone receptor 1 Literature-origin; SNP mapped; Protein mapped 7(6/1)
FSHB follicle stimulating hormone, beta polypeptide Protein mapped 0(0/0)
CRH corticotropin releasing hormone SNP mapped; Protein mapped 0(0/0)
TSHB thyroid stimulating hormone, beta Protein mapped 0(0/0)
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 Literature-origin; SNP mapped 2(2/0)
PTH1R parathyroid hormone 1 receptor Literature-origin 1(1/0)
PDE10A phosphodiesterase 10A Literature-origin 1(1/0)
PDE8A phosphodiesterase 8A Literature-origin 2(2/0)
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) Literature-origin 1(1/0)
POMC proopiomelanocortin Protein mapped 0(0/0)
ADRB2 adrenoceptor beta 2, surface Literature-origin 1(1/0)
CALCA calcitonin-related polypeptide alpha Protein mapped 0(0/0)
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled Literature-origin 1(1/0)
DRD1 dopamine receptor D1 Literature-origin; Protein mapped 2(2/0)
ADCY8 adenylate cyclase 8 (brain) Literature-origin 2(2/0)
ADCY7 adenylate cyclase 7 Literature-origin 2(2/0)
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 Literature-origin 1(1/0)
PDE1A phosphodiesterase 1A, calmodulin-dependent Literature-origin 2(2/0)
ADCY3 adenylate cyclase 3 Literature-origin 2(1/1)
PDE4B phosphodiesterase 4B, cAMP-specific Literature-origin 2(2/0)
CALCB calcitonin-related polypeptide beta Protein mapped 0(0/0)
PDE11A phosphodiesterase 11A Literature-origin 2(2/0)
PDE4A phosphodiesterase 4A, cAMP-specific Literature-origin 1(1/0)
GNG3 guanine nucleotide binding protein (G protein), gamma 3 Literature-origin 1(1/0)
PTH parathyroid hormone Protein mapped 0(0/0)
PDE1B phosphodiesterase 1B, calmodulin-dependent Literature-origin 1(1/0)