Gene Report

Basic Information

Approved Symbol	PDE10A
Approved Name	phosphodiesterase 10A
Location	6q26
Position	chr6:165740776-166075588 (-)
External Links	Entrez Gene: 10846 Ensembl: ENSG00000112541 UCSC: uc003quo.3 HGNC ID: 8772
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin; SNP mapped

Positive relationships between PDE10A and MDD (count: 0)

Positive relationships between PDE10A and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
Pde10a		SLC17A7(vesicular glutamate transporter 1 (VGLUT1))	gene	Tordera RM, 2011	animal model		gene was regulated in frontal cortex of VGLUT1(+/-) mice gene was regulated in frontal cortex of VGLUT1(+/-) mice

Positive relationship network of PDE10A in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between PDE10A and MDD (count: 0)

Negative relationships between PDE10A and other components at different levels (count: 0)

PDE10A related SNPs in MK4MDD (count: 3)

#rs	Location	Annotation	No. of Studies (Positive/Negative)
rs717602	chr6:165807107(Forward)	intron_variant	1(1/0)
rs676389	chr6:165912970(Forward)	intron_variant	1(1/0)
rs220818	chr6:165850104(Forward)	intron_variant	1(1/0)

PDE10A related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	0(0/0)	Gene mapped

PDE10A related GO terms (count: 15)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0030553	cGMP binding	molecular function	NAS[15938621]
GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	molecular function	IEA
GO:0030552	cAMP binding	molecular function	IDA[19689430]; NAS[15938621]
GO:0004118	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	molecular function	IDA[19689430]
GO:0046069	cGMP catabolic process	biological process	IEA
GO:0007165	signal transduction	biological process	IEA
GO:0005829	cytosol	cellular component	TAS
GO:0010738	regulation of protein kinase A signaling cascade	biological process	IEA
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	molecular function	TAS[10373451]
GO:0043949	regulation of cAMP-mediated signaling	biological process	IEA
GO:0007596	blood coagulation	biological process	TAS
GO:0046872	metal ion binding	molecular function	IEA
GO:0006198	cAMP catabolic process	biological process	IEA

PDE10A related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa00230	purine metabolism	Purine metabolism

PDE10A related BioCarta pathways (count: 0)

PDE10A related Reactome pathways (count: 2)

ID	Name	Description
Gene mapped Reactome pathways
REACT_19327	g alpha_s_signalling_events	The general function of the G alpha (s) subunit (Gs) is to a...... The general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to collectively as Protein Kinase A). The signal from the ligand-stimulated GPCR is amplified because the receptor can activate several Gs heterotrimers before it is inactivated. More...
REACT_19184	downstream events_in_gpcr_signaling	G protein-coupled receptors. The beta:gamma G-protein dimer ...... G protein-coupled receptors. The beta:gamma G-protein dimer is also involved in downstream signaling , and some receptors form part of metastable complexes of receptor and accessory proteins such as the arrestins. GPCRs are involved in many diverse signaling events , using a variety of pathways that include modulation of adenylyl cyclase, phospholipase C, the mitogen activated protein kinases (MAPKs), extracellular signal regulated kinase (ERK) c-Jun-NH2-terminal kinase (JNK) and p38 MAPK. More...

PDE10A related interactors from protein-protein interaction data in HPRD (count: 2)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
PDE10A	CASP3	No	in vitro	11602184
PDE10A	WDR3	No	yeast 2-hybrid	16169070

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways