Reactome Pathway Report
Basic Information
| ID |
|
| Name |
neurotransmitter release_cycle
|
| Description |
Neurotransmitter is stored in the synaptic vesicle in the pre-synaptic terminal prior to its release in the synaptic cleft upon depolarization of the pre-synaptic membrane. The release of the neurotransmitter is a multi-step process that is controlled by electrical signals passing through the axons in form of action potential. Neurotransmitters include glutamate, acetylcholine, nor-epinephrine, dopamine and seratonin. Each of the neurotransmitter cycle is independently described.
|
REACT_13723 related genes in MK4MDD (count: 14)
| Approved Symbol |
Approved Name |
Type |
No. of Studies (Positive/Negative) |
| MAOA |
monoamine oxidase A |
Literature-origin; SNP mapped; Protein mapped
|
12(9/3) |
| SLC18A2 |
solute carrier family 18 (vesicular monoamine), member 2 |
Literature-origin; Protein mapped
|
1(1/0) |
| SLC17A7 |
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 |
Literature-origin; Protein mapped
|
4(4/0) |
| SYN2 |
synapsin II |
Literature-origin; Protein mapped
|
1(1/0) |
| SLC18A3 |
solute carrier family 18 (vesicular acetylcholine), member 3 |
SNP mapped
|
0(0/0) |
| CHAT |
choline O-acetyltransferase |
SNP mapped
|
0(0/0) |
| TPH1 |
tryptophan hydroxylase 1 |
Literature-origin; SNP mapped
|
11(9/2) |
| CPLX1 |
complexin 1 |
Protein mapped
|
0(0/0) |
| RAB3A |
RAB3A, member RAS oncogene family |
Literature-origin
|
1(1/0) |
| STX1A |
syntaxin 1A (brain) |
Literature-origin
|
1(1/0) |
| SLC1A6 |
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 |
Protein mapped
|
0(0/0) |
| DBH |
dopamine beta-hydroxylase (dopamine beta-monooxygenase) |
Literature-origin; Protein mapped
|
1(1/0) |
| SYN1 |
synapsin I |
Literature-origin; Protein mapped
|
1(1/0) |
| SNAP25 |
synaptosomal-associated protein, 25kDa |
Literature-origin; Protein mapped
|
1(1/0) |
