MK4MDD

Gene Report

Basic Information
Approved Symbol PDE4B
Approved Name phosphodiesterase 4B, cAMP-specific
Previous Symbol DPDE4
Previous Name "phosphodiesterase 4B, cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E4)", "phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)"
Name Alias "phosphodiesterase E4 dunce homolog (Drosophila)"
Location 1p31
Position chr1:66838362-66840257 (+)
External Links Entrez Gene: 5142
Ensembl: ENSG00000184588
UCSC: uc001dco.3
HGNC ID: 8781
No. of Studies (Positive/Negative) 2(2/0) Help
Type Literature-origin

Positive relationships between PDE4B and MDD (count: 2)
Name in Literature Reference Research Type Statistical Result Relation Description Help
PDE4B Numata, 2009 patients and normal controls P-value < 0.0001 In the leukocytes, a significantly higher expression of the ...... In the leukocytes, a significantly higher expression of the PDE4B mRNA was observed in the drug-naive MDD patients compared with control subjects (P < 0.0001); In the association analysis, we observed significant allelic associations of four SNPs (the most significant, rs472952; P = 0.002) and a significant haplotypic association (permutation P = 0.019) between the PDE4B gene and MDD in the first-set samples. More...
PDE4B Carvalho LA, 2014 patients and normal controls FC=1.9; P-value=0.004 Thirty-four of the 47 monocyte inflammatory-related genes w...... Thirty-four of the 47 monocyte inflammatory-related genes were significantly upregulated and 2 were significantly downregulated as compared to controls More...

Positive relationships between PDE4B and other components at different levels (count: 0) Help
Positive relationship network of PDE4B in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between PDE4B and MDD (count: 0)
Negative relationships between PDE4B and other components at different levels (count: 0) Help
PDE4B related SNPs in MK4MDD (count: 0)
PDE4B related proteins in MK4MDD (count: 0)
PDE4B related GO terms (count: 26)
PDE4B related KEGG pathways (count: 1)
PDE4B related BioCarta pathways (count: 0)
PDE4B related Reactome pathways (count: 4)
PDE4B related interactors from protein-protein interaction data in HPRD (count: 1)