Gene Report

Basic Information

Approved Symbol	PDE4B
Approved Name	phosphodiesterase 4B, cAMP-specific
Previous Symbol	DPDE4
Previous Name	"phosphodiesterase 4B, cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E4)", "phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)"
Name Alias	"phosphodiesterase E4 dunce homolog (Drosophila)"
Location	1p31
Position	chr1:66838362-66840257 (+)
External Links	Entrez Gene: 5142 Ensembl: ENSG00000184588 UCSC: uc001dco.3 HGNC ID: 8781
No. of Studies (Positive/Negative)	2(2/0)
Type	Literature-origin

Positive relationships between PDE4B and MDD (count: 2)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
PDE4B	Numata, 2009	patients and normal controls	P-value < 0.0001	In the leukocytes, a significantly higher expression of the ...... In the leukocytes, a significantly higher expression of the PDE4B mRNA was observed in the drug-naive MDD patients compared with control subjects (P < 0.0001); In the association analysis, we observed significant allelic associations of four SNPs (the most significant, rs472952; P = 0.002) and a significant haplotypic association (permutation P = 0.019) between the PDE4B gene and MDD in the first-set samples. More...
PDE4B	Carvalho LA, 2014	patients and normal controls	FC=1.9; P-value=0.004	Thirty-four of the 47 monocyte inflammatory-related genes w...... Thirty-four of the 47 monocyte inflammatory-related genes were significantly upregulated and 2 were significantly downregulated as compared to controls More...

Positive relationships between PDE4B and other components at different levels (count: 0)

Positive relationship network of PDE4B in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between PDE4B and MDD (count: 0)

Negative relationships between PDE4B and other components at different levels (count: 0)

PDE4B related SNPs in MK4MDD (count: 0)

PDE4B related proteins in MK4MDD (count: 0)

PDE4B related GO terms (count: 26)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0008021	synaptic vesicle	cellular component	IEA
GO:0014069	postsynaptic density	cellular component	IEA
GO:0043197	dendritic spine	cellular component	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005891	voltage-gated calcium channel complex	cellular component	ISS
GO:0032743	positive regulation of interleukin-2 production	biological process	IMP[17404263]
GO:0030552	cAMP binding	molecular function	IGI[8413254]
GO:0086004	regulation of cardiac muscle cell contraction	biological process	ISS
GO:0044325	ion channel binding	molecular function	ISS
GO:1901841	regulation of high voltage-gated calcium channel activity	biological process	ISS
GO:1901898	negative regulation of relaxation of cardiac muscle	biological process	ISS
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	molecular function	IDA[17404263]; IGI[8413254]; ISS
GO:0005829	cytosol	cellular component	TAS
GO:0071222	cellular response to lipopolysaccharide	biological process	ISS
GO:0005813	centrosome	cellular component	IEA
GO:0035690	cellular response to drug	biological process	ISS
GO:0046872	metal ion binding	molecular function	IEA
GO:0043015	gamma-tubulin binding	molecular function	IEA
GO:0032729	positive regulation of interferon-gamma production	biological process	IMP[17404263]
GO:0006198	cAMP catabolic process	biological process	IDA[17404263]; IEA; IGI[8413254]
GO:0001780	neutrophil homeostasis	biological process	ISS
GO:0071872	cellular response to epinephrine stimulus	biological process	ISS
GO:0030593	neutrophil chemotaxis	biological process	ISS
GO:0000930	gamma-tubulin complex	cellular component	IEA
GO:0050900	leukocyte migration	biological process	ISS
GO:0030018	Z disc	cellular component	ISS
GO:0050852	T cell receptor signaling pathway	biological process	IMP[17404263]

PDE4B related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa00230	purine metabolism	Purine metabolism

PDE4B related BioCarta pathways (count: 0)

PDE4B related Reactome pathways (count: 4)

ID	Name	Description
Gene mapped Reactome pathways
REACT_19327	g alpha_s_signalling_events	The general function of the G alpha (s) subunit (Gs) is to a...... The general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to collectively as Protein Kinase A). The signal from the ligand-stimulated GPCR is amplified because the receptor can activate several Gs heterotrimers before it is inactivated. More...
REACT_15334	darpp32 events	Dopamine- and cAMP-regulated phosphoprotein, Mr 32 kDa (DARP...... Dopamine- and cAMP-regulated phosphoprotein, Mr 32 kDa (DARPP-32), was identified as a major target for dopamine and protein kinase A (PKA) in striatum. Recent advances now indicate that regulation DARPP-32 phosphorylation provides a mechanism for integrating information arriving at dopaminoceptive neurons, in multiple brain regions, via a variety of neurotransmitters, neuromodulators, neuropeptides, and steroid hormones. Activation of PKA or PKG stimulates DARPP-32 phosphorylation at Thr34, converting DARPP-32 into a potent inhibitor of protein phosphatase-1 (PP-1). DARPP-32 is also phosphorylated at Thr75 by Cdk5, converting DARPP-32 into an inhibitor of PKA. Thus, DARPP-32 has the unique property of being a dual-function protein, acting either as an inhibitor of PP-1 or of PKA. More...
REACT_15295	opioid signalling	Opioids are chemical substances similar to opiates, the acti...... Opioids are chemical substances similar to opiates, the active substances found in opium (morphine, codeine etc.). Opioid action is mediated by the receptors for endogenous opioids; peptides such as the enkephalins, the endorphins or the dynorphins. Opioids possess powerful analgesic and sedative effects, and are widely used as pain-killers. Their main side-effect is the rapid establishment of a strong addiction. Opioids receptors are G-protein coupled receptors (GPCR). There are four classes of receptors: mu (MOR), kappa (KOR) and delta (DOR), and the nociceptin receptor (NOP). More...
REACT_19184	downstream events_in_gpcr_signaling	G protein-coupled receptors. The beta:gamma G-protein dimer ...... G protein-coupled receptors. The beta:gamma G-protein dimer is also involved in downstream signaling , and some receptors form part of metastable complexes of receptor and accessory proteins such as the arrestins. GPCRs are involved in many diverse signaling events , using a variety of pathways that include modulation of adenylyl cyclase, phospholipase C, the mitogen activated protein kinases (MAPKs), extracellular signal regulated kinase (ERK) c-Jun-NH2-terminal kinase (JNK) and p38 MAPK. More...

PDE4B related interactors from protein-protein interaction data in HPRD (count: 1)

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways