Gene Report

Basic Information

Approved Symbol	SLC17A7
Approved Name	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
Symbol Alias	BNPI, VGLUT1
Name Alias	vesicular glutamate transporter 1
Location	19q13.33
Position	chr19:49932655-49944808 (-)
External Links	Entrez Gene: 57030 Ensembl: ENSG00000104888 UCSC: uc002pnp.3 HGNC ID: 16704
No. of Studies (Positive/Negative)	4(4/0)
Type	Literature-origin; Protein mapped

Positive relationships between SLC17A7 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
VGLUT1	Uezato, 2009	patients and normal controls		We found decreased VGLUT1 mRNA expression in both MDD and BD...... We found decreased VGLUT1 mRNA expression in both MDD and BD in the entorhinal cortex (ERC), decreased VGLUT2 mRNA expression in MDD in the middle temporal gyrus More...

Positive relationships between SLC17A7 and other components at different levels (count: 40)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Related Components
Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
vesicular glutamate transporter 1 (VGLUT1)		SLC1A3(excitatory amino acid transporter 1 (EAAT1))	gene	Garcia-Garcia AL, 2009	animal model		VGLUT1+/- mice showed decreased excitatory amino acid transp...... VGLUT1+/- mice showed decreased excitatory amino acid transporter 1 (EAAT1) More...
vesicular glutamate transporter 1 (VGLUT1)		ADCY8(Adcy8)	gene	Tordera RM, 2011	animal model		gene was regulated in frontal cortex of VGLUT1(+/-) mice gene was regulated in frontal cortex of VGLUT1(+/-) mice
vesicular glutamate transporter 1 (VGLUT1)		CNR1(Cnr1)	gene	Tordera RM, 2011	animal model		gene was regulated in frontal cortex of VGLUT1(+/-) mice gene was regulated in frontal cortex of VGLUT1(+/-) mice
vesicular glutamate transporter 1 (VGLUT1)		DRD1(Drd1a)	gene	Tordera RM, 2011	animal model		gene was regulated in frontal cortex of VGLUT1(+/-) mice gene was regulated in frontal cortex of VGLUT1(+/-) mice
vesicular glutamate transporter 1 (VGLUT1)		GABBR1(Gabbr1)	gene	Tordera RM, 2011	animal model		gene was regulated in frontal cortex of VGLUT1(+/-) mice gene was regulated in frontal cortex of VGLUT1(+/-) mice
vesicular glutamate transporter 1 (VGLUT1)		GABRA3(Gabra3)	gene	Tordera RM, 2011	animal model		gene was regulated in frontal cortex of VGLUT1(+/-) mice gene was regulated in frontal cortex of VGLUT1(+/-) mice
vesicular glutamate transporter 1 (VGLUT1)		GABRG2(Gabrg2)	gene	Tordera RM, 2011	animal model		gene was regulated in frontal cortex of VGLUT1(+/-) mice gene was regulated in frontal cortex of VGLUT1(+/-) mice
vesicular glutamate transporter 1 (VGLUT1)		GLRB(Glrb)	gene	Tordera RM, 2011	animal model		gene was regulated in frontal cortex of VGLUT1(+/-) mice gene was regulated in frontal cortex of VGLUT1(+/-) mice
vesicular glutamate transporter 1 (VGLUT1)		GRIK5(Grik5)	gene	Tordera RM, 2011	animal model		gene was regulated in frontal cortex of VGLUT1(+/-) mice gene was regulated in frontal cortex of VGLUT1(+/-) mice
vesicular glutamate transporter 1 (VGLUT1)		GRM1(Grm1)	gene	Tordera RM, 2011	animal model		gene was regulated in frontal cortex of VGLUT1(+/-) mice gene was regulated in frontal cortex of VGLUT1(+/-) mice
vesicular glutamate transporter 1 (VGLUT1)		HTR1A(Htr1a)	gene	Tordera RM, 2011	animal model		gene was regulated in frontal cortex of VGLUT1(+/-) mice gene was regulated in frontal cortex of VGLUT1(+/-) mice
vesicular glutamate transporter 1 (VGLUT1)		MAPK12(Mapk12)	gene	Tordera RM, 2011	animal model		gene was regulated in frontal cortex of VGLUT1(+/-) mice gene was regulated in frontal cortex of VGLUT1(+/-) mice
vesicular glutamate transporter 1 (VGLUT1)		NOSIP(Nosip)	gene	Tordera RM, 2011	animal model		gene was regulated in frontal cortex of VGLUT1(+/-) mice gene was regulated in frontal cortex of VGLUT1(+/-) mice
vesicular glutamate transporter 1 (VGLUT1)		NTRK3(Ntrk3)	gene	Tordera RM, 2011	animal model		gene was regulated in frontal cortex of VGLUT1(+/-) mice gene was regulated in frontal cortex of VGLUT1(+/-) mice
vesicular glutamate transporter 1 (VGLUT1)		SIGMAR1(Oprs1)	gene	Tordera RM, 2011	animal model		gene was regulated in frontal cortex of VGLUT1(+/-) mice gene was regulated in frontal cortex of VGLUT1(+/-) mice
vesicular glutamate transporter 1 (VGLUT1)		PDE10A(Pde10a)	gene	Tordera RM, 2011	animal model		gene was regulated in frontal cortex of VGLUT1(+/-) mice gene was regulated in frontal cortex of VGLUT1(+/-) mice
vesicular glutamate transporter 1 (VGLUT1)		PDE1B(Pde1b)	gene	Tordera RM, 2011	animal model		gene was regulated in frontal cortex of VGLUT1(+/-) mice gene was regulated in frontal cortex of VGLUT1(+/-) mice
vesicular glutamate transporter 1 (VGLUT1)		PDE4A(Pde4a)	gene	Tordera RM, 2011	animal model		gene was regulated in frontal cortex of VGLUT1(+/-) mice gene was regulated in frontal cortex of VGLUT1(+/-) mice
vesicular glutamate transporter 1 (VGLUT1)		RAB8B(Rab8b)	gene	Tordera RM, 2011	animal model		gene was regulated in frontal cortex of VGLUT1(+/-) mice gene was regulated in frontal cortex of VGLUT1(+/-) mice
vesicular glutamate transporter 1 (VGLUT1)		RHOA(Rhoa)	gene	Tordera RM, 2011	animal model		gene was regulated in frontal cortex of VGLUT1(+/-) mice gene was regulated in frontal cortex of VGLUT1(+/-) mice
vesicular glutamate transporter 1 (VGLUT1)		Ras subfamily(Ras GTPase)	protein	Tordera RM, 2011	animal model		genes invovled in this pathwy were regulated in frontal cort...... genes invovled in this pathwy were regulated in frontal cortex of VGLUT1(+/-) mice More...
vesicular glutamate transporter 1 (VGLUT1)		gamma-Aminobutyric Acid(GABA)	molecule	Garcia-Garcia AL, 2009	animal model		VGLUT1+/- mice showed decreased GABA VGLUT1+/- mice showed decreased GABA
vesicular glutamate transporter 1 (VGLUT1)		apoptosis(Apoptosis)	pathway	Tordera RM, 2011	animal model		genes invovled in this pathwy were regulated in frontal cort...... genes invovled in this pathwy were regulated in frontal cortex of VGLUT1(+/-) mice More...
vesicular glutamate transporter 1 (VGLUT1)		cell junction(Cell junction)	pathway	Tordera RM, 2011	animal model		genes invovled in this pathwy were regulated in frontal cort...... genes invovled in this pathwy were regulated in frontal cortex of VGLUT1(+/-) mice More...
vesicular glutamate transporter 1 (VGLUT1)		cytoskeleton(Cytoskeleton)	pathway	Tordera RM, 2011	animal model		genes invovled in this pathwy were regulated in frontal cort...... genes invovled in this pathwy were regulated in frontal cortex of VGLUT1(+/-) mice More...
vesicular glutamate transporter 1 (VGLUT1)		ion Channels(ion channels)	pathway	Tordera RM, 2011	animal model		genes invovled in this pathwy were regulated in frontal cort...... genes invovled in this pathwy were regulated in frontal cortex of VGLUT1(+/-) mice More...
vesicular glutamate transporter 1 (VGLUT1)		kinase activity(Kinase activity)	pathway	Tordera RM, 2011	animal model		genes invovled in this pathwy were regulated in frontal cort...... genes invovled in this pathwy were regulated in frontal cortex of VGLUT1(+/-) mice More...
vesicular glutamate transporter 1 (VGLUT1)		metabolic process(Metabolic process)	pathway	Tordera RM, 2011	animal model		genes invovled in this pathwy were regulated in frontal cort...... genes invovled in this pathwy were regulated in frontal cortex of VGLUT1(+/-) mice More...
vesicular glutamate transporter 1 (VGLUT1)		neurogenesis(Neurogenesis)	pathway	Tordera RM, 2011	animal model		genes invovled in this pathwy were regulated in frontal cort...... genes invovled in this pathwy were regulated in frontal cortex of VGLUT1(+/-) mice More...
vesicular glutamate transporter 1 (VGLUT1)		neuron differentiation(Neuron differentiation)	pathway	Tordera RM, 2011	animal model		genes invovled in this pathwy were regulated in frontal cort...... genes invovled in this pathwy were regulated in frontal cortex of VGLUT1(+/-) mice More...
vesicular glutamate transporter 1 (VGLUT1)		nucleotide binding(Nucleotide binding)	pathway	Tordera RM, 2011	animal model		genes invovled in this pathwy were regulated in frontal cort...... genes invovled in this pathwy were regulated in frontal cortex of VGLUT1(+/-) mice More...
vesicular glutamate transporter 1 (VGLUT1)		postsynaptic membrane(Postsynaptic membrane)	pathway	Tordera RM, 2011	animal model		genes invovled in this pathwy were regulated in frontal cort...... genes invovled in this pathwy were regulated in frontal cortex of VGLUT1(+/-) mice More...
vesicular glutamate transporter 1 (VGLUT1)		protein catabolic process(Protein catabolic process)	pathway	Tordera RM, 2011	animal model		genes invovled in this pathwy were regulated in frontal cort...... genes invovled in this pathwy were regulated in frontal cortex of VGLUT1(+/-) mice More...
vesicular glutamate transporter 1 (VGLUT1)		protein metabolic process(Protein metabolic process)	pathway	Tordera RM, 2011	animal model		genes invovled in this pathwy were regulated in frontal cort...... genes invovled in this pathwy were regulated in frontal cortex of VGLUT1(+/-) mice More...
vesicular glutamate transporter 1 (VGLUT1)		synaptic transmission(Synaptic transmission)	pathway	Tordera RM, 2011	animal model		genes invovled in this pathwy were regulated in frontal cort...... genes invovled in this pathwy were regulated in frontal cortex of VGLUT1(+/-) mice More...
vesicular glutamate transporter 1 (VGLUT1)		synaptic vesicle(Synaptic vesicle)	pathway	Tordera RM, 2011	animal model		genes invovled in this pathwy were regulated in frontal cort...... genes invovled in this pathwy were regulated in frontal cortex of VGLUT1(+/-) mice More...
vesicular glutamate transporter 1 (VGLUT1)		Learning(Learning)	cognition and behavior	Tordera RM, 2011	animal model		genes invovled in this pathwy were regulated in frontal cort...... genes invovled in this pathwy were regulated in frontal cortex of VGLUT1(+/-) mice More...
vesicular glutamate transporter 1 (VGLUT1)		Memory(memory)	cognition and behavior	Tordera RM, 2011	animal model		genes invovled in this pathwy were regulated in frontal cort...... genes invovled in this pathwy were regulated in frontal cortex of VGLUT1(+/-) mice More...
VGLUT1		anhedonic-like behavior from animal model(anhedonic-like behavior)	cognition and behavior	Tordera RM, 2011	animal model		VGLUT1 mice showed helpless and anhedonic-like behavior VGLUT1 mice showed helpless and anhedonic-like behavior
VGLUT1		Stress(stress)	environment	Elizalde N, 2010	animal model		CMS downregulated the GAD65 and VGLUT1 expressions CMS downregulated the GAD65 and VGLUT1 expressions

Positive relationship network of SLC17A7 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between SLC17A7 and MDD (count: 0)

Negative relationships between SLC17A7 and other components at different levels (count: 0)

SLC17A7 related SNPs in MK4MDD (count: 0)

SLC17A7 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Vesicular glutamate transporter 1	Q9P2U7	1(1/0)	Literature-origin

SLC17A7 related GO terms (count: 23)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0030054	cell junction	cellular component	IEA
GO:0007268	synaptic transmission	biological process	TAS
GO:0035249	synaptic transmission, glutamatergic	biological process	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0014047	glutamate secretion	biological process	TAS
GO:0006811	ion transport	biological process	TAS
GO:0060203	clathrin-sculpted glutamate transport vesicle membrane	cellular component	TAS
GO:0007269	neurotransmitter secretion	biological process	TAS
GO:0015319	sodium:inorganic phosphate symporter activity	molecular function	IDA[10820226]
GO:0005315	inorganic phosphate transmembrane transporter activity	molecular function	IEA
GO:0016021	integral to membrane	cellular component	IDA[10820226]
GO:0043005	neuron projection	cellular component	IEA
GO:0042137	sequestering of neurotransmitter	biological process	IEA
GO:0006817	phosphate ion transport	biological process	TAS[8632143]
GO:0005886	plasma membrane	cellular component	TAS
GO:0051938	L-glutamate import	biological process	IEA
GO:0015321	sodium-dependent phosphate transmembrane transporter activity	molecular function	IEA
GO:0060076	excitatory synapse	cellular component	IEA
GO:0030672	synaptic vesicle membrane	cellular component	TAS
GO:0055085	transmembrane transport	biological process	TAS
GO:0005313	L-glutamate transmembrane transporter activity	molecular function	TAS
GO:0048786	presynaptic active zone	cellular component	IEA
GO:0007616	long-term memory	biological process	IEA
GO:0060079	regulation of excitatory postsynaptic membrane potential	biological process	IEA

SLC17A7 related KEGG pathways (count: 0)

SLC17A7 related BioCarta pathways (count: 0)

SLC17A7 related Reactome pathways (count: 7)

ID	Name	Description
Gene mapped Reactome pathways
REACT_13723	neurotransmitter release_cycle	Neurotransmitter is stored in the synaptic vesicle in the pr...... Neurotransmitter is stored in the synaptic vesicle in the pre-synaptic terminal prior to its release in the synaptic cleft upon depolarization of the pre-synaptic membrane. The release of the neurotransmitter is a multi-step process that is controlled by electrical signals passing through the axons in form of action potential. Neurotransmitters include glutamate, acetylcholine, nor-epinephrine, dopamine and seratonin. Each of the neurotransmitter cycle is independently described. More...
REACT_19419	amino acid_and_oligopeptide_slc_transporters	Eight SLC gene families are involved in the transport of ami...... Eight SLC gene families are involved in the transport of amino acids and oligopeptides. More...
REACT_12591	glutamate neurotransmitter_release_cycle	Communication at the synapse involves the release of glutama...... Communication at the synapse involves the release of glutamate from the presynaptic neuron and its binding to glutamate receptors on the postsynaptic cell to generate a series of events that lead to propagation of the synaptic transmission. This process begins with the formation of synaptic vesicles in the presynaptic neuron, proceeds to the loading of glutamate into the vesicles, and concludes with the release of glutamate into the synaptic cleft. The glutamate life cycle in the neuron begins with the loading of the nascent synaptic vesicles with cytosolic glutamate with the help the transporter protein, VGLUT1, located in the synaptic vesicular membrane. Glutamate loaded vesicles are formed in the cytoplasm and then transported to a site close to the plasma membrane where the vesicle is docked with the help of several proteins. One of the key players in the docking process in Munc 18, which interacts with syntaxin (in the plasma membrane), MINT (Munc18 interacting molecule), and DOC2. These interactions along with the secondary interactions are needed for docking the synaptic vesicle to the plasma membrane. The docked synaptic vesicle is not ready for release until it undergoes molecular changes to prime it for fusion with the plasma membrane. Munc13 is one of the main players in the priming process. Munc 13 interacts with RIM (Rab3A interacting molecule) located in the synaptic vesicle. Munc 13 also interacts with DOC2. The precise molecular mechanisms of the interactions that result in docking versus priming are not clear and the docking and priming process have been combined in this annotation of this pathway. Once primed the synaptic vesicle is ready for release. Synaptic transmission involves an action potential that is generated in the presynaptic cell which induces the opening of voltage gated Ca2+ channels (VGCC) located in the plasma membrane of the presynaptic neuron. Typically N, P/Q and R type of VGCCs are involved in the neurotransmitter release. Ca2+ influx through these channels results in the rise of intracellular Ca2+ concentration. In the microdomain of glutamatergic synapses, the Ca2+ concentration could rise between 10-25 micro molar. Synaptotagmin, a Ca2+-binding protein located in the synaptic vesicular membrane, responds to the rise in the Ca2+ levels in the microdomain and induces a synaptic vesicle membrane curvature that favors vesicle fusion. Fusion of the synaptic vesicle with the plasma membrane is characterized by the formation of a trimeric trans-SNARE complex that involves VAMP2 from the synaptic vesicle membrane, and syntaxin and SNAP-25 from plasma membrane. Vesicle fusion incorporates the synaptic vesicle membrane into the plasma membrane, releasing the vesicle contents (glutamate) into the synaptic cleft. Postfusion the synaptic vesicle membrane proteins (VAMP2, Rab3A, VGLUT1, and synaptotagmin) are also found in the plasma membrane. More...
REACT_19397	inorganic cation_anion_slc_transporters	Teleologically, one might argue that inorganic cation and an...... Teleologically, one might argue that inorganic cation and anion transport would be evolutionarily among the oldest transport functions. Eight families comprise the group that transports exclusively inorganic cations and anions across membranes : SLC4 plays a pivotal role in mediating Na+- and/or Cl-dependent transport of basic anions [e.g. HCO3, ; SLC8 is a group of Na+/Ca2+ exchangers ; SLC24 is a group of Na+/Ca2+ or Na+/K+ exchangers ; SLC9 comprises Na+/H+ exchanger proteins involved in the electroneutral exchange of sodium ion and protons ; SLC12 functions as Na+, K+ and Cl ion electroneutral symporters ; SLC26 is the trans-epithelial multifunctional anion. SLC34 is an important Type II Na+/; SLC20 was originally identified as a viral receptor, and functions as a Type III Na+/. Eight SLC gene families are involved in the transport of amino acids and oligopeptides. More...
REACT_15518	transmembrane transport_of_small_molecules
REACT_19118	slc mediated_transmembrane_transport	Proteins with transporting functions can be roughly classifi...... Proteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the movement of the substrates across the membrane, against their electrochemical gradient. Channels at the open state can transfer the substrates. At least 20-25% amino-acid sequence identity is shared by members belonging to the same SLC family. No homology is shared between different SLC families. While the HUGO nomenclature system by definition only includes human genes, the nomenclature system has been informally extended to include rodent species through the use of lower cases letters (e.g., Slc1a1 denotes the rodent ortholog of the human SLC1A1 gene). And it's worthwhile to mention that pumps, channels and aquporins are not included in SLC superfamily. More...
REACT_13477	transmission across_chemical_synapses	Chemical synapses are specialized junctions that are used fo...... Chemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron, muscle cell or glad cell. The pre and the post-synaptic cell are separated by a gap of 20nm called the synaptic cleft. The signals pass in a unidirection from pre-synaptic to post-synaptic. The pre-synaptic neuron communicates via the release of neurotransmitter which bind the receptors on the post-synaptic cell. More...

SLC17A7 related interactors from protein-protein interaction data in HPRD (count: 1)

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped Reactome pathways