
Gene Report
Approved Symbol | SYN1 |
---|---|
Approved Name | synapsin I |
Location | Xp11.2 |
Position | chrX:47431300-47479256 (-) |
External Links |
Entrez Gene: 6853 Ensembl: ENSG00000008056 UCSC: uc004die.3 HGNC ID: 11494 |
No. of Studies (Positive/Negative) | 1(1/0)
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Type | Literature-origin; Protein mapped |
Name in Literature | Reference | Research Type | Statistical Result | Relation Description | ![]() |
---|---|---|---|---|---|
SYN1 | Kang HJ, 2012 | patients and normal controls | Here we use microarray gene profiling and electron microscop...... Here we use microarray gene profiling and electron microscopic stereology to reveal lower expression of synaptic-function-related genes (CALM2, SYN1, RAB3A, RAB4B and TUBB4) in the dlPFC of subjects with MDD and a corresponding lower number of synapses. We also identify a transcriptional repressor, GATA1, expression of which is higher in MDD More... |
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus | Protein and Other Molecule | Cell and Molecular Pathway | Neural System | Cognition and Behavior | Symptoms and Signs | Environment | MDD |
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2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Approved Name | UniportKB | No. of Studies (Positive/Negative) | Source | |
---|---|---|---|---|
Synapsin-1 | P17600 | 1(1/0) | Literature-origin |
Literature-origin GO terms | ||||
ID | Name | Type | Evidence | |
---|---|---|---|---|
GO:0032553 | ribonucleotide binding | molecular function | IEA | |
GO:0007268 | synaptic transmission | biological process | TAS[2110562] | |
GO:0030054 | cell junction | cellular component | IEA |
Gene mapped GO terms | ||||
ID | Name | Type | Evidence | |
---|---|---|---|---|
GO:0003824 | catalytic activity | molecular function | IEA | |
GO:0000795 | synaptonemal complex | cellular component | IEA | |
GO:0007269 | neurotransmitter secretion | biological process | IEA | |
GO:0005794 | Golgi apparatus | cellular component | IEA | |
GO:0005215 | transporter activity | molecular function | TAS[2110562] | |
GO:0030425 | dendrite | cellular component | IEA | |
GO:0048786 | presynaptic active zone | cellular component | IEA | |
GO:0003779 | actin binding | molecular function | IEA | |
GO:0005829 | cytosol | cellular component | IEA | |
GO:0030672 | synaptic vesicle membrane | cellular component | IEA | |
GO:0005524 | ATP binding | molecular function | IEA |
Gene mapped Reactome pathways | |||
ID | Name | Description | |
---|---|---|---|
REACT_15425 | serotonin neurotransmitter_release_cycle | Serotonin is synthesized in the serotonergic neurons in the ...... Serotonin is synthesized in the serotonergic neurons in the central nervous system and the enterochrommaffin cells of the gastroinetstinal system. Serotonin is loaded into the clathrin sculpted monoamine transport vesicles. The vesicles are docked, primed and release after the change in the membrane potential that activates voltage gated calcium channels and the reponse by several proetins to the changes in intracellular Ca2+ increase leads to fusion of the vesicle and release of serotonin into the synapse. More... | |
REACT_15293 | dopamine neurotransmitter_release_cycle | Dopamine neurotransmitter cycle occurs in dopaminergic neuro...... Dopamine neurotransmitter cycle occurs in dopaminergic neurons. Dopamine is synthesized and loaded into the clathrin sculpted monoamine transport vesicles. The vesicles are docked, primed and fused with the plasmamembrane in the synapse to release dopamine into the synaptic cleft. More... | |
REACT_13477 | transmission across_chemical_synapses | Chemical synapses are specialized junctions that are used fo...... Chemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron, muscle cell or glad cell. The pre and the post-synaptic cell are separated by a gap of 20nm called the synaptic cleft. The signals pass in a unidirection from pre-synaptic to post-synaptic. The pre-synaptic neuron communicates via the release of neurotransmitter which bind the receptors on the post-synaptic cell. More... | |
REACT_13723 | neurotransmitter release_cycle | Neurotransmitter is stored in the synaptic vesicle in the pr...... Neurotransmitter is stored in the synaptic vesicle in the pre-synaptic terminal prior to its release in the synaptic cleft upon depolarization of the pre-synaptic membrane. The release of the neurotransmitter is a multi-step process that is controlled by electrical signals passing through the axons in form of action potential. Neurotransmitters include glutamate, acetylcholine, nor-epinephrine, dopamine and seratonin. Each of the neurotransmitter cycle is independently described. More... |

Gene | Interactor | Interactor in MK4MDD? | Experiment Type | PMID | |
---|---|---|---|---|---|
SYN1 | PAK1 | No | in vitro | 12237306 | |
SYN1 | NOS1AP | No | in vivo | 11867766 | |
SYN1 | PIK3R1 | Yes | in vitro;in vivo | 10899172 | |
SYN1 | BIN1 | Yes | in vitro;in vivo | 10899172 | |
SYN1 | RASA1 | No | in vivo | 10899172 | |
SYN1 | CRK | No | in vivo | 10899172 | |
SYN1 | CAMK1 | No | in vitro | 10571231 , 12237306 , 9395448 | |
SYN1 | SPTAN1 | No | in vitro | 1905928 | |
SYN1 | PAK2 | No | in vitro;in vivo | 10571231 , 12237306 | |
SYN1 | KAT5 | Yes | yeast 2-hybrid | 16169070 | |
SYN1 | SYN2 | Yes | in vitro;in vivo;yeast 2-hybrid | 10358015 | |
SYN1 | CDK5 | No | in vitro;in vivo | 8702879 | |
SYN1 | SRC | No | in vivo | 10899172 | |
SYN1 | MAPK3 | No | in vitro;in vivo | 10725920 | |
SYN1 | NCF1 | No | in vitro;in vivo | 10899172 | |
SYN1 | CAMK2G | No | in vitro | 3118371 | |
SYN1 | AMPH | Yes | in vitro;in vivo | 10899172 | |
SYN1 | GRB2 | No | in vitro;in vivo | 10899172 , 8022809 | |
SYN1 | PLCG1 | No | in vitro | 10899172 | |
SYN1 | SYN3 | No | in vitro;in vivo;yeast 2-hybrid | 10358015 | |
SYN1 | PRKACA | No | in vitro | 10571231 , 12237306 | |
SYN1 | PFN2 | No | in vitro | 9463375 | |
SYN1 | S100A1 | No | in vitro;in vivo | 15147519 | |
SYN1 | PAK3 | No | in vitro | 12237306 | |
SYN1 | VIM | Yes | yeast 2-hybrid | 16169070 | |
SYN1 | SYN1 | Yes | in vitro | 9463375 |