Gene Report

Basic Information

Approved Symbol	SYN1
Approved Name	synapsin I
Location	Xp11.2
Position	chrX:47479128-47479256 (-)
External Links	Entrez Gene: 6853 Ensembl: ENSG00000008056 UCSC: uc004die.3 HGNC ID: 11494
No. of Studies (Positive/Negative)	2(2/0)
Type	Literature-origin; Protein mapped

Positive relationships between SYN1 and MDD (count: 3)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
SYN1	Kang HJ, 2012	patients and normal controls		Here we use microarray gene profiling and electron microscop...... Here we use microarray gene profiling and electron microscopic stereology to reveal lower expression of synaptic-function-related genes (CALM2, SYN1, RAB3A, RAB4B and TUBB4) in the dlPFC of subjects with MDD and a corresponding lower number of synapses. We also identify a transcriptional repressor, GATA1, expression of which is higher in MDD More...
SYN1a	Cruceanu C, 2013	patients and normal controls	FC=2.20; P-value<0.01
SYN1b	Cruceanu C, 2013	patients and normal controls	FC=1.76; P-value<0.05

Positive relationships between SYN1 and other components at different levels (count: 0)

Positive relationship network of SYN1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between SYN1 and MDD (count: 0)

Negative relationships between SYN1 and other components at different levels (count: 0)

SYN1 related SNPs in MK4MDD (count: 0)

SYN1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Synapsin-1	P17600	1(1/0)	Literature-origin

SYN1 related GO terms (count: 21)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0007268	synaptic transmission	biological process	TAS[2110562]
GO:0008152	metabolic process	biological process	IEA
GO:0008021	synaptic vesicle	cellular component	TAS[16141272]
GO:0030054	cell junction	cellular component	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0048306	calcium-dependent protein binding	molecular function	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0005524	ATP binding	molecular function	TAS[15217342]
GO:0005794	Golgi apparatus	cellular component	IEA
GO:0043195	terminal bouton	cellular component	IEA
GO:0003779	actin binding	molecular function	IEA
GO:0046928	regulation of neurotransmitter secretion	biological process	TAS[21563316]
GO:0043209	myelin sheath	cellular component	IEA
GO:0005215	transporter activity	molecular function	TAS[2110562]
GO:0005829	cytosol	cellular component	IEA
GO:0048786	presynaptic active zone	cellular component	IEA
GO:0030425	dendrite	cellular component	IEA
GO:2000300	regulation of synaptic vesicle exocytosis	biological process	NAS[10099709]
GO:0019901	protein kinase binding	molecular function	ISS
GO:0007269	neurotransmitter secretion	biological process	IEA
GO:0005515	protein binding	molecular function	IPI[22163275]
GO:0003824	catalytic activity	molecular function	IEA

SYN1 related KEGG pathways (count: 0)

SYN1 related BioCarta pathways (count: 0)

SYN1 related Reactome pathways (count: 4)

ID	Name	Description
Gene mapped Reactome pathways
REACT_15425	serotonin neurotransmitter_release_cycle	Serotonin is synthesized in the serotonergic neurons in the ...... Serotonin is synthesized in the serotonergic neurons in the central nervous system and the enterochrommaffin cells of the gastroinetstinal system. Serotonin is loaded into the clathrin sculpted monoamine transport vesicles. The vesicles are docked, primed and release after the change in the membrane potential that activates voltage gated calcium channels and the reponse by several proetins to the changes in intracellular Ca2+ increase leads to fusion of the vesicle and release of serotonin into the synapse. More...
REACT_15293	dopamine neurotransmitter_release_cycle	Dopamine neurotransmitter cycle occurs in dopaminergic neuro...... Dopamine neurotransmitter cycle occurs in dopaminergic neurons. Dopamine is synthesized and loaded into the clathrin sculpted monoamine transport vesicles. The vesicles are docked, primed and fused with the plasmamembrane in the synapse to release dopamine into the synaptic cleft. More...
REACT_13477	transmission across_chemical_synapses	Chemical synapses are specialized junctions that are used fo...... Chemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron, muscle cell or glad cell. The pre and the post-synaptic cell are separated by a gap of 20nm called the synaptic cleft. The signals pass in a unidirection from pre-synaptic to post-synaptic. The pre-synaptic neuron communicates via the release of neurotransmitter which bind the receptors on the post-synaptic cell. More...
REACT_13723	neurotransmitter release_cycle	Neurotransmitter is stored in the synaptic vesicle in the pr...... Neurotransmitter is stored in the synaptic vesicle in the pre-synaptic terminal prior to its release in the synaptic cleft upon depolarization of the pre-synaptic membrane. The release of the neurotransmitter is a multi-step process that is controlled by electrical signals passing through the axons in form of action potential. Neurotransmitters include glutamate, acetylcholine, nor-epinephrine, dopamine and seratonin. Each of the neurotransmitter cycle is independently described. More...

SYN1 related interactors from protein-protein interaction data in HPRD (count: 26)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
SYN1	PFN2	No	in vitro	9463375
SYN1	PRKACA	No	in vitro	10571231 , 12237306
SYN1	PLCG1	No	in vitro	10899172
SYN1	SYN1	Yes	in vitro	9463375
SYN1	SYN2	Yes	in vitro;in vivo;yeast 2-hybrid	10358015
SYN1	KAT5	Yes	yeast 2-hybrid	16169070
SYN1	SYN3	Yes	in vitro;in vivo;yeast 2-hybrid	10358015
SYN1	PAK3	No	in vitro	12237306
SYN1	VIM	Yes	yeast 2-hybrid	16169070
SYN1	S100A1	No	in vitro;in vivo	15147519
SYN1	AMPH	Yes	in vitro;in vivo	10899172
SYN1	RASA1	No	in vivo	10899172
SYN1	MAPK3	No	in vitro;in vivo	10725920
SYN1	NOS1AP	No	in vivo	11867766
SYN1	PIK3R1	Yes	in vitro;in vivo	10899172
SYN1	BIN1	Yes	in vitro;in vivo	10899172
SYN1	SRC	No	in vivo	10899172
SYN1	CRK	No	in vivo	10899172
SYN1	CAMK2G	No	in vitro	3118371
SYN1	CAMK1	No	in vitro	10571231 , 12237306 , 9395448
SYN1	GRB2	No	in vitro;in vivo	10899172 , 8022809
SYN1	PAK2	No	in vitro;in vivo	10571231 , 12237306
SYN1	PAK1	No	in vitro	12237306
SYN1	NCF1	No	in vitro;in vivo	10899172
SYN1	CDK5	No	in vitro;in vivo	8702879
SYN1	SPTAN1	No	in vitro	1905928

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped Reactome pathways